UniProtKB - Q9P2S6 (ANKY1_HUMAN)
Protein
Ankyrin repeat and MYND domain-containing protein 1
Gene
ANKMY1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 880 – 920 | MYND-typePROSITE-ProRule annotationAdd BLAST | 41 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9P2S6 |
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat and MYND domain-containing protein 1Alternative name(s): Testis-specific ankyrin-like protein 1 Zinc finger MYND domain-containing protein 13 |
Gene namesi | Name:ANKMY1 Synonyms:TSAL1, ZMYND13 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20987, ANKMY1 |
neXtProti | NX_Q9P2S6 |
VEuPathDBi | HostDB:ENSG00000144504.15 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51281 |
OpenTargetsi | ENSG00000144504 |
PharmGKBi | PA134925670 |
Miscellaneous databases
Pharosi | Q9P2S6, Tbio |
Genetic variation databases
BioMutai | ANKMY1 |
DMDMi | 30912747 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066894 | 1 – 941 | Ankyrin repeat and MYND domain-containing protein 1Add BLAST | 941 |
Proteomic databases
MassIVEi | Q9P2S6 |
PaxDbi | Q9P2S6 |
PeptideAtlasi | Q9P2S6 |
PRIDEi | Q9P2S6 |
ProteomicsDBi | 83890 [Q9P2S6-1] 83891 [Q9P2S6-2] 83892 [Q9P2S6-3] 83893 [Q9P2S6-4] |
PTM databases
iPTMneti | Q9P2S6 |
PhosphoSitePlusi | Q9P2S6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000144504, Expressed in right testis and 172 other tissues |
ExpressionAtlasi | Q9P2S6, baseline and differential |
Genevisiblei | Q9P2S6, HS |
Organism-specific databases
HPAi | ENSG00000144504, Tissue enhanced (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 119433, 2 interactors |
STRINGi | 9606.ENSP00000385887 |
Miscellaneous databases
RNActi | Q9P2S6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 2 – 24 | MORN 1Add BLAST | 23 | |
Repeati | 25 – 47 | MORN 2Add BLAST | 23 | |
Repeati | 70 – 92 | MORN 3Add BLAST | 23 | |
Repeati | 292 – 321 | ANK 1Add BLAST | 30 | |
Repeati | 513 – 542 | ANK 2Add BLAST | 30 | |
Repeati | 545 – 574 | ANK 3Add BLAST | 30 | |
Repeati | 581 – 613 | ANK 4Add BLAST | 33 | |
Repeati | 657 – 691 | ANK 5Add BLAST | 35 | |
Repeati | 694 – 723 | ANK 6Add BLAST | 30 | |
Repeati | 737 – 766 | ANK 7Add BLAST | 30 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 880 – 920 | MYND-typePROSITE-ProRule annotationAdd BLAST | 41 |
Keywords - Domaini
ANK repeat, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QQJP, Eukaryota |
GeneTreei | ENSGT00460000041630 |
HOGENOMi | CLU_050860_0_0_1 |
InParanoidi | Q9P2S6 |
OrthoDBi | 323321at2759 |
PhylomeDBi | Q9P2S6 |
TreeFami | TF328860 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR003409, MORN IPR002893, Znf_MYND |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 2 hits PF02493, MORN, 3 hits PF01753, zf-MYND, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00698, MORN, 3 hits |
SUPFAMi | SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 2 hits PS50088, ANK_REPEAT, 4 hits PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P2S6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYQGEFGLNM KLGYGKFSWP TGESYHGQFY RDHCHGLGTY MWPDGSSFTG
60 70 80 90 100
TFYLSHREGY GTMYMKTRLF QGLYKADQRF GPGVETYPDG SQDVGLWFRE
110 120 130 140 150
QLIKLCTQIP SGFSLLRYPE FSSFITHSPA RISLSEEEKT EWGLQEGQDP
160 170 180 190 200
FFYDYKRFLL NDNLTLPPEM YVYSTNSDHL PMTSSFRKEL DARIFLNEIP
210 220 230 240 250
PFVEDGEPWF IINETPLLVK IQKQTYKFRN KPAHTSWNMG AILEGKRSGF
260 270 280 290 300
APCGPKEQLS MEMILKAEEG NHEWICRILK DNFASADVAD AKGYTVLAAA
310 320 330 340 350
ATHCHNDIVN LLLDCGADVN KCSDEGLTAL SMCFLLHYPA QSFKPNVAER
360 370 380 390 400
TIPEPQEPPK FPVVPILSSS FMDTNLESLY YEVNVPSQGS YELRPPPAPL
410 420 430 440 450
LLPRVSGSHE GGHFQDTGQC GGSIDHRSSS LKGDSPLVKG SLGHVESGLE
460 470 480 490 500
DVLGNTDRGS LCSAETKFES NVCVCDFSIE LSQAMLERSA QSHSLLKMAS
510 520 530 540 550
PSPCTSSFDK GTMRRMALSM IERRKRWRTI KLLLRRGADP NLCCVPMQVL
560 570 580 590 600
FLAVKAGDVD GVRLLLEHGA RTDICFPPQL STLTPLHIAA ALPGEEGVQI
610 620 630 640 650
VELLLHAITD VDAKASDEDD TYKPGKLDLL PSSLKLSNEP GPPQAYYSTD
660 670 680 690 700
TALPEEGGRT ALHMACERED DNKCARDIVR LLLSHGANPN LLWSGHSPLS
710 720 730 740 750
LSIASGNELV VKELLTQGAD PNLPLTKGLG SALCVACDLT YEHQRNMDSK
760 770 780 790 800
LALIDRLISH GADILKPVML RQGEKEAVGT AVDYGYFRFF QDRRIARCPF
810 820 830 840 850
HTLMPAERET FLARKRLLEY MGLQLRQAVF AKESQWDPTW LYLCKRAELI
860 870 880 890 900
PSHRMKKKGP SLPRGLDVKE QGQIPFFKFC YQCGRSIGVR LLPCPRCYGI
910 920 930 940
LTCSKYCKTK AWTEFHKKDC GDLVAIVTQL EQVSRRREEF Q
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KPY5 | J3KPY5_HUMAN | Ankyrin repeat and MYND domain-cont... | ANKMY1 | 843 | Annotation score: | ||
B5MBY4 | B5MBY4_HUMAN | Ankyrin repeat and MYND domain cont... | ANKMY1 hCG_1811573 | 702 | Annotation score: | ||
J3KQ21 | J3KQ21_HUMAN | Ankyrin repeat and MYND domain-cont... | ANKMY1 | 1,030 | Annotation score: | ||
Q6GPI0 | Q6GPI0_HUMAN | ANKMY1 protein | ANKMY1 | 720 | Annotation score: | ||
C9JGS7 | C9JGS7_HUMAN | Ankyrin repeat and MYND domain-cont... | ANKMY1 | 74 | Annotation score: | ||
H7BYI0 | H7BYI0_HUMAN | Ankyrin repeat and MYND domain-cont... | ANKMY1 | 190 | Annotation score: | ||
C9J5V7 | C9J5V7_HUMAN | Ankyrin repeat and MYND domain-cont... | ANKMY1 | 168 | Annotation score: | ||
Q5CZB7 | Q5CZB7_HUMAN | Ankyrin repeat and MYND domain-cont... | ANKMY1 DKFZp686L21237 | 246 | Annotation score: | ||
C9JZ56 | C9JZ56_HUMAN | Ankyrin repeat and MYND domain-cont... | ANKMY1 | 227 | Annotation score: | ||
J3KQ07 | J3KQ07_HUMAN | Ankyrin repeat and MYND domain-cont... | ANKMY1 | 292 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 455 | N → D in CAB66553 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 531 | K → E in BAA91213 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048264 | 89 | D → N. Corresponds to variant dbSNP:rs35278753Ensembl. | 1 | |
Natural variantiVAR_048265 | 424 | I → M1 PublicationCorresponds to variant dbSNP:rs35996697Ensembl. | 1 | |
Natural variantiVAR_048266 | 451 | D → V. Corresponds to variant dbSNP:rs3796118Ensembl. | 1 | |
Natural variantiVAR_048267 | 472 | V → L2 PublicationsCorresponds to variant dbSNP:rs3821348Ensembl. | 1 | |
Natural variantiVAR_048268 | 649 | T → M. Corresponds to variant dbSNP:rs35044862Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007442 | 1 – 301 | MYQGE…LAAAA → MEGAHASLSLEDEVSGAGSR QRPLEGKGGETPAAEEPGSL KNYAVFATRDVSAAPEKEEE EAEGPLRAQDLRESYIQLVQ GVQEWQDGCMYQGEFGLNMK LGYGKFSWPTGESYHGQFYR DHCHGLGTYMWPDGSSFTGT FYLSHREGYGTMYMKTRLFQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 301 | |
Alternative sequenceiVSP_039104 | 72 – 301 | Missing in isoform 4. 1 PublicationAdd BLAST | 230 | |
Alternative sequenceiVSP_007443 | 580 | L → C in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_007444 | 581 – 941 | Missing in isoform 3. 1 PublicationAdd BLAST | 361 | |
Alternative sequenceiVSP_007445 | 627 – 709 | Missing in isoform 2. 1 PublicationAdd BLAST | 83 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB034636 mRNA Translation: BAA92844.1 AK000506 mRNA Translation: BAA91213.1 AK314534 mRNA Translation: BAG37125.1 AC124862 Genomic DNA Translation: AAX88942.1 CH471063 Genomic DNA Translation: EAW71190.1 BC033495 mRNA Translation: AAH33495.1 AL136618 mRNA Translation: CAB66553.1 AL833866 mRNA Translation: CAD38724.1 |
CCDSi | CCDS2535.1 [Q9P2S6-2] CCDS2536.1 [Q9P2S6-1] |
RefSeqi | NP_001269709.1, NM_001282780.1 NP_001269710.1, NM_001282781.1 NP_001295304.1, NM_001308375.1 NP_057636.2, NM_016552.3 [Q9P2S6-1] NP_060314.2, NM_017844.3 [Q9P2S6-2] |
Genome annotation databases
Ensembli | ENST00000272972; ENSP00000272972; ENSG00000144504 [Q9P2S6-1] ENST00000361678; ENSP00000355097; ENSG00000144504 [Q9P2S6-2] ENST00000405523; ENSP00000385635; ENSG00000144504 [Q9P2S6-3] |
GeneIDi | 51281 |
KEGGi | hsa:51281 |
UCSCi | uc002vyz.3, human [Q9P2S6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB034636 mRNA Translation: BAA92844.1 AK000506 mRNA Translation: BAA91213.1 AK314534 mRNA Translation: BAG37125.1 AC124862 Genomic DNA Translation: AAX88942.1 CH471063 Genomic DNA Translation: EAW71190.1 BC033495 mRNA Translation: AAH33495.1 AL136618 mRNA Translation: CAB66553.1 AL833866 mRNA Translation: CAD38724.1 |
CCDSi | CCDS2535.1 [Q9P2S6-2] CCDS2536.1 [Q9P2S6-1] |
RefSeqi | NP_001269709.1, NM_001282780.1 NP_001269710.1, NM_001282781.1 NP_001295304.1, NM_001308375.1 NP_057636.2, NM_016552.3 [Q9P2S6-1] NP_060314.2, NM_017844.3 [Q9P2S6-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119433, 2 interactors |
STRINGi | 9606.ENSP00000385887 |
PTM databases
iPTMneti | Q9P2S6 |
PhosphoSitePlusi | Q9P2S6 |
Genetic variation databases
BioMutai | ANKMY1 |
DMDMi | 30912747 |
Proteomic databases
MassIVEi | Q9P2S6 |
PaxDbi | Q9P2S6 |
PeptideAtlasi | Q9P2S6 |
PRIDEi | Q9P2S6 |
ProteomicsDBi | 83890 [Q9P2S6-1] 83891 [Q9P2S6-2] 83892 [Q9P2S6-3] 83893 [Q9P2S6-4] |
Protocols and materials databases
Antibodypediai | 20289, 115 antibodies |
DNASUi | 51281 |
Genome annotation databases
Ensembli | ENST00000272972; ENSP00000272972; ENSG00000144504 [Q9P2S6-1] ENST00000361678; ENSP00000355097; ENSG00000144504 [Q9P2S6-2] ENST00000405523; ENSP00000385635; ENSG00000144504 [Q9P2S6-3] |
GeneIDi | 51281 |
KEGGi | hsa:51281 |
UCSCi | uc002vyz.3, human [Q9P2S6-1] |
Organism-specific databases
CTDi | 51281 |
DisGeNETi | 51281 |
GeneCardsi | ANKMY1 |
HGNCi | HGNC:20987, ANKMY1 |
HPAi | ENSG00000144504, Tissue enhanced (testis) |
neXtProti | NX_Q9P2S6 |
OpenTargetsi | ENSG00000144504 |
PharmGKBi | PA134925670 |
VEuPathDBi | HostDB:ENSG00000144504.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQJP, Eukaryota |
GeneTreei | ENSGT00460000041630 |
HOGENOMi | CLU_050860_0_0_1 |
InParanoidi | Q9P2S6 |
OrthoDBi | 323321at2759 |
PhylomeDBi | Q9P2S6 |
TreeFami | TF328860 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2S6 |
Miscellaneous databases
BioGRID-ORCSi | 51281, 4 hits in 995 CRISPR screens |
ChiTaRSi | ANKMY1, human |
GenomeRNAii | 51281 |
Pharosi | Q9P2S6, Tbio |
PROi | PR:Q9P2S6 |
RNActi | Q9P2S6, protein |
Gene expression databases
Bgeei | ENSG00000144504, Expressed in right testis and 172 other tissues |
ExpressionAtlasi | Q9P2S6, baseline and differential |
Genevisiblei | Q9P2S6, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR003409, MORN IPR002893, Znf_MYND |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 2 hits PF02493, MORN, 3 hits PF01753, zf-MYND, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00698, MORN, 3 hits |
SUPFAMi | SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 2 hits PS50088, ANK_REPEAT, 4 hits PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANKY1_HUMAN | |
Accessioni | Q9P2S6Primary (citable) accession number: Q9P2S6 Secondary accession number(s): B2RB78 Q9NX10 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2003 |
Last sequence update: | May 16, 2003 | |
Last modified: | April 7, 2021 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports