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Protein

Deleted in esophageal cancer 1

Gene

DEC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Candidate tumor suppressor.1 Publication

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Deleted in esophageal cancer 1
Alternative name(s):
Candidate tumor suppressor CTS9
Gene namesi
Name:DEC1
Synonyms:CTS9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000173077.14
HGNCiHGNC:23658 DEC1
MIMi604767 gene
neXtProtiNX_Q9P2X7

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi50514
MalaCardsiDEC1
OpenTargetsiENSG00000173077
PharmGKBiPA134898625

Polymorphism and mutation databases

BioMutaiDEC1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406311 – 70Deleted in esophageal cancer 1Add BLAST70

Proteomic databases

PaxDbiQ9P2X7
PRIDEiQ9P2X7
ProteomicsDBi83911

Expressioni

Tissue specificityi

Expressed in many tissues, with highest expression in prostate and testis. Reduced expression in esophageal carcinomas.1 Publication

Gene expression databases

BgeeiENSG00000173077 Expressed in 66 organ(s), highest expression level in tibial nerve
CleanExiHS_DEC1
ExpressionAtlasiQ9P2X7 baseline and differential
GenevisibleiQ9P2X7 HS

Interactioni

Protein-protein interaction databases

BioGridi119083, 32 interactors
STRINGi9606.ENSP00000363128

Structurei

3D structure databases

ProteinModelPortaliQ9P2X7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410KEC0 Eukaryota
ENOG4111BDC LUCA
GeneTreeiENSGT00390000016096
HOGENOMiHOG000112187
InParanoidiQ9P2X7
OMAiVFTDALH
PhylomeDBiQ9P2X7
TreeFamiTF340655

Family and domain databases

InterProiView protein in InterPro
IPR031718 DEC1
PfamiView protein in Pfam
PF15859 DEC1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9P2X7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMNVLEAGK WKSIVPAPGE GLLAVLHMMV FTDALHRERS VKWQAGVCYN
60 70
GGKDFAVSLA RPKAAEGIAD
Length:70
Mass (Da):7,542
Last modified:October 1, 2000 - v1
Checksum:i91FA5AD3C402EF43
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT93A0A087WT93_HUMAN
Deleted in esophageal cancer 1
DEC1
70Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05094860A → V. Corresponds to variant dbSNP:rs2269700Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022761 mRNA Translation: BAA96242.1
AL714001 Genomic DNA No translation available.
CCDSiCCDS6812.1
RefSeqiNP_059114.1, NM_017418.2
UniGeneiHs.148841

Genome annotation databases

EnsembliENST00000374016; ENSP00000363128; ENSG00000173077
GeneIDi50514
KEGGihsa:50514
UCSCiuc004bjk.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022761 mRNA Translation: BAA96242.1
AL714001 Genomic DNA No translation available.
CCDSiCCDS6812.1
RefSeqiNP_059114.1, NM_017418.2
UniGeneiHs.148841

3D structure databases

ProteinModelPortaliQ9P2X7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119083, 32 interactors
STRINGi9606.ENSP00000363128

Polymorphism and mutation databases

BioMutaiDEC1

Proteomic databases

PaxDbiQ9P2X7
PRIDEiQ9P2X7
ProteomicsDBi83911

Protocols and materials databases

DNASUi50514
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374016; ENSP00000363128; ENSG00000173077
GeneIDi50514
KEGGihsa:50514
UCSCiuc004bjk.1 human

Organism-specific databases

CTDi50514
DisGeNETi50514
EuPathDBiHostDB:ENSG00000173077.14
GeneCardsiDEC1
HGNCiHGNC:23658 DEC1
MalaCardsiDEC1
MIMi604767 gene
neXtProtiNX_Q9P2X7
OpenTargetsiENSG00000173077
PharmGKBiPA134898625
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KEC0 Eukaryota
ENOG4111BDC LUCA
GeneTreeiENSGT00390000016096
HOGENOMiHOG000112187
InParanoidiQ9P2X7
OMAiVFTDALH
PhylomeDBiQ9P2X7
TreeFamiTF340655

Miscellaneous databases

ChiTaRSiDEC1 human
GeneWikiiDEC1
GenomeRNAii50514
PROiPR:Q9P2X7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173077 Expressed in 66 organ(s), highest expression level in tibial nerve
CleanExiHS_DEC1
ExpressionAtlasiQ9P2X7 baseline and differential
GenevisibleiQ9P2X7 HS

Family and domain databases

InterProiView protein in InterPro
IPR031718 DEC1
PfamiView protein in Pfam
PF15859 DEC1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEC1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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