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Protein

L-lactate dehydrogenase B-A chain

Gene

ldhba

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase B-A chain (ldhba), L-lactate dehydrogenase A chain (ldha), L-lactate dehydrogenase B-B chain (ldhbb), L-lactate dehydrogenase (ldhbb), L-lactate dehydrogenase (ldhbb), L-lactate dehydrogenase (ldha)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100NADBy similarity1
Binding sitei107SubstrateBy similarity1
Binding sitei139NAD or substrateBy similarity1
Binding sitei170SubstrateBy similarity1
Active sitei194Proton acceptorBy similarity1
Binding sitei249SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 58NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-DRE-70268 Pyruvate metabolism
UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase B-A chain (EC:1.1.1.27)
Short name:
LDH-B-A
Gene namesi
Name:ldhba
Synonyms:ldhb
ORF Names:si:dkey-13i19.5
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-991026-6 ldhba

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001684752 – 334L-lactate dehydrogenase B-A chainAdd BLAST333

Proteomic databases

PaxDbiQ9PVK4
PRIDEiQ9PVK4

Expressioni

Gene expression databases

BgeeiENSDARG00000019644 Expressed in 44 organ(s), highest expression level in heart

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9PVK4, 1 interactor
MINTiQ9PVK4
STRINGi7955.ENSDARP00000013329

Structurei

3D structure databases

ProteinModelPortaliQ9PVK4
SMRiQ9PVK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00550000074541
HOGENOMiHOG000213793
HOVERGENiHBG000462
InParanoidiQ9PVK4
KOiK00016
OMAiMDLMQTA
OrthoDBiEOG091G0HME
PhylomeDBiQ9PVK4
TreeFamiTF314963

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PVK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVMQKLIT PLASGPAEPP RNKVTIVGVG QVGMACAVSV LLRELADELA
60 70 80 90 100
LVDVVEDRLK GEMLDLQHGS LFLKTPKIVA DKDYSVTANS RIVVVTAGVR
110 120 130 140 150
QQEGESRLNL VQRNVNIFKH IIPQIVKYSP DCILVVVSNP VDVLTYVTWK
160 170 180 190 200
LSGLPKHRVI GSGTNLDSAR FRYIMAEKLG IHASSFNGYI LGEHGDTSVP
210 220 230 240 250
VWSGANVAGV SLQKLNPDIG TDKDAENWKE AHKMVVDSAY EVIKLKGYTN
260 270 280 290 300
WAIGLSVADL TETLVKNLNR VHPVSTMVKG MYGINEEVYL SLPCVLNSSG
310 320 330
VGSVINMTLT DGEIGQLKSS ADTLWGIQKD LKDL
Length:334
Mass (Da):36,247
Last modified:November 30, 2010 - v4
Checksum:i68BEDFD7FB0D8574
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164T → P in AAF02213 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067202 mRNA Translation: AAF02213.1
BX649476 Genomic DNA Translation: CAI20632.1
BC044190 mRNA Translation: AAH44190.1
BC068981 mRNA Translation: AAH68981.1
RefSeqiNP_571322.1, NM_131247.1
UniGeneiDr.75894

Genome annotation databases

EnsembliENSDART00000010777; ENSDARP00000013329; ENSDARG00000019644
ENSDART00000179867; ENSDARP00000156680; ENSDARG00000019644
GeneIDi30497
KEGGidre:30497

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067202 mRNA Translation: AAF02213.1
BX649476 Genomic DNA Translation: CAI20632.1
BC044190 mRNA Translation: AAH44190.1
BC068981 mRNA Translation: AAH68981.1
RefSeqiNP_571322.1, NM_131247.1
UniGeneiDr.75894

3D structure databases

ProteinModelPortaliQ9PVK4
SMRiQ9PVK4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9PVK4, 1 interactor
MINTiQ9PVK4
STRINGi7955.ENSDARP00000013329

Proteomic databases

PaxDbiQ9PVK4
PRIDEiQ9PVK4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000010777; ENSDARP00000013329; ENSDARG00000019644
ENSDART00000179867; ENSDARP00000156680; ENSDARG00000019644
GeneIDi30497
KEGGidre:30497

Organism-specific databases

CTDi30497
ZFINiZDB-GENE-991026-6 ldhba

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00550000074541
HOGENOMiHOG000213793
HOVERGENiHBG000462
InParanoidiQ9PVK4
KOiK00016
OMAiMDLMQTA
OrthoDBiEOG091G0HME
PhylomeDBiQ9PVK4
TreeFamiTF314963

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

ReactomeiR-DRE-70268 Pyruvate metabolism

Miscellaneous databases

PROiPR:Q9PVK4

Gene expression databases

BgeeiENSDARG00000019644 Expressed in 44 organ(s), highest expression level in heart

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLDHBA_DANRE
AccessioniPrimary (citable) accession number: Q9PVK4
Secondary accession number(s): Q803U5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 129 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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