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Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-63-MONOMER.
UniPathwayiUPA00077; UER00155.

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
Ordered Locus Names:Cj0065c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682481 – 1572-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseAdd BLAST157

Proteomic databases

PaxDbiQ9PJ54.

Interactioni

Protein-protein interaction databases

IntActiQ9PJ54. 1 interactor.
STRINGi192222.Cj0065c.

Structurei

3D structure databases

ProteinModelPortaliQ9PJ54.
SMRiQ9PJ54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.Curated

Phylogenomic databases

eggNOGiENOG4105K8U. Bacteria.
COG0801. LUCA.
HOGENOMiHOG000217741.
KOiK00950.
OMAiKDERWGP.

Family and domain databases

CDDicd00483. HPPK. 1 hit.
Gene3Di3.30.70.560. 1 hit.
InterProiView protein in InterPro
IPR000550. Hppk.
IPR035907. Hppk_sf.
PfamiView protein in Pfam
PF01288. HPPK. 1 hit.
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiView protein in PROSITE
PS00794. HPPK. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PJ54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIQGVKHF EKSRFFPFFS QNIRSFKYLA LIGLGSNIEP EKKRFDMLFR
60 70 80 90 100
VMMDDKRFKI LSTSPMLINE AFGFKEQKDF TNAVMLIQTN LHARALLKVL
110 120 130 140 150
LYYEVKFKRK RTFKNAPRTL DLDLLYFSQK VKRDKWCEVP HKGAKERVSV

ILPLGMI
Length:157
Mass (Da):18,628
Last modified:December 1, 2000 - v1
Checksum:iF42BBDE39E0D57E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34239.1.
PIRiE81422.
RefSeqiWP_002851803.1. NC_002163.1.
YP_002343529.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34239; CAL34239; Cj0065c.
GeneIDi904396.
KEGGicje:Cj0065c.
PATRICifig|192222.6.peg.64.

Similar proteinsi

Entry informationi

Entry nameiHPPK_CAMJE
AccessioniPrimary (citable) accession number: Q9PJ54
Secondary accession number(s): Q0PC68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: February 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome