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Entry version 46 (28 Feb 2018)
Sequence version 1 (01 Oct 2000)
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Protein
Submitted name:

1,3-beta-glucan synthase

Gene

FKS

Organism
Candida glabrata (Yeast) (Torulopsis glabrata)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT48 Glycosyltransferase Family 48

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
1,3-beta-glucan synthaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FKSImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida glabrata (Yeast) (Torulopsis glabrata)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5478 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei506 – 528HelicalSequence analysisAdd BLAST23
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Transmembranei580 – 605HelicalSequence analysisAdd BLAST26
Transmembranei691 – 714HelicalSequence analysisAdd BLAST24
Transmembranei1375 – 1396HelicalSequence analysisAdd BLAST22
Transmembranei1462 – 1483HelicalSequence analysisAdd BLAST22
Transmembranei1489 – 1506HelicalSequence analysisAdd BLAST18
Transmembranei1577 – 1596HelicalSequence analysisAdd BLAST20
Transmembranei1616 – 1638HelicalSequence analysisAdd BLAST23
Transmembranei1658 – 1681HelicalSequence analysisAdd BLAST24
Transmembranei1687 – 1712HelicalSequence analysisAdd BLAST26
Transmembranei1818 – 1838HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2042

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini312 – 427FKS1_dom1InterPro annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili256 – 276Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0916 Eukaryota
ENOG410XQ8V LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01205 FKS1_dom1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P8N8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANWQNTDPN GNYYYNGAEN NEFYDQDYAS QQPEQQQGGE GYYDEYGQPN
60 70 80 90 100
YNYMNDPQQG QMPQQQPGGY ENDGYYDSYY NNQMNAGVGN GLGPDQTNFS
110 120 130 140 150
DFSSYGPPPF QNNQANYTPS QLSYSNNGMG SNGMNMSGSS TPVYGNYDPN
160 170 180 190 200
AIAMTLPNDP YPAWTADPQS PVSIEQIEDV FIDLTNKFGF QRDSMRNIFD
210 220 230 240 250
LFMTLLDSRT SRMSPDQALL SVHADYIGGD TANYKKWYFA AQLDMDDEVG
260 270 280 290 300
FRNMNLGKLS RKARKAKKKN KKAMEEANPE DAAEVLNKIE GDNSLEASDF
310 320 330 340 350
RWKTKMNMLT PIERVRQVAL YMLIWGEANQ VRFTSECLCF IYKCASDYLE
360 370 380 390 400
SPLCQQRTEP IPEGDYLNRV ITPIYQFIRN QVYEIVDGPF MSKREKEKDH
410 420 430 440 450
NKIIGYDDVN QLFWYPEGIT KIVLEDGTKL TDIPSEERYL RLGEVAWNDV
460 470 480 490 500
FFKTYKETRT WLHLVTNFNR IWIMHVSVYW MYVAYNSPTF YTHNYQQLVN
510 520 530 540 550
NQPVPAYRWA SAALAGTVAS AIQLFATVCE WWFVPRKWAG AQHLSRRFWF
560 570 580 590 600
LCGILGVNLG PLIFVFAYEK DTVQSKAGHA VAAVTFFIAV ATVLFFSIMP
610 620 630 640 650
LGGLFTSYMQ KSSRRYVASQ TFTASFAPLQ GLDRWLSYLV WVTVFAAKYS
660 670 680 690 700
ESYFFLILSL RDPIRILSTT TMRCTGEYWW GSKLCRHQSK IVLGFMIATD
710 720 730 740 750
FILFFLDTYL WYIVVNTVFS VGKSFYLGIS ILTPWRNIFT RLPKRIYSKI
760 770 780 790 800
LATTDMEIKY KPKVLISQIW NAIIISMYRE HLLAIDHVQK LLYHQVPSEI
810 820 830 840 850
EGKRTLRAPT FFVSQDDNNF ETEFFPRNSE AERRISFFAQ SLATPMPEPL
860 870 880 890 900
PVDNMPTFTV LTPHYSERIL LSLREIIRED DQFSRVTLLE YLKQLHPVEW
910 920 930 940 950
ECFVKDTKIL AEETAAYENE EPQDPEKSDA LKTQIDDLPF YCIGFKSAAP
960 970 980 990 1000
EYTLRTRIWA SLRSQTLYRT VSGFMNYARA IKLLYRVENP EIVQMFGGNA
1010 1020 1030 1040 1050
EGLERELEKM ARRKFKFLVS MQRLAKFKPH ELENTEFLLR AYPDLQIAYL
1060 1070 1080 1090 1100
DEEPPLNEGE EPRIYSALID GHCEMLENGR RRPKFRVQLS GNPILGDGKS
1110 1120 1130 1140 1150
DNQNHALIFY RGEYIQLIDA NQDNYLEECL KIRSVLAEFE ELNAEPVYPY
1160 1170 1180 1190 1200
TPGVKYEDQK TNHPVAIVGA REYIFSENSG VLGDVAAGKE QTFGTLFART
1210 1220 1230 1240 1250
LAQIGGKLHY GHPDFINATF MTTRSGLSKA QKGLHLNEDI YAGMNALLRG
1260 1270 1280 1290 1300
GRIKHCEYYQ CGKGRDLGFG TILNFTTKIG AGMGEQMLSR EYYYLGTQLP
1310 1320 1330 1340 1350
VDRFLTFYYA HPGFHLNNLF IQLSLQMFML TLVNLHALAH ESILCIYDRN
1360 1370 1380 1390 1400
KPKTDVLYPI GCYNFSPAID WIRRYTLSIF IVFWIAFVPI VVQELIERGL
1410 1420 1430 1440 1450
WKATQRFFRH ILSLSPMFEV FAGQIYSAAL LSDMTVGGAR YISTGRGFAT
1460 1470 1480 1490 1500
SRIPFSILYS RFASSAIYMG ARSMLMLLFG TVAHWQAPLL WFWASLSALL
1510 1520 1530 1540 1550
FSPFIFNPHQ FSWEDFFLDY RDYIRWLSRG NNKYHKNSWI GYVRMARSRI
1560 1570 1580 1590 1600
TGFKRKLIGD DSEKAAGDAN RAHRTNLILA ELIPTAINAG SCFIGFTFIN
1610 1620 1630 1640 1650
AQTGVKATDD DRVNSVLRVV LCTLGPIAVD VGVLFFCLGM SCCSGPLFGM
1660 1670 1680 1690 1700
CCKKTGAVMA AVAHGVSVVI HIGFFIVMWV LEGFNFTRML VGVATVIQCQ
1710 1720 1730 1740 1750
RFIFQLMTIL LLTREFKNDH ANTAFWTGKW YGSGFGYMAW TQPMRELTAK
1760 1770 1780 1790 1800
VIEMSEFAAD FVLGHVILFA QFPVLCIPAI DKFHSIMLFW LKPSRHIRPP
1810 1820 1830 1840 1850
IYSLKQSRLR KRMVKRYLTL YIIIFLVFAG AIVGPAVARL AHVPQDIGHT
1860 1870 1880 1890
LTGPFHNIVQ PRNKSNNDTG LQISTYSNHY YTHTPSLKTW STIK
Length:1,894
Mass (Da):217,384
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3F1A5F5EF72EFFF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF229171 Genomic DNA Translation: AAF34719.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229171 Genomic DNA Translation: AAF34719.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Chemistry databases

ChEMBLiCHEMBL2042

Protein family/group databases

CAZyiGT48 Glycosyltransferase Family 48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0916 Eukaryota
ENOG410XQ8V LUCA

Family and domain databases

InterProiView protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48
PfamiView protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit
SMARTiView protein in SMART
SM01205 FKS1_dom1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9P8N8_CANGB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P8N8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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