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Protein

Proliferating cell nuclear antigen

Gene

pcna

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi61 – 80Sequence analysisAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA polymerase processivity factor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-DRE-110312 Translesion synthesis by REV1
R-DRE-110314 Recognition of DNA damage by PCNA-containing replication complex
R-DRE-110320 Translesion Synthesis by POLH
R-DRE-174411 Polymerase switching on the C-strand of the telomere
R-DRE-174414 Processive synthesis on the C-strand of the telomere
R-DRE-174417 Telomere C-strand (Lagging Strand) Synthesis
R-DRE-174437 Removal of the Flap Intermediate from the C-strand
R-DRE-4615885 SUMOylation of DNA replication proteins
R-DRE-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-DRE-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-DRE-5655862 Translesion synthesis by POLK
R-DRE-5656121 Translesion synthesis by POLI
R-DRE-5656169 Termination of translesion DNA synthesis
R-DRE-5685942 HDR through Homologous Recombination (HRR)
R-DRE-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-DRE-5696400 Dual Incision in GG-NER
R-DRE-6782135 Dual incision in TC-NER
R-DRE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DRE-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-DRE-69091 Polymerase switching
R-DRE-69166 Removal of the Flap Intermediate
R-DRE-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen
Short name:
PCNA
Gene namesi
Name:pcna
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-000210-8 pcna

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491651 – 260Proliferating cell nuclear antigenAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki164Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei259Phosphoserine1 Publication1
Modified residuei260Phosphoserine1 Publication1

Post-translational modificationi

Monoubiquitinated by the ube2b-rad18 complex on Lys-164. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the dcx(dtl) complex, leading to enhance PCNA-dependent translesion DNA synthesis (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9PTP1
PRIDEiQ9PTP1

PTM databases

iPTMnetiQ9PTP1

Expressioni

Gene expression databases

BgeeiENSDARG00000054155 Expressed in 72 organ(s), highest expression level in blastula

Interactioni

Subunit structurei

Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity). Component of the replisome complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000070780

Structurei

3D structure databases

ProteinModelPortaliQ9PTP1
SMRiQ9PTP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Phylogenomic databases

eggNOGiKOG1636 Eukaryota
COG0592 LUCA
GeneTreeiENSGT00390000004965
HOGENOMiHOG000211098
HOVERGENiHBG000947
InParanoidiQ9PTP1
KOiK04802
OMAiKILRCAG
PhylomeDBiQ9PTP1
TreeFamiTF313441

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PTP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEARLVQGS ILKKVLEALK DLITEACWDV SSSGISLQSM DSSHVSLVQL
60 70 80 90 100
TLRSDGFDSY RCDRNLAMGV NLSSMSKILK CAGNEDIITL RAEDNADALA
110 120 130 140 150
LVFETLNQEK VSDYEMKLMD LDVEQLGIPE QEYSCVVKMP SGEFARICRD
160 170 180 190 200
LSQIGDAVMI SCAKDGVKFS ASGELGTGNI KLSQTSNVDK EDEAVTIEMN
210 220 230 240 250
EPVQLIFALN YLNFFTKATP LSKTVTLSMS ADIPLVVEYK IADMGHVKYY
260
LAPKIDEESS
Length:260
Mass (Da):28,611
Last modified:May 24, 2005 - v2
Checksum:i59D27AC8C95B472D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88I → Q in AAF18324 (Ref. 1) Curated1
Sequence conflicti98A → T in AAF18324 (Ref. 1) Curated1
Sequence conflicti105 – 106TL → AQ in AAF18324 (Ref. 1) Curated2
Sequence conflicti218A → P in AAF18324 (Ref. 1) Curated1
Sequence conflicti223K → R in AAF18324 (Ref. 1) Curated1
Sequence conflicti228S → R in AAF18324 (Ref. 1) Curated1
Sequence conflicti232D → H in AAF18324 (Ref. 1) Curated1
Sequence conflicti239Y → D in AAF18324 (Ref. 1) Curated1
Sequence conflicti244 – 245MG → LE in AAF18324 (Ref. 1) Curated2
Sequence conflicti254 – 255KI → QIE in AAF18324 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140608 mRNA Translation: AAF18324.1
BC049535 mRNA Translation: AAH49535.1
BC064299 mRNA Translation: AAH64299.1
RefSeqiNP_571479.2, NM_131404.2
UniGeneiDr.35605

Genome annotation databases

EnsembliENSDART00000076304; ENSDARP00000070780; ENSDARG00000054155
GeneIDi30678
KEGGidre:30678

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140608 mRNA Translation: AAF18324.1
BC049535 mRNA Translation: AAH49535.1
BC064299 mRNA Translation: AAH64299.1
RefSeqiNP_571479.2, NM_131404.2
UniGeneiDr.35605

3D structure databases

ProteinModelPortaliQ9PTP1
SMRiQ9PTP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000070780

PTM databases

iPTMnetiQ9PTP1

Proteomic databases

PaxDbiQ9PTP1
PRIDEiQ9PTP1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000076304; ENSDARP00000070780; ENSDARG00000054155
GeneIDi30678
KEGGidre:30678

Organism-specific databases

CTDi5111
ZFINiZDB-GENE-000210-8 pcna

Phylogenomic databases

eggNOGiKOG1636 Eukaryota
COG0592 LUCA
GeneTreeiENSGT00390000004965
HOGENOMiHOG000211098
HOVERGENiHBG000947
InParanoidiQ9PTP1
KOiK04802
OMAiKILRCAG
PhylomeDBiQ9PTP1
TreeFamiTF313441

Enzyme and pathway databases

ReactomeiR-DRE-110312 Translesion synthesis by REV1
R-DRE-110314 Recognition of DNA damage by PCNA-containing replication complex
R-DRE-110320 Translesion Synthesis by POLH
R-DRE-174411 Polymerase switching on the C-strand of the telomere
R-DRE-174414 Processive synthesis on the C-strand of the telomere
R-DRE-174417 Telomere C-strand (Lagging Strand) Synthesis
R-DRE-174437 Removal of the Flap Intermediate from the C-strand
R-DRE-4615885 SUMOylation of DNA replication proteins
R-DRE-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-DRE-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-DRE-5655862 Translesion synthesis by POLK
R-DRE-5656121 Translesion synthesis by POLI
R-DRE-5656169 Termination of translesion DNA synthesis
R-DRE-5685942 HDR through Homologous Recombination (HRR)
R-DRE-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-DRE-5696400 Dual Incision in GG-NER
R-DRE-6782135 Dual incision in TC-NER
R-DRE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DRE-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-DRE-69091 Polymerase switching
R-DRE-69166 Removal of the Flap Intermediate
R-DRE-69183 Processive synthesis on the lagging strand

Miscellaneous databases

PROiPR:Q9PTP1

Gene expression databases

BgeeiENSDARG00000054155 Expressed in 72 organ(s), highest expression level in blastula

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA_DANRE
AccessioniPrimary (citable) accession number: Q9PTP1
Secondary accession number(s): Q7ZW84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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