UniProtKB - Q9P2Y5 (UVRAG_HUMAN)

BLAST

>sp|Q9P2Y5|UVRAG_HUMAN UV radiation resistance-associated gene protein OS=Homo sapiens OX=9606 GN=UVRAG PE=1 SV=1
MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQ
LLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGG
KENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILL
QVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECL
QLKILVLQNELERQKKALGREVALLHKQQIALQDKGSAFSAEHLKLQLQKESLNELRKEC
TAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDGSI
AVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKL
QFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKR
QSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGET
ERKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTL
LPSEQAGSASVQLPGEFHPVSEAELCCTVEQAEEIIGLEATGFASGDQLEAFNCIPVDSA
VAVECDEQVLGEFEEFSRRIYALNENVSSFRRPRRSSDK

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History
Entry version 145 (07 Nov 2018)
Sequence version 1 (01 Oct 2000)
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Protein

UV radiation resistance-associated gene protein

Gene

UVRAG

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns₃P) (PubMed:24056303). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300).Curated3 Publications

Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840).1 Publication

GO - Molecular functionⁱ

SH3 domain binding Source: Ensembl
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy
Source: CACAO
Inferred from mutant phenotypeⁱ
- 24056303
centrosome cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22542840
chromosome segregation Source: Ensembl
DNA repair
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22542840
double-strand break repair via classical nonhomologous end joining
Source: UniProtKB
Inferred from direct assayⁱ
- 22542840
maintenance of Golgi location
Source: CACAO
Inferred from mutant phenotypeⁱ
- 24056303
multivesicular body sorting pathway
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 21118109
positive regulation of autophagosome maturation
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 21118109
receptor catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20643123
regulation of cytokinesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20643123
regulation of protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22542840
retrograde vesicle-mediated transport, Golgi to ER
Source: CACAO
Inferred from mutant phenotypeⁱ
- 24056303
SNARE complex assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
spindle organization Source: Ensembl
viral entry into host cell Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	DNA damage, DNA repair

Biological process

DNA damage, DNA repair

Enzyme and pathway databases

BRENDAⁱ	2.7.1.137 2681
Reactomeⁱ	R-HSA-1632852 Macroautophagy
SIGNORⁱ	Q9P2Y5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UV radiation resistance-associated gene protein Alternative name(s): p63
Gene namesⁱ	Name:UVRAG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198382.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12640 UVRAG
MIMⁱ	602493 gene
neXtProtⁱ	NX_Q9P2Y5

Keywords - Cellular componentⁱ

Centromere, Chromosome, Endoplasmic reticulum, Endosome, Lysosome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv(11)(q13.5;q25).1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	498	S → A: Abolishes phosphorylation by MTOR, decreases interaction with RUBCN, increases interaction with VPS16 and VPS39, promotes autophagosome maturation and endosome-lysosomal degradation of EGFR. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7405
Open Targets More...OpenTargetsⁱ	ENSG00000198382
PharmGKBⁱ	PA37264

Polymorphism and mutation databases

BioMutaⁱ	UVRAG
DMDMⁱ	20140879

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000065750	1 – 699	UV radiation resistance-associated gene proteinAdd BLAST		699

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	493	Phosphoserine1 Publication	1
Modified residueⁱ	498	Phosphoserine; by MTORCombined sources1 Publication	1
Modified residueⁱ	508	Phosphoserine1 Publication	1
Modified residueⁱ	518	PhosphothreonineCombined sources	1
Modified residueⁱ	522	Phosphoserine1 Publication	1
Modified residueⁱ	549	Phosphoserine1 Publication	1
Modified residueⁱ	550	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	571	PhosphoserineCombined sources	1
Modified residueⁱ	582	Phosphoserine1 Publication	1
Modified residueⁱ	689	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated at Ser-498 by MTOR under basal conditions; increases the interaction with RUBCN implicated in inhibitory effect of RUBCN on PI3KC3 and decreases interaction with RAB7,A and VPS16 and VPS39 (indicative for a class C Vps complex, possibly the HOPS complex) (PubMed:25533187).1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9P2Y5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P2Y5
PaxDbⁱ	Q9P2Y5
PeptideAtlas More...PeptideAtlasⁱ	Q9P2Y5
PRIDEⁱ	Q9P2Y5
ProteomicsDBⁱ	83914

PTM databases

iPTMnetⁱ	Q9P2Y5
PhosphoSitePlusⁱ	Q9P2Y5

Expressionⁱ

Tissue specificityⁱ

Highly expressed in brain, lung, kidney and liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000198382 Expressed in 225 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_UVRAG
ExpressionAtlasⁱ	Q9P2Y5 baseline and differential
Genevisibleⁱ	Q9P2Y5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA016932

HPAⁱ

HPA016932

Interactionⁱ

Subunit structureⁱ

Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex II (PI3KC3-C2) in which the core composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 is associated with UVRAG; in the complex interacts directly with BECN1. PI3KC3-C2 can associate with further regulatory subunits such as RUBCN and probably SH3GLB1/Bif-1 (PubMed:16799551, PubMed:18843052, PubMed:19050071, PubMed:19270696, PubMed:20643123, PubMed:23878393, PubMed:24056303). Interacts with SH3GLB1; UVRAG bridges the interaction to BECN1 indicative for an association with the PI3K complex PI3KC3-C2 (PubMed:17891140). Interacts with RINT1. Associates with the NRZ complex under basal conditions and dissociates from it under autophagy conditions to associate with the PI3K complex; these complex associations seem to be mutually exclusive (PubMed:24056303). Interacts with VPS16; VPS11; VPS18; VPS33 (VPS33A or VPS33B) and VPS39; indicative for an association with a class C Vps tethering complex (possibly the HOPS complex) (PubMed:18552835, PubMed:25533187). Interacts with RAB7A; RAB7A competes with UVRAG for RUBCN binding (PubMed:25533187, PubMed:20974968). Interacts with STX7, VTI1B, STX8 (PubMed:24550300). Interacts with PRKDC, XRCC6 and XRCC5; indicative for an association with the DNA-dependent protein kinase complex DNA-PK. Interacts with CEP63 (PubMed:22542840). Directly interacts with FEZ1 and SCOC; the interaction with SCOC is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1 (PubMed:22354037). Interacts with BECN1P1/BECN2 (PubMed:23954414). Interracts with SLAMF1( PubMed:22493499).16 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BAX	Q07812	6	EBI-2952704,EBI-516580
BECN1	Q14457	42	EBI-2952704,EBI-949378
PIK3C3	Q8NEB9	21	EBI-2952704,EBI-1056470
RINT1	Q6NUQ1	18	EBI-2952704,EBI-726876
RUBCN	Q92622	7	EBI-2952704,EBI-2952709
SH3GLB1	Q9Y371	11	EBI-2952704,EBI-2623095
Slamf1	Q9QUM4	6	EBI-2952704,EBI-7910086	From Mus musculus.
VPS33A	Q96AX1	4	EBI-2952704,EBI-2527283

GO - Molecular functionⁱ

SH3 domain binding Source: Ensembl
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113248, 24 interactors
ComplexPortalⁱ	CPX-74 Phosphatidylinositol 3-kinase complex, class III, UVRAG variant
CORUMⁱ	Q9P2Y5
Database of interacting proteins More...DIPⁱ	DIP-48652N
IntActⁱ	Q9P2Y5, 53 interactors
Molecular INTeraction database More...MINTⁱ	Q9P2Y5
STRINGⁱ	9606.ENSP00000348455

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P2Y5
SMRⁱ	Q9P2Y5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 128	C2Add BLAST		85

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	200 – 269	Sufficient for interaction with STX7; VTI1B AND STX81 PublicationAdd BLAST	70
Regionⁱ	270 – 442	Sufficient for interaction with VPS16, required for interaction with CEP632 PublicationsAdd BLAST	173
Regionⁱ	443 – 699	Required for interaction with PRKDC, XRCC6 and XRCC51 PublicationAdd BLAST	257

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	224 – 305	Sequence analysisAdd BLAST		82

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2896 Eukaryota ENOG410YZ0H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012877
HOGENOMⁱ	HOG000147825
HOVERGENⁱ	HBG059846
InParanoidⁱ	Q9P2Y5
KEGG Orthology (KO) More...KOⁱ	K21249
OMAⁱ	CSVKLPN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HDH
PhylomeDBⁱ	Q9P2Y5
TreeFamⁱ	TF323546

Family and domain databases

Gene3Dⁱ	2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR018791 UV_resistance/autophagy_Atg14
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10186 Atg14, 1 hit
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9P2Y5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASASVGGP VPQPPPGPAA ALPPGSAARA LHVELPSQQR RLRHLRNIAA 
        60         70         80         90        100
RNIVNRNGHQ LLDTYFTLHL CSTEKIYKEF YRSEVIKNSL NPTWRSLDFG 
       110        120        130        140        150
IMPDRLDTSV SCFVVKIWGG KENIYQLLIE WKVCLDGLKY LGQQIHARNQ 
       160        170        180        190        200
NEIIFGLNDG YYGAPFEHKG YSNAQKTILL QVDQNCVRNS YDVFSLLRLH 
       210        220        230        240        250
RAQCAIKQTQ VTVQKIGKEI EEKLRLTSTS NELKKKSECL QLKILVLQNE 
       260        270        280        290        300
LERQKKALGR EVALLHKQQI ALQDKGSAFS AEHLKLQLQK ESLNELRKEC 
       310        320        330        340        350
TAKRELFLKT NAQLTIRCRQ LLSELSYIYP IDLNEHKDYF VCGVKLPNSE 
       360        370        380        390        400
DFQAKDDGSI AVALGYTAHL VSMISFFLQV PLRYPIIHKG SRSTIKDNIN 
       410        420        430        440        450
DKLTEKEREF PLYPKGGEKL QFDYGVYLLN KNIAQLRYQH GLGTPDLRQT 
       460        470        480        490        500
LPNLKNFMEH GLMVRCDRHH TSSAIPVPKR QSSIFGGADV GFSGGIPSPD 
       510        520        530        540        550
KGHRKRASSE NERLQYKTPP PSYNSALAQP VTTVPSMGET ERKITSLSSS 
       560        570        580        590        600
LDTSLDFSKE NKKKGEDLVG SLNGGHANVH PSQEQGEALS GHRATVNGTL 
       610        620        630        640        650
LPSEQAGSAS VQLPGEFHPV SEAELCCTVE QAEEIIGLEA TGFASGDQLE 
       660        670        680        690 
AFNCIPVDSA VAVECDEQVL GEFEEFSRRI YALNENVSSF RRPRRSSDK

Length:699

Mass (Da):78,151

Last modified:October 1, 2000 - v1

Checksum:ⁱ23C4413B10F641BA

Isoform 2 (identifier: Q9P2Y5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-372: Missing.

« Hide

        10         20         30         40         50
MISFFLQVPL RYPIIHKGSR STIKDNINDK LTEKEREFPL YPKGGEKLQF 
        60         70         80         90        100
DYGVYLLNKN IAQLRYQHGL GTPDLRQTLP NLKNFMEHGL MVRCDRHHTS 
       110        120        130        140        150
SAIPVPKRQS SIFGGADVGF SGGIPSPDKG HRKRASSENE RLQYKTPPPS 
       160        170        180        190        200
YNSALAQPVT TVPSMGETER KITSLSSSLD TSLDFSKENK KKGEDLVGSL 
       210        220        230        240        250
NGGHANVHPS QEQGEALSGH RATVNGTLLP SEQAGSASVQ LPGEFHPVSE 
       260        270        280        290        300
AELCCTVEQA EEIIGLEATG FASGDQLEAF NCIPVDSAVA VECDEQVLGE 
       310        320 
FEEFSRRIYA LNENVSSFRR PRRSSDK

Note: No experimental confirmation available.

Show »

Length:327

Mass (Da):35,988

Checksum:ⁱA8CEAAF764965297

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PR71	E9PR71_HUMAN	UV radiation resistance-associated ... UV radiation resistance-associated gene protein	UVRAG	598	Annotation score:
E9PK00	E9PK00_HUMAN	UV radiation resistance-associated ... UV radiation resistance-associated gene protein	UVRAG	132	Annotation score:
H0YDD1	H0YDD1_HUMAN	UV radiation resistance-associated ... UV radiation resistance-associated gene protein	UVRAG	90	Annotation score:

Sequence cautionⁱ

The sequence CAA67507 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059737	10	P → H. Corresponds to variant dbSNP:rs7118567Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056176	1 – 372	Missing in isoform 2. 1 PublicationAdd BLAST		372

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X99050 Genomic DNA Translation: CAA67507.1 Sequence problems. AB012958 mRNA Translation: BAA90829.1 AK095352 mRNA Translation: BAG53033.1 AK296871 mRNA Translation: BAG59434.1 AK316133 mRNA Translation: BAH14504.1 AP002340 Genomic DNA No translation available. AP003031 Genomic DNA No translation available. AP003168 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8241.1 [Q9P2Y5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_003360.2, NM_003369.3 [Q9P2Y5-1]
UniGeneⁱ	Hs.202470

Genome annotation databases

Ensemblⁱ	ENST00000356136; ENSP00000348455; ENSG00000198382 [Q9P2Y5-1] ENST00000531818; ENSP00000434082; ENSG00000198382 [Q9P2Y5-2] ENST00000532130; ENSP00000436270; ENSG00000198382 [Q9P2Y5-2] ENST00000533454; ENSP00000431256; ENSG00000198382 [Q9P2Y5-2]
GeneIDⁱ	7405
KEGGⁱ	hsa:7405
UCSC genome browser More...UCSCⁱ	uc001oxc.4 human [Q9P2Y5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P2Y5	UV radiation resistance-associated gene protein		HUMAN		598	UniRef100_Q9P2Y5
Isoform 2 of UV radiation resistance-associated gene protein		HUMAN		327

Protein	Similar proteins		Species	Score	Length	Source
Q9P2Y5	UV radiation resistance-associated gene protein		HUMAN		598	UniRef90_Q9P2Y5
UV radiation resistance-associated gene protein isoform X1		BALAS		709
Uncharacterized protein		PROCO		701
UV radiation resistance-associated gene protein		DELLE		699
UV radiation resistance associated protein		PANTR		699
+87

Protein	Similar proteins		Species	Score	Length	Source
Q9P2Y5	UV radiation resistance associated protein	)	MOUSE		698	UniRef50_Q9P2Y5
UV radiation resistance-associated gene protein		HUMAN		598
UV radiation resistance-associated gene protein isoform X1		BALAS		709
Uncharacterized protein		PROCO		701
UV radiation resistance-associated gene protein isoform X1		PHYCD		699
+321

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X99050 Genomic DNA Translation: CAA67507.1 Sequence problems. AB012958 mRNA Translation: BAA90829.1 AK095352 mRNA Translation: BAG53033.1 AK296871 mRNA Translation: BAG59434.1 AK316133 mRNA Translation: BAH14504.1 AP002340 Genomic DNA No translation available. AP003031 Genomic DNA No translation available. AP003168 Genomic DNA No translation available.
CCDSⁱ	CCDS8241.1 [Q9P2Y5-1]
RefSeqⁱ	NP_003360.2, NM_003369.3 [Q9P2Y5-1]
UniGeneⁱ	Hs.202470

3D structure databases

ProteinModelPortalⁱ	Q9P2Y5
SMRⁱ	Q9P2Y5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113248, 24 interactors
ComplexPortalⁱ	CPX-74 Phosphatidylinositol 3-kinase complex, class III, UVRAG variant
CORUMⁱ	Q9P2Y5
DIPⁱ	DIP-48652N
IntActⁱ	Q9P2Y5, 53 interactors
MINTⁱ	Q9P2Y5
STRINGⁱ	9606.ENSP00000348455

PTM databases

iPTMnetⁱ	Q9P2Y5
PhosphoSitePlusⁱ	Q9P2Y5

Polymorphism and mutation databases

BioMutaⁱ	UVRAG
DMDMⁱ	20140879

Proteomic databases

EPDⁱ	Q9P2Y5
MaxQBⁱ	Q9P2Y5
PaxDbⁱ	Q9P2Y5
PeptideAtlasⁱ	Q9P2Y5
PRIDEⁱ	Q9P2Y5
ProteomicsDBⁱ	83914

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356136; ENSP00000348455; ENSG00000198382 [Q9P2Y5-1] ENST00000531818; ENSP00000434082; ENSG00000198382 [Q9P2Y5-2] ENST00000532130; ENSP00000436270; ENSG00000198382 [Q9P2Y5-2] ENST00000533454; ENSP00000431256; ENSG00000198382 [Q9P2Y5-2]
GeneIDⁱ	7405
KEGGⁱ	hsa:7405
UCSCⁱ	uc001oxc.4 human [Q9P2Y5-1]

Organism-specific databases

CTDⁱ	7405
DisGeNETⁱ	7405
EuPathDBⁱ	HostDB:ENSG00000198382.8
GeneCardsⁱ	UVRAG
HGNCⁱ	HGNC:12640 UVRAG
HPAⁱ	HPA016932
MIMⁱ	602493 gene
neXtProtⁱ	NX_Q9P2Y5
OpenTargetsⁱ	ENSG00000198382
PharmGKBⁱ	PA37264
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2896 Eukaryota ENOG410YZ0H LUCA
GeneTreeⁱ	ENSGT00390000012877
HOGENOMⁱ	HOG000147825
HOVERGENⁱ	HBG059846
InParanoidⁱ	Q9P2Y5
KOⁱ	K21249
OMAⁱ	CSVKLPN
OrthoDBⁱ	EOG091G0HDH
PhylomeDBⁱ	Q9P2Y5
TreeFamⁱ	TF323546

Enzyme and pathway databases

BRENDAⁱ	2.7.1.137 2681
Reactomeⁱ	R-HSA-1632852 Macroautophagy
SIGNORⁱ	Q9P2Y5

Miscellaneous databases

ChiTaRSⁱ	UVRAG human
GeneWikiⁱ	UVRAG
GenomeRNAiⁱ	7405
Protein Ontology More...PROⁱ	PR:Q9P2Y5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198382 Expressed in 225 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_UVRAG
ExpressionAtlasⁱ	Q9P2Y5 baseline and differential
Genevisibleⁱ	Q9P2Y5 HS

Family and domain databases

Gene3Dⁱ	2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR018791 UV_resistance/autophagy_Atg14
Pfamⁱ	View protein in Pfam PF10186 Atg14, 1 hit
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UVRAG_HUMAN
Accessionⁱ	Q9P2Y5Primary (citable) accession number: Q9P2Y5 Secondary accession number(s): B3KTC1, O00392
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q9P2Y5 (UVRAG_HUMAN)

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UV radiation resistance-associated gene protein

UVRAG

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Endosome

Endoplasmic reticulum

Other locations

Cytoskeleton

Endoplasmic reticulum

Endosome

Lysosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ