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UniProtKB - Q9P6N4 (PEP5_SCHPO)

Entry version 121 (10 Feb 2021)
Sequence version 1 (01 Oct 2000)
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Protein

E3 ubiquitin-protein ligase pep5

Gene

vps11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase ypt7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion. Acts as component of the CORVET complex that is required for transport between endosome and vacuole. CORVET is an effector for the endosomal Rab GTPase ypt5. Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri871 – 906RING-type; degenerateSequence analysisAdd BLAST36

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processProtein transport, Transport, Ubl conjugation pathway
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase pep5By similarity (EC:2.3.2.27By similarity)
Alternative name(s):
Carboxypeptidase Y-deficient protein 5By similarity
Histone E3 ligase pep5By similarity
RING-type E3 ubiquitin transferase pep5Curated
Vacuolar protein sorting-associated protein 11By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vps11By similarity
Synonyms:pep5By similarity
ORF Names:SPAC823.12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...PomBasei		SPAC823.12, vps11

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:SPAC823.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003610171 – 906E3 ubiquitin-protein ligase pep5Add BLAST906

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9P6N4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P6N4

PRoteomics IDEntifications database

More...PRIDEi		Q9P6N4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P6N4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex.

Component of the class C core vacuole/endosome tethering (CORVET) complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		4896.SPAC823.12.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati413 – 557CHCRAdd BLAST145

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS11 family.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri871 – 906RING-type; degenerateSequence analysisAdd BLAST36

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2114, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001287_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P6N4

Identification of Orthologs from Complete Genome Data

More...OMAi		WIAHENG

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P6N4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000547, Clathrin_H-chain/VPS_repeat
IPR011990, TPR-like_helical_dom_sf
IPR016528, VPS11
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
IPR001841, Znf_RING

The PANTHER Classification System

More...PANTHERi		PTHR23323:SF24, PTHR23323:SF24, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00637, Clathrin, 1 hit
PF17122, zf-C3H2C3, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF007860, VPS11, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50236, CHCR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P6N4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTFIKNWKR ITLFQVKAIE ENIDRLTSSF SSNGELVVFA TAFGDVSIYN 
        60         70         80         90        100
SSFKSLQSIK VEDESSIQQI LWLDNKTFLL FSNVEGGTGT NSTVIIYAFS 
       110        120        130        140        150
QADENEPPQF VLVTTHKFSI NESPYPIIAV SQSPIDKTIA CGFGGGLVSC 
       160        170        180        190        200
YHGNPLRERG IKNSYSHNLG EPITGLTYLD DQSSVLFIAT TNKTYSLSGK 
       210        220        230        240        250
SLSCLDNTGV SLNCSSSCKT TPLQSREKNS SSFVCTRSSG LTFYDSKREK 
       260        270        280        290        300
ICFTFPGEKH YMTVMGSILA LCYTPTLGTD SSTNEGLKKS FSSSSSIRKA 
       310        320        330        340        350
DASRNPAFPP RLLLVDLSRN LIVWEGHLKD VAVSILPLKH GFLVVTADDN 
       360        370        380        390        400
VFELKRITLQ EEISLLCQKM MYNLAISLAK KENMDIEFRE SLMRDYASFL 
       410        420        430        440        450
FRRGDFSASM DWYIRSIKSI DIPSVCLEFL KAQEIKQLIR LLEELIKTGL 
       460        470        480        490        500
ATSDHRLLLL SCYVEIHDSP SIRKLIDIGE IDFDQAFKIC YDSNLLDEAK 
       510        520        530        540        550
HLAIRFNNNE RVLDVLVESE QYSEALRFFE SLPPSNLLPL LLKYGRVLLD 
       560        570        580        590        600
KLPEKTTNIF IQFYSNSHRG DLSTSESKGE LKTAKSLRQT YLSLLPYAQV 
       610        620        630        640        650
ANFSLPPSLY EISPSQEENQ RAALFSEDVS YTAPSPQTCF HIFLNHNSEL 
       660        670        680        690        700
ISFLEGILPN ASPNYKTLIN TCLFEAYIRE SFASSNVEKQ EFWQEKSNSL 
       710        720        730        740        750
LKKVEKNVDL NAVFLISQIL GFDDGVRFVQ GKSGQTLDIF RSFCQQNDIE 
       760        770        780        790        800
RALKMVRVHG PDQQELYIMM LNCFASLENV DSWYQDINEI VNIIVSQRLI 
       810        820        830        840        850
SPTQLLDILG KSVNIKLEHI SDSMQSVLDN YRESISKQNE AIEMGKRDIE 
       860        870        880        890        900
EITSQLSILR TRAFVVQESK CSTCGIDLEL PMVHFRCGHS YHQRCVEDEC 

IRCRWL
Length:906
Mass (Da):102,524
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74F8B5B4440F3C80
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB90157.1

NCBI Reference Sequences

More...RefSeqi		NP_593839.1, NM_001019268.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		SPAC823.12.1; SPAC823.12.1:pep; SPAC823.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2543359

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spo:SPAC823.12

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB90157.1
RefSeqiNP_593839.1, NM_001019268.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi4896.SPAC823.12.1

PTM databases

iPTMnetiQ9P6N4

Proteomic databases

MaxQBiQ9P6N4
PaxDbiQ9P6N4
PRIDEiQ9P6N4

Genome annotation databases

EnsemblFungiiSPAC823.12.1; SPAC823.12.1:pep; SPAC823.12
GeneIDi2543359
KEGGispo:SPAC823.12

Organism-specific databases

PomBaseiSPAC823.12, vps11
VEuPathDBiFungiDB:SPAC823.12

Phylogenomic databases

eggNOGiKOG2114, Eukaryota
HOGENOMiCLU_001287_0_0_1
InParanoidiQ9P6N4
OMAiWIAHENG
PhylomeDBiQ9P6N4

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9P6N4

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000547, Clathrin_H-chain/VPS_repeat
IPR011990, TPR-like_helical_dom_sf
IPR016528, VPS11
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
IPR001841, Znf_RING
PANTHERiPTHR23323:SF24, PTHR23323:SF24, 1 hit
PfamiView protein in Pfam
PF00637, Clathrin, 1 hit
PF17122, zf-C3H2C3, 1 hit
PIRSFiPIRSF007860, VPS11, 1 hit
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50236, CHCR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEP5_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P6N4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: October 1, 2000
Last modified: February 10, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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