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Protein

Probable ubiquitin carboxyl-terminal hydrolase 7

Gene

ubp7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei217NucleophilePROSITE-ProRule annotation1
Active sitei812Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 149UBP-typePROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-5689880 Ub-specific processing proteases
R-SPO-5696395 Formation of Incision Complex in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 7
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Gene namesi
Name:ubp7
ORF Names:SPAC23G3.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23G3.08c
PomBaseiSPAC23G3.08c ubp7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806081 – 875Probable ubiquitin carboxyl-terminal hydrolase 7Add BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei333Phosphoserine1 Publication1
Modified residuei337Phosphoserine1 Publication1
Modified residuei486Phosphoserine1 Publication1
Modified residuei493Phosphoserine1 Publication1
Modified residuei645Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P7S5
PaxDbiQ9P7S5
PRIDEiQ9P7S5

PTM databases

iPTMnetiQ9P7S5

Interactioni

Protein-protein interaction databases

BioGridi278336, 16 interactors
STRINGi4896.SPAC23G3.08c.1

Structurei

3D structure databases

ProteinModelPortaliQ9P7S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 875USPAdd BLAST668

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 149UBP-typePROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiQ9P7S5
KOiK11844
OrthoDBiEOG092C1E9C
PhylomeDBiQ9P7S5

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
SUPFAMiSSF54001 SSF54001, 4 hits
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P7S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHSNTLIVP STNPFDDPSS IKNGLNNLTS SELVNQMKKE SLAASVKTPS
60 70 80 90 100
TPPKECSHLK KGVKLSHLKG NARALRDPSK HLCFICTTEK IKREDYELTL
110 120 130 140 150
CANCGYLFCC NHESDHSRKH FEKNKKHCVF VNIITLKCHC YSCDADIVIF
160 170 180 190 200
DKKNLVVRDV QQFICSNLVS SLTKAPNVLK SNSSHFKKEK KSKHSSGKSS
210 220 230 240 250
KKYKVISPGL KNLGATCFFN STLQVLCACE ALHDVISPFQ YSHSSVIVRK
260 270 280 290 300
LTKSPESSLL SAFIKFLETF YKSDGTISVY RPTTFFGEFR RLHPQFSESV
310 320 330 340 350
QQDAHELLRL LLDDLISEEF RVLRFNLNSV SRSLQLSPCL TDDEQLSKSL
360 370 380 390 400
TSFKQVNVTD ASLSPNSHNT SDNEQNNEDY VSVSSLVGSE TEDITYSKEL
410 420 430 440 450
SQSSDSSQHQ HDSFLPANSS PLAASSTKSL PSSELLDSSS DKGQQVFKGQ
460 470 480 490 500
HEVAGTNSFE DPNSHFNVSN SSNHEEASPK KEVLKSPQFQ RRSLDILRLG
510 520 530 540 550
ELSSDDMMLD KATMDEFSSS LVIKSIFTGR LTSVVMCQSC NEITNTPEPI
560 570 580 590 600
QDLSIPIHYP SSRVSRRHRF HRALRSRFSR SPKKSSVKIV VDNANDDTDQ
610 620 630 640 650
APTTNSSSLN ENLLGGHASE NDKSLKQSPF QKLTRRLSDL SVNSSGQISK
660 670 680 690 700
QDFDNSNSIF SESSLSSPII EEPKTLIDCL KNFTHVEELS GENMFACENC
710 720 730 740 750
CNQPNEVGSP AKGGLTSDND KYSFNNSVYR NAYKRMLLDD PLPPVFIIHL
760 770 780 790 800
KRFFQEISHD GYANPKKISD FIEFEQELDL NEFVMPHLRA SSSFRYRLFG
810 820 830 840 850
VIVHSGTLNY GHYVAYVLSH KFLDLSAPST NSKDFRSEAG IPERRWLYIS
860 870
DNIVRESSWD EVSKVEAYML FYERV
Length:875
Mass (Da):98,377
Last modified:October 1, 2000 - v1
Checksum:iB4E4CFAC9A440D54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB72233.1
PIRiT50182
RefSeqiNP_593108.1, NM_001018505.2

Genome annotation databases

EnsemblFungiiSPAC23G3.08c.1; SPAC23G3.08c.1:pep; SPAC23G3.08c
GeneIDi2541845
KEGGispo:SPAC23G3.08c

Entry informationi

Entry nameiUBP7_SCHPO
AccessioniPrimary (citable) accession number: Q9P7S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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