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Protein

Syntaxin-18

Gene

STX18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-18
Alternative name(s):
Cell growth-inhibiting gene 9 protein
Gene namesi
Name:STX18
ORF Names:GIG9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168818.9
HGNCiHGNC:15942 STX18
MIMi606046 gene
neXtProtiNX_Q9P2W9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 309CytoplasmicSequence analysisAdd BLAST309
Transmembranei310 – 330Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini331 – 335VesicularSequence analysis5

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53407
OpenTargetsiENSG00000168818
PharmGKBiPA38061

Polymorphism and mutation databases

BioMutaiSTX18
DMDMi17369347

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102311 – 335Syntaxin-18Add BLAST335

Proteomic databases

EPDiQ9P2W9
MaxQBiQ9P2W9
PaxDbiQ9P2W9
PeptideAtlasiQ9P2W9
PRIDEiQ9P2W9
ProteomicsDBi83906

PTM databases

iPTMnetiQ9P2W9
PhosphoSitePlusiQ9P2W9

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000168818 Expressed in 204 organ(s), highest expression level in endometrium
CleanExiHS_STX18
ExpressionAtlasiQ9P2W9 baseline and differential
GenevisibleiQ9P2W9 HS

Organism-specific databases

HPAiHPA003019

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119782, 47 interactors
DIPiDIP-37617N
IntActiQ9P2W9, 18 interactors
STRINGi9606.ENSP00000305810

Structurei

3D structure databases

ProteinModelPortaliQ9P2W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini243 – 305t-SNARE coiled-coil homologyAdd BLAST63

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3894 Eukaryota
ENOG410XSGT LUCA
GeneTreeiENSGT00390000014853
HOGENOMiHOG000007595
HOVERGENiHBG054890
InParanoidiQ9P2W9
KOiK08492
OMAiLQHRKDY
OrthoDBiEOG091G0FVR
PhylomeDBiQ9P2W9
TreeFamiTF105868

Family and domain databases

InterProiView protein in InterPro
IPR019529 Syntaxin-18_N
IPR006012 Syntaxin/epimorphin_CS
PfamiView protein in Pfam
PF10496 Syntaxin-18_N, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9P2W9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVDITLLFR ASVKTVKTRN KALGVAVGGG VDGSRDELFR RSPRPKGDFS
60 70 80 90 100
SRAREVISHI GKLRDFLLEH RKDYINAYSH TMSEYGRMTD TERDQIDQDA
110 120 130 140 150
QIFMRTCSEA IQQLRTEAHK EIHSQQVKEH RTAVLDFIED YLKRVCKLYS
160 170 180 190 200
EQRAIRVKRV VDKKRLSKLE PEPNTKTRES TSSEKVSQSP SKDSEENPAT
210 220 230 240 250
EERPEKILAE TQPELGTWGD GKGEDELSPE EIQMFEQENQ RLIGEMNSLF
260 270 280 290 300
DEVRQIEGRV VEISRLQEIF TEKVLQQEAE IDSIHQLVVG ATENIKEGNE
310 320 330
DIREAIKNNA GFRVWILFFL VMCSFSLLFL DWYDS
Length:335
Mass (Da):38,674
Last modified:October 1, 2000 - v1
Checksum:iD89B3B52407D77FF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF48D6RF48_HUMAN
Syntaxin-18
STX18
308Annotation score:
D6RC71D6RC71_HUMAN
Syntaxin-18
STX18
169Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11A → V in AAV38937 (Ref. 3) Curated1
Sequence conflicti308N → D in AAS47513 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05225032D → Y. Corresponds to variant dbSNP:rs13134070Ensembl.1
Natural variantiVAR_05225151S → G. Corresponds to variant dbSNP:rs36109375Ensembl.1
Natural variantiVAR_052252228S → T. Corresponds to variant dbSNP:rs33952588Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028741 mRNA Translation: BAA95213.1
AY453396 mRNA Translation: AAS47513.1
BT007150 mRNA Translation: AAP35814.1
BT020135 mRNA Translation: AAV38937.1
BC014613 mRNA Translation: AAH14613.1
CCDSiCCDS3377.1
RefSeqiNP_001333210.1, NM_001346281.1
NP_001333211.1, NM_001346282.1
NP_001333229.1, NM_001346300.1
NP_058626.1, NM_016930.3
UniGeneiHs.584913

Genome annotation databases

EnsembliENST00000306200; ENSP00000305810; ENSG00000168818
GeneIDi53407
KEGGihsa:53407
UCSCiuc003gic.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028741 mRNA Translation: BAA95213.1
AY453396 mRNA Translation: AAS47513.1
BT007150 mRNA Translation: AAP35814.1
BT020135 mRNA Translation: AAV38937.1
BC014613 mRNA Translation: AAH14613.1
CCDSiCCDS3377.1
RefSeqiNP_001333210.1, NM_001346281.1
NP_001333211.1, NM_001346282.1
NP_001333229.1, NM_001346300.1
NP_058626.1, NM_016930.3
UniGeneiHs.584913

3D structure databases

ProteinModelPortaliQ9P2W9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119782, 47 interactors
DIPiDIP-37617N
IntActiQ9P2W9, 18 interactors
STRINGi9606.ENSP00000305810

PTM databases

iPTMnetiQ9P2W9
PhosphoSitePlusiQ9P2W9

Polymorphism and mutation databases

BioMutaiSTX18
DMDMi17369347

Proteomic databases

EPDiQ9P2W9
MaxQBiQ9P2W9
PaxDbiQ9P2W9
PeptideAtlasiQ9P2W9
PRIDEiQ9P2W9
ProteomicsDBi83906

Protocols and materials databases

DNASUi53407
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306200; ENSP00000305810; ENSG00000168818
GeneIDi53407
KEGGihsa:53407
UCSCiuc003gic.4 human

Organism-specific databases

CTDi53407
DisGeNETi53407
EuPathDBiHostDB:ENSG00000168818.9
GeneCardsiSTX18
H-InvDBiHIX0120162
HGNCiHGNC:15942 STX18
HPAiHPA003019
MIMi606046 gene
neXtProtiNX_Q9P2W9
OpenTargetsiENSG00000168818
PharmGKBiPA38061
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3894 Eukaryota
ENOG410XSGT LUCA
GeneTreeiENSGT00390000014853
HOGENOMiHOG000007595
HOVERGENiHBG054890
InParanoidiQ9P2W9
KOiK08492
OMAiLQHRKDY
OrthoDBiEOG091G0FVR
PhylomeDBiQ9P2W9
TreeFamiTF105868

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

GenomeRNAii53407
PROiPR:Q9P2W9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168818 Expressed in 204 organ(s), highest expression level in endometrium
CleanExiHS_STX18
ExpressionAtlasiQ9P2W9 baseline and differential
GenevisibleiQ9P2W9 HS

Family and domain databases

InterProiView protein in InterPro
IPR019529 Syntaxin-18_N
IPR006012 Syntaxin/epimorphin_CS
PfamiView protein in Pfam
PF10496 Syntaxin-18_N, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTX18_HUMAN
AccessioniPrimary (citable) accession number: Q9P2W9
Secondary accession number(s): Q596L3, Q5TZP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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