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Entry version 120 (02 Jun 2021)
Sequence version 4 (19 Mar 2014)
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Protein

E3 ubiquitin-protein ligase TOM1-like

Gene

B11B22.010

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ubiquitin ligase protein, which may be involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4043Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processmRNA transport, Transport, Ubl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TOM1-like (EC:2.3.2.26)
Alternative name(s):
HECT-type E3 ubiquitin transferase TOM1-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:B11B22.010, NCU08501
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 6, Linkage Group II, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:NCU08501

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001203461 – 4076E3 ubiquitin-protein ligase TOM1-likeAdd BLAST4076

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9P4Z1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P4Z1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3740 – 4076HECTPROSITE-ProRule annotationAdd BLAST337

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni225 – 256DisorderedSequence analysisAdd BLAST32
Regioni288 – 360DisorderedSequence analysisAdd BLAST73
Regioni748 – 819DisorderedSequence analysisAdd BLAST72
Regioni921 – 970DisorderedSequence analysisAdd BLAST50
Regioni1083 – 1103DisorderedSequence analysisAdd BLAST21
Regioni1571 – 1646DisorderedSequence analysisAdd BLAST76
Regioni1988 – 2041DisorderedSequence analysisAdd BLAST54
Regioni2067 – 2110DisorderedSequence analysisAdd BLAST44
Regioni2275 – 2295DisorderedSequence analysisAdd BLAST21
Regioni2356 – 2551DisorderedSequence analysisAdd BLAST196
Regioni2581 – 2634DisorderedSequence analysisAdd BLAST54
Regioni2782 – 2817DisorderedSequence analysisAdd BLAST36
Regioni2858 – 2955DisorderedSequence analysisAdd BLAST98
Regioni3037 – 3066DisorderedSequence analysisAdd BLAST30
Regioni3105 – 3132DisorderedSequence analysisAdd BLAST28
Regioni3216 – 3241DisorderedSequence analysisAdd BLAST26
Regioni3353 – 3444DisorderedSequence analysisAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2851 – 2929Sequence analysisAdd BLAST79
Coiled coili3341 – 3375Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi237 – 251Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi307 – 343Polar residuesSequence analysisAdd BLAST37
Compositional biasi748 – 765Polar residuesSequence analysisAdd BLAST18
Compositional biasi939 – 954Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi955 – 970Polar residuesSequence analysisAdd BLAST16
Compositional biasi1590 – 1643Polar residuesSequence analysisAdd BLAST54
Compositional biasi1998 – 2017Polar residuesSequence analysisAdd BLAST20
Compositional biasi2018 – 2041Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi2082 – 2096Polar residuesSequence analysisAdd BLAST15
Compositional biasi2403 – 2451Acidic residuesSequence analysisAdd BLAST49
Compositional biasi2468 – 2551Acidic residuesSequence analysisAdd BLAST84
Compositional biasi2581 – 2596Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi2597 – 2624Acidic residuesSequence analysisAdd BLAST28
Compositional biasi2858 – 2912Basic and acidic residuesSequence analysisAdd BLAST55
Compositional biasi3353 – 3372Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi3375 – 3416Polar residuesSequence analysisAdd BLAST42
Compositional biasi3417 – 3438Basic and acidic residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPL family. TOM1/PTR1 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000215_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P4Z1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078, HECTc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06012, DUF908, 1 hit
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF14377, UBM, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119, HECTc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237, HECT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P4Z1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKITKTMQQ KHRDTLSPWL KEFVDTASSA PLPLILQRLD EFPRRWMFPR
60 70 80 90 100
GDLYHWIPLL NRFDNILESI CATYELSKGP QTRDFGRDVL LNNGGPSLEY
110 120 130 140 150
RDEPWTVERL AEAGYKEDGD CQLLVAILKF TRMLLEHCGN RSIYASSHHI
160 170 180 190 200
DRLLNSPYLE VQAAALEVGL ELAQRYNASV KRMPSPPRSV NPTLLANHYN
210 220 230 240 250
IDLEKVQLLA RPFVRTPIVK SLEASSAAPA VSAGSTAKAK DKEKEKEKAT
260 270 280 290 300
GPKNVASMYA NDLKALASSR PDEEDLWKSW GDLKMSYYPD TTNGEPSARD
310 320 330 340 350
SKDAQPVEPR TTSSPAAPTP LRRSSTMNVS QSSRTQRVGS SEEGSPLKPS
360 370 380 390 400
GAATDDRDGP KVVEIPRSVI ESKRIYDLYD MCPSDMPATM KFEFTSRLRT
410 420 430 440 450
CKALLGTHRE RQLALAVRLL AITNLAYILP EAVFVDKVLK YDKDEPRTFQ
460 470 480 490 500
LVYQLAELIA PSPDGNPSEV PKWLQSITLA LLEAISHQQE KHSDVLAALN
510 520 530 540 550
VNVNHGILLY VIRIAVAEMK EDAPVDDQDE LDADNWRGNL FGLTLQIAMA
560 570 580 590 600
TRIGQEMMTA GLMDCLVEIL NLRTAVASRH YSMVLAFLDS LTYAYQTAFS
610 620 630 640 650
QLNSAGGLDA ITNLIVHTVG ESKTLTEAGL GTKPELHASL VDYSIPFYHQ
660 670 680 690 700
QTLKWLLKFI HHVMANTYSF DGTNTERLLR NLVDNSSLLG SLCTIARQNR
710 720 730 740 750
FFGTVVWSNA TTLLSDFINN DPTSFAAISE SGWIQAFLES VTNRPVSIPA
760 770 780 790 800
EQPSLEPSQS RANDGSEGND ADDDSEDDGS AHDAAPDSDG QAATQPHPPT
810 820 830 840 850
QEMLEAPRDF PPAHGILPSS ESMNIIPTVL NSISLNNRGM KMVLSSGAIQ
860 870 880 890 900
SYMEIFESAT HVQCMAHDPE LASTIGSSLD ELSRHHPALR PAIANAIIDM
910 920 930 940 950
IARVTHLVKT MDATKACGAR LEAPESSASP VAEPAQATEV KGKGKEKATD
960 970 980 990 1000
DTDVEMAEAS SSSSGNNKPA QAPSIPYIQV LSTFLQPIIS NSHLKGALIS
1010 1020 1030 1040 1050
AGVIEILLDL AESPSLPHDF GETPACRMLV AAISQLIESA QIVGLPSLLF
1060 1070 1080 1090 1100
RMENTVKVLQ PRINPTTTEP FFAPFLTLNS SVSPVQDEEP ASEKRTPDVS
1110 1120 1130 1140 1150
SGTETVKALL NIQTMIKILY HCFPFSNRSQ MVSMPAVNVY DYYIRLIQSL
1160 1170 1180 1190 1200
GPLLRGVLKE EAAVNGAVPH HWTLKNKPYQ TNSLGSRTDV QDLLTDSAAQ
1210 1220 1230 1240 1250
DSSANGKKLT PEEQSTAEYK NFQTLRVLLH SFMPSIFPFF QTIGKALLPR
1260 1270 1280 1290 1300
RNNNDPYIRS RHLAIAEASA ETLIQQLQQS KAELTVRDIH NWIIMIHTFG
1310 1320 1330 1340 1350
EMVVDTNHRT ASGGAFLILP VITAFKELGG FEALNVMLKR LADMVSTGAT
1360 1370 1380 1390 1400
EGQEATKAKL SMIGMKKVLD IYCFIISGKN LSDSMAQIAL APKPTERTTR
1410 1420 1430 1440 1450
EFSHQLVVEL RMSILPVVRE IWASNIIEKS TGTVVSKIID IIKTIAAGDL
1460 1470 1480 1490 1500
ESNAQSRSDK ESLPHLFKNR ESVPFKWISR KDAETLATEQ GVDVDLALEA
1510 1520 1530 1540 1550
LYRANGKESD TKEYIKYQKA HLVRNRNPVP AEDAFKEVPS PNLSSSAGMS
1560 1570 1580 1590 1600
LSNLLNTPTF PVSDLLGAEP MALDPVPNQP LGEASGETAL GHATESSEDG
1610 1620 1630 1640 1650
SDEGQPGTSR ETNVGASTTA PQQLPVLPSQ QPATESQSNT PRITREDLVE
1660 1670 1680 1690 1700
ERAKLYDTLI DRSLEVISSH PEAVFEVADL IQNTILKTDN EDRRVEVGEI
1710 1720 1730 1740 1750
LANALMSFAS DDADELKENG SSIAAYAHLL ALLLQQTAFM RTTVDMLRDY
1760 1770 1780 1790 1800
VGDYLGFLKL PPASSNDSLP PWIPYILLIF EIMLFKDAQP PDIKWKQPVK
1810 1820 1830 1840 1850
EDDPIEESVI EVKEPNFLAE HRSSLLTTLL DFLPRIGKEE SLAVSVLRIL
1860 1870 1880 1890 1900
VVLTRDHAVA KIVGEKKNLQ RLFVMAKQLC GAGSTRLKQT HISEHIRQIL
1910 1920 1930 1940 1950
RHIIEDEETL RQIFETDIRH LMTSRQRPSA APGLEPQAYL RTQAHLALRS
1960 1970 1980 1990 2000
PKTFVEVSTE LLKLNRAVSH LGDGTLRSTP FLVLKERPAD ASVSPKESSV
2010 2020 2030 2040 2050
EPAVQATEDL TISDVKPSTE VTDKDMHDAP KNPAQDLKRP ILEHPDGVVH
2060 2070 2080 2090 2100
FLLTELLNYK DVDERENVPA PPAAASKPES DATAANEATP SPSGDEQNSE
2110 2120 2130 2140 2150
SKEKEKKLAK SPFKAEDHPI FIYRCFLLDC LAELLQSYNR AKVEFINFKR
2160 2170 2180 2190 2200
SAPVQANAPV KPRSSVLNYI LNDLLCFSPA SGVPESIAMK KKAATAVPAR
2210 2220 2230 2240 2250
AVLVALVSKT GEKPQNRTHE PFEYDDEPDL LFIRRFVLDT ILRAYKDASV
2260 2270 2280 2290 2300
SGEPADIRYG KMNALAELMA QMIGEGDKDS RPNNPRGTDP SIGRSQAQLK
2310 2320 2330 2340 2350
RLMYEKGYLT SLTASIADID LTFPHNRAPL KPILAVIKTL SKTAVSMSQL
2360 2370 2380 2390 2400
GLIPASGTAG TDQAEDEFLS DGSSVSEDLT DDREETPDLY RNSTLGMLEP
2410 2420 2430 2440 2450
GRDDEFSDED EDDDEDMYDD EQYDDELDYG DDMSQDNEDN PSDEEDDLGE
2460 2470 2480 2490 2500
MGEMGGMPGQ PGVVEVLMGE NDDEEDNDDM DDMDEDDEMD EDDEQELSDE
2510 2520 2530 2540 2550
DEDEEVGSED MDDLEDDIHI VDEEGNAIDD DGASWDDGTD EDEEDEEELD
2560 2570 2580 2590 2600
YEAEAQNMQE AQLHNRRTFP EIMRAAMENA GDDLDAEPIR DFDGHYIDDD
2610 2620 2630 2640 2650
EDGEEDDDED EGEDDMDDDM YFDGDGLHDD LLAPNMPSGL GWDIAIEPNH
2660 2670 2680 2690 2700
RHRPSRSPWP NSPFVVGRHR DAIDFQNFFR RPAHLSRHLP PPADVMSGTN
2710 2720 2730 2740 2750
PLLLPQSRRE VPRHAHSQLV RLGITPNMIG GLGMGMGVEP LAFISDLVQH
2760 2770 2780 2790 2800
LPDVRLSAGG GPLALHFTAD GPGGIIRELN AIPIPPPHSR ESRPTEARRD
2810 2820 2830 2840 2850
TYQEPHQAVQ FSPESTHERW QQEVKMIFGF GYQDKAQKLA PLILSKLTPA
2860 2870 2880 2890 2900
AIQAEKEEKA RKAEADRKAE EERKKRQEEE RKKREAKEAE EKAAREKKEA
2910 2920 2930 2940 2950
EERERLERER AEAAAQAAAQ AAADQEANAV SQEAHPMEGV ETQGPGENAE
2960 2970 2980 2990 3000
QQAEDERPRV YYTLRNQQID ITELGIDAEY LEALPEEFRD EVIAQAISTR
3010 3020 3030 3040 3050
RSQAREQVSQ EGENTEVFQE FLEALPEELR NEILHQEQHE QRRRERQNAA
3060 3070 3080 3090 3100
GGQDLGPADM DPASILLTFP PGLRQQVLLD QGEDIMEHLG PELAAEARTL
3110 3120 3130 3140 3150
VARHRQLHAQ QGGQAASRSR DAQRPTEAGA GTVQKIQKRT VVQMLDKQGI
3160 3170 3180 3190 3200
ATLLRLMFVS QQGSIRSSLF SIFANLCENR QNRLDVISSL LQILQDGCAN
3210 3220 3230 3240 3250
MDAVERSFAQ ISHKAKQLKE KDAKTPHPLK RSLTGGTNNN GQFPASSEVS
3260 3270 3280 3290 3300
PLLIVQQCLD LLVELSKLNP HIPSVFLTEH ETVASTLKRS LSRKGKGKDV
3310 3320 3330 3340 3350
NGKAQKFAIN SLLTLLDRSL VMESSAVMQV LADLLNKVTI PLQAIERRRK
3360 3370 3380 3390 3400
EAEEQAKKKK EAEEKAATER EAANAPEEQA STSTEQTPAQ QEATQQPSES
3410 3420 3430 3440 3450
TPAAASGQQP AQQDQENKEL EAPKEKADEK DVQSDEKKIR QLTPPTIPEH
3460 3470 3480 3490 3500
NLKLVINIFV ARECSSKTFQ NTISTIKNLS NIPGAKKVFG DELVRQARVL
3510 3520 3530 3540 3550
SENILSDLDN LLPHILKAES GTQIQGVALA KFSPGASEQN KLLRVLTALD
3560 3570 3580 3590 3600
HLFDSKSKKQ DKPAEGENTK EDLLGSLYWN PTFGKMWDKL SACLSAIRQR
3610 3620 3630 3640 3650
DNMLNVATIL LPLIESLMVV CKNTTLSDAS AVSNANSQKE MLLTSPPPED
3660 3670 3680 3690 3700
RIAGLFFTFT EEHRRILNEL VRHNPKLMSG TFSLLVKNPK VLEFDNKRNY
3710 3720 3730 3740 3750
FNRSVHSKYQ QTRHSFPPLQ LQVRREHVFH DSFRSLYYKK ADELKFGKLN
3760 3770 3780 3790 3800
IRFQGEEGVD AGGVTREWFQ VLSRQMFDPN YVLFVPVSSD RTTFHPNKLS
3810 3820 3830 3840 3850
PINDEHLPFF KFIGRIIGKA LYEGRLLECY FSRAVYKRIL GKPVSVKDME
3860 3870 3880 3890 3900
SFDPDYYKSL VWMLENDITD IITETFSVED DVFGEVKVVD LIENGRNIPV
3910 3920 3930 3940 3950
TEENKHEYVR LIVEHKLITS VKDQMKAFLT GFHEIIPEEL IAIFNEQELE
3960 3970 3980 3990 4000
LLISGLPDID IDDWKANTEY HNYSAGAPQI QWFWRAVRSF DKEELAKLLQ
4010 4020 4030 4040 4050
FVTGTSKVPL NGFKELEGMN GVSRFNIHRD YGSKDRLPSS HTCFNQLDLP
4060 4070
EYENYETLRS QLLKAITAGS DYFGFA
Length:4,076
Mass (Da):453,670
Last modified:March 19, 2014 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0ED7E2C532706D5D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB92704 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL356834 Genomic DNA Translation: CAB92704.2 Sequence problems.
CM002237 Genomic DNA Translation: EAA34194.3

Protein sequence database of the Protein Information Resource

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PIRi
T49799

NCBI Reference Sequences

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RefSeqi
XP_963430.3, XM_958337.3

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
EAA34194; EAA34194; NCU08501

Database of genes from NCBI RefSeq genomes

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GeneIDi
3879570

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ncr:NCU08501

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356834 Genomic DNA Translation: CAB92704.2 Sequence problems.
CM002237 Genomic DNA Translation: EAA34194.3
PIRiT49799
RefSeqiXP_963430.3, XM_958337.3

3D structure databases

SMRiQ9P4Z1
ModBaseiSearch...

Proteomic databases

PRIDEiQ9P4Z1

Genome annotation databases

EnsemblFungiiEAA34194; EAA34194; NCU08501
GeneIDi3879570
KEGGincr:NCU08501

Organism-specific databases

VEuPathDBiFungiDB:NCU08501

Phylogenomic databases

HOGENOMiCLU_000215_0_1_1
InParanoidiQ9P4Z1

Enzyme and pathway databases

UniPathwayiUPA00143

Family and domain databases

CDDicd00078, HECTc, 1 hit
InterProiView protein in InterPro
IPR010309, E3_Ub_ligase_DUF908
IPR010314, E3_Ub_ligase_DUF913
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR025527, HUWE1/Rev1_UBM
PfamiView protein in Pfam
PF06012, DUF908, 1 hit
PF06025, DUF913, 1 hit
PF00632, HECT, 1 hit
PF14377, UBM, 3 hits
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SUPFAMiSSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOM1_NEUCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P4Z1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 19, 2014
Last modified: June 2, 2021
This is version 120 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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