UniProtKB - Q9P2W3 (GBG13_HUMAN)
Protein
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Gene
GNG13
Organism
Homo sapiens (Human)
Status
Functioni
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
GO - Molecular functioni
- G-protein beta-subunit binding Source: UniProtKB
GO - Biological processi
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- sensory perception of taste Source: Ensembl
Keywordsi
Molecular function | Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q9P2W3 |
Reactomei | R-HSA-1296041, Activation of G protein gated Potassium channels R-HSA-163359, Glucagon signaling in metabolic regulation R-HSA-202040, G-protein activation R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381771, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-392170, ADP signalling through P2Y purinoceptor 12 R-HSA-392451, G beta:gamma signalling through PI3Kgamma R-HSA-392851, Prostacyclin signalling through prostacyclin receptor R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-416482, G alpha (12/13) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-418555, G alpha (s) signalling events R-HSA-418592, ADP signalling through P2Y purinoceptor 1 R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-428930, Thromboxane signalling through TP receptor R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs) R-HSA-500657, Presynaptic function of Kainate receptors R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-8964315, G beta:gamma signalling through BTK R-HSA-8964616, G beta:gamma signalling through CDC42 R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
SignaLinki | Q9P2W3 |
Names & Taxonomyi
Protein namesi | Recommended name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 |
Gene namesi | Name:GNG13 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14131, GNG13 |
MIMi | 607298, gene |
neXtProti | NX_Q9P2W3 |
VEuPathDBi | HostDB:ENSG00000127588.4 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Plasma Membrane
- heterotrimeric G-protein complex Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- dendrite Source: Ensembl
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51764 |
OpenTargetsi | ENSG00000127588 |
PharmGKBi | PA28783 |
Miscellaneous databases
Pharosi | Q9P2W3, Tbio |
Genetic variation databases
BioMutai | GNG13 |
DMDMi | 20138402 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000012671 | 1 – 64 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13Add BLAST | 64 | |
PropeptideiPRO_0000012672 | 65 – 67 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 64 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 64 | S-farnesyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Methylation, PrenylationProteomic databases
MassIVEi | Q9P2W3 |
PaxDbi | Q9P2W3 |
PeptideAtlasi | Q9P2W3 |
PRIDEi | Q9P2W3 |
ProteomicsDBi | 83903 |
PTM databases
iPTMneti | Q9P2W3 |
PhosphoSitePlusi | Q9P2W3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127588, Expressed in right hemisphere of cerebellum and 67 other tissues |
Genevisiblei | Q9P2W3, HS |
Organism-specific databases
HPAi | ENSG00000127588, Group enriched (brain, retina) |
Interactioni
Subunit structurei
G proteins are composed of 3 units, alpha, beta and gamma.
Binary interactionsi
Hide detailsQ9P2W3
GO - Molecular functioni
- G-protein beta-subunit binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119721, 35 interactors |
CORUMi | Q9P2W3 |
IntActi | Q9P2W3, 29 interactors |
STRINGi | 9606.ENSP00000248150 |
Miscellaneous databases
RNActi | Q9P2W3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G protein gamma family.Curated
Phylogenomic databases
eggNOGi | KOG4119, Eukaryota |
GeneTreei | ENSGT00530000064157 |
HOGENOMi | CLU_168377_1_1_1 |
InParanoidi | Q9P2W3 |
OMAi | GQQENDP |
OrthoDBi | 1597581at2759 |
PhylomeDBi | Q9P2W3 |
TreeFami | TF319909 |
Family and domain databases
CDDi | cd00068, GGL, 1 hit |
Gene3Di | 4.10.260.10, 1 hit |
InterProi | View protein in InterPro IPR015898, G-protein_gamma-like_dom IPR036284, GGL_sf IPR039227, GNG13 IPR001770, Gprotein-gamma |
PANTHERi | PTHR15936, PTHR15936, 1 hit |
Pfami | View protein in Pfam PF00631, G-gamma, 1 hit |
PRINTSi | PR00321, GPROTEING |
SMARTi | View protein in SMART SM00224, GGL, 1 hit |
SUPFAMi | SSF48670, SSF48670, 1 hit |
PROSITEi | View protein in PROSITE PS50058, G_PROTEIN_GAMMA, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9P2W3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEWDVPQMK KEVESLKYQL AFQREMASKT IPELLKWIED GIPKDPFLNP
60
DLMKNNPWVE KGKCTIL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY029486 mRNA Translation: AAK40269.1 AB030207 mRNA Translation: BAA92768.1 AF493880 mRNA Translation: AAM12594.1 AK312139 mRNA Translation: BAG35075.1 AE006465 Genomic DNA Translation: AAK61257.1 AL031033 Genomic DNA No translation available. BC093760 mRNA Translation: AAH93760.1 BC095525 mRNA Translation: AAH95525.1 |
CCDSi | CCDS10427.1 |
RefSeqi | NP_057625.1, NM_016541.2 |
Genome annotation databases
Ensembli | ENST00000248150; ENSP00000248150; ENSG00000127588 |
GeneIDi | 51764 |
KEGGi | hsa:51764 |
UCSCi | uc002ckh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY029486 mRNA Translation: AAK40269.1 AB030207 mRNA Translation: BAA92768.1 AF493880 mRNA Translation: AAM12594.1 AK312139 mRNA Translation: BAG35075.1 AE006465 Genomic DNA Translation: AAK61257.1 AL031033 Genomic DNA No translation available. BC093760 mRNA Translation: AAH93760.1 BC095525 mRNA Translation: AAH95525.1 |
CCDSi | CCDS10427.1 |
RefSeqi | NP_057625.1, NM_016541.2 |
3D structure databases
SMRi | Q9P2W3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119721, 35 interactors |
CORUMi | Q9P2W3 |
IntActi | Q9P2W3, 29 interactors |
STRINGi | 9606.ENSP00000248150 |
PTM databases
iPTMneti | Q9P2W3 |
PhosphoSitePlusi | Q9P2W3 |
Genetic variation databases
BioMutai | GNG13 |
DMDMi | 20138402 |
Proteomic databases
MassIVEi | Q9P2W3 |
PaxDbi | Q9P2W3 |
PeptideAtlasi | Q9P2W3 |
PRIDEi | Q9P2W3 |
ProteomicsDBi | 83903 |
Protocols and materials databases
Antibodypediai | 52208, 52 antibodies |
Genome annotation databases
Ensembli | ENST00000248150; ENSP00000248150; ENSG00000127588 |
GeneIDi | 51764 |
KEGGi | hsa:51764 |
UCSCi | uc002ckh.4, human |
Organism-specific databases
CTDi | 51764 |
DisGeNETi | 51764 |
GeneCardsi | GNG13 |
HGNCi | HGNC:14131, GNG13 |
HPAi | ENSG00000127588, Group enriched (brain, retina) |
MIMi | 607298, gene |
neXtProti | NX_Q9P2W3 |
OpenTargetsi | ENSG00000127588 |
PharmGKBi | PA28783 |
VEuPathDBi | HostDB:ENSG00000127588.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4119, Eukaryota |
GeneTreei | ENSGT00530000064157 |
HOGENOMi | CLU_168377_1_1_1 |
InParanoidi | Q9P2W3 |
OMAi | GQQENDP |
OrthoDBi | 1597581at2759 |
PhylomeDBi | Q9P2W3 |
TreeFami | TF319909 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2W3 |
Reactomei | R-HSA-1296041, Activation of G protein gated Potassium channels R-HSA-163359, Glucagon signaling in metabolic regulation R-HSA-202040, G-protein activation R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381771, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-392170, ADP signalling through P2Y purinoceptor 12 R-HSA-392451, G beta:gamma signalling through PI3Kgamma R-HSA-392851, Prostacyclin signalling through prostacyclin receptor R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-416482, G alpha (12/13) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-418555, G alpha (s) signalling events R-HSA-418592, ADP signalling through P2Y purinoceptor 1 R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-428930, Thromboxane signalling through TP receptor R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs) R-HSA-500657, Presynaptic function of Kainate receptors R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-8964315, G beta:gamma signalling through BTK R-HSA-8964616, G beta:gamma signalling through CDC42 R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
SignaLinki | Q9P2W3 |
Miscellaneous databases
BioGRID-ORCSi | 51764, 21 hits in 863 CRISPR screens |
GeneWikii | GNG13 |
GenomeRNAii | 51764 |
Pharosi | Q9P2W3, Tbio |
PROi | PR:Q9P2W3 |
RNActi | Q9P2W3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127588, Expressed in right hemisphere of cerebellum and 67 other tissues |
Genevisiblei | Q9P2W3, HS |
Family and domain databases
CDDi | cd00068, GGL, 1 hit |
Gene3Di | 4.10.260.10, 1 hit |
InterProi | View protein in InterPro IPR015898, G-protein_gamma-like_dom IPR036284, GGL_sf IPR039227, GNG13 IPR001770, Gprotein-gamma |
PANTHERi | PTHR15936, PTHR15936, 1 hit |
Pfami | View protein in Pfam PF00631, G-gamma, 1 hit |
PRINTSi | PR00321, GPROTEING |
SMARTi | View protein in SMART SM00224, GGL, 1 hit |
SUPFAMi | SSF48670, SSF48670, 1 hit |
PROSITEi | View protein in PROSITE PS50058, G_PROTEIN_GAMMA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GBG13_HUMAN | |
Accessioni | Q9P2W3Primary (citable) accession number: Q9P2W3 Secondary accession number(s): B2R5C8, Q52LX0, Q9UJJ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families