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Entry version 181 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Neurexin-2

Gene

NRXN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi335CalciumBy similarity1
Metal bindingi352Calcium; via carbonyl oxygenBy similarity1
Metal bindingi420Calcium; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9P2S2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6794361, Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurexin-2
Alternative name(s):
Neurexin II-alpha
Neurexin-2-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRXN2
Synonyms:KIAA0921
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110076.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8009, NRXN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600566, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P2S2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 1636ExtracellularSequence analysisAdd BLAST1608
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1637 – 1657HelicalSequence analysisAdd BLAST21
Topological domaini1658 – 1712CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9379

Open Targets

More...
OpenTargetsi
ENSG00000110076

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31787

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P2S2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NRXN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17369343

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001949529 – 1712Neurexin-2Add BLAST1684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi206 ↔ 219By similarity
Disulfide bondi213 ↔ 229By similarity
Disulfide bondi231 ↔ 241By similarity
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi450 ↔ 486By similarity
Disulfide bondi657 ↔ 686By similarity
Disulfide bondi694 ↔ 705By similarity
Disulfide bondi699 ↔ 714By similarity
Disulfide bondi716 ↔ 726By similarity
Glycosylationi841N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1065 ↔ 1093By similarity
Disulfide bondi1100 ↔ 1111By similarity
Disulfide bondi1105 ↔ 1120By similarity
Disulfide bondi1122 ↔ 1132By similarity
Glycosylationi1236N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P2S2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9P2S2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2S2

PeptideAtlas

More...
PeptideAtlasi
Q9P2S2

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2S2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83887 [Q9P2S2-1]
83888 [Q9P2S2-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9P2S2, 5 sites, 2 O-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2S2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2S2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110076, Expressed in cerebellar cortex and 180 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P2S2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P2S2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000110076, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The laminin G-like domain 1 binds to NXPH1.

Interacts with PATJ (By similarity).

Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity). Isoforms alpha 2C bind to alpha-dystroglycan (By similarity).

Interacts (via Laminin G-like 1 domain) with IGSF21 (Ig-like 1 domain) in a trans-interaction manner (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114780, 6 interactors

Protein interaction database and analysis system

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IntActi
Q9P2S2, 3 interactors

Molecular INTeraction database

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MINTi
Q9P2S2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265459

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P2S2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P2S2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 206Laminin G-like 1PROSITE-ProRule annotationAdd BLAST178
Domaini202 – 242EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini289 – 486Laminin G-like 2PROSITE-ProRule annotationAdd BLAST198
Domaini493 – 686Laminin G-like 3PROSITE-ProRule annotationAdd BLAST194
Domaini690 – 727EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini732 – 904Laminin G-like 4PROSITE-ProRule annotationAdd BLAST173
Domaini918 – 1093Laminin G-like 5PROSITE-ProRule annotationAdd BLAST176
Domaini1096 – 1133EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini1137 – 1345Laminin G-like 6PROSITE-ProRule annotationAdd BLAST209

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1368 – 1371Poly-Thr4
Compositional biasi1374 – 1377Poly-Thr4
Compositional biasi1444 – 1447Poly-Pro4
Compositional biasi1644 – 1647Poly-Ala4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3514, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155978

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001710_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P2S2

KEGG Orthology (KO)

More...
KOi
K07377

Identification of Orthologs from Complete Genome Data

More...
OMAi
QPRDIKC

Database of Orthologous Groups

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OrthoDBi
35129at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P2S2

TreeFam database of animal gene trees

More...
TreeFami
TF321302

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR001791, Laminin_G
IPR003585, Neurexin-like
IPR027789, Syndecan/Neurexin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02210, Laminin_G_2, 6 hits
PF01034, Syndecan, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00294, 4.1m, 1 hit
SM00181, EGF, 3 hits
SM00282, LamG, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50026, EGF_3, 3 hits
PS50025, LAM_G_DOMAIN, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist.

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1a (identifier: Q9P2S2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGSRWRPT PPPLLLLLLL ALAARADGLE FGGGPGQWAR YARWAGAASS
60 70 80 90 100
GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT
110 120 130 140 150
LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL
160 170 180 190 200
FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA
210 220 230 240 250
TADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEEEHPMEG
260 270 280 290 300
PAHLTLNSEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
310 320 330 340 350
DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI
360 370 380 390 400
NLGSGAFEAL VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV
410 420 430 440 450
TISVDGILTT TGYTQEDYTM LGSDDFFYIG GSPNTADLPG SPVSNNFMGC
460 470 480 490 500
LKDVVYKNND FKLELSRLAK EGDPKMKLQG DLSFRCEDVA ALDPVTFESP
510 520 530 540 550
EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGG GAGSHSSAQR
560 570 580 590 600
ADYFAMELLD GHLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG
610 620 630 640 650
SISVNSRSTP FLATGDSEIL DLESELYLGG LPEGGRVDLP LPPEVWTAAL
660 670 680 690 700
RAGYVGCVRD LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR
710 720 730 740 750
NGGVCREGWN RFICDCIGTG FLGRVCEREA TVLSYDGSMY MKIMLPNAMH
760 770 780 790 800
TEAEDVSLRF MSQRAYGLMM ATTSRESADT LRLELDGGQM KLTVNLDCLR
810 820 830 840 850
VGCAPSKGPE TLFAGHKLND NEWHTVRVVR RGKSLQLSVD NVTVEGQMAG
860 870 880 890 900
AHMRLEFHNI ETGIMTERRF ISVVPSNFIG HLSGLVFNGQ PYMDQCKDGD
910 920 930 940 950
ITYCELNARF GLRAIVADPV TFKSRSSYLA LATLQAYASM HLFFQFKTTA
960 970 980 990 1000
PDGLLLFNSG NGNDFIVIEL VKGYIHYVFD LGNGPSLMKG NSDKPVNDNQ
1010 1020 1030 1040 1050
WHNVVVSRDP GNVHTLKIDS RTVTQHSNGA RNLDLKGELY IGGLSKNMFS
1060 1070 1080 1090 1100
NLPKLVASRD GFQGCLASVD LNGRLPDLIA DALHRIGQVE RGCDGPSTTC
1110 1120 1130 1140 1150
TEESCANQGV CLQQWDGFTC DCTMTSYGGP VCNDPGTTYI FGKGGALITY
1160 1170 1180 1190 1200
TWPPNDRPST RMDRLAVGFS THQRSAVLVR VDSASGLGDY LQLHIDQGTV
1210 1220 1230 1240 1250
GVIFNVGTDD ITIDEPNAIV SDGKYHVVRF TRSGGNATLQ VDSWPVNERY
1260 1270 1280 1290 1300
PAGNFDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN SQAAIKIGGR
1310 1320 1330 1340 1350
DQGRPFQGQV SGLYYNGLKV LALAAESDPN VRTEGHLRLV GEGPSVLLSA
1360 1370 1380 1390 1400
ETTATTLLAD MATTIMETTT TMATTTTRRG RSPTLRDSTT QNTDDLLVAS
1410 1420 1430 1440 1450
AECPSDDEDL EECEPSTGGE LILPIITEDS LDPPPVATRS PFVPPPPTFY
1460 1470 1480 1490 1500
PFLTGVGATQ DTLPPPAARR PPSGGPCQAE RDDSDCEEPI EASGFASGEV
1510 1520 1530 1540 1550
FDSSLPPTDD EDFYTTFPLV TDRTTLLSPR KPAPRPNLRT DGATGAPGVL
1560 1570 1580 1590 1600
FAPSAPAPNL PAGKMNHRDP LQPLLENPPL GPGAPTSFEP RRPPPLRPGV
1610 1620 1630 1640 1650
TSAPGFPHLP TANPTGPGER GPPGAVEVIR ESSSTTGMVV GIVAAAALCI
1660 1670 1680 1690 1700
LILLYAMYKY RNRDEGSYQV DQSRNYISNS AQSNGAVVKE KAPAAPKTPS
1710
KAKKNKDKEY YV
Length:1,712
Mass (Da):184,982
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4E8EC404DA1D0B0
GO
Isoform 2a (identifier: Q9P2S2-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-2B

The sequence of this isoform differs from the canonical sequence as follows:
     260-283: Missing.
     393-399: Missing.
     797-806: DCLRVGCAPS → G
     1253-1282: Missing.

Show »
Length:1,642
Mass (Da):177,293
Checksum:i68040E0B3E151C3A
GO
Isoform 1b (identifier: P58401-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P58401.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:666
Mass (Da):70,927
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9G7G5E9G7_HUMAN
Neurexin 2, isoform CRA_a
NRXN2 hCG_1810991
1,705Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2R8H7C2R8_HUMAN
Neurexin-2
NRXN2
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZC7H7BZC7_HUMAN
Neurexin-2
NRXN2
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3D6H7C3D6_HUMAN
Neurexin-2
NRXN2
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3J4H7C3J4_HUMAN
Neurexin-2
NRXN2
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76765 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05026681L → Q. Corresponds to variant dbSNP:rs12273892EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003505260 – 283Missing in isoform 2a. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_003506393 – 399Missing in isoform 2a. 2 Publications7
Alternative sequenceiVSP_003507797 – 806DCLRVGCAPS → G in isoform 2a. 2 Publications10
Alternative sequenceiVSP_0035081253 – 1282Missing in isoform 2a. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB035266 mRNA Translation: BAA94075.1
AB023138 mRNA Translation: BAA76765.2 Different initiation.
AC044790 Genomic DNA Translation: AAK68154.1
BC150275 mRNA Translation: AAI50276.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31597.1 [Q9P2S2-2]
CCDS8077.1 [Q9P2S2-1]

NCBI Reference Sequences

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RefSeqi
NP_055895.1, NM_015080.3 [Q9P2S2-1]
NP_620060.1, NM_138732.2 [Q9P2S2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265459; ENSP00000265459; ENSG00000110076 [Q9P2S2-1]
ENST00000377559; ENSP00000366782; ENSG00000110076 [Q9P2S2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9379

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9379

UCSC genome browser

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UCSCi
uc021qkw.2, human [Q9P2S2-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035266 mRNA Translation: BAA94075.1
AB023138 mRNA Translation: BAA76765.2 Different initiation.
AC044790 Genomic DNA Translation: AAK68154.1
BC150275 mRNA Translation: AAI50276.1
CCDSiCCDS31597.1 [Q9P2S2-2]
CCDS8077.1 [Q9P2S2-1]
RefSeqiNP_055895.1, NM_015080.3 [Q9P2S2-1]
NP_620060.1, NM_138732.2 [Q9P2S2-2]

3D structure databases

SMRiQ9P2S2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114780, 6 interactors
IntActiQ9P2S2, 3 interactors
MINTiQ9P2S2
STRINGi9606.ENSP00000265459

PTM databases

GlyGeniQ9P2S2, 5 sites, 2 O-linked glycans (1 site)
iPTMnetiQ9P2S2
PhosphoSitePlusiQ9P2S2

Polymorphism and mutation databases

BioMutaiNRXN2
DMDMi17369343

Proteomic databases

jPOSTiQ9P2S2
MassIVEiQ9P2S2
PaxDbiQ9P2S2
PeptideAtlasiQ9P2S2
PRIDEiQ9P2S2
ProteomicsDBi83887 [Q9P2S2-1]
83888 [Q9P2S2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
63686, 47 antibodies

Genome annotation databases

EnsembliENST00000265459; ENSP00000265459; ENSG00000110076 [Q9P2S2-1]
ENST00000377559; ENSP00000366782; ENSG00000110076 [Q9P2S2-2]
GeneIDi9379
KEGGihsa:9379
UCSCiuc021qkw.2, human [Q9P2S2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9379
DisGeNETi9379
EuPathDBiHostDB:ENSG00000110076.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NRXN2
HGNCiHGNC:8009, NRXN2
HPAiENSG00000110076, Tissue enriched (brain)
MIMi600566, gene
neXtProtiNX_Q9P2S2
OpenTargetsiENSG00000110076
PharmGKBiPA31787

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3514, Eukaryota
GeneTreeiENSGT00940000155978
HOGENOMiCLU_001710_1_0_1
InParanoidiQ9P2S2
KOiK07377
OMAiQPRDIKC
OrthoDBi35129at2759
PhylomeDBiQ9P2S2
TreeFamiTF321302

Enzyme and pathway databases

PathwayCommonsiQ9P2S2
ReactomeiR-HSA-6794361, Neurexins and neuroligins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9379, 6 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NRXN2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9379
PharosiQ9P2S2, Tbio
RNActiQ9P2S2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110076, Expressed in cerebellar cortex and 180 other tissues
ExpressionAtlasiQ9P2S2, baseline and differential
GenevisibleiQ9P2S2, HS

Family and domain databases

InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR001791, Laminin_G
IPR003585, Neurexin-like
IPR027789, Syndecan/Neurexin_dom
PfamiView protein in Pfam
PF02210, Laminin_G_2, 6 hits
PF01034, Syndecan, 1 hit
SMARTiView protein in SMART
SM00294, 4.1m, 1 hit
SM00181, EGF, 3 hits
SM00282, LamG, 6 hits
SUPFAMiSSF49899, SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS50026, EGF_3, 3 hits
PS50025, LAM_G_DOMAIN, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRX2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2S2
Secondary accession number(s): A7E2C1, Q9Y2D6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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