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Protein

Estrogen receptor beta

Gene

ESR2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi105 – 170Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri105 – 125NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri141 – 165NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor beta
Short name:
ER-beta
Short name:
cERb
Alternative name(s):
Nuclear receptor subfamily 3 group A member 2
Gene namesi
Name:ESR2
Synonyms:NR3A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536481 – 472Estrogen receptor betaAdd BLAST472

Proteomic databases

PaxDbiQ9PTU5
PRIDEiQ9PTU5

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-alpha.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019234

Structurei

3D structure databases

ProteinModelPortaliQ9PTU5
SMRiQ9PTU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 449NR LBDPROSITE-ProRule annotationAdd BLAST233

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 104ModulatingAdd BLAST104

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri105 – 125NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri141 – 165NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000233468
HOVERGENiHBG108344
InParanoidiQ9PTU5
KOiK08551
PhylomeDBiQ9PTU5

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR028355 ER-beta/gamma
IPR021064 Estrogen_rcpt_beta_N
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12497 ERbeta_N, 1 hit
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500102 ER-b, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 2 hits
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PTU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFCSPAMLN YNIASNFGDS ESASVRQTSS PSVLWSAPGH LSPLTLHCQS
60 70 80 90 100
SLLYAEQPKS PWCEVRPLDP VLPVTRETLK RKTNGSDCTS PIASNPGSKR
110 120 130 140 150
DAHFCAVCSD YASGYHYGVW SCEGCKAFFK RSIQGHNDYI CPATNQCTID
160 170 180 190 200
KNRRKSCQAC RLRKCYEVGM MKCGSRRERC GYRILRRHRN SEDCMGKTKK
210 220 230 240 250
YNEAATRVKE ILLSTVSPEQ FVLTLLEAEP PNVLVSRPSK PFTEASMMMS
260 270 280 290 300
LTKLADKELV HMIGWAKKIP GFIDLSLYDQ VRLLESCWME VLMIGLMWRS
310 320 330 340 350
IDHPGKLIFA PDLVLDRDEG KCVEGILEIF DMLLAMTSRF RELKLQHKEY
360 370 380 390 400
LCVKAMILLN SSMFPLSPEE PESNRKLHHL LNVVTDALVW VIAKSGIPSQ
410 420 430 440 450
QQTTRLANLL MLLSHVRHAS NKGMEHLLSM KCKNVVPVYD LLLEMLNAHT
460 470
LRGQRKSPVT HPEFEQVSHF QV
Length:472
Mass (Da):53,439
Last modified:May 1, 2000 - v1
Checksum:iA8CBBB8CACA65650
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036415 mRNA Translation: BAA88667.1
RefSeqiNP_990125.1, NM_204794.2
UniGeneiGga.314

Genome annotation databases

GeneIDi395575
KEGGigga:395575

Similar proteinsi

Entry informationi

Entry nameiESR2_CHICK
AccessioniPrimary (citable) accession number: Q9PTU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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