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Entry version 105 (03 Jul 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Adenylate cyclase activation protein git1

Gene

git1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the glucose/cAMP-signaling pathway. Required for maintaining basal cAMP levels and for producing a glucose-triggered cAMP response.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylate cyclase activation protein git1
Alternative name(s):
Glucose-insensitive transcription protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:git1
ORF Names:SPBC21C3.20c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPBC21C3.20c

Schizosaccharomyces pombe database

More...
PomBasei
SPBC21C3.20c git1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002562531 – 1098Adenylate cyclase activation protein git1Add BLAST1098

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P7K5

PRoteomics IDEntifications database

More...
PRIDEi
Q9P7K5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cyr1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
cyr1P146053EBI-1542810,EBI-1542835

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
277143, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P7K5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPBC21C3.20c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P7K5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini567 – 700MHD1PROSITE-ProRule annotationAdd BLAST134
Domaini981 – 1097MHD2PROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P7K5

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRIHPGT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P7K5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014770 Munc13_1
IPR014772 Munc13_dom-2

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51258 MHD1, 1 hit
PS51259 MHD2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P7K5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFTSVEPPD FFDWTARAIF LLSTLRSRRN AKQIERENAL LDQIKELLSI
60 70 80 90 100
AIIQCHERNI PSIDLPPSFF NYVCEQLPRH PFAKIASSYI DTHTLFFQIS
110 120 130 140 150
ISSFLCRFSN CSEDEIRLFK QHQSLDSFLL SLFDLLCSHH FSVEFTSISL
160 170 180 190 200
IIKSSQWLFY TLSDYAHESL TGVEADITTK FLSTLADTWP EFEEQCTLSK
210 220 230 240 250
HLFLLGDFSL ISYVKVLCGV FNIPNYNAFI LSVEDLLPEN ISFAAVADFQ
260 270 280 290 300
LSKYRAINDN SVLRSDDFSS KAVFDKYVER ECYYSENAIS KIFQNYPDLA
310 320 330 340 350
VLFEELQYAE GNNDLLSAIL NTNKYTLRPD DCAPYFYRLM DLCLRYCYSQ
360 370 380 390 400
SNEIGTNVLW SMTTSFINIW RIHPGTCCCV VLSIYWPYLE DKLLKFSDLG
410 420 430 440 450
DIFEYFFSLI HDCDYAIWSV HDEHQFSELL AFYHRRALND LVEELGSCPR
460 470 480 490 500
SSDSCRAILD ILNNYIFSCP LFLVTPEELE EQYTDFFKKL KEKYGEFFQN
510 520 530 540 550
LLKKELTGKP ESDLEGLRLV GVQLQATYEN LKSNFSARIF NQLSVHSFFA
560 570 580 590 600
EATCHLFLEK LPTITKTYVY SNCKEIPDHI LEMINALYQQ TRALVACTGY
610 620 630 640 650
LSSDYPKIYE AFSGTFVYRN LSLIIDKGLA NVLQTVLRES FIPKRSRFYS
660 670 680 690 700
DSTKMILAPL QDCYDFLQKI DWPSSKDANR FYLHLGKLSE NYIHYYVDSM
710 720 730 740 750
YALFIYSTDI PLKAEPLVPD LPVKQLKEKA SHFKRHSGDP NFLKLYRESF
760 770 780 790 800
TLINTVSLVS GWLKMLHQRI DYKILTEKVM HFKDMEVPSA TVIISIKMAH
810 820 830 840 850
LLVTPKAPYS FSVLLQDPES EFCVHTRDVY DELVPNWKET YQMEITNVKR
860 870 880 890 900
FKLIIYQRNI HTGLETVYGH ATLEVDPDKL KQGHGKDVWL DITNKGQILI
910 920 930 940 950
GLRVLLKRET PNYYCFAQME YLTVTEVKML NVLMISLSKF IRNSLRNSGL
960 970 980 990 1000
MDFVRYLDGD ENDNAEAETK EKMDELQARC EKEQQSLLAE LDDFFYWIYV
1010 1020 1030 1040 1050
NLLPKPLFYL LSRLWFGLLE TFRDILVPPV TDSTLRRIPL NKRELKMVYS
1060 1070 1080 1090
WLQLFYDFFR NFQDIAPFDF LNTDEYKSVM AIKDYYFVKS KDVKRVSS
Length:1,098
Mass (Da):128,300
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C3697EF3E16EFF2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB76056.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T50364

NCBI Reference Sequences

More...
RefSeqi
NP_596600.1, NM_001022520.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC21C3.20c.1; SPBC21C3.20c.1:pep; SPBC21C3.20c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540617

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC21C3.20c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB76056.1
PIRiT50364
RefSeqiNP_596600.1, NM_001022520.2

3D structure databases

SMRiQ9P7K5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi277143, 6 interactors
IntActiQ9P7K5, 1 interactor
STRINGi4896.SPBC21C3.20c.1

Proteomic databases

PaxDbiQ9P7K5
PRIDEiQ9P7K5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC21C3.20c.1; SPBC21C3.20c.1:pep; SPBC21C3.20c
GeneIDi2540617
KEGGispo:SPBC21C3.20c

Organism-specific databases

EuPathDBiFungiDB:SPBC21C3.20c
PomBaseiSPBC21C3.20c git1

Phylogenomic databases

InParanoidiQ9P7K5
OMAiWRIHPGT
PhylomeDBiQ9P7K5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9P7K5

Family and domain databases

InterProiView protein in InterPro
IPR014770 Munc13_1
IPR014772 Munc13_dom-2
PROSITEiView protein in PROSITE
PS51258 MHD1, 1 hit
PS51259 MHD2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGIT1_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P7K5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: July 3, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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