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UniProtKB - Q9P2S6 (ANKY1_HUMAN)

Entry version 159 (07 Apr 2021)
Sequence version 2 (16 May 2003)
Previous versions | rss
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Protein

Ankyrin repeat and MYND domain-containing protein 1

Gene

ANKMY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri880 – 920MYND-typePROSITE-ProRule annotationAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9P2S6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and MYND domain-containing protein 1
Alternative name(s):
Testis-specific ankyrin-like protein 1
Zinc finger MYND domain-containing protein 13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKMY1
Synonyms:TSAL1, ZMYND13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20987, ANKMY1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P2S6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000144504.15

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51281

Open Targets

More...OpenTargetsi		ENSG00000144504

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134925670

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P2S6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ANKMY1

Domain mapping of disease mutations (DMDM)

More...DMDMi		30912747

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000668941 – 941Ankyrin repeat and MYND domain-containing protein 1Add BLAST941

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P2S6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P2S6

PeptideAtlas

More...PeptideAtlasi		Q9P2S6

PRoteomics IDEntifications database

More...PRIDEi		Q9P2S6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83890 [Q9P2S6-1]
83891 [Q9P2S6-2]
83892 [Q9P2S6-3]
83893 [Q9P2S6-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P2S6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P2S6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144504, Expressed in right testis and 172 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9P2S6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P2S6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000144504, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119433, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385887

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9P2S6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2 – 24MORN 1Add BLAST23
Repeati25 – 47MORN 2Add BLAST23
Repeati70 – 92MORN 3Add BLAST23
Repeati292 – 321ANK 1Add BLAST30
Repeati513 – 542ANK 2Add BLAST30
Repeati545 – 574ANK 3Add BLAST30
Repeati581 – 613ANK 4Add BLAST33
Repeati657 – 691ANK 5Add BLAST35
Repeati694 – 723ANK 6Add BLAST30
Repeati737 – 766ANK 7Add BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri880 – 920MYND-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQJP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00460000041630

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_050860_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P2S6

Database of Orthologous Groups

More...OrthoDBi		323321at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P2S6

TreeFam database of animal gene trees

More...TreeFami		TF328860

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR003409, MORN
IPR002893, Znf_MYND

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 2 hits
PF02493, MORN, 3 hits
PF01753, zf-MYND, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits
SM00698, MORN, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 2 hits
PS50088, ANK_REPEAT, 4 hits
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2S6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYQGEFGLNM KLGYGKFSWP TGESYHGQFY RDHCHGLGTY MWPDGSSFTG 
        60         70         80         90        100
TFYLSHREGY GTMYMKTRLF QGLYKADQRF GPGVETYPDG SQDVGLWFRE 
       110        120        130        140        150
QLIKLCTQIP SGFSLLRYPE FSSFITHSPA RISLSEEEKT EWGLQEGQDP 
       160        170        180        190        200
FFYDYKRFLL NDNLTLPPEM YVYSTNSDHL PMTSSFRKEL DARIFLNEIP 
       210        220        230        240        250
PFVEDGEPWF IINETPLLVK IQKQTYKFRN KPAHTSWNMG AILEGKRSGF 
       260        270        280        290        300
APCGPKEQLS MEMILKAEEG NHEWICRILK DNFASADVAD AKGYTVLAAA 
       310        320        330        340        350
ATHCHNDIVN LLLDCGADVN KCSDEGLTAL SMCFLLHYPA QSFKPNVAER 
       360        370        380        390        400
TIPEPQEPPK FPVVPILSSS FMDTNLESLY YEVNVPSQGS YELRPPPAPL 
       410        420        430        440        450
LLPRVSGSHE GGHFQDTGQC GGSIDHRSSS LKGDSPLVKG SLGHVESGLE 
       460        470        480        490        500
DVLGNTDRGS LCSAETKFES NVCVCDFSIE LSQAMLERSA QSHSLLKMAS 
       510        520        530        540        550
PSPCTSSFDK GTMRRMALSM IERRKRWRTI KLLLRRGADP NLCCVPMQVL 
       560        570        580        590        600
FLAVKAGDVD GVRLLLEHGA RTDICFPPQL STLTPLHIAA ALPGEEGVQI 
       610        620        630        640        650
VELLLHAITD VDAKASDEDD TYKPGKLDLL PSSLKLSNEP GPPQAYYSTD 
       660        670        680        690        700
TALPEEGGRT ALHMACERED DNKCARDIVR LLLSHGANPN LLWSGHSPLS 
       710        720        730        740        750
LSIASGNELV VKELLTQGAD PNLPLTKGLG SALCVACDLT YEHQRNMDSK 
       760        770        780        790        800
LALIDRLISH GADILKPVML RQGEKEAVGT AVDYGYFRFF QDRRIARCPF 
       810        820        830        840        850
HTLMPAERET FLARKRLLEY MGLQLRQAVF AKESQWDPTW LYLCKRAELI 
       860        870        880        890        900
PSHRMKKKGP SLPRGLDVKE QGQIPFFKFC YQCGRSIGVR LLPCPRCYGI 
       910        920        930        940 
LTCSKYCKTK AWTEFHKKDC GDLVAIVTQL EQVSRRREEF Q
Length:941
Mass (Da):105,516
Last modified:May 16, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6FCEE5C22EBD30A
GO
Isoform 2 (identifier: Q9P2S6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-301: MYQGEFGLNM...KGYTVLAAAA → MEGAHASLSL...TMYMKTRLFQ
     627-709: Missing.

Show »
Length:717
Mass (Da):79,878
Checksum:iF4CBCCEA5CDC79D4
GO
Isoform 3 (identifier: Q9P2S6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-301: MYQGEFGLNM...KGYTVLAAAA → MEGAHASLSL...TMYMKTRLFQ
     580-580: L → C
     581-941: Missing.

Show »
Length:439
Mass (Da):48,326
Checksum:i8D1069B175FD63FD
GO
Isoform 4 (identifier: Q9P2S6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-301: Missing.

Show »
Length:711
Mass (Da):79,259
Checksum:i4A64601EDD4DA741
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPY5J3KPY5_HUMAN
Ankyrin repeat and MYND domain-cont...
ANKMY1
843Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MBY4B5MBY4_HUMAN
Ankyrin repeat and MYND domain cont...
ANKMY1 hCG_1811573
702Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQ21J3KQ21_HUMAN
Ankyrin repeat and MYND domain-cont...
ANKMY1
1,030Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6GPI0Q6GPI0_HUMAN
ANKMY1 protein
ANKMY1
720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGS7C9JGS7_HUMAN
Ankyrin repeat and MYND domain-cont...
ANKMY1
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYI0H7BYI0_HUMAN
Ankyrin repeat and MYND domain-cont...
ANKMY1
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5V7C9J5V7_HUMAN
Ankyrin repeat and MYND domain-cont...
ANKMY1
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5CZB7Q5CZB7_HUMAN
Ankyrin repeat and MYND domain-cont...
ANKMY1 DKFZp686L21237
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ56C9JZ56_HUMAN
Ankyrin repeat and MYND domain-cont...
ANKMY1
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQ07J3KQ07_HUMAN
Ankyrin repeat and MYND domain-cont...
ANKMY1
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti455N → D in CAB66553 (PubMed:11230166).Curated1
Sequence conflicti531K → E in BAA91213 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04826489D → N. Corresponds to variant dbSNP:rs35278753Ensembl.1
Natural variantiVAR_048265424I → M1 PublicationCorresponds to variant dbSNP:rs35996697Ensembl.1
Natural variantiVAR_048266451D → V. Corresponds to variant dbSNP:rs3796118Ensembl.1
Natural variantiVAR_048267472V → L2 PublicationsCorresponds to variant dbSNP:rs3821348Ensembl.1
Natural variantiVAR_048268649T → M. Corresponds to variant dbSNP:rs35044862Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0074421 – 301MYQGE…LAAAA → MEGAHASLSLEDEVSGAGSR QRPLEGKGGETPAAEEPGSL KNYAVFATRDVSAAPEKEEE EAEGPLRAQDLRESYIQLVQ GVQEWQDGCMYQGEFGLNMK LGYGKFSWPTGESYHGQFYR DHCHGLGTYMWPDGSSFTGT FYLSHREGYGTMYMKTRLFQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST301
Alternative sequenceiVSP_03910472 – 301Missing in isoform 4. 1 PublicationAdd BLAST230
Alternative sequenceiVSP_007443580L → C in isoform 3. 1 Publication1
Alternative sequenceiVSP_007444581 – 941Missing in isoform 3. 1 PublicationAdd BLAST361
Alternative sequenceiVSP_007445627 – 709Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB034636 mRNA Translation: BAA92844.1
AK000506 mRNA Translation: BAA91213.1
AK314534 mRNA Translation: BAG37125.1
AC124862 Genomic DNA Translation: AAX88942.1
CH471063 Genomic DNA Translation: EAW71190.1
BC033495 mRNA Translation: AAH33495.1
AL136618 mRNA Translation: CAB66553.1
AL833866 mRNA Translation: CAD38724.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2535.1 [Q9P2S6-2]
CCDS2536.1 [Q9P2S6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001269709.1, NM_001282780.1
NP_001269710.1, NM_001282781.1
NP_001295304.1, NM_001308375.1
NP_057636.2, NM_016552.3 [Q9P2S6-1]
NP_060314.2, NM_017844.3 [Q9P2S6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000272972; ENSP00000272972; ENSG00000144504 [Q9P2S6-1]
ENST00000361678; ENSP00000355097; ENSG00000144504 [Q9P2S6-2]
ENST00000405523; ENSP00000385635; ENSG00000144504 [Q9P2S6-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51281

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51281

UCSC genome browser

More...UCSCi		uc002vyz.3, human [Q9P2S6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034636 mRNA Translation: BAA92844.1
AK000506 mRNA Translation: BAA91213.1
AK314534 mRNA Translation: BAG37125.1
AC124862 Genomic DNA Translation: AAX88942.1
CH471063 Genomic DNA Translation: EAW71190.1
BC033495 mRNA Translation: AAH33495.1
AL136618 mRNA Translation: CAB66553.1
AL833866 mRNA Translation: CAD38724.1
CCDSiCCDS2535.1 [Q9P2S6-2]
CCDS2536.1 [Q9P2S6-1]
RefSeqiNP_001269709.1, NM_001282780.1
NP_001269710.1, NM_001282781.1
NP_001295304.1, NM_001308375.1
NP_057636.2, NM_016552.3 [Q9P2S6-1]
NP_060314.2, NM_017844.3 [Q9P2S6-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119433, 2 interactors
STRINGi9606.ENSP00000385887

PTM databases

iPTMnetiQ9P2S6
PhosphoSitePlusiQ9P2S6

Genetic variation databases

BioMutaiANKMY1
DMDMi30912747

Proteomic databases

MassIVEiQ9P2S6
PaxDbiQ9P2S6
PeptideAtlasiQ9P2S6
PRIDEiQ9P2S6
ProteomicsDBi83890 [Q9P2S6-1]
83891 [Q9P2S6-2]
83892 [Q9P2S6-3]
83893 [Q9P2S6-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20289, 115 antibodies

The DNASU plasmid repository

More...DNASUi		51281

Genome annotation databases

EnsembliENST00000272972; ENSP00000272972; ENSG00000144504 [Q9P2S6-1]
ENST00000361678; ENSP00000355097; ENSG00000144504 [Q9P2S6-2]
ENST00000405523; ENSP00000385635; ENSG00000144504 [Q9P2S6-3]
GeneIDi51281
KEGGihsa:51281
UCSCiuc002vyz.3, human [Q9P2S6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51281
DisGeNETi51281

GeneCards: human genes, protein and diseases

More...GeneCardsi		ANKMY1
HGNCiHGNC:20987, ANKMY1
HPAiENSG00000144504, Tissue enhanced (testis)
neXtProtiNX_Q9P2S6
OpenTargetsiENSG00000144504
PharmGKBiPA134925670
VEuPathDBiHostDB:ENSG00000144504.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQJP, Eukaryota
GeneTreeiENSGT00460000041630
HOGENOMiCLU_050860_0_0_1
InParanoidiQ9P2S6
OrthoDBi323321at2759
PhylomeDBiQ9P2S6
TreeFamiTF328860

Enzyme and pathway databases

PathwayCommonsiQ9P2S6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51281, 4 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ANKMY1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51281
PharosiQ9P2S6, Tbio

Protein Ontology

More...PROi		PR:Q9P2S6
RNActiQ9P2S6, protein

Gene expression databases

BgeeiENSG00000144504, Expressed in right testis and 172 other tissues
ExpressionAtlasiQ9P2S6, baseline and differential
GenevisibleiQ9P2S6, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR003409, MORN
IPR002893, Znf_MYND
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 2 hits
PF02493, MORN, 3 hits
PF01753, zf-MYND, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00698, MORN, 3 hits
SUPFAMiSSF48403, SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 2 hits
PS50088, ANK_REPEAT, 4 hits
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANKY1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2S6
Secondary accession number(s): B2RB78
, Q4ZFV3, Q8IYX5, Q8NDK5, Q9H0V8, Q9NX10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 16, 2003
Last modified: April 7, 2021
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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