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Entry version 147 (13 Feb 2019)
Sequence version 2 (06 Feb 2007)
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Protein

Dolichol-phosphate mannosyltransferase subunit 3

Gene

DPM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • GPI anchor biosynthetic process Source: UniProtKB
  • protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan Source: HGNC
  • protein mannosylation Source: HGNC
  • protein O-linked mannosylation Source: HGNC
  • regulation of protein stability Source: UniProtKB

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000179085-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-162699 Synthesis of dolichyl-phosphate mannose
R-HSA-4719360 Defective DPM3 causes DPM3-CDG (CDG-1o)

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dolichol-phosphate mannosyltransferase subunit 3
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 3
Short name:
DPM synthase subunit 3
Dolichyl-phosphate beta-D-mannosyltransferase subunit 3
Mannose-P-dolichol synthase subunit 3
Short name:
MPD synthase subunit 3
Prostin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPM3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000179085.7

Human Gene Nomenclature Database

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HGNCi
HGNC:3007 DPM3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605951 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P2X0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Muscular dystrophy-dystroglycanopathy limb-girdle C15 (MDDGC15)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive muscular dystrophy associated with a disorder of glycosylation resulting in under-glycosylated serum glycoproteins. MDDGC15 patients have muscle weakness, increased serum creatine kinase, dystrophic changes on muscle biopsy, and reduced O-mannosylation of alpha-dystroglycan.
See also OMIM:612937
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06251885L → S in MDDGC15; affects interaction with DPM1. 1 PublicationCorresponds to variant dbSNP:rs121908155EnsemblClinVar.1

Keywords - Diseasei

Congenital disorder of glycosylation, Congenital muscular dystrophy, Disease mutation, Dystroglycanopathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
54344

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DPM3

MalaCards human disease database

More...
MalaCardsi
DPM3
MIMi612937 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000179085

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
263494 DPM3-CDG

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27465

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DPM3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
125987822

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001950001 – 92Dolichol-phosphate mannosyltransferase subunit 3Add BLAST92

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9P2X0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9P2X0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9P2X0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2X0

PeptideAtlas

More...
PeptideAtlasi
Q9P2X0

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2X0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83907
83908 [Q9P2X0-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9P2X0-1 [Q9P2X0-1]
Q9P2X0-2 [Q9P2X0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2X0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2X0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9P2X0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179085 Expressed in 217 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P2X0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P2X0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014667

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119935, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9P2X0

Protein interaction database and analysis system

More...
IntActi
Q9P2X0, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357384

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9P2X0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DPM3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4841 Eukaryota
ENOG41121C3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008892

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038272

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG018968

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9P2X0

KEGG Orthology (KO)

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KOi
K09659

Identification of Orthologs from Complete Genome Data

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OMAi
YRVATFN

Database of Orthologous Groups

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OrthoDBi
1612544at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P2X0

TreeFam database of animal gene trees

More...
TreeFami
TF300274

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013174 DPM3

The PANTHER Classification System

More...
PANTHERi
PTHR16433 PTHR16433, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08285 DPM3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9P2X0-1) [UniParc]FASTAAdd to basket
Also known as: Short

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKLAQWLWG LAILGSTWVA LTTGALGLEL PLSCQEVLWP LPAYLLVSAG
60 70 80 90
CYALGTVGYR VATFHDCEDA ARELQSQIQE ARADLARRGL RF
Length:92
Mass (Da):10,094
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC350A6896842A877
GO
Isoform 2 (identifier: Q9P2X0-2) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLSVGGLRLSLVRFSFLLLRGALLPSLAVTM

Show »
Length:122
Mass (Da):13,277
Checksum:iDD8661D41C2AE5C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti90L → V in BAA96291 (PubMed:10835346).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06251885L → S in MDDGC15; affects interaction with DPM1. 1 PublicationCorresponds to variant dbSNP:rs121908155EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0013081M → MLSVGGLRLSLVRFSFLLLR GALLPSLAVTM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB028128 mRNA Translation: BAA96291.1
AF312922 mRNA Translation: AAK28487.1
AF312923 mRNA Translation: AAK28486.1
AL691442 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53126.1
BC104202 mRNA Translation: AAI04203.1
BC104203 mRNA Translation: AAI04204.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1094.1 [Q9P2X0-2]
CCDS1095.1 [Q9P2X0-1]

NCBI Reference Sequences

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RefSeqi
NP_061846.2, NM_018973.3 [Q9P2X0-2]
NP_714963.1, NM_153741.1 [Q9P2X0-1]
XP_016856987.1, XM_017001498.1 [Q9P2X0-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.110477

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341298; ENSP00000344338; ENSG00000179085 [Q9P2X0-1]
ENST00000368399; ENSP00000357384; ENSG00000179085 [Q9P2X0-2]
ENST00000368400; ENSP00000357385; ENSG00000179085 [Q9P2X0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54344

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54344

UCSC genome browser

More...
UCSCi
uc001fhm.3 human [Q9P2X0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028128 mRNA Translation: BAA96291.1
AF312922 mRNA Translation: AAK28487.1
AF312923 mRNA Translation: AAK28486.1
AL691442 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53126.1
BC104202 mRNA Translation: AAI04203.1
BC104203 mRNA Translation: AAI04204.1
CCDSiCCDS1094.1 [Q9P2X0-2]
CCDS1095.1 [Q9P2X0-1]
RefSeqiNP_061846.2, NM_018973.3 [Q9P2X0-2]
NP_714963.1, NM_153741.1 [Q9P2X0-1]
XP_016856987.1, XM_017001498.1 [Q9P2X0-1]
UniGeneiHs.110477

3D structure databases

ProteinModelPortaliQ9P2X0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119935, 10 interactors
CORUMiQ9P2X0
IntActiQ9P2X0, 15 interactors
STRINGi9606.ENSP00000357384

PTM databases

iPTMnetiQ9P2X0
PhosphoSitePlusiQ9P2X0
SwissPalmiQ9P2X0

Polymorphism and mutation databases

BioMutaiDPM3
DMDMi125987822

Proteomic databases

EPDiQ9P2X0
jPOSTiQ9P2X0
MaxQBiQ9P2X0
PaxDbiQ9P2X0
PeptideAtlasiQ9P2X0
PRIDEiQ9P2X0
ProteomicsDBi83907
83908 [Q9P2X0-2]
TopDownProteomicsiQ9P2X0-1 [Q9P2X0-1]
Q9P2X0-2 [Q9P2X0-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54344
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341298; ENSP00000344338; ENSG00000179085 [Q9P2X0-1]
ENST00000368399; ENSP00000357384; ENSG00000179085 [Q9P2X0-2]
ENST00000368400; ENSP00000357385; ENSG00000179085 [Q9P2X0-1]
GeneIDi54344
KEGGihsa:54344
UCSCiuc001fhm.3 human [Q9P2X0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54344
DisGeNETi54344
EuPathDBiHostDB:ENSG00000179085.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DPM3
GeneReviewsiDPM3
HGNCiHGNC:3007 DPM3
HPAiHPA014667
MalaCardsiDPM3
MIMi605951 gene
612937 phenotype
neXtProtiNX_Q9P2X0
OpenTargetsiENSG00000179085
Orphaneti263494 DPM3-CDG
PharmGKBiPA27465

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4841 Eukaryota
ENOG41121C3 LUCA
GeneTreeiENSGT00390000008892
HOGENOMiHOG000038272
HOVERGENiHBG018968
InParanoidiQ9P2X0
KOiK09659
OMAiYRVATFN
OrthoDBi1612544at2759
PhylomeDBiQ9P2X0
TreeFamiTF300274

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:ENSG00000179085-MONOMER
ReactomeiR-HSA-162699 Synthesis of dolichyl-phosphate mannose
R-HSA-4719360 Defective DPM3 causes DPM3-CDG (CDG-1o)

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DPM3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54344

Protein Ontology

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PROi
PR:Q9P2X0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000179085 Expressed in 217 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ9P2X0 baseline and differential
GenevisibleiQ9P2X0 HS

Family and domain databases

InterProiView protein in InterPro
IPR013174 DPM3
PANTHERiPTHR16433 PTHR16433, 1 hit
PfamiView protein in Pfam
PF08285 DPM3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPM3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2X0
Secondary accession number(s): Q5SR62
, Q5SR63, Q9BXN4, Q9BXN5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: February 6, 2007
Last modified: February 13, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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