UniProtKB - Q9P2W9 (STX18_HUMAN)
Protein
Syntaxin-18
Gene
STX18
Organism
Homo sapiens (Human)
Status
Functioni
Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication
GO - Molecular functioni
- protein domain specific binding Source: Ensembl
- SNAP receptor activity Source: InterPro
GO - Biological processi
- endoplasmic reticulum membrane organization Source: UniProtKB
- intracellular protein transport Source: InterPro
- positive regulation of ER to Golgi vesicle-mediated transport Source: UniProtKB
- positive regulation of organelle assembly Source: UniProtKB
- regulation of Golgi organization Source: UniProtKB
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9P2W9 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-18Alternative name(s): Cell growth-inhibiting gene 9 protein |
Gene namesi | Name:STX18 ORF Names:GIG9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168818.9 |
HGNCi | HGNC:15942, STX18 |
MIMi | 606046, gene |
neXtProti | NX_Q9P2W9 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type IV membrane protein 1 Publication
Golgi apparatus
- Golgi apparatus membrane Curated; Single-pass type IV membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: Reactome
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- SNARE complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 309 | CytoplasmicSequence analysisAdd BLAST | 309 | |
Transmembranei | 310 – 330 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 331 – 335 | VesicularSequence analysis | 5 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 53407 |
OpenTargetsi | ENSG00000168818 |
PharmGKBi | PA38061 |
Miscellaneous databases
Pharosi | Q9P2W9, Tbio |
Polymorphism and mutation databases
BioMutai | STX18 |
DMDMi | 17369347 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210231 | 1 – 335 | Syntaxin-18Add BLAST | 335 |
Proteomic databases
EPDi | Q9P2W9 |
jPOSTi | Q9P2W9 |
MassIVEi | Q9P2W9 |
MaxQBi | Q9P2W9 |
PaxDbi | Q9P2W9 |
PeptideAtlasi | Q9P2W9 |
PRIDEi | Q9P2W9 |
ProteomicsDBi | 83906 |
PTM databases
iPTMneti | Q9P2W9 |
PhosphoSitePlusi | Q9P2W9 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000168818, Expressed in endometrium and 213 other tissues |
ExpressionAtlasi | Q9P2W9, baseline and differential |
Genevisiblei | Q9P2W9, HS |
Organism-specific databases
HPAi | ENSG00000168818, Tissue enhanced (enhanced) |
Interactioni
Subunit structurei
Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L.
Interacts directly with USE1L and BNIP1/SEC20L.
2 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- protein domain specific binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 119782, 58 interactors |
DIPi | DIP-37617N |
IntActi | Q9P2W9, 44 interactors |
MINTi | Q9P2W9 |
STRINGi | 9606.ENSP00000305810 |
Miscellaneous databases
RNActi | Q9P2W9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 243 – 305 | t-SNARE coiled-coil homologyAdd BLAST | 63 |
Sequence similaritiesi
Belongs to the syntaxin family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3894, Eukaryota |
GeneTreei | ENSGT00390000014853 |
HOGENOMi | CLU_071402_1_0_1 |
InParanoidi | Q9P2W9 |
OMAi | SPMKIQE |
OrthoDBi | 1141750at2759 |
PhylomeDBi | Q9P2W9 |
TreeFami | TF105868 |
Family and domain databases
InterProi | View protein in InterPro IPR019529, Syntaxin-18_N IPR006012, Syntaxin/epimorphin_CS |
Pfami | View protein in Pfam PF10496, Syntaxin-18_N, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9P2W9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVDITLLFR ASVKTVKTRN KALGVAVGGG VDGSRDELFR RSPRPKGDFS
60 70 80 90 100
SRAREVISHI GKLRDFLLEH RKDYINAYSH TMSEYGRMTD TERDQIDQDA
110 120 130 140 150
QIFMRTCSEA IQQLRTEAHK EIHSQQVKEH RTAVLDFIED YLKRVCKLYS
160 170 180 190 200
EQRAIRVKRV VDKKRLSKLE PEPNTKTRES TSSEKVSQSP SKDSEENPAT
210 220 230 240 250
EERPEKILAE TQPELGTWGD GKGEDELSPE EIQMFEQENQ RLIGEMNSLF
260 270 280 290 300
DEVRQIEGRV VEISRLQEIF TEKVLQQEAE IDSIHQLVVG ATENIKEGNE
310 320 330
DIREAIKNNA GFRVWILFFL VMCSFSLLFL DWYDS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RF48 | D6RF48_HUMAN | Syntaxin-18 | STX18 | 308 | Annotation score: | ||
D6RC71 | D6RC71_HUMAN | Syntaxin-18 | STX18 | 169 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | A → V in AAV38937 (Ref. 3) Curated | 1 | |
Sequence conflicti | 308 | N → D in AAS47513 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052250 | 32 | D → Y. Corresponds to variant dbSNP:rs13134070Ensembl. | 1 | |
Natural variantiVAR_052251 | 51 | S → G. Corresponds to variant dbSNP:rs36109375Ensembl. | 1 | |
Natural variantiVAR_052252 | 228 | S → T. Corresponds to variant dbSNP:rs33952588Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028741 mRNA Translation: BAA95213.1 AY453396 mRNA Translation: AAS47513.1 BT007150 mRNA Translation: AAP35814.1 BT020135 mRNA Translation: AAV38937.1 BC014613 mRNA Translation: AAH14613.1 |
CCDSi | CCDS3377.1 |
RefSeqi | NP_001333210.1, NM_001346281.1 NP_001333211.1, NM_001346282.1 NP_001333229.1, NM_001346300.1 NP_058626.1, NM_016930.3 |
Genome annotation databases
Ensembli | ENST00000306200; ENSP00000305810; ENSG00000168818 |
GeneIDi | 53407 |
KEGGi | hsa:53407 |
UCSCi | uc003gic.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028741 mRNA Translation: BAA95213.1 AY453396 mRNA Translation: AAS47513.1 BT007150 mRNA Translation: AAP35814.1 BT020135 mRNA Translation: AAV38937.1 BC014613 mRNA Translation: AAH14613.1 |
CCDSi | CCDS3377.1 |
RefSeqi | NP_001333210.1, NM_001346281.1 NP_001333211.1, NM_001346282.1 NP_001333229.1, NM_001346300.1 NP_058626.1, NM_016930.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119782, 58 interactors |
DIPi | DIP-37617N |
IntActi | Q9P2W9, 44 interactors |
MINTi | Q9P2W9 |
STRINGi | 9606.ENSP00000305810 |
PTM databases
iPTMneti | Q9P2W9 |
PhosphoSitePlusi | Q9P2W9 |
Polymorphism and mutation databases
BioMutai | STX18 |
DMDMi | 17369347 |
Proteomic databases
EPDi | Q9P2W9 |
jPOSTi | Q9P2W9 |
MassIVEi | Q9P2W9 |
MaxQBi | Q9P2W9 |
PaxDbi | Q9P2W9 |
PeptideAtlasi | Q9P2W9 |
PRIDEi | Q9P2W9 |
ProteomicsDBi | 83906 |
Protocols and materials databases
Antibodypediai | 727, 116 antibodies |
DNASUi | 53407 |
Genome annotation databases
Ensembli | ENST00000306200; ENSP00000305810; ENSG00000168818 |
GeneIDi | 53407 |
KEGGi | hsa:53407 |
UCSCi | uc003gic.4, human |
Organism-specific databases
CTDi | 53407 |
DisGeNETi | 53407 |
EuPathDBi | HostDB:ENSG00000168818.9 |
GeneCardsi | STX18 |
HGNCi | HGNC:15942, STX18 |
HPAi | ENSG00000168818, Tissue enhanced (enhanced) |
MIMi | 606046, gene |
neXtProti | NX_Q9P2W9 |
OpenTargetsi | ENSG00000168818 |
PharmGKBi | PA38061 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3894, Eukaryota |
GeneTreei | ENSGT00390000014853 |
HOGENOMi | CLU_071402_1_0_1 |
InParanoidi | Q9P2W9 |
OMAi | SPMKIQE |
OrthoDBi | 1141750at2759 |
PhylomeDBi | Q9P2W9 |
TreeFami | TF105868 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2W9 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 53407, 663 hits in 851 CRISPR screens |
GenomeRNAii | 53407 |
Pharosi | Q9P2W9, Tbio |
PROi | PR:Q9P2W9 |
RNActi | Q9P2W9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168818, Expressed in endometrium and 213 other tissues |
ExpressionAtlasi | Q9P2W9, baseline and differential |
Genevisiblei | Q9P2W9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019529, Syntaxin-18_N IPR006012, Syntaxin/epimorphin_CS |
Pfami | View protein in Pfam PF10496, Syntaxin-18_N, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STX18_HUMAN | |
Accessioni | Q9P2W9Primary (citable) accession number: Q9P2W9 Secondary accession number(s): Q596L3, Q5TZP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations