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Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation1 Publication

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54IronUniRule annotation1
Metal bindingi58IronUniRule annotation1
Metal bindingi128IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAutoinducer synthesis, Quorum sensing
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-1155-MONOMER
BRENDAi4.4.1.21 1087

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
Alternative name(s):
AI-2 synthesis proteinUniRule annotation
Autoinducer-2 production protein LuxSUniRule annotation
Gene namesi
Name:luxSUniRule annotation
Ordered Locus Names:Cj1198
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001722141 – 164S-ribosylhomocysteine lyaseAdd BLAST164

Proteomic databases

PaxDbiQ9PN97
PRIDEiQ9PN97

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ9PN97, 32 interactors
STRINGi192222.Cj1198

Structurei

3D structure databases

ProteinModelPortaliQ9PN97
SMRiQ9PN97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106762 Bacteria
COG1854 LUCA
HOGENOMiHOG000040371
KOiK07173
OMAiAIHTLEH

Family and domain databases

Gene3Di3.30.1360.80, 1 hit
HAMAPiMF_00091 LuxS, 1 hit
InterProiView protein in InterPro
IPR037005 LuxS_sf
IPR011249 Metalloenz_LuxS/M16
IPR003815 S-ribosylhomocysteinase
PANTHERiPTHR35799 PTHR35799, 1 hit
PfamiView protein in Pfam
PF02664 LuxS, 1 hit
PIRSFiPIRSF006160 AI2, 1 hit
PRINTSiPR01487 LUXSPROTEIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013172 S-ribosylhomocysteinase, 1 hit
SUPFAMiSSF63411 SSF63411, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PN97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLDSFKVD HTKMPAPAVR LAKVMKTPKG DDISVFDLRF CIPNKDIMSE
60 70 80 90 100
KGTHTLEHLF AGFMRDHLNS NSVEIIDISP MGCRTGFYMS LIGTPDEKSI
110 120 130 140 150
AKAWEAAMKD VLSVSDQSKI PELNIYQCGT CAMHSLDEAK QIAQKVLNLG
160
ISIINNKELK LENA
Length:164
Mass (Da):18,209
Last modified:October 1, 2000 - v1
Checksum:i717CEADF980E1EC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA Translation: CAL35313.1
PIRiH81325
RefSeqiWP_002857890.1, NC_002163.1
YP_002344589.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL35313; CAL35313; Cj1198
GeneIDi905488
KEGGicje:Cj1198
PATRICifig|192222.6.peg.1179

Similar proteinsi

Entry informationi

Entry nameiLUXS_CAMJE
AccessioniPrimary (citable) accession number: Q9PN97
Secondary accession number(s): Q0P958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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