UniProtKB - Q9PVN4 (Q9PVN4_CHICK)
Protein
Left-right determination factor
Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-UniRule
- growth factor activity Source: UniProtKB-UniRule
- transforming growth factor beta receptor binding Source: InterPro
GO - Biological processi
- embryonic digestive tract development Source: AgBase
- response to protozoan Source: AgBase
- spleen development Source: AgBase
Keywordsi
Molecular function | CytokineUniRule annotation, Developmental proteinUniRule annotation, Growth factorUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Left-right determination factorUniRule annotation |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-UniRule
Keywords - Cellular componenti
SecretedUniRule annotationARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5004331163 | 21 – 362 | Left-right determination factorSequence analysisAdd BLAST | 342 |
Keywords - PTMi
Cleavage on pair of basic residuesARBA annotationInteractioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-UniRule
- growth factor activity Source: UniProtKB-UniRule
- transforming growth factor beta receptor binding Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 240 – 351 | TGF_BETA_2InterPro annotationAdd BLAST | 112 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
PhylomeDBi | Q9PVN4 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR003942, LRDF IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF037402, TGFb4, 1 hit |
PRINTSi | PR01427, TGFBETA4 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9PVN4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVSFTRMLY VLCLVAMACA FTQEGFKEVM LKQLGLSEVP KLHKRDLVDL
60 70 80 90 100
VIPEHVKNKY ISMLKRHRGK RRASPSLASI LQGIPGNAEV FYSDPMRQNF
110 120 130 140 150
IFDMEGRIPK NSEVTMAELK LFKKPLDRVN LPARQPHRPV SNARVSIYWV
160 170 180 190 200
QRQHDGTNRT SLIDSRLVPI RESGWKNFDV TQAVHYWLRN KRQEPMVLQV
210 220 230 240 250
WIEGERVASY AAEVAKSVRF TSQDAGDRAV GRPELVLYTL DLEDYGGPGD
260 270 280 290 300
CKDGVQAGKS TCCRQKHYIN FRELSWTQYW VIEPAGYQAY SCRGGCLQLP
310 320 330 340 350
GPLQLWGGRE RACAVAESSP LPIMYLVRRG NHTEIEATEF PNMIIEKCSC
360
MADGADFCEG LT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB031398 mRNA Translation: BAA85114.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB031398 mRNA Translation: BAA85114.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Phylogenomic databases
PhylomeDBi | Q9PVN4 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR003942, LRDF IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF037402, TGFb4, 1 hit |
PRINTSi | PR01427, TGFBETA4 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9PVN4_CHICK | |
Accessioni | Q9PVN4Primary (citable) accession number: Q9PVN4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |