UniProtKB - Q9P7W3 (ACL1_SCHPO)
Protein
Probable ATP-citrate synthase subunit 1
Gene
SPBC1703.07
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.By similarity
Catalytic activityi
- EC:2.3.3.8
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 238 | MagnesiumBy similarity | 1 | |
Active sitei | 280 | Tele-phosphohistidine intermediateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 221 – 241 | ATPBy similarityAdd BLAST | 21 | |
Nucleotide bindingi | 272 – 298 | ATPBy similarityAdd BLAST | 27 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP citrate synthase activity Source: GO_Central
- cofactor binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- acetyl-CoA biosynthetic process Source: PomBase
- citrate metabolic process Source: PomBase
- fatty acid biosynthetic process Source: GO_Central
- generation of precursor metabolites and energy Source: PomBase
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-163765 ChREBP activates metabolic gene expression R-SPO-6798695 Neutrophil degranulation R-SPO-75105 Fatty acyl-CoA biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ATP-citrate synthase subunit 1 (EC:2.3.3.8)Alternative name(s): ATP-citrate (pro-S-)-lyase 1 Citrate cleavage enzyme subunit 1 |
Gene namesi | ORF Names:SPBC1703.07 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPBC1703.07 |
PomBasei | SPBC1703.07 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000102786 | 1 – 615 | Probable ATP-citrate synthase subunit 1Add BLAST | 615 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 359 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q9P7W3 |
PaxDbi | Q9P7W3 |
PRIDEi | Q9P7W3 |
PTM databases
iPTMneti | Q9P7W3 |
Interactioni
Subunit structurei
Composed of two subunits.
By similarityProtein-protein interaction databases
BioGridi | 276425, 5 interactors |
STRINGi | 4896.SPBC1703.07.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 299 – 309 | CoA-bindingSequence analysisAdd BLAST | 11 |
Sequence similaritiesi
Belongs to the succinate/malate CoA ligase alpha subunit family.Curated
Phylogenomic databases
HOGENOMi | HOG000151479 |
InParanoidi | Q9P7W3 |
KOi | K01648 |
OMAi | HAGAKEG |
PhylomeDBi | Q9P7W3 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit 3.40.50.261, 1 hit |
InterProi | View protein in InterPro IPR016142 Citrate_synth-like_lrg_a-sub IPR016143 Citrate_synth-like_sm_a-sub IPR002020 Citrate_synthase IPR036969 Citrate_synthase_sf IPR033847 Citrt_syn/SCS-alpha_CS IPR003781 CoA-bd IPR005811 CoA_ligase IPR036291 NAD(P)-bd_dom_sf IPR017866 Succ-CoA_synthase_bsu_CS IPR016102 Succinyl-CoA_synth-like |
Pfami | View protein in Pfam PF00285 Citrate_synt, 1 hit PF02629 CoA_binding, 1 hit PF00549 Ligase_CoA, 1 hit |
SMARTi | View protein in SMART SM00881 CoA_binding, 1 hit |
SUPFAMi | SSF48256 SSF48256, 1 hit SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01216 SUCCINYL_COA_LIG_1, 1 hit PS01217 SUCCINYL_COA_LIG_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9P7W3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGSVDKPSY ELFSKDTRAF VYGMQTKAVQ GMLDFDYMCG RTVPSVAAII
60 70 80 90 100
YTFGSQSISK LYWGTKEILL PVYRTIEEAC TKHPEVDVVV NFASSRSAYA
110 120 130 140 150
STMELMEFPQ IRCIAIIAEG VPERRAREIL VTSKEKNVVI IGPATVGGIK
160 170 180 190 200
PGCFKIGNTG GMMDNIVASK LYRPGSVAYV SKSGGMSNEL NNIISHTTDG
210 220 230 240 250
VYEGIAIGGD RYPGTTFIDH LIRFEADPAC KLMVLLGEVG GVEEYRVIEA
260 270 280 290 300
VKNGTIKKPI VAWAIGTCSS MFKTEVQFGH AGSFANSELE TAVAKNQAMR
310 320 330 340 350
EAGIYVPETF EKLPALLQEV YEGLVKKGVI VPQPEVAPPN IPLDYAWAKE
360 370 380 390 400
LGLVRKPSSF ICTISNDRGS ELTYNNVPIS KVFEEELGIG GVISLLWLRR
410 420 430 440 450
RLPSYATKFL EMVLQLTADH GPCVSGAMNT IITTRAGKDL ISSLVAGLLT
460 470 480 490 500
IGTRFGGALD GAAQEFSKAY DAGLSPRAFV DSCRKANKLI PGIGHRIKSR
510 520 530 540 550
NNPDLRVELV KGYVKKNFPS TKLLDYALAV ENVTTSKKDN LILNVDGCIA
560 570 580 590 600
VCFVDLLRNC GAFTLEEANE YINLGILNGM FVLGRSIGLI GHHLDQKRLR
610
APLYRHPWDD FLYLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAB66451.1 D89194 mRNA Translation: BAA13855.1 |
PIRi | T42753 T50320 |
RefSeqi | NP_596202.1, NM_001022121.2 |
Genome annotation databases
EnsemblFungii | SPBC1703.07.1; SPBC1703.07.1:pep; SPBC1703.07 |
GeneIDi | 2539879 |
KEGGi | spo:SPBC1703.07 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAB66451.1 D89194 mRNA Translation: BAA13855.1 |
PIRi | T42753 T50320 |
RefSeqi | NP_596202.1, NM_001022121.2 |
3D structure databases
SMRi | Q9P7W3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 276425, 5 interactors |
STRINGi | 4896.SPBC1703.07.1 |
PTM databases
iPTMneti | Q9P7W3 |
Proteomic databases
MaxQBi | Q9P7W3 |
PaxDbi | Q9P7W3 |
PRIDEi | Q9P7W3 |
Genome annotation databases
EnsemblFungii | SPBC1703.07.1; SPBC1703.07.1:pep; SPBC1703.07 |
GeneIDi | 2539879 |
KEGGi | spo:SPBC1703.07 |
Organism-specific databases
EuPathDBi | FungiDB:SPBC1703.07 |
PomBasei | SPBC1703.07 |
Phylogenomic databases
HOGENOMi | HOG000151479 |
InParanoidi | Q9P7W3 |
KOi | K01648 |
OMAi | HAGAKEG |
PhylomeDBi | Q9P7W3 |
Enzyme and pathway databases
Reactomei | R-SPO-163765 ChREBP activates metabolic gene expression R-SPO-6798695 Neutrophil degranulation R-SPO-75105 Fatty acyl-CoA biosynthesis |
Miscellaneous databases
PROi | PR:Q9P7W3 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit 3.40.50.261, 1 hit |
InterProi | View protein in InterPro IPR016142 Citrate_synth-like_lrg_a-sub IPR016143 Citrate_synth-like_sm_a-sub IPR002020 Citrate_synthase IPR036969 Citrate_synthase_sf IPR033847 Citrt_syn/SCS-alpha_CS IPR003781 CoA-bd IPR005811 CoA_ligase IPR036291 NAD(P)-bd_dom_sf IPR017866 Succ-CoA_synthase_bsu_CS IPR016102 Succinyl-CoA_synth-like |
Pfami | View protein in Pfam PF00285 Citrate_synt, 1 hit PF02629 CoA_binding, 1 hit PF00549 Ligase_CoA, 1 hit |
SMARTi | View protein in SMART SM00881 CoA_binding, 1 hit |
SUPFAMi | SSF48256 SSF48256, 1 hit SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01216 SUCCINYL_COA_LIG_1, 1 hit PS01217 SUCCINYL_COA_LIG_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACL1_SCHPO | |
Accessioni | Q9P7W3Primary (citable) accession number: Q9P7W3 Secondary accession number(s): P78844 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | October 16, 2019 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names