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Protein

Insulin-like growth factor-binding protein 2-A

Gene

igfbp2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.2 Publications

GO - Molecular functioni

  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: UniProtKB

GO - Biological processi

  • angiogenesis Source: ZFIN
  • growth Source: ZFIN
  • heart development Source: ZFIN
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of developmental growth Source: UniProtKB
  • negative regulation of DNA replication Source: UniProtKB
  • regulation of cell growth Source: InterPro
  • regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, Growth factor binding
Biological processGrowth regulation

Enzyme and pathway databases

ReactomeiR-DRE-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiI31.953

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2-A
Short name:
IGF-binding protein 2-A
Short name:
IGFBP-2-A
Short name:
IGFBP-2a
Gene namesi
Name:igfbp2a
Synonyms:igfbp2, igfbp2b
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-000125-12 igfbp2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001437623 – 276Insulin-like growth factor-binding protein 2-AAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi180 ↔ 214PROSITE-ProRule annotation
Disulfide bondi225 ↔ 236PROSITE-ProRule annotation
Disulfide bondi238 ↔ 259PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9PTH3

Expressioni

Tissue specificityi

In embryos at 24 hpf, initially expressed in the lens and cranial region, and at 48 and 72 hpf in the brain boundary vasculature. Expression in these regions persists throughout the hatching period and by 96 hpf expression is most abundant in the liver. In both male and female adults, highest expression is in the liver with modest expression in the brain. In male but not females adults, expressed at a low level in muscle and gonad. Also expressed in the adult intestine.2 Publications

Developmental stagei

Not expressed until 10 hpf. Expression gradually increases from 10 to 36 hpf and is maintained at high levels thereafter.1 Publication

Inductioni

Expression increases in response to prolonged fasting but decreases in response to growth hormone (GH).1 Publication

Gene expression databases

BgeeiENSDARG00000052470

Interactioni

Subunit structurei

Interacts equally well with igf1 and igf2.1 Publication

GO - Molecular functioni

  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: UniProtKB

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068816

Structurei

3D structure databases

ProteinModelPortaliQ9PTH3
SMRiQ9PTH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 105IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST82
Domaini177 – 259Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi254 – 256Cell attachment siteSequence analysis3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUR Eukaryota
ENOG4111GWQ LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
InParanoidiQ9PTH3
OMAiDGTMNML
OrthoDBiEOG091G0EIN
PhylomeDBiQ9PTH3
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012210 IGFBP-2
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01978 IGFBPFAMILY2
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PTH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSYVSCGLL LALVTFHGTA RSEMVFRCPS CTAERQAACP MLTETCGEIV
60 70 80 90 100
REPGCGCCPV CARQEGEQCG VYTPRCSSGL RCYPKPDSEL PLELLVQGLG
110 120 130 140 150
RCGRKVDTEP TGSAEPREVS GEVQDPLDIG LTEVPPIRKP TKDSPWKESA
160 170 180 190 200
VLQHRQQLKS KMKYHKVEDP KAPHAKQSQC QQELDQVLER ISKITFKDNR
210 220 230 240 250
TPLEDLYSLH IPNCDKRGQY NLKQCKMSVN GYRGECWCVN PHTGRPMPTS
260 270
PLIRGDPNCN QYLDGQEMDP SVDPPN
Length:276
Mass (Da):30,764
Last modified:May 1, 2000 - v1
Checksum:i37AB561B7C9947D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198033 mRNA Translation: AAF23123.1
BC056331 mRNA Translation: AAH56331.1
BC153606 mRNA Translation: AAI53607.1
RefSeqiNP_571533.1, NM_131458.2
UniGeneiDr.78120

Genome annotation databases

EnsembliENSDART00000074327; ENSDARP00000068816; ENSDARG00000052470
ENSDART00000182607; ENSDARP00000150294; ENSDARG00000111105
GeneIDi794176
KEGGidre:794176

Similar proteinsi

Entry informationi

Entry nameiIBP2A_DANRE
AccessioniPrimary (citable) accession number: Q9PTH3
Secondary accession number(s): A8E5I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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