UniProtKB - Q9PTT3 (Q9PTT3_SPAAU)
Protein
Transthyretin
Gene
N/A
Organism
Sparus aurata (Gilthead sea bream)
Status
Functioni
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.UniRule annotation
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- thyroid hormone binding Source: InterPro
GO - Biological processi
- retinol metabolic process Source: InterPro
- thyroid hormone transport Source: InterPro
Keywordsi
Molecular function | Hormone, Thyroid hormoneUniRule annotationARBA annotation |
Biological process | TransportARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: TransthyretinUniRule annotation |
Organismi | Sparus aurata (Gilthead sea bream)Imported |
Taxonomic identifieri | 8175 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Eupercaria › Spariformes › Sparidae › Sparus |
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedUniRule annotationARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | UniRule annotationAdd BLAST | 19 | |
ChainiPRO_5005144836 | 20 – 151 | TransthyretinUniRule annotationAdd BLAST | 132 |
Interactioni
Subunit structurei
Homotetramer.
UniRule annotationGO - Molecular functioni
- hormone activity Source: UniProtKB-KW
Structurei
3D structure databases
SMRi | Q9PTT3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9PTT3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 151 | TR_THYInterPro annotationAdd BLAST | 121 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationFamily and domain databases
Gene3Di | 2.60.40.180, 1 hit |
InterProi | View protein in InterPro IPR030178, Transthyretin IPR000895, Transthyretin/HIU_hydrolase IPR023416, Transthyretin/HIU_hydrolase_d IPR036817, Transthyretin/HIU_hydrolase_sf |
PANTHERi | PTHR10395, PTHR10395, 1 hit PTHR10395:SF12, PTHR10395:SF12, 1 hit |
Pfami | View protein in Pfam PF00576, Transthyretin, 1 hit |
PRINTSi | PR00189, TRNSTHYRETIN |
SMARTi | View protein in SMART SM00095, TR_THY, 1 hit |
SUPFAMi | SSF49472, SSF49472, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9PTT3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLQPLHCLLL ASAVLLCNTA PTPTDKHGGS DTRCPLMVKI LDAVKGTPAG
60 70 80 90 100
SVALKVSQKT ADGGWTQIAT GVTDATGEIH NLITEQQFPA GVYRVEFDTK
110 120 130 140 150
AYWTNQGSTP FHEVAEVVFD AHPEGHRHYT LALLLSPFSY TTTAVVSSVR
E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF047443 mRNA Translation: AAF21245.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF047443 mRNA Translation: AAF21245.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OO2 | X-ray | 1.56 | A/B/C/D | 33-151 | [»] | |
1SN0 | X-ray | 1.90 | A/B/C/D | 22-151 | [»] | |
1SN2 | X-ray | 1.75 | A/B/C/D | 22-151 | [»] | |
1SN5 | X-ray | 1.90 | A/B/C/D | 22-151 | [»] | |
6GNM | X-ray | 2.24 | A/B/C/D | 20-149 | [»] | |
6GNO | X-ray | 1.65 | A/B | 20-149 | [»] | |
6GNP | X-ray | 2.02 | A/B/C/D | 20-149 | [»] | |
6GNR | X-ray | 1.40 | A/B | 20-149 | [»] | |
6GNW | X-ray | 1.75 | A/B/C/D | 20-149 | [»] | |
6GON | X-ray | 1.65 | A/B/C/D | 20-149 | [»] | |
6GOO | X-ray | 1.80 | A/B | 20-149 | [»] | |
SMRi | Q9PTT3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9PTT3 |
Family and domain databases
Gene3Di | 2.60.40.180, 1 hit |
InterProi | View protein in InterPro IPR030178, Transthyretin IPR000895, Transthyretin/HIU_hydrolase IPR023416, Transthyretin/HIU_hydrolase_d IPR036817, Transthyretin/HIU_hydrolase_sf |
PANTHERi | PTHR10395, PTHR10395, 1 hit PTHR10395:SF12, PTHR10395:SF12, 1 hit |
Pfami | View protein in Pfam PF00576, Transthyretin, 1 hit |
PRINTSi | PR00189, TRNSTHYRETIN |
SMARTi | View protein in SMART SM00095, TR_THY, 1 hit |
SUPFAMi | SSF49472, SSF49472, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9PTT3_SPAAU | |
Accessioni | Q9PTT3Primary (citable) accession number: Q9PTT3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | October 7, 2020 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |