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Entry version 93 (18 Sep 2019)
Sequence version 2 (27 Jan 2003)
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Protein

Cingulin

Gene

cgn

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier, possibly by linking ZO proteins to the actomyosin cytoskeleton.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • motor activity Source: InterPro

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cingulin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cgn
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1009260 cgn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897651 – 1360CingulinAdd BLAST1360

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

A maternally synthesized protein. Found in the apical cortex in the fertilized egg, where it is associated with cytoskeleton filaments, it is recruited to tight junctions before ZO-1 and occludin. Nascent tight junctions are in place by the two-cell stage.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Parallel homodimer (By similarity). Binds ZO-1 and ZO-2 in vivo, and ZO-3, myosin and occludin in vitro, possibly directly. Acts as an F-actin bundling protein in vitro.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
99484, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9PTD7, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9PTD7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9PTD7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 427HeadAdd BLAST427
Regioni1 – 370Interaction with ZO-3 and myosinAdd BLAST370
Regioni93 – 286Interaction with F-actinAdd BLAST194
Regioni142 – 287Interaction with ZO-2Add BLAST146
Regioni369 – 1360Interaction with myosinAdd BLAST992
Regioni1323 – 1360TailAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili428 – 1322Sequence analysisAdd BLAST895

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi33 – 47ZIMAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi88 – 261Ser-richAdd BLAST174

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Deletion of the ZO-1 interaction motif (ZIM) decreases but does not abolish colocalization with ZO-1.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cingulin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K06102

Database of Orthologous Groups

More...
OrthoDBi
110948at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002928 Myosin_tail

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01576 Myosin_tail_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9PTD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADQHIPVGQ GVQIRFIGDL KENGKPRGKR SKQDSYGVAV RVQGIDGQPF
60 70 80 90 100
VVLNSGDKAK SSFGVQIKSQ EPYLNASNTS PPNYQNYSSK PRGPSRSISS
110 120 130 140 150
ESELPENPYG SRGYRPSSSH YSSASDEEQK PRGNIRGSDG LSSLPRPLQA
160 170 180 190 200
SRREELRRSQ SHSSLLEPDV EESYDYDHHY SERSSTLDTT YSQSSRDSAW
210 220 230 240 250
SRSSQKKIDN GDYPSLGYRS ATSQQSTSVS NKTKKNGLST SSPSNQSNED
260 270 280 290 300
IDTKPLSSVD SLINKFDIKG QVRGRTARRS QALKDERKRS QSLDGRKNYH
310 320 330 340 350
DTADSREIIV EKQNEVQTMR EPVNASNRSF NRQTLERGDI SKTRLTKEWL
360 370 380 390 400
DQDREEPVIL KQQRTVQSEF QLKSTPDLLR DQQPDGSDPT REMIFGILRE
410 420 430 440 450
GSLESENTLR KKTSILLEKL PSLQVQPGED TISLGSQKKE LERKVAELQR
460 470 480 490 500
QLDDEMKQRM KLETSQGRPK AGMQRLEIEL EESKEECSRL KELYEKKKNE
510 520 530 540 550
LSAMSQELME VRMGKEQVET KLRTMEDKLM DSKEELSHLR AKGGTSPDKL
560 570 580 590 600
ALLKELEEVQ DELDEVLQIR QKQEELLRQK DRELTALKGA LKDEVANHDK
610 620 630 640 650
DLDRVREQYQ NDMQQLRKNM DNVSQDQLSL ESERQKINQV VRNLQRELEE
660 670 680 690 700
SSDEISQWKE MFQKNKEELR STKQELLQMK LEKEESEDEL KETRDRFSLL
710 720 730 740 750
QSELAQVKKG SVDPGEVASV RKELQRVQDQ LKQLSVDKQK VEENLQQRER
760 770 780 790 800
EMSALKGTLK EEVSGRDRET VRLREQLQSE VMHVKKENEG LAKESRRIQD
810 820 830 840 850
QLKQVLLEKQ RHEETVHQRE RELSVLKGAL KDEVSGRDRE TEKLRERLEQ
860 870 880 890 900
DALMTKRSYE ELVKINKRLE SEKTDLERVR QVIENNLQES REENDDLRRK
910 920 930 940 950
ILGLEAQLKE TNTFCDDLQR AESRLKDKIN KLEAERKRME DSLGEVADQE
960 970 980 990 1000
QELAFVKRDL ESKLDEAQRS LKRLSLEYEE LQECYQEEMK QKDHLKKTKN
1010 1020 1030 1040 1050
ELEEQKRLLD KSMDKLTREL DNMSNESRGS LQLLQTQLEE YREKSRKEIG
1060 1070 1080 1090 1100
EAQKQAKEKT AEAERHQFNS SRMQEEVQKL KLALQELQVE KETVELDKQM
1110 1120 1130 1140 1150
ISQRLQSLEQ DIESKKRVQD DRSRQVKVLE DKLKRMEAEL DEEKNTVELL
1160 1170 1180 1190 1200
TDRVNRSRDQ MEQQRAELNQ ERSRGQDLEC DKISLERQNK ELKNRLASME
1210 1220 1230 1240 1250
GQQKPSVNVS HLEAKLQEIQ ERLQLEEREK ATLLSTNRKL ERKLKELNIQ
1260 1270 1280 1290 1300
LEDERLQVND QKDQLNLRVK ALKRQVDEAE EEIERLEGLR KKAVREMEEQ
1310 1320 1330 1340 1350
QEINEQLQTR VKVMEKESKR KPIRPAHDDD LSSDGEFGGP YDPSSITSLL
1360
TESNLQTSSC
Length:1,360
Mass (Da):158,466
Last modified:January 27, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D66CA572401B7B0
GO
Isoform 2 (identifier: Q9PTD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-625: Missing.

Note: No experimental confirmation available.
Show »
Length:1,289
Mass (Da):149,933
Checksum:i5B96FB33828B7BAA
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF20208 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti387S → N in AAH91650 (Ref. 2) Curated1
Sequence conflicti783H → Q in AAH91650 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037042555 – 625Missing in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF207901 mRNA Translation: AAF20208.1 Different initiation.
BC091650 mRNA Translation: AAH91650.1

NCBI Reference Sequences

More...
RefSeqi
NP_001081970.1, NM_001088501.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
398149

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:398149

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207901 mRNA Translation: AAF20208.1 Different initiation.
BC091650 mRNA Translation: AAH91650.1
RefSeqiNP_001081970.1, NM_001088501.1

3D structure databases

SMRiQ9PTD7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi99484, 5 interactors
IntActiQ9PTD7, 5 interactors
MINTiQ9PTD7

Genome annotation databases

GeneIDi398149
KEGGixla:398149

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
398149
XenbaseiXB-GENE-1009260 cgn

Phylogenomic databases

KOiK06102
OrthoDBi110948at2759

Family and domain databases

InterProiView protein in InterPro
IPR002928 Myosin_tail
PfamiView protein in Pfam
PF01576 Myosin_tail_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCING_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9PTD7
Secondary accession number(s): Q5BJ25
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 27, 2003
Last modified: September 18, 2019
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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