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Protein

T-box transcription factor TBX5

Gene

TBX5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. May bind to the core DNA motif of promoters.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi63 – 238T-boxPROSITE-ProRule annotationBy similarityAdd BLAST176

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX5
Short name:
T-box protein 5
Gene namesi
Name:TBX5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002624671 – 521T-box transcription factor TBX5Add BLAST521

Proteomic databases

PaxDbiQ9PWE8
PRIDEiQ9PWE8

Expressioni

Developmental stagei

Early in the developing heart, uniformly expressed throughout the entire cardiac crescent. Upon formation of the linear heart tube, expressed in a graded fashion, stronger near the posterior end and weaker at the anterior end. As the heart tube loops, asymmetric expression continues; it is expressed in the presumptive left ventricle, but not the right ventricle or outflow tract. This pattern of expression is maintained in more mature hearts (PubMed:10373308). First detected in the presumptive wing and leg mesoderm respectively at around stages 14-15. As limb outgrowth proceeds, expressed throughout the mesoderm and in the wing (PubMed:9550719).2 Publications

Gene expression databases

BgeeiENSGALG00000008253
ExpressionAtlasiQ9PWE8 baseline and differential

Interactioni

Subunit structurei

Monomer. Homodimer (via the T-box); binds DNA as homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PDLIM7Q679P34EBI-6663870,EBI-6693710

GO - Molecular functioni

  • chaperone binding Source: AgBase
  • LIM domain binding Source: AgBase
  • scaffold protein binding Source: AgBase
  • transcription factor binding Source: Ensembl

Protein-protein interaction databases

IntActiQ9PWE8, 1 interactor
STRINGi9031.ENSGALP00000013419

Structurei

3D structure databases

ProteinModelPortaliQ9PWE8
SMRiQ9PWE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The T-Box domain binds to double-stranded DNA.By similarity

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
HOGENOMiHOG000286001
HOVERGENiHBG007310
InParanoidiQ9PWE8
KOiK10179
OrthoDBiEOG091G0I8R
PhylomeDBiQ9PWE8
TreeFamiTF106341

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PWE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTEEGFGL PSTPVDSEAK ELQAEAKQDP QLGTTSKAPT SPQAAFTQQG
60 70 80 90 100
MEGIKVFLHE RELWLKFHEV GTEMIITKAG RRMFPSYKVK VTGLNPKTKY
110 120 130 140 150
ILLMDIVPAD DHRYKFADNK WSVTGKAEPA MPGRLYVHPD SPATGAHWMR
160 170 180 190 200
QLVSFQKLKL TNNHLDPFGH IILNSMHKYQ PRLHIVKADE NNGFGSKNTA
210 220 230 240 250
FCTHVFPETA FIAVTSYQNH KITQLKIENN PFAKGFRGSD DMELHRMSRM
260 270 280 290 300
QSKEYPVVPR STVRQKVSSN HSPFSGETRV LSTSSNLGSQ YQCENGVSST
310 320 330 340 350
SQDLLPPTNP YPISQEHSQI YHCTKRKDEE CSTTEHPYKK PYMETSPAEE
360 370 380 390 400
DPFYRSSYPQ QQGLNTSYRT ESAQRQACMY ASSAPPTDPV PSLEDISCNT
410 420 430 440 450
WPSVPSYSSC TVSAMQPMDR LPYQHFSAHF TSGPLMPRLS SVANHTSPQI
460 470 480 490 500
GDTHSMFQHQ TSVSHQPIVR QCGPQTGIQS PPSSLQPAEF LYSHGVPRTL
510 520
SPHQYHSVHG VGMVPEWSEN S
Length:521
Mass (Da):58,402
Last modified:May 1, 2000 - v1
Checksum:i17633D0F1DBCE30B
GO

Sequence cautioni

The sequence AAC41299 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033671 mRNA Translation: AAC41299.1 Frameshift.
AF069396 mRNA Translation: AAC23683.2
RefSeqiNP_989504.1, NM_204173.1
XP_015150318.1, XM_015294832.1
UniGeneiGga.961

Genome annotation databases

EnsembliENSGALT00000013434; ENSGALP00000013419; ENSGALG00000008253
GeneIDi373988
KEGGigga:373988

Similar proteinsi

Entry informationi

Entry nameiTBX5_CHICK
AccessioniPrimary (citable) accession number: Q9PWE8
Secondary accession number(s): O73719
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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