UniProtKB - Q9P2Y5 (UVRAG_HUMAN)
UV radiation resistance-associated gene protein
UVRAG
Functioni
GO - Molecular functioni
- SH3 domain binding Source: Ensembl
- SNARE binding Source: GO_Central
GO - Biological processi
- autophagosome maturation Source: UniProtKB
- autophagy Source: CACAO
- centrosome cycle Source: UniProtKB
- chromosome segregation Source: Ensembl
- DNA repair Source: UniProtKB
- double-strand break repair via classical nonhomologous end joining Source: UniProtKB
- maintenance of Golgi location Source: CACAO
- multivesicular body sorting pathway Source: ParkinsonsUK-UCL
- positive regulation of autophagosome maturation Source: ParkinsonsUK-UCL
- receptor catabolic process Source: UniProtKB
- regulation of cytokinesis Source: UniProtKB
- regulation of protein serine/threonine kinase activity Source: UniProtKB
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: CACAO
- SNARE complex assembly Source: GO_Central
- spindle organization Source: Ensembl
- viral entry into host cell Source: Ensembl
Keywordsi
Biological process | DNA damage, DNA repair |
Enzyme and pathway databases
BRENDAi | 2.7.1.137, 2681 |
PathwayCommonsi | Q9P2Y5 |
Reactomei | R-HSA-1632852, Macroautophagy R-HSA-9679504, Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676, Translation of Replicase and Assembly of the Replication Transcription Complex |
SIGNORi | Q9P2Y5 |
Names & Taxonomyi
Protein namesi | Recommended name: UV radiation resistance-associated gene proteinAlternative name(s): p63 |
Gene namesi | Name:UVRAG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12640, UVRAG |
MIMi | 602493, gene |
neXtProti | NX_Q9P2Y5 |
VEuPathDBi | HostDB:ENSG00000198382.8 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Lysosome
- Lysosome 1 Publication
Endosome
- Late endosome 1 Publication
- Early endosome 2 Publications
Other locations
- autophagosome 1 Publication
- Midbody 1 Publication
- centromere 1 Publication
Note: Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial (PubMed:24056303). Recruited to autophagosome following interaction with RUBCNL/PACER (PubMed:28306502).2 Publications
Cytoskeleton
- centrosome Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: CACAO
Endosome
- early endosome Source: UniProtKB
- endosome Source: GO_Central
- late endosome Source: UniProtKB
Lysosome
- lysosome Source: UniProtKB
Other locations
- autophagosome membrane Source: UniProtKB
- chromosome, centromeric region Source: UniProtKB-SubCell
- cytoplasm Source: ProtInc
- lytic vacuole Source: GO_Central
- midbody Source: UniProtKB
- phagocytic vesicle Source: Ensembl
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, LysosomePathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 498 | S → A: Abolishes phosphorylation by MTOR, decreases interaction with RUBCN, increases interaction with VPS16 and VPS39, promotes autophagosome maturation and endosome-lysosomal degradation of EGFR. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7405 |
OpenTargetsi | ENSG00000198382 |
PharmGKBi | PA37264 |
Miscellaneous databases
Pharosi | Q9P2Y5, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4296018 |
Genetic variation databases
BioMutai | UVRAG |
DMDMi | 20140879 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000065750 | 1 – 699 | UV radiation resistance-associated gene proteinAdd BLAST | 699 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 493 | Phosphoserine1 Publication | 1 | |
Modified residuei | 498 | Phosphoserine; by MTORCombined sources1 Publication | 1 | |
Modified residuei | 508 | Phosphoserine1 Publication | 1 | |
Modified residuei | 518 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 522 | Phosphoserine1 Publication | 1 | |
Modified residuei | 549 | Phosphoserine1 Publication | 1 | |
Modified residuei | 550 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 571 | PhosphoserineCombined sources | 1 | |
Modified residuei | 582 | Phosphoserine1 Publication | 1 | |
Modified residuei | 689 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9P2Y5 |
jPOSTi | Q9P2Y5 |
MassIVEi | Q9P2Y5 |
MaxQBi | Q9P2Y5 |
PaxDbi | Q9P2Y5 |
PeptideAtlasi | Q9P2Y5 |
PRIDEi | Q9P2Y5 |
ProteomicsDBi | 3674 83914 [Q9P2Y5-1] |
PTM databases
iPTMneti | Q9P2Y5 |
PhosphoSitePlusi | Q9P2Y5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000198382, Expressed in corpus callosum and 236 other tissues |
ExpressionAtlasi | Q9P2Y5, baseline and differential |
Genevisiblei | Q9P2Y5, HS |
Organism-specific databases
HPAi | ENSG00000198382, Low tissue specificity |
Interactioni
Subunit structurei
Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex II (PI3KC3-C2) in which the core composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 is associated with UVRAG; in the complex interacts directly with BECN1. PI3KC3-C2 can associate with further regulatory subunits such as RUBCN and probably SH3GLB1/Bif-1 (PubMed:16799551, PubMed:18843052, PubMed:19050071, PubMed:19270696, PubMed:20643123, PubMed:23878393, PubMed:24056303).
Interacts with SH3GLB1; UVRAG bridges the interaction to BECN1 indicative for an association with the PI3K complex PI3KC3-C2 (PubMed:17891140).
Interacts with RINT1. Associates with the NRZ complex under basal conditions and dissociates from it under autophagy conditions to associate with the PI3K complex; these complex associations seem to be mutually exclusive (PubMed:24056303).
Interacts with VPS16; VPS11; VPS18; VPS33 (VPS33A or VPS33B) and VPS39; indicative for an association with a class C Vps tethering complex (possibly the HOPS complex) (PubMed:18552835, PubMed:25533187).
Interacts with RAB7A; RAB7A competes with UVRAG for RUBCN binding (PubMed:25533187, PubMed:20974968).
Interacts with STX7, VTI1B, STX8 (PubMed:24550300).
Interacts with PRKDC, XRCC6 and XRCC5; indicative for an association with the DNA-dependent protein kinase complex DNA-PK.
Interacts with CEP63 (PubMed:22542840). Directly interacts with FEZ1 and SCOC; the interaction with SCOC is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1 (PubMed:22354037).
Interacts with BECN1P1/BECN2 (PubMed:23954414).
Interacts with SLAMF1 (PubMed:22493499).
Interacts with RUBCNL/PACER; promoting targeting of UVRAG to autophagosome (PubMed:28306502).
17 PublicationsBinary interactionsi
Hide detailsQ9P2Y5
GO - Molecular functioni
- SH3 domain binding Source: Ensembl
- SNARE binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 113248, 40 interactors |
ComplexPortali | CPX-74, Phosphatidylinositol 3-kinase complex, class III, UVRAG variant |
CORUMi | Q9P2Y5 |
DIPi | DIP-48652N |
IntActi | Q9P2Y5, 56 interactors |
MINTi | Q9P2Y5 |
STRINGi | 9606.ENSP00000348455 |
Miscellaneous databases
RNActi | Q9P2Y5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 149 | C2PROSITE-ProRule annotationAdd BLAST | 127 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 200 – 269 | Sufficient for interaction with STX7; VTI1B AND STX81 PublicationAdd BLAST | 70 | |
Regioni | 270 – 442 | Sufficient for interaction with VPS16, required for interaction with CEP632 PublicationsAdd BLAST | 173 | |
Regioni | 443 – 699 | Required for interaction with PRKDC, XRCC6 and XRCC51 PublicationAdd BLAST | 257 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 224 – 305 | Sequence analysisAdd BLAST | 82 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2896, Eukaryota |
GeneTreei | ENSGT00390000012877 |
HOGENOMi | CLU_009375_2_0_1 |
InParanoidi | Q9P2Y5 |
OMAi | XELFLKT |
OrthoDBi | 1081121at2759 |
PhylomeDBi | Q9P2Y5 |
TreeFami | TF323546 |
Family and domain databases
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR018791, UV_resistance/autophagy_Atg14 |
Pfami | View protein in Pfam PF10186, Atg14, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSASASVGGP VPQPPPGPAA ALPPGSAARA LHVELPSQQR RLRHLRNIAA
60 70 80 90 100
RNIVNRNGHQ LLDTYFTLHL CSTEKIYKEF YRSEVIKNSL NPTWRSLDFG
110 120 130 140 150
IMPDRLDTSV SCFVVKIWGG KENIYQLLIE WKVCLDGLKY LGQQIHARNQ
160 170 180 190 200
NEIIFGLNDG YYGAPFEHKG YSNAQKTILL QVDQNCVRNS YDVFSLLRLH
210 220 230 240 250
RAQCAIKQTQ VTVQKIGKEI EEKLRLTSTS NELKKKSECL QLKILVLQNE
260 270 280 290 300
LERQKKALGR EVALLHKQQI ALQDKGSAFS AEHLKLQLQK ESLNELRKEC
310 320 330 340 350
TAKRELFLKT NAQLTIRCRQ LLSELSYIYP IDLNEHKDYF VCGVKLPNSE
360 370 380 390 400
DFQAKDDGSI AVALGYTAHL VSMISFFLQV PLRYPIIHKG SRSTIKDNIN
410 420 430 440 450
DKLTEKEREF PLYPKGGEKL QFDYGVYLLN KNIAQLRYQH GLGTPDLRQT
460 470 480 490 500
LPNLKNFMEH GLMVRCDRHH TSSAIPVPKR QSSIFGGADV GFSGGIPSPD
510 520 530 540 550
KGHRKRASSE NERLQYKTPP PSYNSALAQP VTTVPSMGET ERKITSLSSS
560 570 580 590 600
LDTSLDFSKE NKKKGEDLVG SLNGGHANVH PSQEQGEALS GHRATVNGTL
610 620 630 640 650
LPSEQAGSAS VQLPGEFHPV SEAELCCTVE QAEEIIGLEA TGFASGDQLE
660 670 680 690
AFNCIPVDSA VAVECDEQVL GEFEEFSRRI YALNENVSSF RRPRRSSDK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PR71 | E9PR71_HUMAN | UV radiation resistance-associated ... | UVRAG | 598 | Annotation score: | ||
H0YDD1 | H0YDD1_HUMAN | UV radiation resistance-associated ... | UVRAG | 90 | Annotation score: | ||
E9PK00 | E9PK00_HUMAN | UV radiation resistance-associated ... | UVRAG | 132 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059737 | 10 | P → H. Corresponds to variant dbSNP:rs7118567Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056176 | 1 – 372 | Missing in isoform 2. 1 PublicationAdd BLAST | 372 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99050 Genomic DNA Translation: CAA67507.1 Sequence problems. AB012958 mRNA Translation: BAA90829.1 AK095352 mRNA Translation: BAG53033.1 AK296871 mRNA Translation: BAG59434.1 AK316133 mRNA Translation: BAH14504.1 AP002340 Genomic DNA No translation available. AP003031 Genomic DNA No translation available. AP003168 Genomic DNA No translation available. |
CCDSi | CCDS8241.1 [Q9P2Y5-1] |
RefSeqi | NP_003360.2, NM_003369.3 [Q9P2Y5-1] |
Genome annotation databases
Ensembli | ENST00000356136; ENSP00000348455; ENSG00000198382 [Q9P2Y5-1] ENST00000531818; ENSP00000434082; ENSG00000198382 [Q9P2Y5-2] ENST00000532130; ENSP00000436270; ENSG00000198382 [Q9P2Y5-2] ENST00000533454; ENSP00000431256; ENSG00000198382 [Q9P2Y5-2] |
GeneIDi | 7405 |
KEGGi | hsa:7405 |
UCSCi | uc001oxc.4, human [Q9P2Y5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99050 Genomic DNA Translation: CAA67507.1 Sequence problems. AB012958 mRNA Translation: BAA90829.1 AK095352 mRNA Translation: BAG53033.1 AK296871 mRNA Translation: BAG59434.1 AK316133 mRNA Translation: BAH14504.1 AP002340 Genomic DNA No translation available. AP003031 Genomic DNA No translation available. AP003168 Genomic DNA No translation available. |
CCDSi | CCDS8241.1 [Q9P2Y5-1] |
RefSeqi | NP_003360.2, NM_003369.3 [Q9P2Y5-1] |
3D structure databases
SMRi | Q9P2Y5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113248, 40 interactors |
ComplexPortali | CPX-74, Phosphatidylinositol 3-kinase complex, class III, UVRAG variant |
CORUMi | Q9P2Y5 |
DIPi | DIP-48652N |
IntActi | Q9P2Y5, 56 interactors |
MINTi | Q9P2Y5 |
STRINGi | 9606.ENSP00000348455 |
Chemistry databases
ChEMBLi | CHEMBL4296018 |
PTM databases
iPTMneti | Q9P2Y5 |
PhosphoSitePlusi | Q9P2Y5 |
Genetic variation databases
BioMutai | UVRAG |
DMDMi | 20140879 |
Proteomic databases
EPDi | Q9P2Y5 |
jPOSTi | Q9P2Y5 |
MassIVEi | Q9P2Y5 |
MaxQBi | Q9P2Y5 |
PaxDbi | Q9P2Y5 |
PeptideAtlasi | Q9P2Y5 |
PRIDEi | Q9P2Y5 |
ProteomicsDBi | 3674 83914 [Q9P2Y5-1] |
Protocols and materials databases
Antibodypediai | 2165, 418 antibodies |
Genome annotation databases
Ensembli | ENST00000356136; ENSP00000348455; ENSG00000198382 [Q9P2Y5-1] ENST00000531818; ENSP00000434082; ENSG00000198382 [Q9P2Y5-2] ENST00000532130; ENSP00000436270; ENSG00000198382 [Q9P2Y5-2] ENST00000533454; ENSP00000431256; ENSG00000198382 [Q9P2Y5-2] |
GeneIDi | 7405 |
KEGGi | hsa:7405 |
UCSCi | uc001oxc.4, human [Q9P2Y5-1] |
Organism-specific databases
CTDi | 7405 |
DisGeNETi | 7405 |
GeneCardsi | UVRAG |
HGNCi | HGNC:12640, UVRAG |
HPAi | ENSG00000198382, Low tissue specificity |
MIMi | 602493, gene |
neXtProti | NX_Q9P2Y5 |
OpenTargetsi | ENSG00000198382 |
PharmGKBi | PA37264 |
VEuPathDBi | HostDB:ENSG00000198382.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2896, Eukaryota |
GeneTreei | ENSGT00390000012877 |
HOGENOMi | CLU_009375_2_0_1 |
InParanoidi | Q9P2Y5 |
OMAi | XELFLKT |
OrthoDBi | 1081121at2759 |
PhylomeDBi | Q9P2Y5 |
TreeFami | TF323546 |
Enzyme and pathway databases
BRENDAi | 2.7.1.137, 2681 |
PathwayCommonsi | Q9P2Y5 |
Reactomei | R-HSA-1632852, Macroautophagy R-HSA-9679504, Translation of Replicase and Assembly of the Replication Transcription Complex R-HSA-9694676, Translation of Replicase and Assembly of the Replication Transcription Complex |
SIGNORi | Q9P2Y5 |
Miscellaneous databases
BioGRID-ORCSi | 7405, 85 hits in 1003 CRISPR screens |
ChiTaRSi | UVRAG, human |
GeneWikii | UVRAG |
GenomeRNAii | 7405 |
Pharosi | Q9P2Y5, Tbio |
PROi | PR:Q9P2Y5 |
RNActi | Q9P2Y5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198382, Expressed in corpus callosum and 236 other tissues |
ExpressionAtlasi | Q9P2Y5, baseline and differential |
Genevisiblei | Q9P2Y5, HS |
Family and domain databases
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR018791, UV_resistance/autophagy_Atg14 |
Pfami | View protein in Pfam PF10186, Atg14, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UVRAG_HUMAN | |
Accessioni | Q9P2Y5Primary (citable) accession number: Q9P2Y5 Secondary accession number(s): B3KTC1, O00392 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot