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Protein

Alcohol dehydrogenase 1

Gene

adh-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi157Zinc 1; catalyticBy similarity1
Binding sitei205NADBy similarity1
Binding sitei210NADBy similarity1
Binding sitei346NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi181 – 187NADBy similarity7
Nucleotide bindingi274 – 276NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1 3627

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase I
Gene namesi
Name:adh-1
ORF Names:B17C10.210, NCU01754
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU01754

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607261 – 353Alcohol dehydrogenase 1Add BLAST353

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9P6C8
SMRiQ9P6C8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685
InParanoidiQ9P6C8
KOiK13953
OrthoDBiEOG092C2Q8E

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9P6C8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQFEIPEQQ WAQVVEKKGG PVVFKQIPVQ KPGPDEVLIN VKYSGVCHTD
60 70 80 90 100
LHAMKGDWPL ATKMPLVGGH EGAGVVVAKG ELVTEVEVGD HAGIKWLNGS
110 120 130 140 150
CLACSFCMQA DEPLCPHALL SGYTVDGSFQ QYAIAKAAHV AKIPKGCDLE
160 170 180 190 200
TTAPVLCAGI TVYKGLKESG VRPGQCVAIV GAGGGLGSMA IQYANAMGLH
210 220 230 240 250
AIAIDGGEEK GKNCRELGAQ AYVDFTTTKD LVADVKAATP DGLGPHAVIL
260 270 280 290 300
LAVSEKPFHQ AVDYVRSRGT IICIGLPAGA KFQAPVFDTV IRMITIKGSY
310 320 330 340 350
VGNRQDTQEA LDFFARGLIK VPIKTVGLSK LQEVYDLMEE GKIVGRYVVD

TSK
Length:353
Mass (Da):37,443
Last modified:October 1, 2000 - v1
Checksum:i66B71D891324C854
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V5IR31V5IR31_NEUCR
Alcohol dehydrogenase I, variant
adh-1 NCU01754
327Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355926 Genomic DNA Translation: CAB91241.1
CM002237 Genomic DNA Translation: ESA43622.1
PIRiT49440
RefSeqiXP_011393501.1, XM_011395199.1

Genome annotation databases

EnsemblFungiiESA43622; ESA43622; NCU01754
GeneIDi3873329
KEGGincr:NCU01754

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355926 Genomic DNA Translation: CAB91241.1
CM002237 Genomic DNA Translation: ESA43622.1
PIRiT49440
RefSeqiXP_011393501.1, XM_011395199.1

3D structure databases

ProteinModelPortaliQ9P6C8
SMRiQ9P6C8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiESA43622; ESA43622; NCU01754
GeneIDi3873329
KEGGincr:NCU01754

Organism-specific databases

EuPathDBiFungiDB:NCU01754

Phylogenomic databases

HOGENOMiHOG000294685
InParanoidiQ9P6C8
KOiK13953
OrthoDBiEOG092C2Q8E

Enzyme and pathway databases

BRENDAi1.1.1.1 3627

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_NEUCR
AccessioniPrimary (citable) accession number: Q9P6C8
Secondary accession number(s): Q7RV68, V5INI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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