Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vesicular glutamate transporter 1

Gene

SLC17A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Neurotransmitter transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-428643 Organic anion transporters

Protein family/group databases

TCDBi2.A.1.14.30 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular glutamate transporter 1
Short name:
VGluT1
Alternative name(s):
Brain-specific Na(+)-dependent inorganic phosphate cotransporter
Solute carrier family 17 member 7
Gene namesi
Name:SLC17A7
Synonyms:BNPI, VGLUT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104888.9
HGNCiHGNC:16704 SLC17A7
MIMi605208 gene
neXtProtiNX_Q9P2U7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 116ExtracellularSequence analysisAdd BLAST32
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 140CytoplasmicSequence analysis3
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 169ExtracellularSequence analysis8
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 208CytoplasmicSequence analysisAdd BLAST18
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 236ExtracellularSequence analysis7
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 302CytoplasmicSequence analysisAdd BLAST45
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 341ExtracellularSequence analysisAdd BLAST18
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 378CytoplasmicSequence analysisAdd BLAST16
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 401ExtracellularSequence analysis2
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 435CytoplasmicSequence analysisAdd BLAST13
Transmembranei436 – 456HelicalSequence analysisAdd BLAST21
Topological domaini457 – 469ExtracellularSequence analysisAdd BLAST13
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 560CytoplasmicSequence analysisAdd BLAST70

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi57030
OpenTargetsiENSG00000104888
PharmGKBiPA423

Polymorphism and mutation databases

BioMutaiSLC17A7
DMDMi74725387

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316111 – 560Vesicular glutamate transporter 1Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei504PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9P2U7
PeptideAtlasiQ9P2U7
PRIDEiQ9P2U7
ProteomicsDBi83898
TopDownProteomicsiQ9P2U7-1 [Q9P2U7-1]

PTM databases

iPTMnetiQ9P2U7
PhosphoSitePlusiQ9P2U7
SwissPalmiQ9P2U7

Expressioni

Tissue specificityi

Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.1 Publication

Gene expression databases

BgeeiENSG00000104888 Expressed in 135 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SLC17A7
ExpressionAtlasiQ9P2U7 baseline and differential
GenevisibleiQ9P2U7 HS

Organism-specific databases

HPAiCAB037183
HPA050458
HPA063679

Interactioni

Subunit structurei

Interacts with SHANK3.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000221485

Structurei

3D structure databases

ProteinModelPortaliQ9P2U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi530 – 556Pro-richAdd BLAST27

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532 Eukaryota
ENOG410XPWC LUCA
GeneTreeiENSGT00760000119079
HOGENOMiHOG000230812
HOVERGENiHBG008834
InParanoidiQ9P2U7
KOiK12302
OMAiSAARCHY
OrthoDBiEOG091G06DG
PhylomeDBiQ9P2U7
TreeFamiTF313535

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2U7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFRQEEFRK LAGRALGKLH RLLEKRQEGA ETLELSADGR PVTTQTRDPP
60 70 80 90 100
VVDCTCFGLP RRYIIAIMSG LGFCISFGIR CNLGVAIVSM VNNSTTHRGG
110 120 130 140 150
HVVVQKAQFS WDPETVGLIH GSFFWGYIVT QIPGGFICQK FAANRVFGFA
160 170 180 190 200
IVATSTLNML IPSAARVHYG CVIFVRILQG LVEGVTYPAC HGIWSKWAPP
210 220 230 240 250
LERSRLATTA FCGSYAGAVV AMPLAGVLVQ YSGWSSVFYV YGSFGIFWYL
260 270 280 290 300
FWLLVSYESP ALHPSISEEE RKYIEDAIGE SAKLMNPLTK FSTPWRRFFT
310 320 330 340 350
SMPVYAIIVA NFCRSWTFYL LLISQPAYFE EVFGFEISKV GLVSALPHLV
360 370 380 390 400
MTIIVPIGGQ IADFLRSRRI MSTTNVRKLM NCGGFGMEAT LLLVVGYSHS
410 420 430 440 450
KGVAISFLVL AVGFSGFAIS GFNVNHLDIA PRYASILMGI SNGVGTLSGM
460 470 480 490 500
VCPIIVGAMT KHKTREEWQY VFLIASLVHY GGVIFYGVFA SGEKQPWAEP
510 520 530 540 550
EEMSEEKCGF VGHDQLAGSD DSEMEDEAEP PGAPPAPPPS YGATHSTFQP
560
PRPPPPVRDY
Length:560
Mass (Da):61,613
Last modified:October 1, 2000 - v1
Checksum:iC88DAFB34B6E45B6
GO
Isoform 2 (identifier: Q9P2U7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Note: No experimental confirmation available.
Show »
Length:493
Mass (Da):53,946
Checksum:i6333DBF37546389F
GO
Isoform 3 (identifier: Q9P2U7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEFRQEEFRKLAGRALGKLHR → MGSQLALAG

Note: No experimental confirmation available.
Show »
Length:548
Mass (Da):59,887
Checksum:i4FFF0B4E78E6BE69
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1S5M0R1S5_HUMAN
Vesicular glutamate transporter 1
SLC17A7
116Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042904431P → R1 PublicationCorresponds to variant dbSNP:rs17855709Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561101 – 67Missing in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_0561111 – 21MEFRQ…GKLHR → MGSQLALAG in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032436 mRNA Translation: BAA92875.1
AK294226 mRNA Translation: BAG57530.1
AK294405 mRNA Translation: BAG57657.1
AC010619 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52485.1
BC059379 mRNA Translation: AAH59379.1
CCDSiCCDS12764.1 [Q9P2U7-1]
RefSeqiNP_064705.1, NM_020309.3 [Q9P2U7-1]
UniGeneiHs.375616

Genome annotation databases

EnsembliENST00000221485; ENSP00000221485; ENSG00000104888 [Q9P2U7-1]
ENST00000600601; ENSP00000470338; ENSG00000104888 [Q9P2U7-2]
GeneIDi57030
KEGGihsa:57030
UCSCiuc002pnp.4 human [Q9P2U7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032436 mRNA Translation: BAA92875.1
AK294226 mRNA Translation: BAG57530.1
AK294405 mRNA Translation: BAG57657.1
AC010619 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52485.1
BC059379 mRNA Translation: AAH59379.1
CCDSiCCDS12764.1 [Q9P2U7-1]
RefSeqiNP_064705.1, NM_020309.3 [Q9P2U7-1]
UniGeneiHs.375616

3D structure databases

ProteinModelPortaliQ9P2U7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000221485

Protein family/group databases

TCDBi2.A.1.14.30 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ9P2U7
PhosphoSitePlusiQ9P2U7
SwissPalmiQ9P2U7

Polymorphism and mutation databases

BioMutaiSLC17A7
DMDMi74725387

Proteomic databases

PaxDbiQ9P2U7
PeptideAtlasiQ9P2U7
PRIDEiQ9P2U7
ProteomicsDBi83898
TopDownProteomicsiQ9P2U7-1 [Q9P2U7-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221485; ENSP00000221485; ENSG00000104888 [Q9P2U7-1]
ENST00000600601; ENSP00000470338; ENSG00000104888 [Q9P2U7-2]
GeneIDi57030
KEGGihsa:57030
UCSCiuc002pnp.4 human [Q9P2U7-1]

Organism-specific databases

CTDi57030
DisGeNETi57030
EuPathDBiHostDB:ENSG00000104888.9
GeneCardsiSLC17A7
HGNCiHGNC:16704 SLC17A7
HPAiCAB037183
HPA050458
HPA063679
MIMi605208 gene
neXtProtiNX_Q9P2U7
OpenTargetsiENSG00000104888
PharmGKBiPA423
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2532 Eukaryota
ENOG410XPWC LUCA
GeneTreeiENSGT00760000119079
HOGENOMiHOG000230812
HOVERGENiHBG008834
InParanoidiQ9P2U7
KOiK12302
OMAiSAARCHY
OrthoDBiEOG091G06DG
PhylomeDBiQ9P2U7
TreeFamiTF313535

Enzyme and pathway databases

ReactomeiR-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-428643 Organic anion transporters

Miscellaneous databases

ChiTaRSiSLC17A7 human
GeneWikiiVesicular_glutamate_transporter_1
GenomeRNAii57030
PROiPR:Q9P2U7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104888 Expressed in 135 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SLC17A7
ExpressionAtlasiQ9P2U7 baseline and differential
GenevisibleiQ9P2U7 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVGLU1_HUMAN
AccessioniPrimary (citable) accession number: Q9P2U7
Secondary accession number(s): B4DFR9, B4DG46, Q6PCD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again