PSMC3IP

Functionⁱ

Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.3 Publications

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
nuclear receptor transcription coactivator activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21963259

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

reciprocal meiotic recombination Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	DNA recombination, Meiosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-912446 Meiotic recombination

Reactomeⁱ

R-HSA-912446 Meiotic recombination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homologous-pairing protein 2 homolog Alternative name(s): Nuclear receptor coactivator GT198 PSMC3-interacting protein Proteasome 26S ATPase subunit 3-interacting protein Tat-binding protein 1-interacting protein Short name: TBP-1-interacting protein
Gene namesⁱ	Name:PSMC3IP Synonyms:HOP2, TBPIP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131470.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17928 PSMC3IP
MIMⁱ	608665 gene
neXtProtⁱ	NX_Q9P2W1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ovarian dysgenesis 3 (ODG3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_066636	201	Missing in ODG3; impairs function as estrogen receptor coactivator. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	29893
MalaCards human disease database More...MalaCardsⁱ	PSMC3IP
MIMⁱ	614324 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000131470
Orphanetⁱ	243 46,XX gonadal dysgenesis
PharmGKBⁱ	PA143485584

Polymorphism and mutation databases

BioMutaⁱ	PSMC3IP
DMDMⁱ	74719969

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000314135	1 – 217	Homologous-pairing protein 2 homologAdd BLAST		217

Post-translational modificationⁱ

PTM: Phosphorylated by PKA, PKC and MAPK.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9P2W1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P2W1
PaxDbⁱ	Q9P2W1
PeptideAtlas More...PeptideAtlasⁱ	Q9P2W1
PRIDEⁱ	Q9P2W1
ProteomicsDBⁱ	83901 83902 [Q9P2W1-2]

PTM databases

iPTMnetⁱ	Q9P2W1
PhosphoSitePlusⁱ	Q9P2W1

Expressionⁱ

Tissue specificityⁱ

Inductionⁱ

Overexpressed in leiomyomas compared to myometrium.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000131470 Expressed in 217 organ(s), highest expression level in vagina
CleanExⁱ	HS_PSMC3IP
ExpressionAtlasⁱ	Q9P2W1 baseline and differential
Genevisibleⁱ	Q9P2W1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044439

HPAⁱ

HPA044439

Interactionⁱ

Subunit structureⁱ

Interacts with the DNA-binding domain of the nuclear receptors NR3C1/GR, ESR2/ER-beta, THRB and RXRA (By similarity). Forms a stable heterodimer with MND1. Interacts with PSMC3/TBP1.By similarity2 Publications

Protein-protein interaction databases

BioGridⁱ	118945, 20 interactors
CORUMⁱ	Q9P2W1
IntActⁱ	Q9P2W1, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q9P2W1
STRINGⁱ	9606.ENSP00000377384

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P2W1
SMRⁱ	Q9P2W1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	118 – 182	DNA bindingBy similarityAdd BLAST		65

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	93 – 153	Sequence analysisAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the HOP2 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG4603 Eukaryota ENOG410XT3U LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006890
HOGENOMⁱ	HOG000005789
HOVERGENⁱ	HBG105257
InParanoidⁱ	Q9P2W1
KEGG Orthology (KO) More...KOⁱ	K06695
OMAⁱ	YRERQKY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XHF
PhylomeDBⁱ	Q9P2W1
TreeFamⁱ	TF328666

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR010776 Hop2 IPR036388 WH-like_DNA-bd_sf
PANTHERⁱ	PTHR15938 PTHR15938, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07106 TBPIP, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9P2W1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKGRAEAAA GAAGILLRYL QEQNRPYSSQ DVFGNLQREH GLGKAVVVKT 
        60         70         80         90        100
LEQLAQQGKI KEKMYGKQKI YFADQDQFDM VSDADLQVLD GKIVALTAKV 
       110        120        130        140        150
QSLQQSCRYM EAELKELSSA LTTPEMQKEI QELKKECAGY RERLKNIKAA 
       160        170        180        190        200
TNHVTPEEKE QVYRERQKYC KEWRKRKRMA TELSDAILEG YPKSKKQFFE 
       210 
EVGIETDEDY NVTLPDP

Length:217

Mass (Da):24,906

Last modified:October 1, 2000 - v1

Checksum:ⁱ892B7D20CAA0A121

GO

Isoform 2 (identifier: Q9P2W1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
113-124: Missing.

« Hide

        10         20         30         40         50
MSKGRAEAAA GAAGILLRYL QEQNRPYSSQ DVFGNLQREH GLGKAVVVKT 
        60         70         80         90        100
LEQLAQQGKI KEKMYGKQKI YFADQDQFDM VSDADLQVLD GKIVALTAKV 
       110        120        130        140        150
QSLQQSCRYM EAEMQKEIQE LKKECAGYRE RLKNIKAATN HVTPEEKEQV 
       160        170        180        190        200
YRERQKYCKE WRKRKRMATE LSDAILEGYP KSKKQFFEEV GIETDEDYNV 

TLPDP

Show »

Length:205

Mass (Da):23,636

Checksum:ⁱ19AD8471B6931FC1

GO

Isoform 3 (identifier: Q9P2W1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-125: Missing.

« Hide

        10         20         30         40         50
MQKEIQELKK ECAGYRERLK NIKAATNHVT PEEKEQVYRE RQKYCKEWRK 
        60         70         80         90 
RKRMATELSD AILEGYPKSK KQFFEEVGIE TDEDYNVTLP DP

Show »

Length:92

Mass (Da):11,070

Checksum:ⁱABBF9881ED662F38

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7ERB6	K7ERB6_HUMAN	Homologous-pairing protein 2 homolo... Homologous-pairing protein 2 homolog (PSMC3 interacting protein, isoform CRA_b)	PSMC3IP hCG_16948	154	Annotation score:
K7EK12	K7EK12_HUMAN	Homologous-pairing protein 2 homolo... Homologous-pairing protein 2 homolog	PSMC3IP	85	Annotation score:
K7EQS1	K7EQS1_HUMAN	Homologous-pairing protein 2 homolo... Homologous-pairing protein 2 homolog	PSMC3IP	116	Annotation score:
K7ELD8	K7ELD8_HUMAN	Homologous-pairing protein 2 homolo... Homologous-pairing protein 2 homolog	PSMC3IP	84	Annotation score:

Sequence cautionⁱ

The sequence AAC41915 differs from that shown. Reason: Frameshift at positions 174 and 184.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	8	Missing in AAC41915 (PubMed:7490091).Curated	1
Sequence conflictⁱ	106	S → T in AAC41915 (PubMed:7490091).Curated	1
Sequence conflictⁱ	106	S → T in AAL33609 (PubMed:11739747).Curated	1
Sequence conflictⁱ	184	S → L in AAL33609 (PubMed:11739747).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_037841	163	Y → N. Corresponds to variant dbSNP:rs2292754EnsemblClinVar.		1
Natural variantⁱVAR_066636	201	Missing in ODG3; impairs function as estrogen receptor coactivator. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047716	1 – 125	Missing in isoform 3. 1 PublicationAdd BLAST		125
Alternative sequenceⁱVSP_030213	113 – 124	Missing in isoform 2. 1 PublicationAdd BLAST		12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L38933 mRNA Translation: AAC41915.1 Frameshift. AB030304 mRNA Translation: BAA92872.1 AF440240 mRNA Translation: AAL33609.1 FJ952180 mRNA Translation: ACR46655.1 FJ952181 mRNA Translation: ACR46656.1 FJ952182 mRNA Translation: ACR46657.1 FJ952183 mRNA Translation: ACR46658.1 GQ851964 mRNA Translation: ACX30903.1 GQ851965 mRNA Translation: ACX30904.1 AC067852 Genomic DNA No translation available. BC008792 mRNA Translation: AAH08792.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11431.1 [Q9P2W1-2] CCDS45688.1 [Q9P2W1-1]
PIRⁱ	I68521
NCBI Reference Sequences More...RefSeqⁱ	NP_001242943.1, NM_001256014.1 NP_001242944.1, NM_001256015.1 NP_001242945.1, NM_001256016.1 NP_037422.2, NM_013290.6 [Q9P2W1-2] NP_057640.1, NM_016556.3 [Q9P2W1-1]
UniGeneⁱ	Hs.383019

Genome annotation databases

Ensemblⁱ	ENST00000253789; ENSP00000253789; ENSG00000131470 [Q9P2W1-2] ENST00000393795; ENSP00000377384; ENSG00000131470 [Q9P2W1-1] ENST00000590760; ENSP00000466381; ENSG00000131470 [Q9P2W1-3]
GeneIDⁱ	29893
KEGGⁱ	hsa:29893
UCSC genome browser More...UCSCⁱ	uc002iai.4 human [Q9P2W1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W1	PSMC3 interacting protein, isoform CRA_a		HUMAN		266	UniRef100_Q9P2W1
Homologous-pairing protein 2 homolog		HUMAN		154
GT198		HUMAN		217
UPI0001EE3FE6		HUMAN		138
Q9P2W1-2	PSMC3 interacting protein, isoform CRA_c		HUMAN		254	UniRef100_A0A024R1W9
Q9P2W1-3	PSMC3IP isoform 6		PONAB		154	UniRef100_A0A2J8REZ7
PSMC3IP isoform 7		PANTR		92
Uncharacterized protein		RHIBE		217
UPI000273DED3		COLAP		138
PSMC3IP isoform 7		PONAB		92
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W1	PSMC3 interacting protein, isoform CRA_a		HUMAN		266	UniRef90_Q9P2W1
Uncharacterized protein		PONAB		254
PSMC3 interacting protein		CALJA		217
Uncharacterized protein		Cebus capucinus imitator		217
PSMC3 interacting protein		PANTR		217
+16
Q9P2W1-3	PSMC3 interacting protein		CHLSB		217	UniRef90_A0A0D9S1R5
Uncharacterized protein		MACMU		154
Uncharacterized protein		RHIRO		217
PSMC3IP isoform 6		PONAB		154
PSMC3IP isoform 7		PANTR		92
+13

Protein	Similar proteins		Species	Score	Length	Source
Q9P2W1	Homologous-pairing protein 2 homolog		RAT		217	UniRef50_Q91ZY6
Homologous-pairing protein 2 homolog	)	MOUSE		217
PSMC3 interacting protein		AILME		218
homologous-pairing protein 2 homolog isoform X2		MESAU		217
Homologous-pairing protein 2-like		CRIGR		217
+132

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L38933 mRNA Translation: AAC41915.1 Frameshift. AB030304 mRNA Translation: BAA92872.1 AF440240 mRNA Translation: AAL33609.1 FJ952180 mRNA Translation: ACR46655.1 FJ952181 mRNA Translation: ACR46656.1 FJ952182 mRNA Translation: ACR46657.1 FJ952183 mRNA Translation: ACR46658.1 GQ851964 mRNA Translation: ACX30903.1 GQ851965 mRNA Translation: ACX30904.1 AC067852 Genomic DNA No translation available. BC008792 mRNA Translation: AAH08792.1
CCDSⁱ	CCDS11431.1 [Q9P2W1-2] CCDS45688.1 [Q9P2W1-1]
PIRⁱ	I68521
RefSeqⁱ	NP_001242943.1, NM_001256014.1 NP_001242944.1, NM_001256015.1 NP_001242945.1, NM_001256016.1 NP_037422.2, NM_013290.6 [Q9P2W1-2] NP_057640.1, NM_016556.3 [Q9P2W1-1]
UniGeneⁱ	Hs.383019

3D structure databases

ProteinModelPortalⁱ	Q9P2W1
SMRⁱ	Q9P2W1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118945, 20 interactors
CORUMⁱ	Q9P2W1
IntActⁱ	Q9P2W1, 15 interactors
MINTⁱ	Q9P2W1
STRINGⁱ	9606.ENSP00000377384

PTM databases

iPTMnetⁱ	Q9P2W1
PhosphoSitePlusⁱ	Q9P2W1

Polymorphism and mutation databases

BioMutaⁱ	PSMC3IP
DMDMⁱ	74719969

Proteomic databases

EPDⁱ	Q9P2W1
MaxQBⁱ	Q9P2W1
PaxDbⁱ	Q9P2W1
PeptideAtlasⁱ	Q9P2W1
PRIDEⁱ	Q9P2W1
ProteomicsDBⁱ	83901 83902 [Q9P2W1-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000253789; ENSP00000253789; ENSG00000131470 [Q9P2W1-2] ENST00000393795; ENSP00000377384; ENSG00000131470 [Q9P2W1-1] ENST00000590760; ENSP00000466381; ENSG00000131470 [Q9P2W1-3]
GeneIDⁱ	29893
KEGGⁱ	hsa:29893
UCSCⁱ	uc002iai.4 human [Q9P2W1-1]

Organism-specific databases

CTDⁱ	29893
DisGeNETⁱ	29893
EuPathDBⁱ	HostDB:ENSG00000131470.14
GeneCardsⁱ	PSMC3IP
HGNCⁱ	HGNC:17928 PSMC3IP
HPAⁱ	HPA044439
MalaCardsⁱ	PSMC3IP
MIMⁱ	608665 gene 614324 phenotype
neXtProtⁱ	NX_Q9P2W1
OpenTargetsⁱ	ENSG00000131470
Orphanetⁱ	243 46,XX gonadal dysgenesis
PharmGKBⁱ	PA143485584
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4603 Eukaryota ENOG410XT3U LUCA
GeneTreeⁱ	ENSGT00390000006890
HOGENOMⁱ	HOG000005789
HOVERGENⁱ	HBG105257
InParanoidⁱ	Q9P2W1
KOⁱ	K06695
OMAⁱ	YRERQKY
OrthoDBⁱ	EOG091G0XHF
PhylomeDBⁱ	Q9P2W1
TreeFamⁱ	TF328666

Enzyme and pathway databases

Reactomeⁱ	R-HSA-912446 Meiotic recombination

Reactomeⁱ

R-HSA-912446 Meiotic recombination

Miscellaneous databases

ChiTaRSⁱ	PSMC3IP human
GenomeRNAiⁱ	29893
Protein Ontology More...PROⁱ	PR:Q9P2W1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131470 Expressed in 217 organ(s), highest expression level in vagina
CleanExⁱ	HS_PSMC3IP
ExpressionAtlasⁱ	Q9P2W1 baseline and differential
Genevisibleⁱ	Q9P2W1 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR010776 Hop2 IPR036388 WH-like_DNA-bd_sf
PANTHERⁱ	PTHR15938 PTHR15938, 1 hit
Pfamⁱ	View protein in Pfam PF07106 TBPIP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HOP2_HUMAN
Accessionⁱ	Q9P2W1Primary (citable) accession number: Q9P2W1 Secondary accession number(s): C5ILB7 , Q14458, Q8WXG2, Q96HA2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - Q9P2W1 (HOP2_HUMAN)

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Homologous-pairing protein 2 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ