B3GAT1

Functionⁱ

Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.By similarity

Catalytic activityⁱ

UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.By similarity

Cofactorⁱ

Mn²⁺

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	122	UDP-glucuronate	1
Binding siteⁱ	165	UDP-glucuronate	1
Binding siteⁱ	170	UDP-glucuronateBy similarity	1
Metal bindingⁱ	197	ManganeseBy similarity	1
Active siteⁱ	284	Proton donor/acceptor	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	91 – 93	UDP-glucuronate binding	3
Nucleotide bindingⁱ	195 – 197	UDP-glucuronate binding	3
Nucleotide bindingⁱ	311 – 313	UDP-glucuronate binding	3

GO - Molecular functionⁱ

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Source: UniProtKB
metal ion binding Source: UniProtKB-KW
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process
Source: ProtInc
Traceable author statementⁱ
- 10783264
chondroitin sulfate proteoglycan biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
glycosaminoglycan metabolic process Source: Reactome
protein glycosylation Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Ligand	Manganese, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS03272-MONOMER
BRENDAⁱ	2.4.1.135 2681
Reactomeⁱ	R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
UniPathwayⁱ	UPA00378

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT43 Glycosyltransferase Family 43

CAZyⁱ

GT43 Glycosyltransferase Family 43

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1Curated (EC:2.4.1.135By similarity) Alternative name(s): Beta-1,3-glucuronyltransferase 1 Glucuronosyltransferase P Short name: GlcAT-PBy similarity UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase Short name: GlcUAT-P
Gene namesⁱ	Name:B3GAT1Imported Synonyms:GLCATP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000109956.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:921 B3GAT1
MIMⁱ	151290 gene
neXtProtⁱ	NX_Q9P2W7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 6	CytoplasmicSequence analysis	6
Transmembraneⁱ	7 – 27	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	28 – 334	LumenalSequence analysisAdd BLAST	307

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	27087
Open Targets More...OpenTargetsⁱ	ENSG00000109956
PharmGKBⁱ	PA25215

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB01694 D-tartaric acid DB09459 Tartaric acid DB03435 Uridine-5'-Diphosphate

DrugBankⁱ

DB01694 D-tartaric acid
DB09459 Tartaric acid
DB03435 Uridine-5'-Diphosphate

Polymorphism and mutation databases

BioMutaⁱ	B3GAT1
DMDMⁱ	205830910

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000195167	1 – 334	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1Add BLAST		334

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	103	PhosphothreonineBy similarity	1
Modified residueⁱ	108	PhosphothreonineBy similarity	1
Glycosylationⁱ	140	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	184	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	303	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

The soluble form derives from the membrane form by proteolytic processing.By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9P2W7
PeptideAtlas More...PeptideAtlasⁱ	Q9P2W7
PRIDEⁱ	Q9P2W7
ProteomicsDBⁱ	83905

PTM databases

GlyConnectⁱ	1254
iPTMnetⁱ	Q9P2W7
PhosphoSitePlusⁱ	Q9P2W7

Expressionⁱ

Tissue specificityⁱ

Mainly expressed in the brain.

Gene expression databases

Bgeeⁱ	ENSG00000109956 Expressed in 123 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_B3GAT1
Genevisibleⁱ	Q9P2W7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002500 CAB010893 HPA069468

HPAⁱ

CAB002500
CAB010893
HPA069468

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with SAR1A.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	228	Interaction with galactose moiety of substrate glycoprotein		1
Siteⁱ	321	Interaction with galactose moiety of substrate glycoproteinBy similarity		1

Protein-protein interaction databases

BioGridⁱ	117990, 2 interactors
IntActⁱ	Q9P2W7, 3 interactors
STRINGⁱ	9606.ENSP00000307875

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	85 – 92	Combined sources	8
Helixⁱ	98 – 109	Combined sources	12
Beta strandⁱ	112 – 125	Combined sources	14
Helixⁱ	128 – 137	Combined sources	10
Beta strandⁱ	140 – 145	Combined sources	6
Helixⁱ	150 – 153	Combined sources	4
Helixⁱ	167 – 180	Combined sources	14
Beta strandⁱ	183 – 185	Combined sources	3
Beta strandⁱ	189 – 193	Combined sources	5
Beta strandⁱ	198 – 200	Combined sources	3
Helixⁱ	202 – 209	Combined sources	8
Beta strandⁱ	212 – 216	Combined sources	5
Beta strandⁱ	219 – 221	Combined sources	3
Beta strandⁱ	225 – 232	Combined sources	8
Beta strandⁱ	238 – 242	Combined sources	5
Beta strandⁱ	244 – 246	Combined sources	3
Helixⁱ	255 – 257	Combined sources	3
Beta strandⁱ	258 – 261	Combined sources	4
Helixⁱ	262 – 267	Combined sources	6
Beta strandⁱ	275 – 278	Combined sources	4
Helixⁱ	283 – 291	Combined sources	9
Helixⁱ	294 – 296	Combined sources	3
Beta strandⁱ	297 – 299	Combined sources	3
Helixⁱ	301 – 304	Combined sources	4
Helixⁱ	320 – 322	Combined sources	3
Turnⁱ	323 – 325	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9P2W7
SMRⁱ	Q9P2W7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9P2W7

EvolutionaryTraceⁱ

Q9P2W7

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	3 – 5	Essential for transport from endoplasmic reticulum to Golgi apparatus and interaction with SAR1ABy similarity		3
Regionⁱ	245 – 254	Interaction with galactose moiety of substrate glycoprotein		10

Sequence similaritiesⁱ

Belongs to the glycosyltransferase 43 family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1476 Eukaryota ENOG410XP79 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017640
HOGENOMⁱ	HOG000261693
HOVERGENⁱ	HBG050650
InParanoidⁱ	Q9P2W7
KEGG Orthology (KO) More...KOⁱ	K00735
OMAⁱ	WHQSTLA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G8P
PhylomeDBⁱ	Q9P2W7
TreeFamⁱ	TF313522

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00218 GlcAT-I, 1 hit
Gene3Dⁱ	3.90.550.10, 1 hit
InterProⁱ	View protein in InterPro IPR005027 Glyco_trans_43 IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR10896 PTHR10896, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03360 Glyco_transf_43, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9P2W7-1) [UniParc]FASTA Add to basket

Also known as: sGlcAT-PBy similarity

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKRRDILAI VLIVLPWTLL ITVWHQSTLA PLLAVHKDEG SDPRRETPPG 
        60         70         80         90        100
ADPREYCTSD RDIVEVVRTE YVYTRPPPWS DTLPTIHVVT PTYSRPVQKA 
       110        120        130        140        150
ELTRMANTLL HVPNLHWLVV EDAPRRTPLT ARLLRDTGLN YTHLHVETPR 
       160        170        180        190        200
NYKLRGDARD PRIPRGTMQR NLALRWLRET FPRNSSQPGV VYFADDDNTY 
       210        220        230        240        250
SLELFEEMRS TRRVSVWPVA FVGGLRYEAP RVNGAGKVVG WKTVFDPHRP 
       260        270        280        290        300
FAIDMAGFAV NLRLILQRSQ AYFKLRGVKG GYQESSLLRE LVTLNDLEPK 
       310        320        330 
AANCTKILVW HTRTEKPVLV NEGKKGFTDP SVEI

Length:334

Mass (Da):38,256

Last modified:July 22, 2008 - v2

Checksum:ⁱ0DF42399D19701B3

GO

Isoform 2 (identifier: Q9P2W7-2) [UniParc]FASTA Add to basket

Also known as: lGlcAT-PBy similarity

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MGNEEPWVQPALEM

« Hide

        10         20         30         40         50
MGNEEPWVQP ALEMPKRRDI LAIVLIVLPW TLLITVWHQS TLAPLLAVHK 
        60         70         80         90        100
DEGSDPRRET PPGADPREYC TSDRDIVEVV RTEYVYTRPP PWSDTLPTIH 
       110        120        130        140        150
VVTPTYSRPV QKAELTRMAN TLLHVPNLHW LVVEDAPRRT PLTARLLRDT 
       160        170        180        190        200
GLNYTHLHVE TPRNYKLRGD ARDPRIPRGT MQRNLALRWL RETFPRNSSQ 
       210        220        230        240        250
PGVVYFADDD NTYSLELFEE MRSTRRVSVW PVAFVGGLRY EAPRVNGAGK 
       260        270        280        290        300
VVGWKTVFDP HRPFAIDMAG FAVNLRLILQ RSQAYFKLRG VKGGYQESSL 
       310        320        330        340 
LRELVTLNDL EPKAANCTKI LVWHTRTEKP VLVNEGKKGF TDPSVEI

Show »

Length:347

Mass (Da):39,738

Checksum:ⁱ9A9A4FCE8345C240

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	240	G → R in BAA96077 (PubMed:10783264).Curated	1
Sequence conflictⁱ	267	Q → K in BAH13084 (PubMed:14702039).Curated	1
Sequence conflictⁱ	306	K → R in BAH13084 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_044538	131	A → T. Corresponds to variant dbSNP:rs35434644Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_058538	1	M → MGNEEPWVQPALEM in isoform 2.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB029396 mRNA Translation: BAA96077.1 AK299637 mRNA Translation: BAH13084.1 CR457098 mRNA Translation: CAG33379.1 BC010466 mRNA Translation: AAH10466.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8500.1 [Q9P2W7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_061114.2, NM_018644.3 [Q9P2W7-1] NP_473366.1, NM_054025.2 [Q9P2W7-1] XP_005271563.1, XM_005271506.3 [Q9P2W7-2] XP_011541053.1, XM_011542751.2 [Q9P2W7-2] XP_011541055.1, XM_011542753.2 [Q9P2W7-2] XP_016873039.1, XM_017017550.1 [Q9P2W7-1] XP_016873040.1, XM_017017551.1 [Q9P2W7-2]
UniGeneⁱ	Hs.381050

Genome annotation databases

Ensemblⁱ	ENST00000312527; ENSP00000307875; ENSG00000109956 [Q9P2W7-1] ENST00000392580; ENSP00000376359; ENSG00000109956 [Q9P2W7-1] ENST00000524765; ENSP00000433847; ENSG00000109956 [Q9P2W7-1]
GeneIDⁱ	27087
KEGGⁱ	hsa:27087
UCSC genome browser More...UCSCⁱ	uc001qhq.4 human [Q9P2W7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W7	Isoform 2 of Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1		RAT		347	UniRef90_O35789-2
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1		CANLF		335
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1		MOUSE		334
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase		DELLE		347
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase		Yangtze finless porpoise		347
+113

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W7	Isoform 2 of Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1		RAT		347	UniRef50_O35789-2
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1		CANLF		335
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1		MOUSE		334
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1		PANTR		332
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase		CHLSB		347
+344

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB029396 mRNA Translation: BAA96077.1 AK299637 mRNA Translation: BAH13084.1 CR457098 mRNA Translation: CAG33379.1 BC010466 mRNA Translation: AAH10466.1
CCDSⁱ	CCDS8500.1 [Q9P2W7-1]
RefSeqⁱ	NP_061114.2, NM_018644.3 [Q9P2W7-1] NP_473366.1, NM_054025.2 [Q9P2W7-1] XP_005271563.1, XM_005271506.3 [Q9P2W7-2] XP_011541053.1, XM_011542751.2 [Q9P2W7-2] XP_011541055.1, XM_011542753.2 [Q9P2W7-2] XP_016873039.1, XM_017017550.1 [Q9P2W7-1] XP_016873040.1, XM_017017551.1 [Q9P2W7-2]
UniGeneⁱ	Hs.381050

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1V82	X-ray	1.85	A/B	83-334	[»]
	1V83	X-ray	1.90	A/B	83-334	[»]
	1V84	X-ray	1.82	A/B	83-334	[»]
ProteinModelPortalⁱ	Q9P2W7
SMRⁱ	Q9P2W7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117990, 2 interactors
IntActⁱ	Q9P2W7, 3 interactors
STRINGⁱ	9606.ENSP00000307875

Chemistry databases

DrugBankⁱ	DB01694 D-tartaric acid DB09459 Tartaric acid DB03435 Uridine-5'-Diphosphate

DrugBankⁱ

DB01694 D-tartaric acid
DB09459 Tartaric acid
DB03435 Uridine-5'-Diphosphate

Protein family/group databases

CAZyⁱ	GT43 Glycosyltransferase Family 43

CAZyⁱ

GT43 Glycosyltransferase Family 43

PTM databases

GlyConnectⁱ	1254
iPTMnetⁱ	Q9P2W7
PhosphoSitePlusⁱ	Q9P2W7

Polymorphism and mutation databases

BioMutaⁱ	B3GAT1
DMDMⁱ	205830910

Proteomic databases

PaxDbⁱ	Q9P2W7
PeptideAtlasⁱ	Q9P2W7
PRIDEⁱ	Q9P2W7
ProteomicsDBⁱ	83905

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	27087
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000312527; ENSP00000307875; ENSG00000109956 [Q9P2W7-1] ENST00000392580; ENSP00000376359; ENSG00000109956 [Q9P2W7-1] ENST00000524765; ENSP00000433847; ENSG00000109956 [Q9P2W7-1]
GeneIDⁱ	27087
KEGGⁱ	hsa:27087
UCSCⁱ	uc001qhq.4 human [Q9P2W7-1]

Organism-specific databases

CTDⁱ	27087
DisGeNETⁱ	27087
EuPathDBⁱ	HostDB:ENSG00000109956.12
GeneCardsⁱ	B3GAT1
H-InvDBⁱ	HIX0010301
HGNCⁱ	HGNC:921 B3GAT1
HPAⁱ	CAB002500 CAB010893 HPA069468
MIMⁱ	151290 gene
neXtProtⁱ	NX_Q9P2W7
OpenTargetsⁱ	ENSG00000109956
PharmGKBⁱ	PA25215
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1476 Eukaryota ENOG410XP79 LUCA
GeneTreeⁱ	ENSGT00390000017640
HOGENOMⁱ	HOG000261693
HOVERGENⁱ	HBG050650
InParanoidⁱ	Q9P2W7
KOⁱ	K00735
OMAⁱ	WHQSTLA
OrthoDBⁱ	EOG091G0G8P
PhylomeDBⁱ	Q9P2W7
TreeFamⁱ	TF313522

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
BioCycⁱ	MetaCyc:HS03272-MONOMER
BRENDAⁱ	2.4.1.135 2681
Reactomeⁱ	R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis

Miscellaneous databases

ChiTaRSⁱ	B3GAT1 human
EvolutionaryTraceⁱ	Q9P2W7
GeneWikiⁱ	B3GAT1
GenomeRNAiⁱ	27087
Protein Ontology More...PROⁱ	PR:Q9P2W7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000109956 Expressed in 123 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_B3GAT1
Genevisibleⁱ	Q9P2W7 HS

Family and domain databases

CDDⁱ	cd00218 GlcAT-I, 1 hit
Gene3Dⁱ	3.90.550.10, 1 hit
InterProⁱ	View protein in InterPro IPR005027 Glyco_trans_43 IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR10896 PTHR10896, 1 hit
Pfamⁱ	View protein in Pfam PF03360 Glyco_transf_43, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B3GA1_HUMAN
Accessionⁱ	Q9P2W7Primary (citable) accession number: Q9P2W7 Secondary accession number(s): B7Z5Z8, Q96FS7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
	Last sequence update:	July 22, 2008
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9P2W7 (B3GA1_HUMAN)

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Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Golgi apparatus

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

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Functionⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ