T-box transcription factor TBX5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chaperone binding Source: AgBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "An evolutionarily conserved nuclear export signal facilitates cytoplasmic localization of the Tbx5 transcription factor."
    Kulisz A., Simon H.G.
    Mol. Cell. Biol. 28:1553-1564(2008) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: UniProtKB
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: UniProtKB
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
• LIM domain binding Source: AgBaseInferred from physical interactionⁱ
  • "Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development."
    Krause A., Zacharias W., Camarata T., Linkhart B., Law E., Lischke A., Miljan E., Simon H.-G.
    Dev. Biol. 273:106-120(2004) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II activating transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• scaffold protein binding Source: AgBaseInferred from physical interactionⁱ
  • "LMP4 regulates Tbx5 protein subcellular localization and activity."
    Camarata T., Bimber B., Kulisz A., Chew T.L., Yeung J., Simon H.G.
    J. Cell Biol. 174:339-348(2006) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: UniProtKB

GO - Biological processⁱ

• animal organ development Source: UniProtKB
• atrial septum morphogenesis Source: Ensembl
• atrioventricular valve morphogenesis Source: Ensembl
• bundle of His development Source: Ensembl
• cardiac left ventricle formation Source: BHF-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Reptilian heart development and the molecular basis of cardiac chamber evolution."
    Koshiba-Takeuchi K., Mori A.D., Kaynak B.L., Cebra-Thomas J., Sukonnik T., Georges R.O., Latham S., Beck L., Beck L., Henkelman R.M., Black B.L., Olson E.N., Wade J., Takeuchi J.K., Nemer M., Gilbert S.F., Bruneau B.G.
    Nature 461:95-98(2009) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle cell differentiation Source: Ensembl
• cell-cell signaling Source: UniProtKB
• cell fate specification Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• embryonic forelimb morphogenesis Source: AgBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade."
    Takeuchi J.K., Koshiba-Takeuchi K., Suzuki T., Kamimura M., Ogura K., Ogura T.
    Development 130:2729-2739(2003) [PubMed] [Europe PMC] [Abstract]
• embryonic limb morphogenesis Source: UniProtKB
• endocardial cushion development Source: Ensembl
• heart development Source: UniProtKB
• hindlimb morphogenesis Source: AgBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development."
    Krause A., Zacharias W., Camarata T., Linkhart B., Law E., Lischke A., Miljan E., Simon H.-G.
    Dev. Biol. 273:106-120(2004) [PubMed] [Europe PMC] [Abstract]
• limb bud formation Source: AgBaseInferred from mutant phenotypeⁱ
  • "Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade."
    Takeuchi J.K., Koshiba-Takeuchi K., Suzuki T., Kamimura M., Ogura K., Ogura T.
    Development 130:2729-2739(2003) [PubMed] [Europe PMC] [Abstract]
• limb development Source: AgBaseTraceable author statementⁱ
  • "Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development."
    Krause A., Zacharias W., Camarata T., Linkhart B., Law E., Lischke A., Miljan E., Simon H.-G.
    Dev. Biol. 273:106-120(2004) [PubMed] [Europe PMC] [Abstract]
• lung development Source: Ensembl
• morphogenesis of an epithelium Source: Ensembl
• negative regulation of cardiac muscle cell proliferation Source: UniProtKB
• negative regulation of cell migration Source: UniProtKB
• negative regulation of cell population proliferation Source: UniProtKB
• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• pattern specification process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• pericardium development Source: UniProtKB
• positive regulation of cardiac muscle cell proliferation Source: Ensembl
• positive regulation of cardioblast differentiation Source: UniProtKB
• positive regulation of secondary heart field cardioblast proliferation Source: Ensembl
• positive regulation of transcription, DNA-templated Source: AgBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "LMP4 regulates Tbx5 protein subcellular localization and activity."
    Camarata T., Bimber B., Kulisz A., Chew T.L., Yeung J., Simon H.G.
    J. Cell Biol. 174:339-348(2006) [PubMed] [Europe PMC] [Abstract]
  • "An evolutionarily conserved nuclear export signal facilitates cytoplasmic localization of the Tbx5 transcription factor."
    Kulisz A., Simon H.G.
    Mol. Cell. Biol. 28:1553-1564(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: UniProtKB
• regulation of gene expression Source: AgBaseInferred from mutant phenotypeⁱ
  • "Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade."
    Takeuchi J.K., Koshiba-Takeuchi K., Suzuki T., Kamimura M., Ogura K., Ogura T.
    Development 130:2729-2739(2003) [PubMed] [Europe PMC] [Abstract]
• response to retinoic acid Source: AgBaseTraceable author statementⁱ
  • "Gene expression of FK506-binding proteins 12.6 and 12 during chicken development."
    Yazawa S., Obata K., Iio A., Koide M., Yokota M., Sasaki S., Kagami H., Ono T.
    Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 136:391-399(2003) [PubMed] [Europe PMC] [Abstract]
• ventricular septum development Source: BHF-UCLInferred from expression patternⁱ
  • "Reptilian heart development and the molecular basis of cardiac chamber evolution."
    Koshiba-Takeuchi K., Mori A.D., Kaynak B.L., Cebra-Thomas J., Sukonnik T., Georges R.O., Latham S., Beck L., Beck L., Henkelman R.M., Black B.L., Olson E.N., Wade J., Takeuchi J.K., Nemer M., Gilbert S.F., Bruneau B.G.
    Nature 461:95-98(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• chaperone binding Source: AgBaseInferred from physical interactionⁱ
  • "An evolutionarily conserved nuclear export signal facilitates cytoplasmic localization of the Tbx5 transcription factor."
    Kulisz A., Simon H.G.
    Mol. Cell. Biol. 28:1553-1564(2008) [PubMed] [Europe PMC] [Abstract]
• LIM domain binding Source: AgBaseInferred from physical interactionⁱ
  • "Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development."
    Krause A., Zacharias W., Camarata T., Linkhart B., Law E., Lischke A., Miljan E., Simon H.-G.
    Dev. Biol. 273:106-120(2004) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II activating transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• scaffold protein binding Source: AgBaseInferred from physical interactionⁱ
  • "LMP4 regulates Tbx5 protein subcellular localization and activity."
    Camarata T., Bimber B., Kulisz A., Chew T.L., Yeung J., Simon H.G.
    J. Cell Biol. 174:339-348(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MADTEEGFGL PSTPVDSEAK ELQAEAKQDP QLGTTSKAPT SPQAAFTQQG 
        60         70         80         90        100
MEGIKVFLHE RELWLKFHEV GTEMIITKAG RRMFPSYKVK VTGLNPKTKY 
       110        120        130        140        150
ILLMDIVPAD DHRYKFADNK WSVTGKAEPA MPGRLYVHPD SPATGAHWMR 
       160        170        180        190        200
QLVSFQKLKL TNNHLDPFGH IILNSMHKYQ PRLHIVKADE NNGFGSKNTA 
       210        220        230        240        250
FCTHVFPETA FIAVTSYQNH KITQLKIENN PFAKGFRGSD DMELHRMSRM 
       260        270        280        290        300
QSKEYPVVPR STVRQKVSSN HSPFSGETRV LSTSSNLGSQ YQCENGVSST 
       310        320        330        340        350
SQDLLPPTNP YPISQEHSQI YHCTKRKDEE CSTTEHPYKK PYMETSPAEE 
       360        370        380        390        400
DPFYRSSYPQ QQGLNTSYRT ESAQRQACMY ASSAPPTDPV PSLEDISCNT 
       410        420        430        440        450
WPSVPSYSSC TVSAMQPMDR LPYQHFSAHF TSGPLMPRLS SVANHTSPQI 
       460        470        480        490        500
GDTHSMFQHQ TSVSHQPIVR QCGPQTGIQS PPSSLQPAEF LYSHGVPRTL 
       510        520 
SPHQYHSVHG VGMVPEWSEN S                                

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ