GNG13

Functionⁱ

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functionⁱ

G-protein beta-subunit binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12606627
GTPase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
sensory perception of taste Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transducer

Molecular function

Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163359 Glucagon signaling in metabolic regulation R-HSA-202040 G-protein activation R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-392170 ADP signalling through P2Y purinoceptor 12 R-HSA-392451 G beta:gamma signalling through PI3Kgamma R-HSA-392851 Prostacyclin signalling through prostacyclin receptor R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-4086398 Ca2+ pathway R-HSA-416476 G alpha (q) signalling events R-HSA-416482 G alpha (12/13) signalling events R-HSA-418217 G beta:gamma signalling through PLC beta R-HSA-418555 G alpha (s) signalling events R-HSA-418592 ADP signalling through P2Y purinoceptor 1 R-HSA-418594 G alpha (i) signalling events R-HSA-418597 G alpha (z) signalling events R-HSA-420092 Glucagon-type ligand receptors R-HSA-428930 Thromboxane signalling through TP receptor R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-500657 Presynaptic function of Kainate receptors R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SignaLinkⁱ	Q9P2W3

Reactomeⁱ

R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

SignaLinkⁱ

Q9P2W3

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Gene namesⁱ	Name:GNG13
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000127588.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14131 GNG13
MIMⁱ	607298 gene
neXtProtⁱ	NX_Q9P2W3

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000127588
PharmGKBⁱ	PA28783

Polymorphism and mutation databases

BioMutaⁱ	GNG13
DMDMⁱ	20138402

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000012671	1 – 64	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13Add BLAST		64
PropeptideⁱPRO_0000012672	65 – 67	Removed in mature formBy similarity		3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	64	Cysteine methyl esterBy similarity		1
Lipidationⁱ	64	S-farnesyl cysteineBy similarity		1

Keywords - PTMⁱ

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbⁱ	Q9P2W3
PeptideAtlas More...PeptideAtlasⁱ	Q9P2W3
PRIDEⁱ	Q9P2W3
ProteomicsDBⁱ	83903

PTM databases

iPTMnetⁱ	Q9P2W3
PhosphoSitePlusⁱ	Q9P2W3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000127588 Expressed in 49 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_GNG13
Genevisibleⁱ	Q9P2W3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046272

HPAⁱ

HPA046272

Interactionⁱ

Subunit structureⁱ

G proteins are composed of 3 units, alpha, beta and gamma.

GO - Molecular functionⁱ

G-protein beta-subunit binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12606627

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119721, 5 interactors
IntActⁱ	Q9P2W3, 30 interactors
STRINGⁱ	9606.ENSP00000248150

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P2W3
SMRⁱ	Q9P2W3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4119 Eukaryota ENOG41122JF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064157
HOGENOMⁱ	HOG000231034
HOVERGENⁱ	HBG098057
InParanoidⁱ	Q9P2W3
KEGG Orthology (KO) More...KOⁱ	K04547
OMAⁱ	GQQENDP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G17J0
PhylomeDBⁱ	Q9P2W3
TreeFamⁱ	TF319909

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00068 GGL, 1 hit
Gene3Dⁱ	4.10.260.10, 1 hit
InterProⁱ	View protein in InterPro IPR015898 G-protein_gamma-like_dom IPR036284 GGL_sf IPR039227 GNG13 IPR001770 Gprotein-gamma
PANTHERⁱ	PTHR15936 PTHR15936, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00631 G-gamma, 1 hit
PRINTSⁱ	PR00321 GPROTEING
SMARTⁱ	View protein in SMART SM00224 GGL, 1 hit
SUPFAMⁱ	SSF48670 SSF48670, 1 hit
PROSITEⁱ	View protein in PROSITE PS50058 G_PROTEIN_GAMMA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9P2W3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEEWDVPQMK KEVESLKYQL AFQREMASKT IPELLKWIED GIPKDPFLNP 
        60 
DLMKNNPWVE KGKCTIL

Length:67

Mass (Da):7,949

Last modified:October 1, 2000 - v1

Checksum:ⁱ080E0C34A8F70327

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY029486 mRNA Translation: AAK40269.1 AB030207 mRNA Translation: BAA92768.1 AF493880 mRNA Translation: AAM12594.1 AK312139 mRNA Translation: BAG35075.1 AE006465 Genomic DNA Translation: AAK61257.1 AL031033 Genomic DNA No translation available. BC093760 mRNA Translation: AAH93760.1 BC095525 mRNA Translation: AAH95525.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10427.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057625.1, NM_016541.2
UniGeneⁱ	Hs.247888

Genome annotation databases

Ensemblⁱ	ENST00000248150; ENSP00000248150; ENSG00000127588
GeneIDⁱ	51764
KEGGⁱ	hsa:51764
UCSC genome browser More...UCSCⁱ	uc002ckh.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W3	Guanine nucleotide-binding protein subunit gamma		MACMU		67	UniRef100_Q9P2W3
Guanine nucleotide-binding protein subunit gamma		PANTR		67
Guanine nucleotide-binding protein subunit gamma		CERAT		67
Guanine nucleotide-binding protein subunit gamma		PANPA		67
Guanine nucleotide-binding protein subunit gamma		MANLE		67
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W3	Guanine nucleotide-binding protein subunit gamma		MACMU		67	UniRef90_Q9P2W3
Guanine nucleotide-binding protein subunit gamma		PANTR		67
Guanine nucleotide-binding protein subunit gamma		CERAT		67
Guanine nucleotide-binding protein subunit gamma		PANPA		67
Guanine nucleotide-binding protein subunit gamma		MANLE		67
+40

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W3	Guanine nucleotide-binding protein subunit gamma		MACMU		67	UniRef50_Q9P2W3
Guanine nucleotide-binding protein subunit gamma		PANTR		67
Guanine nucleotide-binding protein subunit gamma		CERAT		67
Guanine nucleotide-binding protein subunit gamma		PANPA		67
Guanine nucleotide-binding protein subunit gamma		MANLE		67
+148

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY029486 mRNA Translation: AAK40269.1 AB030207 mRNA Translation: BAA92768.1 AF493880 mRNA Translation: AAM12594.1 AK312139 mRNA Translation: BAG35075.1 AE006465 Genomic DNA Translation: AAK61257.1 AL031033 Genomic DNA No translation available. BC093760 mRNA Translation: AAH93760.1 BC095525 mRNA Translation: AAH95525.1
CCDSⁱ	CCDS10427.1
RefSeqⁱ	NP_057625.1, NM_016541.2
UniGeneⁱ	Hs.247888

3D structure databases

ProteinModelPortalⁱ	Q9P2W3
SMRⁱ	Q9P2W3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119721, 5 interactors
IntActⁱ	Q9P2W3, 30 interactors
STRINGⁱ	9606.ENSP00000248150

PTM databases

iPTMnetⁱ	Q9P2W3
PhosphoSitePlusⁱ	Q9P2W3

Polymorphism and mutation databases

BioMutaⁱ	GNG13
DMDMⁱ	20138402

Proteomic databases

PaxDbⁱ	Q9P2W3
PeptideAtlasⁱ	Q9P2W3
PRIDEⁱ	Q9P2W3
ProteomicsDBⁱ	83903

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000248150; ENSP00000248150; ENSG00000127588
GeneIDⁱ	51764
KEGGⁱ	hsa:51764
UCSCⁱ	uc002ckh.4 human

Organism-specific databases

CTDⁱ	51764
EuPathDBⁱ	HostDB:ENSG00000127588.4
GeneCardsⁱ	GNG13
HGNCⁱ	HGNC:14131 GNG13
HPAⁱ	HPA046272
MIMⁱ	607298 gene
neXtProtⁱ	NX_Q9P2W3
OpenTargetsⁱ	ENSG00000127588
PharmGKBⁱ	PA28783
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4119 Eukaryota ENOG41122JF LUCA
GeneTreeⁱ	ENSGT00530000064157
HOGENOMⁱ	HOG000231034
HOVERGENⁱ	HBG098057
InParanoidⁱ	Q9P2W3
KOⁱ	K04547
OMAⁱ	GQQENDP
OrthoDBⁱ	EOG091G17J0
PhylomeDBⁱ	Q9P2W3
TreeFamⁱ	TF319909

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163359 Glucagon signaling in metabolic regulation R-HSA-202040 G-protein activation R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-392170 ADP signalling through P2Y purinoceptor 12 R-HSA-392451 G beta:gamma signalling through PI3Kgamma R-HSA-392851 Prostacyclin signalling through prostacyclin receptor R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-4086398 Ca2+ pathway R-HSA-416476 G alpha (q) signalling events R-HSA-416482 G alpha (12/13) signalling events R-HSA-418217 G beta:gamma signalling through PLC beta R-HSA-418555 G alpha (s) signalling events R-HSA-418592 ADP signalling through P2Y purinoceptor 1 R-HSA-418594 G alpha (i) signalling events R-HSA-418597 G alpha (z) signalling events R-HSA-420092 Glucagon-type ligand receptors R-HSA-428930 Thromboxane signalling through TP receptor R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-500657 Presynaptic function of Kainate receptors R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SignaLinkⁱ	Q9P2W3

Reactomeⁱ

R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

SignaLinkⁱ

Q9P2W3

Miscellaneous databases

GeneWikiⁱ	GNG13
GenomeRNAiⁱ	51764
Protein Ontology More...PROⁱ	PR:Q9P2W3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000127588 Expressed in 49 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_GNG13
Genevisibleⁱ	Q9P2W3 HS

Family and domain databases

CDDⁱ	cd00068 GGL, 1 hit
Gene3Dⁱ	4.10.260.10, 1 hit
InterProⁱ	View protein in InterPro IPR015898 G-protein_gamma-like_dom IPR036284 GGL_sf IPR039227 GNG13 IPR001770 Gprotein-gamma
PANTHERⁱ	PTHR15936 PTHR15936, 1 hit
Pfamⁱ	View protein in Pfam PF00631 G-gamma, 1 hit
PRINTSⁱ	PR00321 GPROTEING
SMARTⁱ	View protein in SMART SM00224 GGL, 1 hit
SUPFAMⁱ	SSF48670 SSF48670, 1 hit
PROSITEⁱ	View protein in PROSITE PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GBG13_HUMAN
Accessionⁱ	Q9P2W3Primary (citable) accession number: Q9P2W3 Secondary accession number(s): B2R5C8, Q52LX0, Q9UJJ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9P2W3 (GBG13_HUMAN)

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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ