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Entry version 51 (07 Oct 2020)
Sequence version 1 (01 May 2000)
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Protein

RNA2 polyprotein

Gene
N/A
Organism
Broad bean wilt virus 2 (BBWV-2)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as suppressor of post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (PubMed:25173697). Binds ssRNA (PubMed:25173697).1 Publication
Transports the viral genome to neighboring plant cells directly through plasmosdesmata, without any budding (PubMed:19463725). The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier (PubMed:19463725). Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids (PubMed:20832435, PubMed:26903400). Binds to GTP and to single-stranded RNA and single-stranded DNA in a non-sequence-specific manner (PubMed:12021864). Also acts as suppressor of post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (PubMed:25173697).5 Publications
Together with the small capsid protein, forms an icosahedral capsid (T=3) enclosing the viral positive strand RNA genome, with a diameter of approximately 300 Angstroms (By similarity). The large capsid protein interacts with the viral RNA (By similarity). Also acts as suppressor of post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (PubMed:25173697). Binds ssRNA (PubMed:25173697).By similarity1 Publication
Together with the large capsid protein, forms an icosahedral capsid (T=3) enclosing the viral positive strand RNA genome, with a diameter of approximately 300 Angstroms (By similarity). The capsid is formed from 60 copies each of the large and the small capsid protein. The small capsid protein forms the turrets at the fivefold axes of the viral particle (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding, Suppressor of RNA silencing, Viral movement protein
Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA2 polyprotein
Alternative name(s):
119kDa protein
Genome polyprotein M
Cleaved into the following 4 chains:
Alternative name(s):
53 kDa protein
Movement protein
Short name:
MP
Alternative name(s):
37 kDa protein
VP37
Large capsid protein
Short name:
LCP
Alternative name(s):
44 kDa protein
Small capsid protein
Short name:
SCP
Alternative name(s):
22 kDa protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBroad bean wilt virus 2 (BBWV-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri76875 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesPicornaviralesSecoviridaeComovirinaeFabavirus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host cell junction, Host endoplasmic reticulum, T=3 icosahedral capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004458631 – 1065RNA2 polyproteinAdd BLAST1065
ChainiPRO_00004458641 – 466VP53Add BLAST466
ChainiPRO_0000445865129 – 466Movement proteinAdd BLAST338
ChainiPRO_0000445866467 – 868Large capsid proteinAdd BLAST402
ChainiPRO_0000445867869 – 1065Small capsid proteinAdd BLAST197

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages by picornain 3C-like protease in vivo yield mature proteins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei466 – 467Cleavage; by viral proteaseBy similarity2
Sitei868 – 869Cleavage; by viral proteaseBy similarity2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the large capsid protein (By similarity).

Interacts with the movement protein (via C-terminus) (PubMed:19463725).

By similarity1 Publication

Interacts with the small capsid protein (By similarity). Homomultimer; assembles as pentons (By similarity).

By similarity

Interacts (via C-terminus) with the small capsid protein (PubMed:19463725).

1 Publication

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus is important for targeting the movement protein to the plasmodesmata.1 Publication
The N-terminus is involved in ssRNA-binding.1 Publication

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003181, Como_LCP
IPR003182, RNA2_polyprotein
IPR029053, Viral_coat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02247, Como_LCP, 1 hit
PF02248, Como_SCP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform RNA2 polyprotein (identifier: Q9Q2Q3-1) [UniParc]FASTAAdd to basket
Also known as: 119kDa protein

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPELVAVLD RYFSEIISCF FLGWLLNFLL VWFCSTKSTF LLWSVFLYIC
60 70 80 90 100
YYILRIEFAY IVAPFLKTIY TNSSQYHTVD WAYAYTALPK GLWEQITDYN
110 120 130 140 150
YCYNFPPPRV EGFVSDFSPR FTLKELEIMN EANITPVHTI PKDTLLKRAS
160 170 180 190 200
DYKLAVESKK SILPRVQDLY EMDKWHNLRS KLSKNAPSYV TTSEIAVGAM
210 220 230 240 250
SGAGNTKLAI PVVEKYTEEV ADDRLPDRVR AKADQIMVAA IELVADGFAS
260 270 280 290 300
VNSDVTMAGA LYDKRHKTIA SSFKGAFASR ASGVPSHVIY FPMHRVPACD
310 320 330 340 350
DPNTTLELSM VSRDSDFDEG YTLANISART LYVRAKGPEK VTETRHLLKA
360 370 380 390 400
KTEDVVKARQ FASEAQVVFA TPRLFPEVNL DNYNLPGPSN AQQTEAITTD
410 420 430 440 450
RGILFPKPKF KGNEVVLNYT GSGKIRNVGS QRFETKKNAT GEQFVRSVDD
460 470 480 490 500
LGCLSDEDGK DYRYGQGLME EDVLNVQTNN FAIESATETM RLLFSGYASI
510 520 530 540 550
PLNVIPGTKI TVAYLNELSK HSAVHTGLLN MLSKIPGSLK VKINCQVAPT
560 570 580 590 600
CGIGLAVSYV EGNESANLGS SLGRLLGIQH YKWNPAIEPY VEFVFKPFSC
610 620 630 640 650
ADWWNMHYLG SFKFAPVVVI QTLSKWLNAP KVDARISFAI YYEPTVVLPK
660 670 680 690 700
QIATLEHAPA FMFRKEVGTL AFKQGERVAY SFEVNLGKPQ TDGKEVTSTF
710 720 730 740 750
ASSYCGLSQY MQSDVILDFT LMSSPMIGGT FSIAYVAGAY IEKVGNMQIL
760 770 780 790 800
DSLPHIDFTF SSGSKSTRSV RFPKEVFGVY QALDRWDLDS ARGDDVSGNF
810 820 830 840 850
VLYQRDAVSS ALEGELTFRI AARLSGDISF TGVSAGYPTT ITRIGKGKTI
860 870 880 890 900
GRSLDPEIRK PLRYMLGQAH ATPKDFSSVR FVMGHWKYRA GLYPGSKSDE
910 920 930 940 950
DIHPFSLKMR LDGSKSSENF EIIHSPFVRL LQNCAWMRGT LRFYVVARAS
960 970 980 990 1000
SDYMSYRRTS QLTVSAHENS LSSNQFYSGV LTSPSGELSF SREVVGPVDG
1010 1020 1030 1040 1050
FASMGWNVRG SKKFYKIHVE MGNVHEYDTV VLYGQFDSNV EFAGQRKGGH
1060
YLLEKETPIF KTIKY
Length:1,065
Mass (Da):119,214
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3B9CDF05AF74A7D
GO
Isoform RNA2 polyprotein 104kDa (identifier: Q9Q2Q3-2) [UniParc]FASTAAdd to basket
Also known as: 104kDa protein

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Show »
Length:937
Mass (Da):103,868
Checksum:i43568360457802D5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0599831 – 128Missing in isoform RNA2 polyprotein 104kDa. Add BLAST128

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ132844 Genomic RNA Translation: CAB63086.1
AJ132844 Genomic RNA Translation: CAB63085.1

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132844 Genomic RNA Translation: CAB63086.1
AJ132844 Genomic RNA Translation: CAB63085.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di2.60.120.20, 2 hits
InterProiView protein in InterPro
IPR003181, Como_LCP
IPR003182, RNA2_polyprotein
IPR029053, Viral_coat
PfamiView protein in Pfam
PF02247, Como_LCP, 1 hit
PF02248, Como_SCP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOL2_BBWV2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Q2Q3
Secondary accession number(s): Q9Q2Q2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2018
Last sequence update: May 1, 2000
Last modified: October 7, 2020
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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