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Entry version 108 (17 Jun 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Mediator of replication checkpoint protein 1

Gene

mrc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the replisome and is required for rad3-dependent activation of the checkpoint kinase cds1 in response to replication fork arrest. Phosphorylation allows it to mediate the activation of cds1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of replication checkpoint protein 1
Alternative name(s):
DNA replication checkpoint mediator mrc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mrc1
ORF Names:SPAC694.06c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC694.06c

Schizosaccharomyces pombe database

More...
PomBasei
SPAC694.06c mrc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi599S → A: Severe hydroxyurea (HU) sensitivity. 1 Publication1
Mutagenesisi604S → A: Severe hydroxyurea (HU) sensitivity. 1 Publication1
Mutagenesisi614S → A: Severe hydroxyurea (HU) sensitivity. 1 Publication1
Mutagenesisi634T → A: Hydroxyurea (HU) sensitivity. 1 Publication1
Mutagenesisi637S → A: Hydroxyurea (HU) sensitivity. 1 Publication1
Mutagenesisi645T → A: Hydroxyurea (HU) sensitivity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000965731 – 1019Mediator of replication checkpoint protein 1Add BLAST1019

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei604Phosphoserine1 Publication1
Modified residuei645Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by rad3 and tel1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P7T4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P7T4

PRoteomics IDEntifications database

More...
PRIDEi
Q9P7T4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P7T4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cds1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
279668, 123 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9P7T4

Protein interaction database and analysis system

More...
IntActi
Q9P7T4, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9P7T4

STRING: functional protein association networks

More...
STRINGi
4896.SPAC694.06c.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_301308_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P7T4

KEGG Orthology (KO)

More...
KOi
K11272

Identification of Orthologs from Complete Genome Data

More...
OMAi
NMIDDET

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P7T4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024146 Claspin
IPR018564 Repl_chkpnt_MRC1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR14396 PTHR14396, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09444 MRC1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P7T4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLDENADE LHRMDSSDEA SINDDQEDIL DTPRTRVRKM LASVDMQLSS
60 70 80 90 100
NAVSEASLDK ESTVGNLENQ KNRSYSSEIY LHSDTNFLSN FDSAYERVRR
110 120 130 140 150
LLNQQGGKSS LQKKEVEQIE TQEGGDNAKG SPSSENKDSD RNSRLQQLIE
160 170 180 190 200
KKRNALKKEQ EDLIQNSATS HSKSDNLDSE SADDSDLADE SELSKKYTSD
210 220 230 240 250
RKIRNASKKA LLELHRNTAR LTRETALKPE VVVKKKVTLR EFFQKIGFKN
260 270 280 290 300
DNQLENKAIS EEEANSTEPP NVEKEEPKPS VDRSTGIVNS EDIKELSVED
310 320 330 340 350
DSLELKEITP EALDIGQTSL FTTLNQTQVK KEDNKKFLLK EINAKLNEDD
360 370 380 390 400
IDSELEIEVK PKTTALDNIE KSKLSEENEH GIKGKLKQLA EIKLSKDGKP
410 420 430 440 450
FENEFNIKSF NRNLVKRAAV MAKLQRNQLE EELKAKGIYK PTIQGEKEEE
460 470 480 490 500
EDPLERARND AEKIRQLEKA SGNASDEGEL NDEEEVISSS NTPSTKAKTT
510 520 530 540 550
NKVIISDVII EATQAEPKRR QKNSRVVFDE EDLTGDSHGS SNMKISESDD
560 570 580 590 600
ESNGDMIRDS FDRLSSESIK DSQKTEELHD SFGINDEVDQ STSLYVQNSQ
610 620 630 640 650
PSASQLTIVD ATYSQPPPRW ESSSRDDKTN TSSTQPSQVD SLVPTQLDST
660 670 680 690 700
IPTQIDSVQR NKDQDDEEIL EERRESRRDS KTFLSRTMLY NKDTGKADSA
710 720 730 740 750
WASDLIEEQA IESDDEYAGI GGLSDDGLSD SDAELEVQNM IDDETTIQKG
760 770 780 790 800
EVASMAQFAK DQEMDRDEKL VKQLMKDVTT GALRKRNRNG FAALDDSDDE
810 820 830 840 850
DYSNLRREKL KELRRQKLLE DGNLNVLEGD KRKAFLATVE DSLVSSKDNL
860 870 880 890 900
TWLDATVEDS GVGSSDLGDE YLYSEQSLNH EEEEQMEEEL SEIFSSGGPN
910 920 930 940 950
VVDRVYLKKS STRHTSDNNS LEEVLPIFPG VRKLVSNSQS EKIGDLSNDN
960 970 980 990 1000
SMGAKSYKTP IISSTQRPQG RKFRGLMNQS SKADISRTVD AGSIKVVPNS
1010
QSANPPRLLA SLNNYSDFD
Length:1,019
Mass (Da):114,319
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B5E7A4B5ABE5380
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB71844.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T50251

NCBI Reference Sequences

More...
RefSeqi
NP_594486.1, NM_001019915.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC694.06c.1; SPAC694.06c.1:pep; SPAC694.06c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2543240

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC694.06c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB71844.1
PIRiT50251
RefSeqiNP_594486.1, NM_001019915.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi279668, 123 interactors
ELMiQ9P7T4
IntActiQ9P7T4, 1 interactor
MINTiQ9P7T4
STRINGi4896.SPAC694.06c.1

PTM databases

iPTMnetiQ9P7T4

Proteomic databases

MaxQBiQ9P7T4
PaxDbiQ9P7T4
PRIDEiQ9P7T4

Genome annotation databases

EnsemblFungiiSPAC694.06c.1; SPAC694.06c.1:pep; SPAC694.06c
GeneIDi2543240
KEGGispo:SPAC694.06c

Organism-specific databases

EuPathDBiFungiDB:SPAC694.06c
PomBaseiSPAC694.06c mrc1

Phylogenomic databases

HOGENOMiCLU_301308_0_0_1
InParanoidiQ9P7T4
KOiK11272
OMAiNMIDDET
PhylomeDBiQ9P7T4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9P7T4

Family and domain databases

InterProiView protein in InterPro
IPR024146 Claspin
IPR018564 Repl_chkpnt_MRC1_dom
PANTHERiPTHR14396 PTHR14396, 1 hit
PfamiView protein in Pfam
PF09444 MRC1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRC1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P7T4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: June 17, 2020
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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