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Protein

Argininosuccinate lyase

Gene

argH

Organism
Xylella fastidiosa (strain 9a5c)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:XF_1003
OrganismiXylella fastidiosa (strain 9a5c)
Taxonomic identifieri160492 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
Proteomesi
  • UP000000812 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001378531 – 445Argininosuccinate lyaseAdd BLAST445

Proteomic databases

PRIDEiQ9PEM5

Interactioni

Protein-protein interaction databases

STRINGi160492.XF1003

Structurei

3D structure databases

ProteinModelPortaliQ9PEM5
SMRiQ9PEM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PEM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTPPMPSLL WHKPGVAIDA NIQTFLAADD VLLDREFFLY DITASTAHAQ
60 70 80 90 100
ALQRIGLLTP DELDNILREL QHLTDEYRNG TFLLDTQYED GHSAIESRLT
110 120 130 140 150
ERLGETGRKI HTGRSRNDQI LVATRLWLKD RLTQLSTLNR DIAHHALQRA
160 170 180 190 200
AAEQHLPMPG YTHLQRAVVS SAGMWWAGWA ESFIDNAVRA ADTHALIDCN
210 220 230 240 250
PLGTAAGYGV NLPLDRPHTT AALGFARLQV NPICAQLSRG KFELAALEAL
260 270 280 290 300
GSATLDLRRI AWDLSLFTTS EFAFITLPPE YSTGSSIMPN KRNPDVIELM
310 320 330 340 350
RATHASVAAA RTEIEQLLSL PSGYHRDLQN SKGAIVRGFK RGLAALELLP
360 370 380 390 400
ALLSRLQWRP DTLRAAIDPG MYATDAAIEA AIAGIPFRDA YQMAAKTADT
410 420 430 440
AAQGRTPETS LTARRSPGAA ADLCLETLRA RWHTLTQPTS DPDPR
Length:445
Mass (Da):48,928
Last modified:October 1, 2000 - v1
Checksum:iA1709A3A3D65A3A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003849 Genomic DNA Translation: AAF83813.1
PIRiB82735

Genome annotation databases

EnsemblBacteriaiAAF83813; AAF83813; XF_1003
KEGGixfa:XF_1003

Similar proteinsi

Entry informationi

Entry nameiARLY_XYLFA
AccessioniPrimary (citable) accession number: Q9PEM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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