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Protein

Vesicular glutamate transporter 2

Gene

SLC17A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.2 Publications

GO - Molecular functioni

  • L-glutamate transmembrane transporter activity Source: GO_Central
  • neurotransmitter transporter activity Source: GO_Central
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • ion transport Source: Reactome
  • neurotransmitter loading into synaptic vesicle Source: SynGO
  • sodium ion transport Source: UniProtKB-KW
  • synaptic transmission, glutamatergic Source: GO_Central

Keywordsi

Biological processIon transport, Neurotransmitter transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-428643 Organic anion transporters

Protein family/group databases

TCDBi2.A.1.14.31 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular glutamate transporter 2
Short name:
VGluT2
Alternative name(s):
Differentiation-associated BNPI
Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
Solute carrier family 17 member 6
Gene namesi
Name:SLC17A6
Synonyms:DNPI, VGLUT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000091664.7
HGNCiHGNC:16703 SLC17A6
MIMi607563 gene
neXtProtiNX_Q9P2U8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 71CytoplasmicSequence analysisAdd BLAST71
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93 – 125VesicularSequence analysisAdd BLAST33
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 148CytoplasmicSequence analysis2
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 177VesicularSequence analysis8
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 216CytoplasmicSequence analysisAdd BLAST18
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 244VesicularSequence analysis7
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 310CytoplasmicSequence analysisAdd BLAST45
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 349VesicularSequence analysisAdd BLAST18
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 386CytoplasmicSequence analysisAdd BLAST16
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 409VesicularSequence analysis2
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 443CytoplasmicSequence analysisAdd BLAST13
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 477VesicularSequence analysisAdd BLAST13
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Topological domaini499 – 582CytoplasmicSequence analysisAdd BLAST84

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi57084
OpenTargetsiENSG00000091664
PharmGKBiPA424

Polymorphism and mutation databases

BioMutaiSLC17A6
DMDMi74734915

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181691 – 582Vesicular glutamate transporter 2Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9P2U8
PeptideAtlasiQ9P2U8
PRIDEiQ9P2U8
ProteomicsDBi83899

PTM databases

iPTMnetiQ9P2U8
PhosphoSitePlusiQ9P2U8

Expressioni

Tissue specificityi

Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus.1 Publication

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000091664 Expressed in 61 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExiHS_SLC17A6
GenevisibleiQ9P2U8 HS

Organism-specific databases

HPAiCAB037130
CAB078204
HPA039226

Interactioni

Protein-protein interaction databases

BioGridi121355, 1 interactor
STRINGi9606.ENSP00000263160

Structurei

3D structure databases

ProteinModelPortaliQ9P2U8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532 Eukaryota
ENOG410XPWC LUCA
GeneTreeiENSGT00760000119079
HOGENOMiHOG000230812
HOVERGENiHBG008834
InParanoidiQ9P2U8
KOiK12302
OMAiTQVNGGW
OrthoDBiEOG091G06DG
PhylomeDBiQ9P2U8
TreeFamiTF313535

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P2U8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL
60 70 80 90 100
EVPERKAPLC DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN
110 120 130 140 150
NSTIHRGGKV IKEKAKFNWD PETVGMIHGS FFWGYIITQI PGGYIASRLA
160 170 180 190 200
ANRVFGAAIL LTSTLNMLIP SAARVHYGCV IFVRILQGLV EGVTYPACHG
210 220 230 240 250
IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT GWSSVFYVYG
260 270 280 290 300
SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK
310 320 330 340 350
TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM
360 370 380 390 400
LSAVPHLVMT IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL
410 420 430 440 450
LVVGYSHTRG VAISFLVLAV GFSGFAISGF NVNHLDIAPR YASILMGISN
460 470 480 490 500
GVGTLSGMVC PIIVGAMTKN KSREEWQYVF LIAALVHYGG VIFYAIFASG
510 520 530 540 550
EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT TKSYGATTQA
560 570 580
NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS
Length:582
Mass (Da):64,392
Last modified:October 1, 2000 - v1
Checksum:iCE761E56FA18C6AD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03871040T → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_038711551N → S. Corresponds to variant dbSNP:rs7117340Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032435 mRNA Translation: BAA92874.1
AC040936 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68324.1
BC069629 mRNA Translation: AAH69629.1
BC069640 mRNA Translation: AAH69640.1
BC069646 mRNA Translation: AAH69646.1
CCDSiCCDS7856.1
RefSeqiNP_065079.1, NM_020346.2
UniGeneiHs.242821

Genome annotation databases

EnsembliENST00000263160; ENSP00000263160; ENSG00000091664
GeneIDi57084
KEGGihsa:57084
UCSCiuc001mqk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032435 mRNA Translation: BAA92874.1
AC040936 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68324.1
BC069629 mRNA Translation: AAH69629.1
BC069640 mRNA Translation: AAH69640.1
BC069646 mRNA Translation: AAH69646.1
CCDSiCCDS7856.1
RefSeqiNP_065079.1, NM_020346.2
UniGeneiHs.242821

3D structure databases

ProteinModelPortaliQ9P2U8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121355, 1 interactor
STRINGi9606.ENSP00000263160

Protein family/group databases

TCDBi2.A.1.14.31 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ9P2U8
PhosphoSitePlusiQ9P2U8

Polymorphism and mutation databases

BioMutaiSLC17A6
DMDMi74734915

Proteomic databases

PaxDbiQ9P2U8
PeptideAtlasiQ9P2U8
PRIDEiQ9P2U8
ProteomicsDBi83899

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263160; ENSP00000263160; ENSG00000091664
GeneIDi57084
KEGGihsa:57084
UCSCiuc001mqk.4 human

Organism-specific databases

CTDi57084
DisGeNETi57084
EuPathDBiHostDB:ENSG00000091664.7
GeneCardsiSLC17A6
HGNCiHGNC:16703 SLC17A6
HPAiCAB037130
CAB078204
HPA039226
MIMi607563 gene
neXtProtiNX_Q9P2U8
OpenTargetsiENSG00000091664
PharmGKBiPA424
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2532 Eukaryota
ENOG410XPWC LUCA
GeneTreeiENSGT00760000119079
HOGENOMiHOG000230812
HOVERGENiHBG008834
InParanoidiQ9P2U8
KOiK12302
OMAiTQVNGGW
OrthoDBiEOG091G06DG
PhylomeDBiQ9P2U8
TreeFamiTF313535

Enzyme and pathway databases

ReactomeiR-HSA-428643 Organic anion transporters

Miscellaneous databases

GenomeRNAii57084
PROiPR:Q9P2U8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091664 Expressed in 61 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExiHS_SLC17A6
GenevisibleiQ9P2U8 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVGLU2_HUMAN
AccessioniPrimary (citable) accession number: Q9P2U8
Secondary accession number(s): A6NKS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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