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UniProtKB - Q9PVK4 (LDHBA_DANRE)
Protein
L-lactate dehydrogenase B-A chain
Gene
ldhba
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- EC:1.1.1.27
: pyruvate fermentation to lactate Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate. This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 100 | NADBy similarity | 1 | |
Binding sitei | 107 | SubstrateBy similarity | 1 | |
Binding sitei | 139 | NADBy similarity | 1 | |
Binding sitei | 139 | SubstrateBy similarity | 1 | |
Binding sitei | 170 | SubstrateBy similarity | 1 | |
Active sitei | 194 | Proton acceptorBy similarity | 1 | |
Binding sitei | 249 | SubstrateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 30 – 58 | NADBy similarityAdd BLAST | 29 |
GO - Molecular functioni
- L-lactate dehydrogenase activity Source: GO_Central
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- carboxylic acid metabolic process Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-DRE-70268, Pyruvate metabolism |
UniPathwayi | UPA00554;UER00611 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ldhba Synonyms:ldhb ORF Names:si:dkey-13i19.5 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-991026-6, ldhba |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000168475 | 2 – 334 | L-lactate dehydrogenase B-A chainAdd BLAST | 333 |
Proteomic databases
PaxDbi | Q9PVK4 |
PRIDEi | Q9PVK4 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000019644, Expressed in brain and 49 other tissues |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
IntActi | Q9PVK4, 1 interactor |
MINTi | Q9PVK4 |
STRINGi | 7955.ENSDARP00000013329 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1495, Eukaryota |
GeneTreei | ENSGT00940000153525 |
HOGENOMi | CLU_045401_0_2_1 |
InParanoidi | Q9PVK4 |
OMAi | FRYIMAE |
OrthoDBi | 1204514at2759 |
PhylomeDBi | Q9PVK4 |
TreeFami | TF314963 |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
HAMAPi | MF_00488, Lactate_dehydrog, 1 hit |
InterProi | View protein in InterPro IPR001557, L-lactate/malate_DH IPR011304, L-lactate_DH IPR018177, L-lactate_DH_AS IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102, Lac_mal_DH, 1 hit |
PRINTSi | PR00086, LLDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01771, L-LDH-NAD, 1 hit |
PROSITEi | View protein in PROSITE PS00064, L_LDH, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9PVK4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASVMQKLIT PLASGPAEPP RNKVTIVGVG QVGMACAVSV LLRELADELA
60 70 80 90 100
LVDVVEDRLK GEMLDLQHGS LFLKTPKIVA DKDYSVTANS RIVVVTAGVR
110 120 130 140 150
QQEGESRLNL VQRNVNIFKH IIPQIVKYSP DCILVVVSNP VDVLTYVTWK
160 170 180 190 200
LSGLPKHRVI GSGTNLDSAR FRYIMAEKLG IHASSFNGYI LGEHGDTSVP
210 220 230 240 250
VWSGANVAGV SLQKLNPDIG TDKDAENWKE AHKMVVDSAY EVIKLKGYTN
260 270 280 290 300
WAIGLSVADL TETLVKNLNR VHPVSTMVKG MYGINEEVYL SLPCVLNSSG
310 320 330
VGSVINMTLT DGEIGQLKSS ADTLWGIQKD LKDL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 164 | T → P in AAF02213 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF067202 mRNA Translation: AAF02213.1 BX649476 Genomic DNA Translation: CAI20632.1 BC044190 mRNA Translation: AAH44190.1 BC068981 mRNA Translation: AAH68981.1 |
RefSeqi | NP_571322.1, NM_131247.1 |
Genome annotation databases
Ensembli | ENSDART00000010777; ENSDARP00000013329; ENSDARG00000019644 ENSDART00000179867; ENSDARP00000156680; ENSDARG00000019644 |
GeneIDi | 30497 |
KEGGi | dre:30497 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF067202 mRNA Translation: AAF02213.1 BX649476 Genomic DNA Translation: CAI20632.1 BC044190 mRNA Translation: AAH44190.1 BC068981 mRNA Translation: AAH68981.1 |
RefSeqi | NP_571322.1, NM_131247.1 |
3D structure databases
SMRi | Q9PVK4 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9PVK4, 1 interactor |
MINTi | Q9PVK4 |
STRINGi | 7955.ENSDARP00000013329 |
Proteomic databases
PaxDbi | Q9PVK4 |
PRIDEi | Q9PVK4 |
Genome annotation databases
Ensembli | ENSDART00000010777; ENSDARP00000013329; ENSDARG00000019644 ENSDART00000179867; ENSDARP00000156680; ENSDARG00000019644 |
GeneIDi | 30497 |
KEGGi | dre:30497 |
Organism-specific databases
CTDi | 30497 |
ZFINi | ZDB-GENE-991026-6, ldhba |
Phylogenomic databases
eggNOGi | KOG1495, Eukaryota |
GeneTreei | ENSGT00940000153525 |
HOGENOMi | CLU_045401_0_2_1 |
InParanoidi | Q9PVK4 |
OMAi | FRYIMAE |
OrthoDBi | 1204514at2759 |
PhylomeDBi | Q9PVK4 |
TreeFami | TF314963 |
Enzyme and pathway databases
UniPathwayi | UPA00554;UER00611 |
Reactomei | R-DRE-70268, Pyruvate metabolism |
Miscellaneous databases
PROi | PR:Q9PVK4 |
Gene expression databases
Bgeei | ENSDARG00000019644, Expressed in brain and 49 other tissues |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
HAMAPi | MF_00488, Lactate_dehydrog, 1 hit |
InterProi | View protein in InterPro IPR001557, L-lactate/malate_DH IPR011304, L-lactate_DH IPR018177, L-lactate_DH_AS IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102, Lac_mal_DH, 1 hit |
PRINTSi | PR00086, LLDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01771, L-LDH-NAD, 1 hit |
PROSITEi | View protein in PROSITE PS00064, L_LDH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LDHBA_DANRE | |
Accessioni | Q9PVK4Primary (citable) accession number: Q9PVK4 Secondary accession number(s): Q803U5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families