ldhba

Functionⁱ

Catalytic activityⁱ

(S)-lactate + NAD⁺ = pyruvate + NADH.

Pathwayⁱ: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:

L-lactate dehydrogenase B-A chain (ldhba), L-lactate dehydrogenase A chain (ldha), L-lactate dehydrogenase B-B chain (ldhbb), L-lactate dehydrogenase (ldhbb), L-lactate dehydrogenase (ldhbb), L-lactate dehydrogenase (ldha)

This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	100	NADBy similarity	1
Binding siteⁱ	107	SubstrateBy similarity	1
Binding siteⁱ	139	NAD or substrateBy similarity	1
Binding siteⁱ	170	SubstrateBy similarity	1
Active siteⁱ	194	Proton acceptorBy similarity	1
Binding siteⁱ	249	SubstrateBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	30 – 58	NADBy similarityAdd BLAST		29

GO - Molecular functionⁱ

L-lactate dehydrogenase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro
carboxylic acid metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NAD

Enzyme and pathway databases

Reactomeⁱ	R-DRE-70268 Pyruvate metabolism
UniPathwayⁱ	UPA00554;UER00611

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: L-lactate dehydrogenase B-A chain (EC:1.1.1.27) Short name: LDH-B-A
Gene namesⁱ	Name:ldhba Synonyms:ldhb ORF Names:si:dkey-13i19.5
Organismⁱ	Danio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifierⁱ	7955 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Osteoglossocephalai › Clupeocephala › Otomorpha › Ostariophysi › Otophysi › Cypriniphysae › Cypriniformes › Cyprinoidea › Cyprinidae › Danio
Proteomesⁱ	UP000000437 Componentⁱ: Chromosome 4

Organism-specific databases

ZFINⁱ	ZDB-GENE-991026-6 ldhba

ZFINⁱ

ZDB-GENE-991026-6 ldhba

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000168475	2 – 334	L-lactate dehydrogenase B-A chainAdd BLAST		333

Proteomic databases

PaxDbⁱ	Q9PVK4
PRIDEⁱ	Q9PVK4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSDARG00000019644 Expressed in 44 organ(s), highest expression level in heart

Bgeeⁱ

ENSDARG00000019644 Expressed in 44 organ(s), highest expression level in heart

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Protein-protein interaction databases

IntActⁱ	Q9PVK4, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q9PVK4
STRINGⁱ	7955.ENSDARP00000013329

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9PVK4
SMRⁱ	Q9PVK4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1495 Eukaryota COG0039 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074541
HOGENOMⁱ	HOG000213793
HOVERGENⁱ	HBG000462
InParanoidⁱ	Q9PVK4
KEGG Orthology (KO) More...KOⁱ	K00016
OMAⁱ	MDLMQTA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HME
PhylomeDBⁱ	Q9PVK4
TreeFamⁱ	TF314963

Family and domain databases

Gene3Dⁱ	3.90.110.10, 1 hit
HAMAPⁱ	MF_00488 Lactate_dehydrog, 1 hit
InterProⁱ	View protein in InterPro IPR001557 L-lactate/malate_DH IPR011304 L-lactate_DH IPR018177 L-lactate_DH_AS IPR022383 Lactate/malate_DH_C IPR001236 Lactate/malate_DH_N IPR015955 Lactate_DH/Glyco_Ohase_4_C IPR036291 NAD(P)-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02866 Ldh_1_C, 1 hit PF00056 Ldh_1_N, 1 hit
PIRSFⁱ	PIRSF000102 Lac_mal_DH, 1 hit
PRINTSⁱ	PR00086 LLDHDRGNASE
SUPFAMⁱ	SSF51735 SSF51735, 1 hit SSF56327 SSF56327, 1 hit
TIGRFAMsⁱ	TIGR01771 L-LDH-NAD, 1 hit
PROSITEⁱ	View protein in PROSITE PS00064 L_LDH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9PVK4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASVMQKLIT PLASGPAEPP RNKVTIVGVG QVGMACAVSV LLRELADELA 
        60         70         80         90        100
LVDVVEDRLK GEMLDLQHGS LFLKTPKIVA DKDYSVTANS RIVVVTAGVR 
       110        120        130        140        150
QQEGESRLNL VQRNVNIFKH IIPQIVKYSP DCILVVVSNP VDVLTYVTWK 
       160        170        180        190        200
LSGLPKHRVI GSGTNLDSAR FRYIMAEKLG IHASSFNGYI LGEHGDTSVP 
       210        220        230        240        250
VWSGANVAGV SLQKLNPDIG TDKDAENWKE AHKMVVDSAY EVIKLKGYTN 
       260        270        280        290        300
WAIGLSVADL TETLVKNLNR VHPVSTMVKG MYGINEEVYL SLPCVLNSSG 
       310        320        330 
VGSVINMTLT DGEIGQLKSS ADTLWGIQKD LKDL

Length:334

Mass (Da):36,247

Last modified:November 30, 2010 - v4

Checksum:ⁱ68BEDFD7FB0D8574

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	164	T → P in AAF02213 (Ref. 1) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF067202 mRNA Translation: AAF02213.1 BX649476 Genomic DNA Translation: CAI20632.1 BC044190 mRNA Translation: AAH44190.1 BC068981 mRNA Translation: AAH68981.1
NCBI Reference Sequences More...RefSeqⁱ	NP_571322.1, NM_131247.1
UniGeneⁱ	Dr.75894

Genome annotation databases

Ensemblⁱ	ENSDART00000010777; ENSDARP00000013329; ENSDARG00000019644 ENSDART00000179867; ENSDARP00000156680; ENSDARG00000019644
GeneIDⁱ	30497
KEGGⁱ	dre:30497

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9PVK4	L-lactate dehydrogenase B chain		ANGRO		333	UniRef90_Q9PVK4
L-lactate dehydrogenase		ASTMX		333
Lactate dehydrogenase B4 (Fragment)		PIMPR		77
UPI0007B892DC		Sinocyclocheilus anshuiensis		400
UPI0007AC8293		SINGR		396
+9

Protein	Similar proteins		Species	Score	Length	Source
Q9PVK4	L-lactate dehydrogenase B chain		ANAPL		333	UniRef50_P13743
L-lactate dehydrogenase B chain		PANTR		334
L-lactate dehydrogenase B chain		PELSJ		333
L-lactate dehydrogenase B chain		ALLMI		333
L-lactate dehydrogenase B chain		TRASE		333
+220

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF067202 mRNA Translation: AAF02213.1 BX649476 Genomic DNA Translation: CAI20632.1 BC044190 mRNA Translation: AAH44190.1 BC068981 mRNA Translation: AAH68981.1
RefSeqⁱ	NP_571322.1, NM_131247.1
UniGeneⁱ	Dr.75894

3D structure databases

ProteinModelPortalⁱ	Q9PVK4
SMRⁱ	Q9PVK4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9PVK4, 1 interactor
MINTⁱ	Q9PVK4
STRINGⁱ	7955.ENSDARP00000013329

Proteomic databases

PaxDbⁱ	Q9PVK4
PRIDEⁱ	Q9PVK4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSDART00000010777; ENSDARP00000013329; ENSDARG00000019644 ENSDART00000179867; ENSDARP00000156680; ENSDARG00000019644
GeneIDⁱ	30497
KEGGⁱ	dre:30497

Organism-specific databases

CTDⁱ	30497
ZFINⁱ	ZDB-GENE-991026-6 ldhba

Phylogenomic databases

eggNOGⁱ	KOG1495 Eukaryota COG0039 LUCA
GeneTreeⁱ	ENSGT00550000074541
HOGENOMⁱ	HOG000213793
HOVERGENⁱ	HBG000462
InParanoidⁱ	Q9PVK4
KOⁱ	K00016
OMAⁱ	MDLMQTA
OrthoDBⁱ	EOG091G0HME
PhylomeDBⁱ	Q9PVK4
TreeFamⁱ	TF314963

Enzyme and pathway databases

UniPathwayⁱ	UPA00554;UER00611
Reactomeⁱ	R-DRE-70268 Pyruvate metabolism

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9PVK4

PROⁱ

PR:Q9PVK4

Gene expression databases

Bgeeⁱ	ENSDARG00000019644 Expressed in 44 organ(s), highest expression level in heart

Bgeeⁱ

ENSDARG00000019644 Expressed in 44 organ(s), highest expression level in heart

Family and domain databases

Gene3Dⁱ	3.90.110.10, 1 hit
HAMAPⁱ	MF_00488 Lactate_dehydrog, 1 hit
InterProⁱ	View protein in InterPro IPR001557 L-lactate/malate_DH IPR011304 L-lactate_DH IPR018177 L-lactate_DH_AS IPR022383 Lactate/malate_DH_C IPR001236 Lactate/malate_DH_N IPR015955 Lactate_DH/Glyco_Ohase_4_C IPR036291 NAD(P)-bd_dom_sf
Pfamⁱ	View protein in Pfam PF02866 Ldh_1_C, 1 hit PF00056 Ldh_1_N, 1 hit
PIRSFⁱ	PIRSF000102 Lac_mal_DH, 1 hit
PRINTSⁱ	PR00086 LLDHDRGNASE
SUPFAMⁱ	SSF51735 SSF51735, 1 hit SSF56327 SSF56327, 1 hit
TIGRFAMsⁱ	TIGR01771 L-LDH-NAD, 1 hit
PROSITEⁱ	View protein in PROSITE PS00064 L_LDH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LDHBA_DANRE
Accessionⁱ	Q9PVK4Primary (citable) accession number: Q9PVK4 Secondary accession number(s): Q803U5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	November 30, 2010
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9PVK4 (LDHBA_DANRE)

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L-lactate dehydrogenase B-A chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pyruvate fermentation to lactate

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: pyruvate fermentation to lactate

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ