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Entry version 102 (19 Jan 2022)
Sequence version 1 (01 May 2000)
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Submitted name:

V-1 protease



Human immunodeficiency virus 1
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl proteaseARBA annotation, Hydrolase, Protease

Protein family/group databases

MEROPS protease database


<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
V-1 proteaseImported
<p>This subsection of the <a href="">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman immunodeficiency virus 1Imported
<p>This subsection of the <a href="">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11676 [NCBI]
<p>This subsection of the <a href="">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaPararnaviraeArtverviricotaRevtraviricetesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
<p>This subsection of the <a href="">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="">IntAct database</a>. It is updated at every <a href="">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
ANKZF1 [Q9H8Y5] from Homo sapiens.2EBI-6248094,EBI-724848
ARRB2 [P32121] from Homo sapiens.3EBI-6248094,EBI-714559
CCAR2 [Q8N163] from Homo sapiens.5EBI-6248094,EBI-355410
DIAPH1 [O60610] from Homo sapiens.2EBI-6248094,EBI-3959709
DOK1 [Q99704] from Homo sapiens.2EBI-6248094,EBI-1384360
EIF3A [Q14152] from Homo sapiens.5EBI-6248094,EBI-366617
EIF3C [Q99613] from Homo sapiens.5EBI-6248094,EBI-353741
EIF3D [O15371] from Homo sapiens.5EBI-6248094,EBI-353818
EIF3E [P60228] from Homo sapiens.5EBI-6248094,EBI-347740
EIF3F [O00303] from Homo sapiens.3EBI-6248094,EBI-711990
EIF3H [O15372] from Homo sapiens.3EBI-6248094,EBI-709735
EIF3K [Q9UBQ5] from Homo sapiens.5EBI-6248094,EBI-354344
EIF3L [Q9Y262] from Homo sapiens.5EBI-6248094,EBI-373519
EIF3M [Q7L2H7] from Homo sapiens.2EBI-6248094,EBI-353901
FNIP1 [Q8TF40] from Homo sapiens.3EBI-6248094,EBI-2946919
FOXC1 [Q12948] from Homo sapiens.3EBI-6248094,EBI-1175253
IFT122 [Q9HBG6] from Homo sapiens.3EBI-6248094,EBI-2805994
LIMD1 [Q9UGP4] from Homo sapiens.5EBI-6248094,EBI-2652871
MCM4 [P33991] from Homo sapiens.3EBI-6248094,EBI-374938
NFU1 [Q9UMS0] from Homo sapiens.3EBI-6248094,EBI-725252
OSBPL3 [Q9H4L5] from Homo sapiens.5EBI-6248094,EBI-1051317
OSBPL6 [Q9BZF3] from Homo sapiens.3EBI-6248094,EBI-2372709
PARP4 [Q9UKK3] from Homo sapiens.3EBI-6248094,EBI-2623021
POLE3 [Q9NRF9] from Homo sapiens.5EBI-6248094,EBI-744901
POLE4 [Q9NR33] from Homo sapiens.2EBI-6248094,EBI-867034
PUM2 [Q8TB72] from Homo sapiens.3EBI-6248094,EBI-311190
SF3A3 [Q12874] from Homo sapiens.3EBI-6248094,EBI-1051880
TRPS1 [Q9UHF7] from Homo sapiens.3EBI-6248094,EBI-2556151
VBP1 [P61758] from Homo sapiens.3EBI-6248094,EBI-357430
ZNRD2 [O60232] from Homo sapiens.4EBI-6248094,EBI-741415

Protein-protein interaction databases

Protein interaction database and analysis system

Q9Q2G4, 55 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models


Database of comparative protein structure models


<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 89Peptidase A2InterPro annotationAdd BLAST70

Family and domain databases

Conserved Domains Database

cd05482, HIV_retropepsin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

Gene3Di, 1 hit

Integrated resource of protein families, domains and functional sites

View protein in InterPro
IPR001969, Aspartic_peptidase_AS
IPR001995, Peptidase_A2_cat
IPR021109, Peptidase_aspartic_dom_sf
IPR034170, Retropepsin-like_cat_dom
IPR018061, Retropepsins

Pfam protein domain database

View protein in Pfam
PF00077, RVP, 1 hit

Superfamily database of structural and functional annotation

SSF50630, SSF50630, 1 hit

PROSITE; a protein domain and family database

View protein in PROSITE
PS50175, ASP_PROT_RETROV, 1 hit
PS00141, ASP_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="">length</a> and <a href="">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="">Sequence</a> section indicates if the <a href="">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q9Q2G4-1 [UniParc]FASTAAdd to basket
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        10         20         30         40         50
60 70 80 90
Mass (Da):10,820
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i189F5EE42D82533D

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei99Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database


GenBank nucleotide sequence database


DNA Data Bank of Japan; a nucleotide sequence database

Links Updated
AJ279608 mRNA Translation: CAB66021.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
Links Updated
AJ279608 mRNA Translation: CAB66021.1

3D structure databases


Protein-protein interaction databases

IntActiQ9Q2G4, 55 interactors

Protein family/group databases


Family and domain databases

CDDicd05482, HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001969, Aspartic_peptidase_AS
IPR001995, Peptidase_A2_cat
IPR021109, Peptidase_aspartic_dom_sf
IPR034170, Retropepsin-like_cat_dom
IPR018061, Retropepsins
PfamiView protein in Pfam
PF00077, RVP, 1 hit
SUPFAMiSSF50630, SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175, ASP_PROT_RETROV, 1 hit
PS00141, ASP_PROTEASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations


<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9Q2G4_9HIV1
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Q2G4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: January 19, 2022
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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