UniProtKB - Q9P2W9 (STX18_HUMAN)

BLAST

>sp|Q9P2W9|STX18_HUMAN Syntaxin-18 OS=Homo sapiens OX=9606 GN=STX18 PE=1 SV=1
MAVDITLLFRASVKTVKTRNKALGVAVGGGVDGSRDELFRRSPRPKGDFSSRAREVISHI
GKLRDFLLEHRKDYINAYSHTMSEYGRMTDTERDQIDQDAQIFMRTCSEAIQQLRTEAHK
EIHSQQVKEHRTAVLDFIEDYLKRVCKLYSEQRAIRVKRVVDKKRLSKLEPEPNTKTRES
TSSEKVSQSPSKDSEENPATEERPEKILAETQPELGTWGDGKGEDELSPEEIQMFEQENQ
RLIGEMNSLFDEVRQIEGRVVEISRLQEIFTEKVLQQEAEIDSIHQLVVGATENIKEGNE
DIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS

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History
Entry version 146 (12 Sep 2018)
Sequence version 1 (01 Oct 2000)
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Protein

Syntaxin-18

Gene

STX18

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication

GO - Molecular functionⁱ

protein domain specific binding Source: Ensembl
SNAP receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endoplasmic reticulum membrane organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19401338
intracellular protein transport Source: InterPro
positive regulation of ER to Golgi vesicle-mediated transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10788491
- 19401338
positive regulation of organelle assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19401338
regulation of Golgi organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19401338
retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ER-Golgi transport, Protein transport, Transport

Biological process

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Reactomeⁱ

R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Syntaxin-18 Alternative name(s): Cell growth-inhibiting gene 9 protein
Gene namesⁱ	Name:STX18 ORF Names:GIG9
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168818.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15942 STX18
MIMⁱ	606046 gene
neXtProtⁱ	NX_Q9P2W9

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 309	CytoplasmicSequence analysisAdd BLAST	309
Transmembraneⁱ	310 – 330	Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	331 – 335	VesicularSequence analysis	5

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	53407
Open Targets More...OpenTargetsⁱ	ENSG00000168818
PharmGKBⁱ	PA38061

Polymorphism and mutation databases

BioMutaⁱ	STX18
DMDMⁱ	17369347

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000210231	1 – 335	Syntaxin-18Add BLAST		335

Proteomic databases

EPDⁱ	Q9P2W9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P2W9
PaxDbⁱ	Q9P2W9
PeptideAtlas More...PeptideAtlasⁱ	Q9P2W9
PRIDEⁱ	Q9P2W9
ProteomicsDBⁱ	83906

PTM databases

iPTMnetⁱ	Q9P2W9
PhosphoSitePlusⁱ	Q9P2W9

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000168818 Expressed in 204 organ(s), highest expression level in endometrium
CleanExⁱ	HS_STX18
ExpressionAtlasⁱ	Q9P2W9 baseline and differential
Genevisibleⁱ	Q9P2W9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003019

HPAⁱ

HPA003019

Interactionⁱ

Subunit structureⁱ

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SEC22B	O75396	2	EBI-725334,EBI-1058865
USE1	Q9NZ43	7	EBI-725334,EBI-742842

GO - Molecular functionⁱ

protein domain specific binding Source: Ensembl
SNAP receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119782, 47 interactors
Database of interacting proteins More...DIPⁱ	DIP-37617N
IntActⁱ	Q9P2W9, 18 interactors
STRINGⁱ	9606.ENSP00000305810

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P2W9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	243 – 305	t-SNARE coiled-coil homologyAdd BLAST		63

Sequence similaritiesⁱ

Belongs to the syntaxin family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3894 Eukaryota ENOG410XSGT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014853
HOGENOMⁱ	HOG000007595
HOVERGENⁱ	HBG054890
InParanoidⁱ	Q9P2W9
KEGG Orthology (KO) More...KOⁱ	K08492
OMAⁱ	LQHRKDY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FVR
PhylomeDBⁱ	Q9P2W9
TreeFamⁱ	TF105868

Family and domain databases

InterProⁱ	View protein in InterPro IPR019529 Syntaxin-18_N IPR006012 Syntaxin/epimorphin_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10496 Syntaxin-18_N, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914 SYNTAXIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9P2W9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVDITLLFR ASVKTVKTRN KALGVAVGGG VDGSRDELFR RSPRPKGDFS 
        60         70         80         90        100
SRAREVISHI GKLRDFLLEH RKDYINAYSH TMSEYGRMTD TERDQIDQDA 
       110        120        130        140        150
QIFMRTCSEA IQQLRTEAHK EIHSQQVKEH RTAVLDFIED YLKRVCKLYS 
       160        170        180        190        200
EQRAIRVKRV VDKKRLSKLE PEPNTKTRES TSSEKVSQSP SKDSEENPAT 
       210        220        230        240        250
EERPEKILAE TQPELGTWGD GKGEDELSPE EIQMFEQENQ RLIGEMNSLF 
       260        270        280        290        300
DEVRQIEGRV VEISRLQEIF TEKVLQQEAE IDSIHQLVVG ATENIKEGNE 
       310        320        330 
DIREAIKNNA GFRVWILFFL VMCSFSLLFL DWYDS

Length:335

Mass (Da):38,674

Last modified:October 1, 2000 - v1

Checksum:ⁱD89B3B52407D77FF

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RF48	D6RF48_HUMAN	Syntaxin-18 Syntaxin-18	STX18	308	Annotation score:
D6RC71	D6RC71_HUMAN	Syntaxin-18 Syntaxin-18	STX18	169	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	11	A → V in AAV38937 (Ref. 3) Curated		1
Sequence conflictⁱ	308	N → D in AAS47513 (Ref. 2) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_052250	32	D → Y. Corresponds to variant dbSNP:rs13134070Ensembl.	1
Natural variantⁱVAR_052251	51	S → G. Corresponds to variant dbSNP:rs36109375Ensembl.	1
Natural variantⁱVAR_052252	228	S → T. Corresponds to variant dbSNP:rs33952588Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028741 mRNA Translation: BAA95213.1 AY453396 mRNA Translation: AAS47513.1 BT007150 mRNA Translation: AAP35814.1 BT020135 mRNA Translation: AAV38937.1 BC014613 mRNA Translation: AAH14613.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3377.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001333210.1, NM_001346281.1 NP_001333211.1, NM_001346282.1 NP_001333229.1, NM_001346300.1 NP_058626.1, NM_016930.3
UniGeneⁱ	Hs.584913

Genome annotation databases

Ensemblⁱ	ENST00000306200; ENSP00000305810; ENSG00000168818
GeneIDⁱ	53407
KEGGⁱ	hsa:53407
UCSC genome browser More...UCSCⁱ	uc003gic.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W9	STX18 isoform 3		PANTR		335	UniRef100_Q9P2W9
STX18 isoform 3		PONAB		335
Uncharacterized protein		PANPA		335
Uncharacterized protein		GORGO		335
Syntaxin-18 (Fragment)		HUMAN		169
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W9	Syntaxin-18		PONAB		335	UniRef90_Q9P2W9
Syntaxin-18		RAT		334
STX18 isoform 3		PANTR		335
Uncharacterized protein		PANPA		335
Uncharacterized protein		GORGO		335
+114

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W9	Syntaxin-18		PONAB		335	UniRef50_Q9P2W9
Syntaxin-18		RAT		334
Syntaxin-18		MOUSE		334
STX18 isoform 3		PANTR		335
Uncharacterized protein		PANPA		335
+300

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028741 mRNA Translation: BAA95213.1 AY453396 mRNA Translation: AAS47513.1 BT007150 mRNA Translation: AAP35814.1 BT020135 mRNA Translation: AAV38937.1 BC014613 mRNA Translation: AAH14613.1
CCDSⁱ	CCDS3377.1
RefSeqⁱ	NP_001333210.1, NM_001346281.1 NP_001333211.1, NM_001346282.1 NP_001333229.1, NM_001346300.1 NP_058626.1, NM_016930.3
UniGeneⁱ	Hs.584913

3D structure databases

ProteinModelPortalⁱ	Q9P2W9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119782, 47 interactors
DIPⁱ	DIP-37617N
IntActⁱ	Q9P2W9, 18 interactors
STRINGⁱ	9606.ENSP00000305810

PTM databases

iPTMnetⁱ	Q9P2W9
PhosphoSitePlusⁱ	Q9P2W9

Polymorphism and mutation databases

BioMutaⁱ	STX18
DMDMⁱ	17369347

Proteomic databases

EPDⁱ	Q9P2W9
MaxQBⁱ	Q9P2W9
PaxDbⁱ	Q9P2W9
PeptideAtlasⁱ	Q9P2W9
PRIDEⁱ	Q9P2W9
ProteomicsDBⁱ	83906

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	53407
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000306200; ENSP00000305810; ENSG00000168818
GeneIDⁱ	53407
KEGGⁱ	hsa:53407
UCSCⁱ	uc003gic.4 human

Organism-specific databases

CTDⁱ	53407
DisGeNETⁱ	53407
EuPathDBⁱ	HostDB:ENSG00000168818.9
GeneCardsⁱ	STX18
H-InvDBⁱ	HIX0120162
HGNCⁱ	HGNC:15942 STX18
HPAⁱ	HPA003019
MIMⁱ	606046 gene
neXtProtⁱ	NX_Q9P2W9
OpenTargetsⁱ	ENSG00000168818
PharmGKBⁱ	PA38061
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3894 Eukaryota ENOG410XSGT LUCA
GeneTreeⁱ	ENSGT00390000014853
HOGENOMⁱ	HOG000007595
HOVERGENⁱ	HBG054890
InParanoidⁱ	Q9P2W9
KOⁱ	K08492
OMAⁱ	LQHRKDY
OrthoDBⁱ	EOG091G0FVR
PhylomeDBⁱ	Q9P2W9
TreeFamⁱ	TF105868

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Reactomeⁱ

R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

GenomeRNAiⁱ	53407
Protein Ontology More...PROⁱ	PR:Q9P2W9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168818 Expressed in 204 organ(s), highest expression level in endometrium
CleanExⁱ	HS_STX18
ExpressionAtlasⁱ	Q9P2W9 baseline and differential
Genevisibleⁱ	Q9P2W9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019529 Syntaxin-18_N IPR006012 Syntaxin/epimorphin_CS
Pfamⁱ	View protein in Pfam PF10496 Syntaxin-18_N, 1 hit
PROSITEⁱ	View protein in PROSITE PS00914 SYNTAXIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STX18_HUMAN
Accessionⁱ	Q9P2W9Primary (citable) accession number: Q9P2W9 Secondary accession number(s): Q596L3, Q5TZP5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9P2W9 (STX18_HUMAN)

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Syntaxin-18

STX18

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Endoplasmic reticulum

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ