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UniProtKB - Q9P4R4 (LYS9_MAGO7)
Protein
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
Gene
LYS3
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Functioni
Catalytic activityi
- EC:1.5.1.10
: L-lysine biosynthesis via AAA pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (fungal route). This subpathway is part of the pathway L-lysine biosynthesis via AAA pathway, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (fungal route), the pathway L-lysine biosynthesis via AAA pathway and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 76 | NADP; via carbonyl oxygenCombined sources1 Publication | 1 | |
Binding sitei | 126 | SaccharopineCombined sources1 Publication | 1 | |
Binding sitei | 175 | NADP; via amide nitrogenCombined sources1 Publication | 1 | |
Binding sitei | 224 | SaccharopineCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 11 – 14 | NADPCombined sources1 Publication | 4 | |
Nucleotide bindingi | 33 – 35 | NADPCombined sources1 Publication | 3 | |
Nucleotide bindingi | 55 – 56 | NADPCombined sources1 Publication | 2 | |
Nucleotide bindingi | 98 – 99 | NADPCombined sources1 Publication | 2 | |
Nucleotide bindingi | 125 – 127 | NADPCombined sources1 Publication | 3 |
GO - Molecular functioni
- saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity Source: UniProtKB-EC
GO - Biological processi
- lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Amino-acid biosynthesis, Lysine biosynthesis |
Ligand | NADP |
Enzyme and pathway databases
BRENDAi | 1.5.1.10, 5238 |
UniPathwayi | UPA00033;UER00033 |
Names & Taxonomyi
Protein namesi | Recommended name: Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] (EC:1.5.1.10)Alternative name(s): Saccharopine reductase |
Gene namesi | Name:LYS3 ORF Names:MGG_08564 |
Organismi | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) |
Taxonomic identifieri | 242507 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Magnaporthales › Pyriculariaceae › Pyricularia › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:MGG_17041 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212838 | 1 – 450 | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]Add BLAST | 450 |
Proteomic databases
PRIDEi | Q9P4R4 |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
STRINGi | 318829.MGG_17041T0 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9P4R4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9P4R4 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 99 – 100 | Saccharopine bindingCombined sources1 Publication | 2 | |
Regioni | 245 – 247 | Saccharopine bindingCombined sources1 Publication | 3 |
Sequence similaritiesi
Belongs to the saccharopine dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG0172, Eukaryota |
HOGENOMi | CLU_016207_3_1_1 |
InParanoidi | Q9P4R4 |
OMAi | WNYKFTW |
OrthoDBi | 535756at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR032095, Sacchrp_dh-like_C IPR005097, Sacchrp_dh_NADP |
Pfami | View protein in Pfam PF16653, Sacchrp_dh_C, 1 hit PF03435, Sacchrp_dh_NADP, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9P4R4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATKSVLMLG SGFVTRPTLD VLTDSGIKVT VACRTLESAK KLSAGVQHST
60 70 80 90 100
PISLDVNDDA ALDAEVAKHD LVISLIPYTF HATVIKSAIR QKKHVVTTSY
110 120 130 140 150
VSPAMMELDQ AAKDAGITVM NEIGLDPGID HLYAIKTIEE VHAAGGKIKT
160 170 180 190 200
FLSYCGGLPA PESSDNPLGY KFSWSSRGVL LALRNAASFY KDGKVTNVAG
210 220 230 240 250
PELMATAKPY FIYPGFAFVA YPNRDSTPYK ERYQIPEADN IVRGTLRYQG
260 270 280 290 300
FPQFIKVLVD IGFLSDEEQP FLKEAIPWKE ATQKIVKASS ASEQDIVSTI
310 320 330 340 350
VSNATFESTE EQKRIVAGLK WLGIFSDKKI TPRGNALDTL CATLEEKMQF
360 370 380 390 400
EEGERDLVML QHKFEIENKD GSRETRTSSL CEYGAPIGSG GYSAMAKLVG
410 420 430 440 450
VPCAVAVKFV LDGTISDRGV LAPMNSKIND PLMKELKEKY GIECKEKVVA
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 140 | E → G in strain: 4091-5-8. | 1 | |
Natural varianti | 398 | L → F in strain: 4091-5-8. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF144424 Genomic DNA Translation: AAF91081.1 CM001234 Genomic DNA Translation: EHA49766.1 |
RefSeqi | XP_003716085.1, XM_003716037.1 |
Genome annotation databases
EnsemblFungii | MGG_17041T0; MGG_17041T0; MGG_17041 |
GeneIDi | 12984319 |
KEGGi | mgr:MGG_17041 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF144424 Genomic DNA Translation: AAF91081.1 CM001234 Genomic DNA Translation: EHA49766.1 |
RefSeqi | XP_003716085.1, XM_003716037.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1E5L | X-ray | 2.40 | A/B | 1-450 | [»] | |
1E5Q | X-ray | 2.10 | A/B/C/D/E/F/G/H | 1-450 | [»] | |
1FF9 | X-ray | 2.00 | A | 1-450 | [»] | |
SMRi | Q9P4R4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 318829.MGG_17041T0 |
Proteomic databases
PRIDEi | Q9P4R4 |
Genome annotation databases
EnsemblFungii | MGG_17041T0; MGG_17041T0; MGG_17041 |
GeneIDi | 12984319 |
KEGGi | mgr:MGG_17041 |
Organism-specific databases
VEuPathDBi | FungiDB:MGG_17041 |
Phylogenomic databases
eggNOGi | KOG0172, Eukaryota |
HOGENOMi | CLU_016207_3_1_1 |
InParanoidi | Q9P4R4 |
OMAi | WNYKFTW |
OrthoDBi | 535756at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00033;UER00033 |
BRENDAi | 1.5.1.10, 5238 |
Miscellaneous databases
EvolutionaryTracei | Q9P4R4 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR032095, Sacchrp_dh-like_C IPR005097, Sacchrp_dh_NADP |
Pfami | View protein in Pfam PF16653, Sacchrp_dh_C, 1 hit PF03435, Sacchrp_dh_NADP, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LYS9_MAGO7 | |
Accessioni | Q9P4R4Primary (citable) accession number: Q9P4R4 Secondary accession number(s): A4QYG4, G4N642 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | June 12, 2007 | |
Last modified: | September 29, 2021 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families