UniProtKB - Q9PVD3 (Q9PVD3_DANRE)
Protein
PTH/PTHrP type I receptor
Gene
pth1r
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- parathyroid hormone receptor activity Source: ZFIN
- peptide hormone binding Source: ZFIN
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- cell surface receptor signaling pathway Source: InterPro
- cellular calcium ion homeostasis Source: GO_Central
- dorsal aorta development Source: ZFIN
- positive regulation of inositol phosphate biosynthetic process Source: ZFIN
Keywordsi
Molecular function | ReceptorImported |
Enzyme and pathway databases
Reactomei | R-DRE-373080, Class B/2 (Secretin family receptors) R-DRE-418555, G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: PTH/PTHrP type I receptorARBA annotationAlternative name(s): Parathyroid hormone 1 receptorARBA annotation Parathyroid hormone/parathyroid hormone-related peptide receptorARBA annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-991123-8, pth1r |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 145 – 169 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 250 – 269 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 274 – 295 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 315 – 339 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 360 – 379 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 399 – 416 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_5015099932 | 29 – 536 | PTH/PTHrP type I receptorSequence analysisAdd BLAST | 508 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000020957, Expressed in trunk and 14 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 129 | G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST | 83 | |
Domaini | 144 – 417 | G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST | 274 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family.ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158574 |
OrthoDBi | 651627at2759 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR002170, GPCR_2_parathyroid_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF27, PTHR45620:SF27, 2 hits |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00393, PTRHORMONER |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9PVD3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGATLIVRTL GFLFCGTLLS FVYGLVDADD VLTKEEQIYL LFNAKRKCER
60 70 80 90 100
AIKSKHKTSE GSCLPEWDGI LCWPEGVPGK MVSTSCPEYI YDFNHKGHAY
110 120 130 140 150
RRCDLNGTWE LASHNNKTWA NYSECAKFFP HYNQNQEREV FDRLYLIYTV
160 170 180 190 200
GYSISLGSLM VATVILGYFR RLHCTRNYIH MHLFLSFMLR AISIFVKDVV
210 220 230 240 250
LYSGSALQEM ERITVEDLKS ITEAPPANKT QFIGCKVAVT LFLYFLATNY
260 270 280 290 300
YWILVEGLYL HSLIFMTFFS DRKYLWGFTL IGWGVPAMFV TIWASVRATL
310 320 330 340 350
ADTECWDLSA GNLKWIVQIP ILTAIVVNFL LFLNIIRVLA TKLRETNAGR
360 370 380 390 400
CDTRQQYRKL LKSTLVLMPL FGVHYIVFMA MPYTEVSGVL WQIQMHYEML
410 420 430 440 450
FNSVQGFFVA IIYCFCNGEV QAEIKKAWNR RTLALDFKRK ARSGSNTYSY
460 470 480 490 500
GPMVSHTSVT NVTARGPLAL HLTNRLGHVT TNGHRNLPGY IKNGSVSENS
510 520 530
IPSSGHELHI QEEEPSKTFQ MEKTIQVVEE ERETVM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2AVI7 | A2AVI7_DANRE | PTH/PTHrP type I receptor | pth1r pth1ra | 511 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL929518 Genomic DNA No translation available. CABZ01079532 Genomic DNA No translation available. CABZ01079533 Genomic DNA No translation available. CU104693 Genomic DNA No translation available. CU929376 Genomic DNA No translation available. FP885916 Genomic DNA No translation available. AF132084 mRNA Translation: AAF01265.1 BC162211 mRNA Translation: AAI62211.1 BC162544 mRNA Translation: AAI62544.1 |
RefSeqi | NP_571432.1, NM_131357.1 |
Genome annotation databases
Ensembli | ENSDART00000101033; ENSDARP00000091807; ENSDARG00000020957 |
GeneIDi | 30629 |
KEGGi | dre:30629 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL929518 Genomic DNA No translation available. CABZ01079532 Genomic DNA No translation available. CABZ01079533 Genomic DNA No translation available. CU104693 Genomic DNA No translation available. CU929376 Genomic DNA No translation available. FP885916 Genomic DNA No translation available. AF132084 mRNA Translation: AAF01265.1 BC162211 mRNA Translation: AAI62211.1 BC162544 mRNA Translation: AAI62544.1 |
RefSeqi | NP_571432.1, NM_131357.1 |
3D structure databases
SMRi | Q9PVD3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000091807 |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
Ensembli | ENSDART00000101033; ENSDARP00000091807; ENSDARG00000020957 |
GeneIDi | 30629 |
KEGGi | dre:30629 |
Organism-specific databases
CTDi | 5745 |
ZFINi | ZDB-GENE-991123-8, pth1r |
Phylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158574 |
OrthoDBi | 651627at2759 |
TreeFami | TF315710 |
Enzyme and pathway databases
Reactomei | R-DRE-373080, Class B/2 (Secretin family receptors) R-DRE-418555, G alpha (s) signalling events |
Gene expression databases
Bgeei | ENSDARG00000020957, Expressed in trunk and 14 other tissues |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR002170, GPCR_2_parathyroid_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF27, PTHR45620:SF27, 2 hits |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00393, PTRHORMONER |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9PVD3_DANRE | |
Accessioni | Q9PVD3Primary (citable) accession number: Q9PVD3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |