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Protein

GMP reductase 2

Gene

GMPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).UniRule annotation4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei78NADPUniRule annotation1 Publication1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi181Potassium; via carbonyl oxygenUniRule annotation1
Metal bindingi183Potassium; via carbonyl oxygenUniRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei186Thioimidate intermediateUniRule annotation1
Metal bindingi186Potassium; via carbonyl oxygenUniRule annotation1
Active sitei188Proton donor/acceptorUniRule annotation1
Metal bindingi189PotassiumUniRule annotation1
Binding sitei269NADP; via carbonyl oxygenUniRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi26 – 27NADP; shared with neighboring subunitUniRule annotation1 Publication2
Nucleotide bindingi129 – 131NADPUniRule annotation1 Publication3
Nucleotide bindingi180 – 181NADPUniRule annotation1 Publication2
Nucleotide bindingi285 – 286NADPUniRule annotation1 Publication2
Nucleotide bindingi314 – 317NADP; shared with neighboring subunitUniRule annotation1 Publication4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GMP reductase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism
LigandMetal-binding, NADP, Potassium

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.7.1.7 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-74217 Purine salvage

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GMP reductase 2UniRule annotation (EC:1.7.1.7UniRule annotation)
Short name:
GMPR 2UniRule annotation
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase 2UniRule annotation
Short name:
Guanosine monophosphate reductase 2UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GMPR2UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100938.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4377 GMPR2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610781 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P2T1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi186C → A: Loss of enzyme activity. 2 Publications1
Mutagenesisi188T → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi289E → Q: Loss of enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51292

Open Targets

More...
OpenTargetsi
ENSG00000100938

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28762

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GMPR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25008511

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000937261 – 348GMP reductase 2Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei291N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P2T1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9P2T1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2T1

PeptideAtlas

More...
PeptideAtlasi
Q9P2T1

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2T1

ProteomicsDB human proteome resource

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ProteomicsDBi
83896
83897 [Q9P2T1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2T1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2T1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100938 Expressed in 221 organ(s), highest expression level in right adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_GMPR2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P2T1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P2T1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000904
HPA067884
HPA068782

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.UniRule annotation2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119443, 8 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-2154 Guanosine monophosphate reductase 2

Protein interaction database and analysis system

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IntActi
Q9P2T1, 2 interactors

Molecular INTeraction database

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MINTi
Q9P2T1

STRING: functional protein association networks

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STRINGi
9606.ENSP00000392859

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1348
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9P2T1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P2T1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9P2T1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni219 – 221GMP bindingUniRule annotation3
Regioni242 – 243GMP bindingUniRule annotation2
Regioni268 – 270GMP bindingUniRule annotation3
Regioni286 – 290GMP bindingUniRule annotation5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2550 Eukaryota
COG0516 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159574

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000165756

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051744

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P2T1

KEGG Orthology (KO)

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KOi
K00364

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P2T1

TreeFam database of animal gene trees

More...
TreeFami
TF300378

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00381 IMPDH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.20.20.70, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00596 GMP_reduct_type1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR005993 GMPR
IPR015875 IMP_DH/GMP_Rdtase_CS
IPR001093 IMP_DH_GMPRt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00478 IMPDH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000235 GMP_reductase, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01305 GMP_reduct_1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00487 IMP_DH_GMP_RED, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2T1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI
60 70 80 90 100
IAANMDTVGT FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA
110 120 130 140 150
ASSGTGSSDF EQLEQILEAI PQVKYICLDV ANGYSEHFVE FVKDVRKRFP
160 170 180 190 200
QHTIMAGNVV TGEMVEELIL SGADIIKVGI GPGSVCTTRK KTGVGYPQLS
210 220 230 240 250
AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM LGGMLAGHSE
260 270 280 290 300
SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD
310 320 330 340
VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC
Length:348
Mass (Da):37,874
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7812A754C433E51
GO
Isoform 2 (identifier: Q9P2T1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTSCLPALRFIATPRLSAM

Show »
Length:366
Mass (Da):39,805
Checksum:i009CF162967F2112
GO
Isoform 3 (identifier: Q9P2T1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-97: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):34,597
Checksum:iA54872F5C9635EAC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNJ6H0YNJ6_HUMAN
GMP reductase
GMPR2 GMPR, hCG_40198
427Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMB3H0YMB3_HUMAN
GMP reductase
GMPR2 GMPR
315Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLV5H0YLV5_HUMAN
GMP reductase
GMPR2 GMPR
333Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAN9F8WAN9_HUMAN
GMP reductase
GMPR2 GMPR
349Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWM4A0A087WWM4_HUMAN
GMP reductase
GMPR2 GMPR
348Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMG3H0YMG3_HUMAN
GMP reductase 2
GMPR2
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKE1H0YKE1_HUMAN
GMP reductase 2
GMPR2
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKK3H0YKK3_HUMAN
GMP reductase 2
GMPR2
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMV5H0YMV5_HUMAN
GMP reductase 2
GMPR2
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK71H0YK71_HUMAN
GMP reductase 2
GMPR2
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91Q → R in CAG33437 (Ref. 5) Curated1
Sequence conflicti200S → G in CAG33437 (Ref. 5) Curated1
Sequence conflicti223S → N in CAG33437 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049602242G → D. Corresponds to variant dbSNP:rs34354104Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0414591M → MTSCLPALRFIATPRLSAM in isoform 2. 1 Publication1
Alternative sequenceiVSP_05458570 – 97Missing in isoform 3. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF419346 mRNA Translation: AAN32701.1
AF135159 mRNA Translation: AAG09132.1
AB032903 mRNA Translation: BAA93080.1
BX161436 mRNA Translation: CAD61908.1
BX247993 mRNA Translation: CAD62327.1
CR457156 mRNA Translation: CAG33437.1
AL096870 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66051.1
CH471078 Genomic DNA Translation: EAW66053.1
CH471078 Genomic DNA Translation: EAW66054.1
CH471078 Genomic DNA Translation: EAW66056.1
CH471078 Genomic DNA Translation: EAW66057.1
BC008021 mRNA Translation: AAH08021.2
BC009832 mRNA Translation: AAH09832.1
BC093039 mRNA Translation: AAH93039.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41935.1 [Q9P2T1-1]
CCDS45087.1 [Q9P2T1-2]
CCDS61419.1 [Q9P2T1-3]

NCBI Reference Sequences

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RefSeqi
NP_001002000.1, NM_001002000.2 [Q9P2T1-1]
NP_001002001.1, NM_001002001.2 [Q9P2T1-1]
NP_001002002.1, NM_001002002.2 [Q9P2T1-1]
NP_001269950.1, NM_001283021.1
NP_001269951.1, NM_001283022.1
NP_001269952.1, NM_001283023.1 [Q9P2T1-3]
NP_057660.2, NM_016576.4 [Q9P2T1-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.368855

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000355299; ENSP00000347449; ENSG00000100938 [Q9P2T1-1]
ENST00000399440; ENSP00000382369; ENSG00000100938 [Q9P2T1-1]
ENST00000420554; ENSP00000392859; ENSG00000100938 [Q9P2T1-2]
ENST00000456667; ENSP00000405743; ENSG00000100938 [Q9P2T1-3]
ENST00000559836; ENSP00000453299; ENSG00000100938 [Q9P2T1-1]
ENST00000642276; ENSP00000496504; ENSG00000284752 [Q9P2T1-1]
ENST00000643803; ENSP00000495708; ENSG00000284752 [Q9P2T1-3]
ENST00000644066; ENSP00000494224; ENSG00000284752 [Q9P2T1-1]
ENST00000645781; ENSP00000496234; ENSG00000284752 [Q9P2T1-2]
ENST00000647320; ENSP00000495583; ENSG00000284752 [Q9P2T1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51292

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51292

UCSC genome browser

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UCSCi
uc001wnr.5 human [Q9P2T1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF419346 mRNA Translation: AAN32701.1
AF135159 mRNA Translation: AAG09132.1
AB032903 mRNA Translation: BAA93080.1
BX161436 mRNA Translation: CAD61908.1
BX247993 mRNA Translation: CAD62327.1
CR457156 mRNA Translation: CAG33437.1
AL096870 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66051.1
CH471078 Genomic DNA Translation: EAW66053.1
CH471078 Genomic DNA Translation: EAW66054.1
CH471078 Genomic DNA Translation: EAW66056.1
CH471078 Genomic DNA Translation: EAW66057.1
BC008021 mRNA Translation: AAH08021.2
BC009832 mRNA Translation: AAH09832.1
BC093039 mRNA Translation: AAH93039.1
CCDSiCCDS41935.1 [Q9P2T1-1]
CCDS45087.1 [Q9P2T1-2]
CCDS61419.1 [Q9P2T1-3]
RefSeqiNP_001002000.1, NM_001002000.2 [Q9P2T1-1]
NP_001002001.1, NM_001002001.2 [Q9P2T1-1]
NP_001002002.1, NM_001002002.2 [Q9P2T1-1]
NP_001269950.1, NM_001283021.1
NP_001269951.1, NM_001283022.1
NP_001269952.1, NM_001283023.1 [Q9P2T1-3]
NP_057660.2, NM_016576.4 [Q9P2T1-2]
UniGeneiHs.368855

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A7RX-ray3.00A/B/C/D1-348[»]
2BZNX-ray2.15A/B/C/D/E/F/G/H10-341[»]
2C6QX-ray1.70A/B/C/D/E/F/G/H10-341[»]
ProteinModelPortaliQ9P2T1
SMRiQ9P2T1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119443, 8 interactors
ComplexPortaliCPX-2154 Guanosine monophosphate reductase 2
IntActiQ9P2T1, 2 interactors
MINTiQ9P2T1
STRINGi9606.ENSP00000392859

PTM databases

iPTMnetiQ9P2T1
PhosphoSitePlusiQ9P2T1

Polymorphism and mutation databases

BioMutaiGMPR2
DMDMi25008511

Proteomic databases

EPDiQ9P2T1
MaxQBiQ9P2T1
PaxDbiQ9P2T1
PeptideAtlasiQ9P2T1
PRIDEiQ9P2T1
ProteomicsDBi83896
83897 [Q9P2T1-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51292
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355299; ENSP00000347449; ENSG00000100938 [Q9P2T1-1]
ENST00000399440; ENSP00000382369; ENSG00000100938 [Q9P2T1-1]
ENST00000420554; ENSP00000392859; ENSG00000100938 [Q9P2T1-2]
ENST00000456667; ENSP00000405743; ENSG00000100938 [Q9P2T1-3]
ENST00000559836; ENSP00000453299; ENSG00000100938 [Q9P2T1-1]
ENST00000642276; ENSP00000496504; ENSG00000284752 [Q9P2T1-1]
ENST00000643803; ENSP00000495708; ENSG00000284752 [Q9P2T1-3]
ENST00000644066; ENSP00000494224; ENSG00000284752 [Q9P2T1-1]
ENST00000645781; ENSP00000496234; ENSG00000284752 [Q9P2T1-2]
ENST00000647320; ENSP00000495583; ENSG00000284752 [Q9P2T1-1]
GeneIDi51292
KEGGihsa:51292
UCSCiuc001wnr.5 human [Q9P2T1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51292
DisGeNETi51292
EuPathDBiHostDB:ENSG00000100938.17

GeneCards: human genes, protein and diseases

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GeneCardsi
GMPR2
HGNCiHGNC:4377 GMPR2
HPAiHPA000904
HPA067884
HPA068782
MIMi610781 gene
neXtProtiNX_Q9P2T1
OpenTargetsiENSG00000100938
PharmGKBiPA28762

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2550 Eukaryota
COG0516 LUCA
GeneTreeiENSGT00940000159574
HOGENOMiHOG000165756
HOVERGENiHBG051744
InParanoidiQ9P2T1
KOiK00364
PhylomeDBiQ9P2T1
TreeFamiTF300378

Enzyme and pathway databases

BRENDAi1.7.1.7 2681
ReactomeiR-HSA-74217 Purine salvage

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GMPR2 human
EvolutionaryTraceiQ9P2T1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51292

Protein Ontology

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PROi
PR:Q9P2T1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100938 Expressed in 221 organ(s), highest expression level in right adrenal gland
CleanExiHS_GMPR2
ExpressionAtlasiQ9P2T1 baseline and differential
GenevisibleiQ9P2T1 HS

Family and domain databases

CDDicd00381 IMPDH, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00596 GMP_reduct_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR005993 GMPR
IPR015875 IMP_DH/GMP_Rdtase_CS
IPR001093 IMP_DH_GMPRt
PfamiView protein in Pfam
PF00478 IMPDH, 1 hit
PIRSFiPIRSF000235 GMP_reductase, 1 hit
TIGRFAMsiTIGR01305 GMP_reduct_1, 1 hit
PROSITEiView protein in PROSITE
PS00487 IMP_DH_GMP_RED, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGMPR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2T1
Secondary accession number(s): D3DS66
, Q567T0, Q6IAJ8, Q86T14
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: December 5, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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