UniProtKB - Q9P2W1 (HOP2_HUMAN)
Homologous-pairing protein 2 homolog
PSMC3IP
Functioni
Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.
3 PublicationsGO - Molecular functioni
- double-stranded DNA binding Source: GO_Central
- nuclear receptor coactivator activity Source: UniProtKB
- recombinase activator activity Source: GO_Central
GO - Biological processi
- homologous chromosome pairing at meiosis Source: GO_Central
- meiotic joint molecule formation Source: GO_Central
- meiotic strand invasion involved in reciprocal meiotic recombination Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA recombination, Meiosis |
Enzyme and pathway databases
PathwayCommonsi | Q9P2W1 |
Reactomei | R-HSA-912446, Meiotic recombination |
SignaLinki | Q9P2W1 |
Names & Taxonomyi
Protein namesi | Recommended name: Homologous-pairing protein 2 homologAlternative name(s): Nuclear receptor coactivator GT198 PSMC3-interacting protein Proteasome 26S ATPase subunit 3-interacting protein Tat-binding protein 1-interacting protein Short name: TBP-1-interacting protein |
Gene namesi | Name:PSMC3IP Synonyms:HOP2, TBPIP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17928, PSMC3IP |
MIMi | 608665, gene |
neXtProti | NX_Q9P2W1 |
VEuPathDBi | HostDB:ENSG00000131470 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- condensed nuclear chromosome Source: GO_Central
- nucleoplasm Source: HPA
Other locations
- DNA recombinase auxiliary factor complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Ovarian dysgenesis 3 (ODG3)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066636 | 201 | Missing in ODG3; impairs function as estrogen receptor coactivator. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 29893 |
MalaCardsi | PSMC3IP |
MIMi | 614324, phenotype |
OpenTargetsi | ENSG00000131470 |
Orphaneti | 243, 46,XX gonadal dysgenesis |
PharmGKBi | PA143485584 |
Miscellaneous databases
Pharosi | Q9P2W1, Tbio |
Genetic variation databases
BioMutai | PSMC3IP |
DMDMi | 74719969 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000314135 | 1 – 217 | Homologous-pairing protein 2 homologAdd BLAST | 217 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9P2W1 |
jPOSTi | Q9P2W1 |
MassIVEi | Q9P2W1 |
MaxQBi | Q9P2W1 |
PaxDbi | Q9P2W1 |
PeptideAtlasi | Q9P2W1 |
PRIDEi | Q9P2W1 |
ProteomicsDBi | 83901 [Q9P2W1-1] 83902 [Q9P2W1-2] |
PTM databases
iPTMneti | Q9P2W1 |
PhosphoSitePlusi | Q9P2W1 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000131470, Expressed in vagina and 230 other tissues |
ExpressionAtlasi | Q9P2W1, baseline and differential |
Genevisiblei | Q9P2W1, HS |
Organism-specific databases
HPAi | ENSG00000131470, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Interacts with the DNA-binding domain of the nuclear receptors NR3C1/GR, ESR2/ER-beta, THRB and RXRA (By similarity).
Forms a stable heterodimer with MND1.
Interacts with PSMC3/TBP1.
By similarity2 PublicationsBinary interactionsi
Q9P2W1
With | #Exp. | IntAct |
---|---|---|
MND1 [Q9BWT6] | 5 | EBI-9057595,EBI-11137441 |
Protein-protein interaction databases
BioGRIDi | 118945, 33 interactors |
CORUMi | Q9P2W1 |
IntActi | Q9P2W1, 16 interactors |
MINTi | Q9P2W1 |
STRINGi | 9606.ENSP00000377384 |
Miscellaneous databases
RNActi | Q9P2W1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 118 – 182 | DNA-bindingBy similarityAdd BLAST | 65 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 93 – 153 | Sequence analysisAdd BLAST | 61 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4603, Eukaryota |
GeneTreei | ENSGT00390000006890 |
HOGENOMi | CLU_181023_0_0_1 |
InParanoidi | Q9P2W1 |
OMAi | IETDEDC |
PhylomeDBi | Q9P2W1 |
TreeFami | TF328666 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR040461, Hop2 IPR010776, Hop2_WH_dom IPR040661, LZ3wCH IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR15938, PTHR15938, 1 hit |
Pfami | View protein in Pfam PF18517, LZ3wCH, 1 hit PF07106, TBPIP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKGRAEAAA GAAGILLRYL QEQNRPYSSQ DVFGNLQREH GLGKAVVVKT
60 70 80 90 100
LEQLAQQGKI KEKMYGKQKI YFADQDQFDM VSDADLQVLD GKIVALTAKV
110 120 130 140 150
QSLQQSCRYM EAELKELSSA LTTPEMQKEI QELKKECAGY RERLKNIKAA
160 170 180 190 200
TNHVTPEEKE QVYRERQKYC KEWRKRKRMA TELSDAILEG YPKSKKQFFE
210
EVGIETDEDY NVTLPDP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ERB6 | K7ERB6_HUMAN | Homologous-pairing protein 2 homolo... | PSMC3IP hCG_16948 | 154 | Annotation score: | ||
K7EK12 | K7EK12_HUMAN | Homologous-pairing protein 2 homolo... | PSMC3IP | 85 | Annotation score: | ||
K7EQS1 | K7EQS1_HUMAN | Homologous-pairing protein 2 homolo... | PSMC3IP | 116 | Annotation score: | ||
K7ELD8 | K7ELD8_HUMAN | Homologous-pairing protein 2 homolo... | PSMC3IP | 84 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | Missing in AAC41915 (PubMed:7490091).Curated | 1 | |
Sequence conflicti | 106 | S → T in AAC41915 (PubMed:7490091).Curated | 1 | |
Sequence conflicti | 106 | S → T in AAL33609 (PubMed:11739747).Curated | 1 | |
Sequence conflicti | 184 | S → L in AAL33609 (PubMed:11739747).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037841 | 163 | Y → N. Corresponds to variant dbSNP:rs2292754EnsemblClinVar. | 1 | |
Natural variantiVAR_066636 | 201 | Missing in ODG3; impairs function as estrogen receptor coactivator. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047716 | 1 – 125 | Missing in isoform 3. 1 PublicationAdd BLAST | 125 | |
Alternative sequenceiVSP_030213 | 113 – 124 | Missing in isoform 2. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L38933 mRNA Translation: AAC41915.1 Frameshift. AB030304 mRNA Translation: BAA92872.1 AF440240 mRNA Translation: AAL33609.1 FJ952180 mRNA Translation: ACR46655.1 FJ952181 mRNA Translation: ACR46656.1 FJ952182 mRNA Translation: ACR46657.1 FJ952183 mRNA Translation: ACR46658.1 GQ851964 mRNA Translation: ACX30903.1 GQ851965 mRNA Translation: ACX30904.1 AC067852 Genomic DNA No translation available. BC008792 mRNA Translation: AAH08792.1 |
CCDSi | CCDS11431.1 [Q9P2W1-2] CCDS45688.1 [Q9P2W1-1] |
PIRi | I68521 |
RefSeqi | NP_001242943.1, NM_001256014.1 NP_001242944.1, NM_001256015.1 NP_001242945.1, NM_001256016.1 NP_037422.2, NM_013290.6 [Q9P2W1-2] NP_057640.1, NM_016556.3 [Q9P2W1-1] |
Genome annotation databases
Ensembli | ENST00000253789.9; ENSP00000253789.4; ENSG00000131470.15 [Q9P2W1-2] ENST00000393795.8; ENSP00000377384.2; ENSG00000131470.15 ENST00000590760.5; ENSP00000466381.1; ENSG00000131470.15 [Q9P2W1-3] |
GeneIDi | 29893 |
KEGGi | hsa:29893 |
MANE-Selecti | ENST00000393795.8; ENSP00000377384.2; NM_016556.4; NP_057640.1 |
UCSCi | uc002iai.4, human [Q9P2W1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L38933 mRNA Translation: AAC41915.1 Frameshift. AB030304 mRNA Translation: BAA92872.1 AF440240 mRNA Translation: AAL33609.1 FJ952180 mRNA Translation: ACR46655.1 FJ952181 mRNA Translation: ACR46656.1 FJ952182 mRNA Translation: ACR46657.1 FJ952183 mRNA Translation: ACR46658.1 GQ851964 mRNA Translation: ACX30903.1 GQ851965 mRNA Translation: ACX30904.1 AC067852 Genomic DNA No translation available. BC008792 mRNA Translation: AAH08792.1 |
CCDSi | CCDS11431.1 [Q9P2W1-2] CCDS45688.1 [Q9P2W1-1] |
PIRi | I68521 |
RefSeqi | NP_001242943.1, NM_001256014.1 NP_001242944.1, NM_001256015.1 NP_001242945.1, NM_001256016.1 NP_037422.2, NM_013290.6 [Q9P2W1-2] NP_057640.1, NM_016556.3 [Q9P2W1-1] |
3D structure databases
AlphaFoldDBi | Q9P2W1 |
SMRi | Q9P2W1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118945, 33 interactors |
CORUMi | Q9P2W1 |
IntActi | Q9P2W1, 16 interactors |
MINTi | Q9P2W1 |
STRINGi | 9606.ENSP00000377384 |
PTM databases
iPTMneti | Q9P2W1 |
PhosphoSitePlusi | Q9P2W1 |
Genetic variation databases
BioMutai | PSMC3IP |
DMDMi | 74719969 |
Proteomic databases
EPDi | Q9P2W1 |
jPOSTi | Q9P2W1 |
MassIVEi | Q9P2W1 |
MaxQBi | Q9P2W1 |
PaxDbi | Q9P2W1 |
PeptideAtlasi | Q9P2W1 |
PRIDEi | Q9P2W1 |
ProteomicsDBi | 83901 [Q9P2W1-1] 83902 [Q9P2W1-2] |
Protocols and materials databases
Antibodypediai | 29297, 71 antibodies from 22 providers |
DNASUi | 29893 |
Genome annotation databases
Ensembli | ENST00000253789.9; ENSP00000253789.4; ENSG00000131470.15 [Q9P2W1-2] ENST00000393795.8; ENSP00000377384.2; ENSG00000131470.15 ENST00000590760.5; ENSP00000466381.1; ENSG00000131470.15 [Q9P2W1-3] |
GeneIDi | 29893 |
KEGGi | hsa:29893 |
MANE-Selecti | ENST00000393795.8; ENSP00000377384.2; NM_016556.4; NP_057640.1 |
UCSCi | uc002iai.4, human [Q9P2W1-1] |
Organism-specific databases
CTDi | 29893 |
DisGeNETi | 29893 |
GeneCardsi | PSMC3IP |
HGNCi | HGNC:17928, PSMC3IP |
HPAi | ENSG00000131470, Tissue enhanced (testis) |
MalaCardsi | PSMC3IP |
MIMi | 608665, gene 614324, phenotype |
neXtProti | NX_Q9P2W1 |
OpenTargetsi | ENSG00000131470 |
Orphaneti | 243, 46,XX gonadal dysgenesis |
PharmGKBi | PA143485584 |
VEuPathDBi | HostDB:ENSG00000131470 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4603, Eukaryota |
GeneTreei | ENSGT00390000006890 |
HOGENOMi | CLU_181023_0_0_1 |
InParanoidi | Q9P2W1 |
OMAi | IETDEDC |
PhylomeDBi | Q9P2W1 |
TreeFami | TF328666 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2W1 |
Reactomei | R-HSA-912446, Meiotic recombination |
SignaLinki | Q9P2W1 |
Miscellaneous databases
BioGRID-ORCSi | 29893, 32 hits in 1083 CRISPR screens |
ChiTaRSi | PSMC3IP, human |
GenomeRNAii | 29893 |
Pharosi | Q9P2W1, Tbio |
PROi | PR:Q9P2W1 |
RNActi | Q9P2W1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131470, Expressed in vagina and 230 other tissues |
ExpressionAtlasi | Q9P2W1, baseline and differential |
Genevisiblei | Q9P2W1, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR040461, Hop2 IPR010776, Hop2_WH_dom IPR040661, LZ3wCH IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR15938, PTHR15938, 1 hit |
Pfami | View protein in Pfam PF18517, LZ3wCH, 1 hit PF07106, TBPIP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HOP2_HUMAN | |
Accessioni | Q9P2W1Primary (citable) accession number: Q9P2W1 Secondary accession number(s): C5ILB7 Q96HA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families