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Protein

RNA-directed RNA polymerase

Gene

VP1

Organism
Avian infectious bursal disease virus (IBDV) (Gumboro disease virus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi259 – 266GTPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RDRP
Alternative name(s):
Protein VP1
Gene namesi
Name:VP1
OrganismiAvian infectious bursal disease virus (IBDV) (Gumboro disease virus)
Taxonomic identifieri10995 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesBirnaviridaeAvibirnavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Meleagris gallopavo (Wild turkey) [TaxID: 9103]

Subcellular locationi

  • Virion By similarity
  • Note: Minor amounts are incorporated in the virion.By similarity

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi401 – 403ADN → GDD: Increases polymerase activity. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002278801 – 881RNA-directed RNA polymeraseAdd BLAST881

Post-translational modificationi

May exist in multiple phosphorylated forms.

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Interactioni

Subunit structurei

Interacts with VP3 in the cytoplasm.1 Publication

Structurei

Secondary structure

1881
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Q6Q5
SMRiQ9Q6Q5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Q6Q5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini398 – 598RdRp catalyticPROSITE-ProRule annotationAdd BLAST201

Family and domain databases

InterProiView protein in InterPro
IPR007100 RNA-dir_pol_birnavirus
IPR007098 RNA-dir_pol_mononegavirus
PfamiView protein in Pfam
PF04197 Birna_RdRp, 1 hit
PROSITEiView protein in PROSITE
PS50524 RDRP_DSRNA_BIR, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Q6Q5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDIFNSPQA RSTISAAFGI KPTAGQDVEE LLIPKVWVPP EDPLASPSRL
60 70 80 90 100
AKFLRENGYK VLQPRSLPEN EEYETDQILP DLAWMRQIEG AVLKPTLSLP
110 120 130 140 150
IGDQEYFPKY YPTHRPSKEK PNAYPPDIAL LKQMIYLFLQ VPEANEGLKD
160 170 180 190 200
EVTLLTQNIR DKAYGSGTYM GQATRLVAMK EVATGRNPNK DPLKLGYTFE
210 220 230 240 250
SIAQLLDITL PVGPPGEDDK PWVPLTRVPS RMLVLTGDVD GDFEVEDYLP
260 270 280 290 300
KINLKSSSGL PYVGRTKGET IGEMIAISNQ FLRELSTLLK QGAGTKGSNK
310 320 330 340 350
KKLLSMLSDY WYLSCGLLFP KAERYDKSTW LTKTRNIWSA PSPTHLMISM
360 370 380 390 400
ITWPVMSNSP NNVLNIEGCP SLYKFNPFRG GLNRIVEWIL APEEPKALVY
410 420 430 440 450
ADNIYIVHSN TWYSIDLEKG EANCTRQHMQ AAMYYILTRG WSDNGDPMFN
460 470 480 490 500
QTWATFAMNI APALVVDSSC LIMNLQIKTY GQGSGNAATF INNHLLSTLV
510 520 530 540 550
LDQWNLMRQP RPDSEEFKSI EDKLGINFKI ERSIDDIRGK LRQLVLLAQP
560 570 580 590 600
GYLSGGVEPE QSSPTVELDL LGWSATYSKD LGIYVPVLDK ERLFCSAAYP
610 620 630 640 650
KGVENKSLKS KVGIEQAYKV VRYEALRLVG GWNYPLLNKA CKNNAGAARR
660 670 680 690 700
HLEAKGFPLD EFLAEWSELS EFGEAFEGFN IKLTVTSESL AELNKPVPPK
710 720 730 740 750
PPNVNRPVNT GGLKAVSNAL KTGRYRNEAG LSGLVLLATA RSRLQDAVKA
760 770 780 790 800
KAEAEKLHKS KPDDPDADWF ERSETLSDLL EKADIASKVA HSALVETSDA
810 820 830 840 850
LEAVQSTSVY TPKYPEVKNP QTASNPVVGL HLPAKRATGV QAALLGAGTS
860 870 880
RPMGMEAPTR SKNAVKMAKR RQRQKESRQQ P
Length:881
Mass (Da):97,911
Last modified:May 1, 2000 - v1
Checksum:i3FBB3EDB3B744D7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194429 mRNA Translation: AAF16083.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194429 mRNA Translation: AAF16083.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PGGX-ray2.50A31-804[»]
2PUSX-ray2.40A1-845[»]
2QJ1X-ray3.48A5-845[»]
2R70X-ray2.70A1-845[»]
2R72X-ray3.15A1-845[»]
ProteinModelPortaliQ9Q6Q5
SMRiQ9Q6Q5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Q6Q5

Family and domain databases

InterProiView protein in InterPro
IPR007100 RNA-dir_pol_birnavirus
IPR007098 RNA-dir_pol_mononegavirus
PfamiView protein in Pfam
PF04197 Birna_RdRp, 1 hit
PROSITEiView protein in PROSITE
PS50524 RDRP_DSRNA_BIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRDRP_IBDV
AccessioniPrimary (citable) accession number: Q9Q6Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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