UniProtKB - Q9P381 (CDSH_SCHPO)
Protein
Putative phosphatidate cytidylyltransferase
Gene
SPBC13A2.03
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade.By similarity
Catalytic activityi
- EC:2.7.7.41
Cofactori
Mg2+By similarity
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- no protein annotated in this organism
- no protein annotated in this organism
- Putative phosphatidate cytidylyltransferase (SPBC13A2.03), Phosphatidate cytidylyltransferase, mitochondrial (tam41)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- phosphatidate cytidylyltransferase activity Source: PomBase
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: PomBase
- phosphatidylglycerol biosynthetic process Source: PomBase
- phosphatidylserine metabolic process Source: PomBase
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Ligand | Magnesium |
Enzyme and pathway databases
Reactomei | R-SPO-1483148 Synthesis of PG R-SPO-1483226 Synthesis of PI |
UniPathwayi | UPA00557;UER00614 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative phosphatidate cytidylyltransferase (EC:2.7.7.41)Alternative name(s): CDP-DAG synthase CDP-DG synthase CDP-diacylglycerol synthase Short name: CDS CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CTP:phosphatidate cytidylyltransferase |
Gene namesi | ORF Names:SPBC13A2.03 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPBC13A2.03 |
PomBasei | SPBC13A2.03 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 52 – 71 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 76 – 98 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 110 – 130 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 145 – 165 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 199 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 245 – 265 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 321 – 341 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000316216 | 1 – 439 | Putative phosphatidate cytidylyltransferaseAdd BLAST | 439 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q9P381 |
PaxDbi | Q9P381 |
PRIDEi | Q9P381 |
PTM databases
iPTMneti | Q9P381 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDS family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | HOG000209582 |
InParanoidi | Q9P381 |
KOi | K00981 |
OMAi | VVQAHFI |
PhylomeDBi | Q9P381 |
Family and domain databases
InterProi | View protein in InterPro IPR000374 PC_trans IPR016720 PC_Trfase_euk |
PANTHERi | PTHR13773 PTHR13773, 1 hit |
PIRSFi | PIRSF018269 PC_trans_euk, 1 hit |
PROSITEi | View protein in PROSITE PS01315 CDS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9P381-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARKRTNKRN NSDKENGNVG VVQNKDSASS KTTEPARLTK HKSLARKPSQ
60 70 80 90 100
NFITRTIWTF LLLGIFFTAL AMGHFWVVLL VTIVQIGVYK EVIAIASVPS
110 120 130 140 150
REKDLPWTRF INWYFLMTTL YYAYGESIYA YFHHLFIMDS FMLPLVLHHR
160 170 180 190 200
FISFMLYIIG FVLFVASLKK GNYKFQFSQF CWTHMTLLLV VGQSHFMINN
210 220 230 240 250
LFEGLFWFFV PVCYVVCNDV FAYLCGKMFG KHPLIQVSPK KTVEGFLGGW
260 270 280 290 300
ICTVVIGSLI SYVLMHFKYF ICPTRDLSTS AFSGLNCTPN SVFLPHTYTI
310 320 330 340 350
PAVFVDTFRL PETITLAPIY FHLAIFATFS SLIAPFGGFF ASGLKRAFKI
360 370 380 390 400
KDFGASIPGH GGLTDRMDCQ FLNGVFVYMY FQSFIAEKST SVADLLDTAV
410 420 430
YSLTTTQQVQ LVEDLQNYLI SHGKTSVQAI CSKLLQNSK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAB99396.1 |
RefSeqi | NP_596416.1, NM_001022335.2 |
Genome annotation databases
EnsemblFungii | SPBC13A2.03.1; SPBC13A2.03.1:pep; SPBC13A2.03 |
GeneIDi | 2540017 |
KEGGi | spo:SPBC13A2.03 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAB99396.1 |
RefSeqi | NP_596416.1, NM_001022335.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 4896.SPBC13A2.03.1 |
PTM databases
iPTMneti | Q9P381 |
Proteomic databases
MaxQBi | Q9P381 |
PaxDbi | Q9P381 |
PRIDEi | Q9P381 |
Genome annotation databases
EnsemblFungii | SPBC13A2.03.1; SPBC13A2.03.1:pep; SPBC13A2.03 |
GeneIDi | 2540017 |
KEGGi | spo:SPBC13A2.03 |
Organism-specific databases
EuPathDBi | FungiDB:SPBC13A2.03 |
PomBasei | SPBC13A2.03 |
Phylogenomic databases
HOGENOMi | HOG000209582 |
InParanoidi | Q9P381 |
KOi | K00981 |
OMAi | VVQAHFI |
PhylomeDBi | Q9P381 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Reactomei | R-SPO-1483148 Synthesis of PG R-SPO-1483226 Synthesis of PI |
Miscellaneous databases
PROi | PR:Q9P381 |
Family and domain databases
InterProi | View protein in InterPro IPR000374 PC_trans IPR016720 PC_Trfase_euk |
PANTHERi | PTHR13773 PTHR13773, 1 hit |
PIRSFi | PIRSF018269 PC_trans_euk, 1 hit |
PROSITEi | View protein in PROSITE PS01315 CDS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDSH_SCHPO | |
Accessioni | Q9P381Primary (citable) accession number: Q9P381 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | October 1, 2000 | |
Last modified: | January 16, 2019 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways