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Protein

H/ACA ribonucleoprotein complex subunit nhp2

Gene

nhp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:10502409). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (By similarity). Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs (By similarity). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (By similarity). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (By similarity). Directly binds H/ACA snoRNAs (By similarity).By similarity1 Publication

GO - Molecular functioni

  • box H/ACA snoRNA binding Source: PomBase
  • rRNA binding Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit nhp2
Alternative name(s):
H/ACA snoRNP protein NHP2
High mobility group-like nuclear protein 2
P17-nhp2
Gene namesi
Name:nhp2
ORF Names:SPAC1782.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1782.10c
PomBaseiSPAC1782.10c nhp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367751 – 154H/ACA ribonucleoprotein complex subunit nhp2Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P7H0
PaxDbiQ9P7H0
PRIDEiQ9P7H0

PTM databases

iPTMnetiQ9P7H0

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).By similarity

Protein-protein interaction databases

BioGridi278833, 9 interactors
STRINGi4896.SPAC1782.10c.1

Structurei

3D structure databases

ProteinModelPortaliQ9P7H0
SMRiQ9P7H0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000055227
InParanoidiQ9P7H0
KOiK11129
OMAiNIPYCYT
OrthoDBiEOG092C5PRN
PhylomeDBiQ9P7H0

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR002415 H/ACA_rnp_Nhp2_euk
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00883 NUCLEARHMG
SUPFAMiSSF55315 SSF55315, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P7H0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKDKKDHKH SGSTEDEYDS YLPALMPIAK PLAPKKLNKK MMKTVKKASK
60 70 80 90 100
QKHILRGVKE VVKAVRKGEK GLVILAGDIS PMDVISHIPV LCEDNNVPYL
110 120 130 140 150
YTVSKELLGE ASNTKRPTSC VMIVPGGKKK DMSKVEEYKE SYEEIIKEVP

ALEV
Length:154
Mass (Da):17,178
Last modified:October 1, 2000 - v1
Checksum:i9E5E8FE5E88B6055
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76A → P in CAA08990 (PubMed:10502409).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010068 mRNA Translation: CAA08990.1
CU329670 Genomic DNA Translation: CAB76272.1
PIRiT43644
T50100
RefSeqiNP_594717.1, NM_001020144.2

Genome annotation databases

EnsemblFungiiSPAC1782.10c.1; SPAC1782.10c.1:pep; SPAC1782.10c
GeneIDi2542369
KEGGispo:SPAC1782.10c

Similar proteinsi

Entry informationi

Entry nameiNHP2_SCHPO
AccessioniPrimary (citable) accession number: Q9P7H0
Secondary accession number(s): O94239
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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