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UniProtKB - Q9P8V9 (LIP8_CANAL)
Protein
Lipase 8
Gene
LIP8
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Functioni
Catalytic activityi
- EC:3.1.1.3
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 194 | Charge relay systemBy similarity | 1 | |
Active sitei | 339 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- triglyceride lipase activity Source: UniProtKB-EC
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Protein family/group databases
ESTHERi | canal-LIP8, Fungal-Bact_LIP |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:LIP8 Ordered Locus Names:CAALFM_C703300CA ORF Names:CaO19.8925 |
Organismi | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Taxonomic identifieri | 237561 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0000193439, LIP8 |
VEuPathDBi | FungiDB:C7_03300C_A |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 14 | Sequence analysisAdd BLAST | 14 | |
ChainiPRO_0000017827 | 15 – 460 | Lipase 8Add BLAST | 446 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 229 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 291 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 417 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SI7U, Eukaryota |
HOGENOMi | CLU_029538_5_0_1 |
InParanoidi | Q9P8V9 |
OrthoDBi | 806580at2759 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR005152, Lipase_secreted |
PANTHERi | PTHR34853, PTHR34853, 1 hit |
Pfami | View protein in Pfam PF03583, LIP, 1 hit |
PIRSFi | PIRSF029171, Esterase_LipA, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9P8V9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLFLLFLLIT PIYAGLIFLT KPSNDPFYNP PKGFEKAAVG DILQSRETPK
60 70 80 90 100
SITGRFAPLE IQNSWQLLVR SEDSFGNPNA IVTTVIQPFN ADPSKVASYQ
110 120 130 140 150
VFEDSAKGDC APSYALQFGS DLSTLATQAE TFLLAPLLEQ GYYVVSPDYE
160 170 180 190 200
GPKSTFTIGK QSGQAVLNSI RAALKSGKIT NIKDDAKVVM WGYSGGSLAS
210 220 230 240 250
GWAAALQPSY APELGGNLLG AALGGFVTNI TATAQAADGT VFAGIVANAL
260 270 280 290 300
GGVANEYPEF KSILQSDTDK KSVFDEFDSH CLADGVIDYI NTSFLTGDNK
310 320 330 340 350
IFKTGWDILK SSTIAKIVKD NGLVYQKQLV PKIPIFVYHG SIDQIVPIVN
360 370 380 390 400
VKKTYQNWCE GGISSLEFAE DGTNGHLTET VVGAPAALTW IIDRFNGKQT
410 420 430 440 450
VSGCQHDKRL SNFQYPNISS SILKYFKVAL DTMMSNGLGS DIQKDKITPD
460
DLRKFLLGGW
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | L → P in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 24 | N → S in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 60 | E → K in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 87 | Q → E in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 89 | F → V in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 96 | V → I in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 105 | S → A in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 108 | G → A in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 123 – 126 | STLA → TTFV in AAF69523 (PubMed:11131027).Curated | 4 | |
Sequence conflicti | 131 – 134 | TFLL → MYLM in AAF69523 (PubMed:11131027).Curated | 4 | |
Sequence conflicti | 139 | E → D in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 173 | A → T in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 177 | G → S in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 184 | D → E in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 215 – 217 | GGN → SSS in AAF69523 (PubMed:11131027).Curated | 3 | |
Sequence conflicti | 312 | S → P in AAF69523 (PubMed:11131027).Curated | 1 | |
Sequence conflicti | 319 | K → E in AAF69523 (PubMed:11131027).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF191321 Genomic DNA Translation: AAF69523.2 CP017629 Genomic DNA Translation: AOW30674.1 |
RefSeqi | XP_711685.2, XM_706593.2 |
Genome annotation databases
GeneIDi | 3646727 |
KEGGi | cal:CAALFM_C703300CA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF191321 Genomic DNA Translation: AAF69523.2 CP017629 Genomic DNA Translation: AOW30674.1 |
RefSeqi | XP_711685.2, XM_706593.2 |
3D structure databases
SMRi | Q9P8V9 |
ModBasei | Search... |
Protein family/group databases
ESTHERi | canal-LIP8, Fungal-Bact_LIP |
Genome annotation databases
GeneIDi | 3646727 |
KEGGi | cal:CAALFM_C703300CA |
Organism-specific databases
CGDi | CAL0000193439, LIP8 |
VEuPathDBi | FungiDB:C7_03300C_A |
Phylogenomic databases
eggNOGi | ENOG502SI7U, Eukaryota |
HOGENOMi | CLU_029538_5_0_1 |
InParanoidi | Q9P8V9 |
OrthoDBi | 806580at2759 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR005152, Lipase_secreted |
PANTHERi | PTHR34853, PTHR34853, 1 hit |
Pfami | View protein in Pfam PF03583, LIP, 1 hit |
PIRSFi | PIRSF029171, Esterase_LipA, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LIP8_CANAL | |
Accessioni | Q9P8V9Primary (citable) accession number: Q9P8V9 Secondary accession number(s): A0A1D8PRC4, Q59PM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 21, 2003 |
Last sequence update: | May 10, 2017 | |
Last modified: | February 23, 2022 | |
This is version 89 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Candida albicans
Candida albicans: entries and gene names - SIMILARITY comments
Index of protein domains and families