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Entry version 136 (07 Apr 2021)
Sequence version 1 (01 Oct 2000)
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Protein

THAP domain-containing protein 10

Gene

THAP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1 – 90THAP-typePROSITE-ProRule annotationAdd BLAST90

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P2Z0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
THAP domain-containing protein 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THAP10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23193, THAP10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612538, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P2Z0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000129028.8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56906

Open Targets

More...
OpenTargetsi
ENSG00000129028

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134988462

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P2Z0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THAP10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41018369

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000686511 – 257THAP domain-containing protein 10Add BLAST257

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P2Z0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P2Z0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2Z0

PeptideAtlas

More...
PeptideAtlasi
Q9P2Z0

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2Z0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83915

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2Z0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2Z0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129028, Expressed in primary visual cortex and 195 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P2Z0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P2Z0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000129028, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121236, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P2Z0, 14 interactors

Molecular INTeraction database

More...
MINTi
Q9P2Z0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000249861

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P2Z0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P2Z0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 90THAP-typePROSITE-ProRule annotationAdd BLAST90

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SDT3, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000050001

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_094625_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P2Z0

Identification of Orthologs from Complete Genome Data

More...
OMAi
TQTDELW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P2Z0

TreeFam database of animal gene trees

More...
TreeFami
TF330127

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006612, THAP_Znf
IPR038441, THAP_Znf_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05485, THAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00692, DM3, 1 hit
SM00980, THAP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50950, ZF_THAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9P2Z0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPARCVAAHC GNTTKSGKSL FRFPKDRAVR LLWDRFVRGC RADWYGGNDR
60 70 80 90 100
SVICSDHFAP ACFDVSSVIQ KNLRFSQRLR LVAGAVPTLH RVPAPAPKRG
110 120 130 140 150
EEGDQAGRLD TRGELQAARH SEAAPGPVSC TRPRAGKQAA ASQITCENEL
160 170 180 190 200
VQTQPHADNP SNTVTSVPTH CEEGPVHKST QISLKRPRHR SVGIQAKVKA
210 220 230 240 250
FGKRLCNATT QTEELWSRTS SLFDIYSSDS ETDTDWDIKS EQSDLSYMAV

QVKEETC
Length:257
Mass (Da):28,351
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i912602126537AD41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN95H0YN95_HUMAN
THAP domain-containing protein 10
THAP10
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL360202 mRNA Translation: CAB96109.1
AK313472 mRNA Translation: BAG36257.1
CH471082 Genomic DNA Translation: EAW77863.1
BC027857 mRNA Translation: AAH27857.1
BC072414 mRNA Translation: AAH72414.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10237.1

NCBI Reference Sequences

More...
RefSeqi
NP_064532.1, NM_020147.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000249861; ENSP00000249861; ENSG00000129028

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56906

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56906

UCSC genome browser

More...
UCSCi
uc002asv.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360202 mRNA Translation: CAB96109.1
AK313472 mRNA Translation: BAG36257.1
CH471082 Genomic DNA Translation: EAW77863.1
BC027857 mRNA Translation: AAH27857.1
BC072414 mRNA Translation: AAH72414.1
CCDSiCCDS10237.1
RefSeqiNP_064532.1, NM_020147.3

3D structure databases

SMRiQ9P2Z0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121236, 15 interactors
IntActiQ9P2Z0, 14 interactors
MINTiQ9P2Z0
STRINGi9606.ENSP00000249861

PTM databases

iPTMnetiQ9P2Z0
PhosphoSitePlusiQ9P2Z0

Genetic variation databases

BioMutaiTHAP10
DMDMi41018369

Proteomic databases

MassIVEiQ9P2Z0
MaxQBiQ9P2Z0
PaxDbiQ9P2Z0
PeptideAtlasiQ9P2Z0
PRIDEiQ9P2Z0
ProteomicsDBi83915

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26487, 72 antibodies

The DNASU plasmid repository

More...
DNASUi
56906

Genome annotation databases

EnsembliENST00000249861; ENSP00000249861; ENSG00000129028
GeneIDi56906
KEGGihsa:56906
UCSCiuc002asv.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56906
DisGeNETi56906

GeneCards: human genes, protein and diseases

More...
GeneCardsi
THAP10
HGNCiHGNC:23193, THAP10
HPAiENSG00000129028, Low tissue specificity
MIMi612538, gene
neXtProtiNX_Q9P2Z0
OpenTargetsiENSG00000129028
PharmGKBiPA134988462
VEuPathDBiHostDB:ENSG00000129028.8

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SDT3, Eukaryota
GeneTreeiENSGT00510000050001
HOGENOMiCLU_094625_0_0_1
InParanoidiQ9P2Z0
OMAiTQTDELW
PhylomeDBiQ9P2Z0
TreeFamiTF330127

Enzyme and pathway databases

PathwayCommonsiQ9P2Z0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
56906, 9 hits in 1008 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56906
PharosiQ9P2Z0, Tdark

Protein Ontology

More...
PROi
PR:Q9P2Z0
RNActiQ9P2Z0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000129028, Expressed in primary visual cortex and 195 other tissues
ExpressionAtlasiQ9P2Z0, baseline and differential
GenevisibleiQ9P2Z0, HS

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR006612, THAP_Znf
IPR038441, THAP_Znf_sf
PfamiView protein in Pfam
PF05485, THAP, 1 hit
SMARTiView protein in SMART
SM00692, DM3, 1 hit
SM00980, THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950, ZF_THAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHA10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2Z0
Secondary accession number(s): B2R8R0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2000
Last modified: April 7, 2021
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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