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Protein

Zinc finger protein 219

Gene

ZNF219

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 79C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri85 – 107C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 186C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri189 – 212C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri274 – 296C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 9Sequence analysisAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 219
Gene namesi
Name:ZNF219
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165804.15
HGNCiHGNC:13011 ZNF219
MIMi605036 gene
neXtProtiNX_Q9P2Y4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165804
PharmGKBiPA37590

Polymorphism and mutation databases

BioMutaiZNF219
DMDMi55977885

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474611 – 722Zinc finger protein 219Add BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei692PhosphoserineBy similarity1
Modified residuei695PhosphothreonineBy similarity1
Modified residuei698PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2Y4
MaxQBiQ9P2Y4
PaxDbiQ9P2Y4
PeptideAtlasiQ9P2Y4
PRIDEiQ9P2Y4
ProteomicsDBi83913

PTM databases

iPTMnetiQ9P2Y4
PhosphoSitePlusiQ9P2Y4

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000165804 Expressed in 190 organ(s), highest expression level in right adrenal gland
CleanExiHS_ZNF219
ExpressionAtlasiQ9P2Y4 baseline and differential
GenevisibleiQ9P2Y4 HS

Organism-specific databases

HPAiHPA030761
HPA056168

Interactioni

Subunit structurei

Interacts with SOX9 (via C-terminus).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi119387, 43 interactors
IntActiQ9P2Y4, 18 interactors
MINTiQ9P2Y4
STRINGi9606.ENSP00000354206

Structurei

3D structure databases

ProteinModelPortaliQ9P2Y4
SMRiQ9P2Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi558 – 612Pro-richPROSITE-ProRule annotationAdd BLAST55

Domaini

C2H2-type zinc-finger domains 5 and 6 are important for the interaction with SOX9.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 79C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri85 – 107C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 186C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri189 – 212C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri274 – 296C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 9Sequence analysisAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063100
HOGENOMiHOG000140857
HOVERGENiHBG054187
InParanoidiQ9P2Y4
OMAiASPPYAR
OrthoDBiEOG091G05JC
PhylomeDBiQ9P2Y4
TreeFamiTF332241

Family and domain databases

InterProiView protein in InterPro
IPR003980 Histamine_H3_rcpt
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
PRINTSiPR01471 HISTAMINEH3R
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9P2Y4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGSRPRAPS GHLAPSPPAF DGELDLQRYS NGPAVSAGSL GMGAVSWSES
60 70 80 90 100
RAGERRFPCP VCGKRFRFNS ILALHLRAHP GAQAFQCPHC GHRAAQRALL
110 120 130 140 150
RSHLRTHQPE RPRSPAARLL LELEERALLR EARLGRARSS GGMQATPATE
160 170 180 190 200
GLARPQAPSS SAFRCPYCKG KFRTSAERER HLHILHRPWK CGLCSFGSSQ
210 220 230 240 250
EEELLHHSLT AHGAPERPLA ATSAAPPPQP QPQPPPQPEP RSVPQPEPEP
260 270 280 290 300
EPEREATPTP APAAPEEPPA PPEFRCQVCG QSFTQSWFLK GHMRKHKASF
310 320 330 340 350
DHACPVCGRC FKEPWFLKNH MKVHASKLGP LRAPGPASGP ARAPQPPDLG
360 370 380 390 400
LLAYEPLGPA LLLAPAPTPA ERREPPSLLG YLSLRAGEGR PNGEGAEPGP
410 420 430 440 450
GRSFGGFRPL SSALPARARR HRAEEPEEEE EVVEAEEETW ARGRSLGSLA
460 470 480 490 500
SLHPRPGEGP GHSASAAGAQ ARSTATQEEN GLLVGGTRPE GGRGATGKDC
510 520 530 540 550
PFCGKSFRSA HHLKVHLRVH TGERPYKCPH CDYAGTQSGS LKYHLQRHHR
560 570 580 590 600
EQRSGAGPGP PPEPPPPSQR GSAPQSGAKP SPQPATWVEG ASSPRPPSSG
610 620 630 640 650
AGPGSRRKPA SPGRTLRNGR GGEAEPLDLS LRAGPGGEAG PGGALHRCLF
660 670 680 690 700
CPFATGAPEL MALHLQVHHS RRARGRRPPQ ADASPPYARV PSGETPPSPS
710 720
QEGEEGSGLS RPGEAGLGGQ ER
Length:722
Mass (Da):76,877
Last modified:November 23, 2004 - v2
Checksum:iAB2B6B37904FC14B
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4M7G3V4M7_HUMAN
Zinc finger protein 219
ZNF219
145Annotation score:
G3V2Q8G3V2Q8_HUMAN
Zinc finger protein 219
ZNF219
211Annotation score:
G3V3F2G3V3F2_HUMAN
Zinc finger protein 219
ZNF219
158Annotation score:
G3V2W3G3V2W3_HUMAN
Zinc finger protein 219
ZNF219
107Annotation score:
G3V2E3G3V2E3_HUMAN
Zinc finger protein 219
ZNF219
111Annotation score:
G3V4T1G3V4T1_HUMAN
Zinc finger protein 219
ZNF219
57Annotation score:
G3V452G3V452_HUMAN
Zinc finger protein 219
ZNF219
31Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232 – 233Missing in AAH00694 (PubMed:15489334).Curated2
Sequence conflicti436E → Q in BAA90526 (PubMed:10819330).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067624260P → T2 PublicationsCorresponds to variant dbSNP:rs17853549Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015427 mRNA Translation: BAA90526.1
BT006956 mRNA Translation: AAP35602.1
CH471078 Genomic DNA Translation: EAW66404.1
CH471078 Genomic DNA Translation: EAW66405.1
CH471078 Genomic DNA Translation: EAW66406.1
CH471078 Genomic DNA Translation: EAW66407.1
BC000694 mRNA Translation: AAH00694.1
BC036105 mRNA Translation: AAH36105.1
CCDSiCCDS9568.1
RefSeqiNP_001095142.1, NM_001101672.1
NP_001095924.1, NM_001102454.1
NP_057507.2, NM_016423.2
XP_006720226.1, XM_006720163.2
XP_006720227.1, XM_006720164.3
XP_016876843.1, XM_017021354.1
XP_016876844.1, XM_017021355.1
UniGeneiHs.250493

Genome annotation databases

EnsembliENST00000360947; ENSP00000354206; ENSG00000165804
ENST00000421093; ENSP00000392401; ENSG00000165804
ENST00000451119; ENSP00000388558; ENSG00000165804
GeneIDi51222
KEGGihsa:51222
UCSCiuc001vzr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015427 mRNA Translation: BAA90526.1
BT006956 mRNA Translation: AAP35602.1
CH471078 Genomic DNA Translation: EAW66404.1
CH471078 Genomic DNA Translation: EAW66405.1
CH471078 Genomic DNA Translation: EAW66406.1
CH471078 Genomic DNA Translation: EAW66407.1
BC000694 mRNA Translation: AAH00694.1
BC036105 mRNA Translation: AAH36105.1
CCDSiCCDS9568.1
RefSeqiNP_001095142.1, NM_001101672.1
NP_001095924.1, NM_001102454.1
NP_057507.2, NM_016423.2
XP_006720226.1, XM_006720163.2
XP_006720227.1, XM_006720164.3
XP_016876843.1, XM_017021354.1
XP_016876844.1, XM_017021355.1
UniGeneiHs.250493

3D structure databases

ProteinModelPortaliQ9P2Y4
SMRiQ9P2Y4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119387, 43 interactors
IntActiQ9P2Y4, 18 interactors
MINTiQ9P2Y4
STRINGi9606.ENSP00000354206

PTM databases

iPTMnetiQ9P2Y4
PhosphoSitePlusiQ9P2Y4

Polymorphism and mutation databases

BioMutaiZNF219
DMDMi55977885

Proteomic databases

EPDiQ9P2Y4
MaxQBiQ9P2Y4
PaxDbiQ9P2Y4
PeptideAtlasiQ9P2Y4
PRIDEiQ9P2Y4
ProteomicsDBi83913

Protocols and materials databases

DNASUi51222
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360947; ENSP00000354206; ENSG00000165804
ENST00000421093; ENSP00000392401; ENSG00000165804
ENST00000451119; ENSP00000388558; ENSG00000165804
GeneIDi51222
KEGGihsa:51222
UCSCiuc001vzr.3 human

Organism-specific databases

CTDi51222
EuPathDBiHostDB:ENSG00000165804.15
GeneCardsiZNF219
HGNCiHGNC:13011 ZNF219
HPAiHPA030761
HPA056168
MIMi605036 gene
neXtProtiNX_Q9P2Y4
OpenTargetsiENSG00000165804
PharmGKBiPA37590
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063100
HOGENOMiHOG000140857
HOVERGENiHBG054187
InParanoidiQ9P2Y4
OMAiASPPYAR
OrthoDBiEOG091G05JC
PhylomeDBiQ9P2Y4
TreeFamiTF332241

Miscellaneous databases

ChiTaRSiZNF219 human
GeneWikiiZNF219
GenomeRNAii51222
PROiPR:Q9P2Y4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165804 Expressed in 190 organ(s), highest expression level in right adrenal gland
CleanExiHS_ZNF219
ExpressionAtlasiQ9P2Y4 baseline and differential
GenevisibleiQ9P2Y4 HS

Family and domain databases

InterProiView protein in InterPro
IPR003980 Histamine_H3_rcpt
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
PRINTSiPR01471 HISTAMINEH3R
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN219_HUMAN
AccessioniPrimary (citable) accession number: Q9P2Y4
Secondary accession number(s): D3DS16
, Q53Y57, Q8IYC1, Q9BW28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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