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UniProtKB - Q9P2W1 (HOP2_HUMAN)

Entry version 137 (25 May 2022)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Homologous-pairing protein 2 homolog

Gene

PSMC3IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA recombination, Meiosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9P2W1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-912446, Meiotic recombination

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9P2W1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homologous-pairing protein 2 homolog
Alternative name(s):
Nuclear receptor coactivator GT198
PSMC3-interacting protein
Proteasome 26S ATPase subunit 3-interacting protein
Tat-binding protein 1-interacting protein
Short name:
TBP-1-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSMC3IP
Synonyms:HOP2, TBPIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17928, PSMC3IP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608665, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P2W1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131470

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ovarian dysgenesis 3 (ODG3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066636201Missing in ODG3; impairs function as estrogen receptor coactivator. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		29893

MalaCards human disease database

More...MalaCardsi		PSMC3IP
MIMi614324, phenotype

Open Targets

More...OpenTargetsi		ENSG00000131470

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		243, 46,XX gonadal dysgenesis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485584

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P2W1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PSMC3IP

Domain mapping of disease mutations (DMDM)

More...DMDMi		74719969

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003141351 – 217Homologous-pairing protein 2 homologAdd BLAST217

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

PTM: Phosphorylated by PKA, PKC and MAPK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9P2W1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9P2W1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P2W1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9P2W1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P2W1

PeptideAtlas

More...PeptideAtlasi		Q9P2W1

PRoteomics IDEntifications database

More...PRIDEi		Q9P2W1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83901 [Q9P2W1-1]
83902 [Q9P2W1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P2W1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P2W1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis and colon.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Overexpressed in leiomyomas compared to myometrium.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131470, Expressed in vagina and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9P2W1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P2W1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131470, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the DNA-binding domain of the nuclear receptors NR3C1/GR, ESR2/ER-beta, THRB and RXRA (By similarity).

Forms a stable heterodimer with MND1.

Interacts with PSMC3/TBP1.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118945, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9P2W1

Protein interaction database and analysis system

More...IntActi		Q9P2W1, 16 interactors

Molecular INTeraction database

More...MINTi		Q9P2W1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377384

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9P2W1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9P2W1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9P2W1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni118 – 182DNA-bindingBy similarityAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili93 – 153Sequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HOP2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4603, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006890

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_181023_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P2W1

Identification of Orthologs from Complete Genome Data

More...OMAi		IETDEDC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P2W1

TreeFam database of animal gene trees

More...TreeFami		TF328666

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040461, Hop2
IPR010776, Hop2_WH_dom
IPR040661, LZ3wCH
IPR036388, WH-like_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR15938, PTHR15938, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18517, LZ3wCH, 1 hit
PF07106, TBPIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2W1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKGRAEAAA GAAGILLRYL QEQNRPYSSQ DVFGNLQREH GLGKAVVVKT 
        60         70         80         90        100
LEQLAQQGKI KEKMYGKQKI YFADQDQFDM VSDADLQVLD GKIVALTAKV 
       110        120        130        140        150
QSLQQSCRYM EAELKELSSA LTTPEMQKEI QELKKECAGY RERLKNIKAA 
       160        170        180        190        200
TNHVTPEEKE QVYRERQKYC KEWRKRKRMA TELSDAILEG YPKSKKQFFE 
       210 
EVGIETDEDY NVTLPDP
Length:217
Mass (Da):24,906
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i892B7D20CAA0A121
GO
Isoform 2 (identifier: Q9P2W1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-124: Missing.

Show »
Length:205
Mass (Da):23,636
Checksum:i19AD8471B6931FC1
GO
Isoform 3 (identifier: Q9P2W1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Show »
Length:92
Mass (Da):11,070
Checksum:iABBF9881ED662F38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERB6K7ERB6_HUMAN
Homologous-pairing protein 2 homolo...
PSMC3IP hCG_16948
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK12K7EK12_HUMAN
Homologous-pairing protein 2 homolo...
PSMC3IP
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQS1K7EQS1_HUMAN
Homologous-pairing protein 2 homolo...
PSMC3IP
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELD8K7ELD8_HUMAN
Homologous-pairing protein 2 homolo...
PSMC3IP
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC41915 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8Missing in AAC41915 (PubMed:7490091).Curated1
Sequence conflicti106S → T in AAC41915 (PubMed:7490091).Curated1
Sequence conflicti106S → T in AAL33609 (PubMed:11739747).Curated1
Sequence conflicti184S → L in AAL33609 (PubMed:11739747).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037841163Y → N. Corresponds to variant dbSNP:rs2292754EnsemblClinVar.1
Natural variantiVAR_066636201Missing in ODG3; impairs function as estrogen receptor coactivator. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0477161 – 125Missing in isoform 3. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_030213113 – 124Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L38933 mRNA Translation: AAC41915.1 Frameshift.
AB030304 mRNA Translation: BAA92872.1
AF440240 mRNA Translation: AAL33609.1
FJ952180 mRNA Translation: ACR46655.1
FJ952181 mRNA Translation: ACR46656.1
FJ952182 mRNA Translation: ACR46657.1
FJ952183 mRNA Translation: ACR46658.1
GQ851964 mRNA Translation: ACX30903.1
GQ851965 mRNA Translation: ACX30904.1
AC067852 Genomic DNA No translation available.
BC008792 mRNA Translation: AAH08792.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11431.1 [Q9P2W1-2]
CCDS45688.1 [Q9P2W1-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I68521

NCBI Reference Sequences

More...RefSeqi		NP_001242943.1, NM_001256014.1
NP_001242944.1, NM_001256015.1
NP_001242945.1, NM_001256016.1
NP_037422.2, NM_013290.6 [Q9P2W1-2]
NP_057640.1, NM_016556.3 [Q9P2W1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000253789.9; ENSP00000253789.4; ENSG00000131470.15 [Q9P2W1-2]
ENST00000393795.8; ENSP00000377384.2; ENSG00000131470.15
ENST00000590760.5; ENSP00000466381.1; ENSG00000131470.15 [Q9P2W1-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29893

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:29893

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000393795.8; ENSP00000377384.2; NM_016556.4; NP_057640.1

UCSC genome browser

More...UCSCi		uc002iai.4, human [Q9P2W1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38933 mRNA Translation: AAC41915.1 Frameshift.
AB030304 mRNA Translation: BAA92872.1
AF440240 mRNA Translation: AAL33609.1
FJ952180 mRNA Translation: ACR46655.1
FJ952181 mRNA Translation: ACR46656.1
FJ952182 mRNA Translation: ACR46657.1
FJ952183 mRNA Translation: ACR46658.1
GQ851964 mRNA Translation: ACX30903.1
GQ851965 mRNA Translation: ACX30904.1
AC067852 Genomic DNA No translation available.
BC008792 mRNA Translation: AAH08792.1
CCDSiCCDS11431.1 [Q9P2W1-2]
CCDS45688.1 [Q9P2W1-1]
PIRiI68521
RefSeqiNP_001242943.1, NM_001256014.1
NP_001242944.1, NM_001256015.1
NP_001242945.1, NM_001256016.1
NP_037422.2, NM_013290.6 [Q9P2W1-2]
NP_057640.1, NM_016556.3 [Q9P2W1-1]

3D structure databases

AlphaFoldDBiQ9P2W1
SMRiQ9P2W1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118945, 33 interactors
CORUMiQ9P2W1
IntActiQ9P2W1, 16 interactors
MINTiQ9P2W1
STRINGi9606.ENSP00000377384

PTM databases

iPTMnetiQ9P2W1
PhosphoSitePlusiQ9P2W1

Genetic variation databases

BioMutaiPSMC3IP
DMDMi74719969

Proteomic databases

EPDiQ9P2W1
jPOSTiQ9P2W1
MassIVEiQ9P2W1
MaxQBiQ9P2W1
PaxDbiQ9P2W1
PeptideAtlasiQ9P2W1
PRIDEiQ9P2W1
ProteomicsDBi83901 [Q9P2W1-1]
83902 [Q9P2W1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29297, 71 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		29893

Genome annotation databases

EnsembliENST00000253789.9; ENSP00000253789.4; ENSG00000131470.15 [Q9P2W1-2]
ENST00000393795.8; ENSP00000377384.2; ENSG00000131470.15
ENST00000590760.5; ENSP00000466381.1; ENSG00000131470.15 [Q9P2W1-3]
GeneIDi29893
KEGGihsa:29893
MANE-SelectiENST00000393795.8; ENSP00000377384.2; NM_016556.4; NP_057640.1
UCSCiuc002iai.4, human [Q9P2W1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29893
DisGeNETi29893

GeneCards: human genes, protein and diseases

More...GeneCardsi		PSMC3IP
HGNCiHGNC:17928, PSMC3IP
HPAiENSG00000131470, Tissue enhanced (testis)
MalaCardsiPSMC3IP
MIMi608665, gene
614324, phenotype
neXtProtiNX_Q9P2W1
OpenTargetsiENSG00000131470
Orphaneti243, 46,XX gonadal dysgenesis
PharmGKBiPA143485584
VEuPathDBiHostDB:ENSG00000131470

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4603, Eukaryota
GeneTreeiENSGT00390000006890
HOGENOMiCLU_181023_0_0_1
InParanoidiQ9P2W1
OMAiIETDEDC
PhylomeDBiQ9P2W1
TreeFamiTF328666

Enzyme and pathway databases

PathwayCommonsiQ9P2W1
ReactomeiR-HSA-912446, Meiotic recombination
SignaLinkiQ9P2W1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		29893, 32 hits in 1083 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PSMC3IP, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		29893
PharosiQ9P2W1, Tbio

Protein Ontology

More...PROi		PR:Q9P2W1
RNActiQ9P2W1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131470, Expressed in vagina and 230 other tissues
ExpressionAtlasiQ9P2W1, baseline and differential
GenevisibleiQ9P2W1, HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR040461, Hop2
IPR010776, Hop2_WH_dom
IPR040661, LZ3wCH
IPR036388, WH-like_DNA-bd_sf
PANTHERiPTHR15938, PTHR15938, 1 hit
PfamiView protein in Pfam
PF18517, LZ3wCH, 1 hit
PF07106, TBPIP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHOP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2W1
Secondary accession number(s): C5ILB7
, Q14458, Q8WXG2, Q96HA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: May 25, 2022
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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