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Protein

DNA polymerase III subunit alpha

Gene

dnaE

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-692-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit alpha (EC:2.7.7.7)
Gene namesi
Name:dnaE
Ordered Locus Names:Cj0718
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001033151 – 1200DNA polymerase III subunit alphaAdd BLAST1200

Proteomic databases

PaxDbiQ9PPI9

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9PPI9, 2 interactors
STRINGi192222.Cj0718

Structurei

3D structure databases

ProteinModelPortaliQ9PPI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C0B Bacteria
COG0587 LUCA
HOGENOMiHOG000021784
KOiK02337
OMAiYLNECRR

Family and domain databases

InterProiView protein in InterPro
IPR011708 DNA_pol3_alpha
IPR029460 DNAPol_HHH
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR016195 Pol/histidinol_Pase-like
IPR004805 PolC_alpha
PANTHERiPTHR32294 PTHR32294, 1 hit
PfamiView protein in Pfam
PF07733 DNA_pol3_alpha, 1 hit
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit
SMARTiView protein in SMART
SM00481 POLIIIAc, 1 hit
SUPFAMiSSF89550 SSF89550, 1 hit
TIGRFAMsiTIGR00594 polc, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PPI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQFTHLHLH TEYSLLDGAN KLKELALTLK EQGATSVAMT DHGNMFGAID
60 70 80 90 100
FYQTMKAQGL KPIIGIEAYL HNHDELDDKS SRQRFHLCLY AKNEIGYQNL
110 120 130 140 150
MYLSSQSYIK GLYYYPRINK KLLEDYSEGL ICSSACLQGE VNWHLNTYSE
160 170 180 190 200
RNVRFGAKGY EAAKEAALWY KKVFKDDFYF EIMRHGIGDQ RMIDDDIIRL
210 220 230 240 250
SKELNIKIIA TNDTHYTFKE RAAAHEVFMC IAMGKKLNDP DRMRHSVHEF
260 270 280 290 300
YVKSPEQMSE LFADIPEAIE NTQEIAQKCN LELNLGNPTP PNFKFTREYA
310 320 330 340 350
KDHNIILPEE TKEFSFDNDD MVFEELCKKG LEERLKFIDE SKHEEYKQRL
360 370 380 390 400
EVEINIIKNM KFSGYMLIVH DFIKVAKDKG IPVGPGRGSA AGSLVSYCLR
410 420 430 440 450
ITDLDPIPYS LLFERFLNPE RVSMPDIDVD FCQDRRAEVI DYVIDKYGAD
460 470 480 490 500
KVAQVITFGK LLAKGVIRDV ARVCDMSIQD ADELAKLVPE ELKITLDAAY
510 520 530 540 550
EKEPKIKEFI DRHPKGLEVW EYARALEGLN RNAGMHAAGV VISNESLWKK
560 570 580 590 600
TPLFRQSKND ERHLVTQYSK DHLEDVDLIK FDFLGLKTLT VINNAIKLIK
610 620 630 640 650
KRYNKDIIWE TIDVNDSKVY KTIQSGNTLG IFQIESGGMQ SLNARLKPER
660 670 680 690 700
FEDIIAVLAL YRPGPMESGM LDDFIDRKHG LKSIEYPFDS LEKVLEPTYG
710 720 730 740 750
VIVYQEQVMQ IVQIIGGFSL GGADVVRRAM GKKDPEKMKK LKTDFADGAE
760 770 780 790 800
KQGYDRAKAE DLWELIVKFA GYGFNKSHSA AYALITFQTA YLKTYYPSEF
810 820 830 840 850
MAALLTSEEN NVDKIAVYID EMKKMNIKLL PPSINKAIRE FSALEQDGKD
860 870 880 890 900
AIIYGLGAIK SVGIPAVENL LEARQDGEFK DINDFLGKID PTKINRRTLE
910 920 930 940 950
SLIKAGAFDE FGFTRKALFD NMENLSEASR KMAEVRKNAA SSLFGEEELT
960 970 980 990 1000
SGVQVNFTPK NEEFEVMEKL GYEKEILGIY VSGHPLDRFY EQINAIDYVK
1010 1020 1030 1040 1050
SLDFESLKNN GEILSIGKIE DFKSMMSKNN KRYGRIEILD YYSSFDATVF
1060 1070 1080 1090 1100
ESNVEEIENI IKDENLKNNA YGFVLGFKAE GGEKPSFFLK AIKDLQSLED
1110 1120 1130 1140 1150
GEIKAIKKFG AKKDFKNKEE NHFTAEPKEF EKNIIELDLT RLNRELIYEI
1160 1170 1180 1190 1200
HEIARNAHNP NEKNNKKLVL KVISAGSCLL YHTDFIISDS IVEEISNKYA
Length:1,200
Mass (Da):137,341
Last modified:October 1, 2000 - v1
Checksum:i17D40CA6623D34FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA Translation: CAL34855.1
PIRiA81343
RefSeqiWP_002852165.1, NC_002163.1
YP_002344136.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL34855; CAL34855; Cj0718
GeneIDi905036
KEGGicje:Cj0718
PATRICifig|192222.6.peg.710

Similar proteinsi

Entry informationi

Entry nameiDPO3A_CAMJE
AccessioniPrimary (citable) accession number: Q9PPI9
Secondary accession number(s): Q0PAG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health