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UniProtKB - Q9P2Q2 (FRM4A_HUMAN)

Entry version 162 (25 May 2022)
Sequence version 3 (02 Sep 2008)
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Protein

FERM domain-containing protein 4A

Gene

FRMD4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity).

Plays a redundant role with FRMD4B in epithelial polarization (By similarity).

May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754).

By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9P2Q2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9P2Q2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FERM domain-containing protein 4A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRMD4AImported
Synonyms:FRMD4, KIAA1294
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25491, FRMD4A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616305, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P2Q2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151474

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Agenesis of the corpus callosum, with facial anomalies and cerebellar ataxia (CCAFCA)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive intellectual disability syndrome characterized by congenital microcephaly, low anterior hairline, bitemporal narrowing, low-set protruding ears, strabismus and tented thick eyebrows with sparse hair in their medial segment.
Related information in OMIM

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		55691

MalaCards human disease database

More...MalaCardsi		FRMD4A
MIMi616819, phenotype

Open Targets

More...OpenTargetsi		ENSG00000151474

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		466688, Severe intellectual disability-corpus callosum agenesis-facial dysmorphism-cerebellar ataxia syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134946784

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P2Q2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FRMD4A

Domain mapping of disease mutations (DMDM)

More...DMDMi		205371790

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002194441 – 1039FERM domain-containing protein 4AAdd BLAST1039

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei530PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei615PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei711PhosphoserineBy similarity1
Modified residuei800PhosphoserineCombined sources1
Modified residuei872PhosphoserineCombined sources1
Modified residuei901PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9P2Q2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9P2Q2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P2Q2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9P2Q2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P2Q2

PeptideAtlas

More...PeptideAtlasi		Q9P2Q2

PRoteomics IDEntifications database

More...PRIDEi		Q9P2Q2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83879

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P2Q2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P2Q2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151474, Expressed in forebrain and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9P2Q2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P2Q2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151474, Tissue enhanced (adipose)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via coiled-coil domain) with CYTH1 (via coiled-coil domain).

Interacts with PARD3 (via coiled-coil domain).

Found in a complex with PARD3, CYTH1 and FRMD4A.

Interacts with CYTH2.

Interacts with CYTH3.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120817, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q9P2Q2, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000350032

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9P2Q2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9P2Q2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9P2Q2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 322FERMPROSITE-ProRule annotationAdd BLAST303

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni358 – 420Necessary for interaction with CYTH1By similarityAdd BLAST63
Regioni366 – 386DisorderedSequence analysisAdd BLAST21
Regioni553 – 680DisorderedSequence analysisAdd BLAST128
Regioni579 – 939Necessary for tight junction and adherens junction localization; Requires for interaction with PARD3By similarityAdd BLAST361
Regioni713 – 756DisorderedSequence analysisAdd BLAST44
Regioni772 – 813DisorderedSequence analysisAdd BLAST42
Regioni879 – 968DisorderedSequence analysisAdd BLAST90
Regioni980 – 1039DisorderedSequence analysisAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili382 – 416Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi569 – 584Pro residuesSequence analysisAdd BLAST16
Compositional biasi593 – 607Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi634 – 676Polar residuesSequence analysisAdd BLAST43
Compositional biasi788 – 802Polar residuesSequence analysisAdd BLAST15
Compositional biasi933 – 947Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi948 – 968Polar residuesSequence analysisAdd BLAST21
Compositional biasi983 – 1039Polar residuesSequence analysisAdd BLAST57

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3529, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01020000230354

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P2Q2

Identification of Orthologs from Complete Genome Data

More...OMAi		XSQESDS

Database of Orthologous Groups

More...OrthoDBi		125121at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P2Q2

TreeFam database of animal gene trees

More...TreeFami		TF328984

Family and domain databases

Conserved Domains Database

More...CDDi		cd14473, FERM_B-lobe, 1 hit
cd13191, FERM_C_FRMD4A_FRMD4B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019749, Band_41_domain
IPR021774, DUF3338
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR041785, FRMD4A/B_FERM_C
IPR011993, PH-like_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11819, CUPID, 1 hit
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00935, BAND41

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00295, B41, 1 hit
SM01196, FERM_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47031, SSF47031, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All

Q9P2Q2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVQLVPDSA LGLLMMTEGR RCQVHLLDDR KLELLVQPKL LAKELLDLVA 
        60         70         80         90        100
SHFNLKEKEY FGIAFTDETG HLNWLQLDRR VLEHDFPKKS GPVVLYFCVR 
       110        120        130        140        150
FYIESISYLK DNATIELFFL NAKSCIYKEL IDVDSEVVFE LASYILQEAK 
       160        170        180        190        200
GDFSSNEVVR SDLKKLPALP TQALKEHPSL AYCEDRVIEH YKKLNGQTRG 
       210        220        230        240        250
QAIVNYMSIV ESLPTYGVHY YAVKDKQGIP WWLGLSYKGI FQYDYHDKVK 
       260        270        280        290        300
PRKIFQWRQL ENLYFREKKF SVEVHDPRRA SVTRRTFGHS GIAVHTWYAC 
       310        320        330        340        350
PALIKSIWAM AISQHQFYLD RKQSKSKIHA ARSLSEIAID LTETGTLKTS 
       360        370        380        390        400
KLANMGSKGK IISGSSGSLL SSGSQESDSS QSAKKDMLAA LKSRQEALEE 
       410        420        430        440        450
TLRQRLEELK KLCLREAELT GKLPVEYPLD PGEEPPIVRR RIGTAFKLDE 
       460        470        480        490        500
QKILPKGEEA ELERLEREFA IQSQITEAAR RLASDPNVSK KLKKQRKTSY 
       510        520        530        540        550
LNALKKLQEI ENAINENRIK SGKKPTQRAS LIIDDGNIAS EDSSLSDALV 
       560        570        580        590        600
LEDEDSQVTS TISPLHSPHK GLPPRPPSHN RPPPPQSLEG LRQMHYHRND 
       610        620        630        640        650
YDKSPIKPKM WSESSLDEPY EKVKKRSSHS HSSSHKRFPS TGSCAEAGGG 
       660        670        680        690        700
SNSLQNSPIR GLPHWNSQSS MPSTPDLRVR SPHYVHSTRS VDISPTRLHS 
       710        720        730        740        750
LALHFRHRSS SLESQGKLLG SENDTGSPDF YTPRTRSSNG SDPMDDCSSC 
       760        770        780        790        800
TSHSSSEHYY PAQMNANYST LAEDSPSKAR QRQRQRQRAA GALGSASSGS 
       810        820        830        840        850
MPNLAARGGA GGAGGAGGGV YLHSQSQPSS QYRIKEYPLY IEGGATPVVV 
       860        870        880        890        900
RSLESDQEGH YSVKAQFKTS NSYTAGGLFK ESWRGGGGDE GDTGRLTPSR 
       910        920        930        940        950
SQILRTPSLG REGAHDKGAG RAAVSDELRQ WYQRSTASHK EHSRLSHTSS 
       960        970        980        990       1000
TSSDSGSQYS TSSQSTFVAH SRVTRMPQMC KATSAALPQS QRSSTPSSEI 
      1010       1020       1030 
GATPPSSPHH ILTWQTGEAT ENSPILDGSE SPPHQSTDE
Length:1,039
Mass (Da):115,458
Last modified:September 2, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD895CD6B569A683F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T376Q5T376_HUMAN
FERM domain containing 4A, isoform ...
FRMD4A hCG_1811390
525Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YYA7A0A0J9YYA7_HUMAN
FERM domain-containing protein 4A
FRMD4A
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQE7A0A1W2PQE7_HUMAN
FERM domain-containing protein 4A
FRMD4A
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXB2A0A0J9YXB2_HUMAN
FERM domain-containing protein 4A
FRMD4A
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R324S4R324_HUMAN
FERM domain-containing protein 4A
FRMD4A
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3Y6S4R3Y6_HUMAN
FERM domain-containing protein 4A
FRMD4A
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWI3A0A0J9YWI3_HUMAN
FERM domain-containing protein 4A
FRMD4A
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISB3A0A3B3ISB3_HUMAN
FERM domain-containing protein 4A
FRMD4A
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS86A0A3B3IS86_HUMAN
FERM domain-containing protein 4A
FRMD4A
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISM0A0A3B3ISM0_HUMAN
FERM domain-containing protein 4A
FRMD4A
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92532 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti859G → C in BAA92532 (PubMed:10718198).Curated1
Sequence conflicti859G → C in AAI51245 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048367242Q → H. Corresponds to variant dbSNP:rs11258565Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB037715 mRNA Translation: BAA92532.1 Different initiation.
AK289693 mRNA Translation: BAF82382.1
AC069025 Genomic DNA No translation available.
AL157392 Genomic DNA No translation available.
AL365495 Genomic DNA No translation available.
BC151244 mRNA Translation: AAI51245.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7101.1

NCBI Reference Sequences

More...RefSeqi		NP_001305265.1, NM_001318336.1
NP_001305266.1, NM_001318337.1
NP_001305267.1, NM_001318338.1
NP_060497.3, NM_018027.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357447.7; ENSP00000350032.2; ENSG00000151474.23

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55691

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55691

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000357447.7; ENSP00000350032.2; NM_018027.5; NP_060497.3

UCSC genome browser

More...UCSCi		uc001ims.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037715 mRNA Translation: BAA92532.1 Different initiation.
AK289693 mRNA Translation: BAF82382.1
AC069025 Genomic DNA No translation available.
AL157392 Genomic DNA No translation available.
AL365495 Genomic DNA No translation available.
BC151244 mRNA Translation: AAI51245.1
CCDSiCCDS7101.1
RefSeqiNP_001305265.1, NM_001318336.1
NP_001305266.1, NM_001318337.1
NP_001305267.1, NM_001318338.1
NP_060497.3, NM_018027.4

3D structure databases

AlphaFoldDBiQ9P2Q2
SMRiQ9P2Q2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120817, 13 interactors
IntActiQ9P2Q2, 8 interactors
STRINGi9606.ENSP00000350032

PTM databases

iPTMnetiQ9P2Q2
PhosphoSitePlusiQ9P2Q2

Genetic variation databases

BioMutaiFRMD4A
DMDMi205371790

Proteomic databases

EPDiQ9P2Q2
jPOSTiQ9P2Q2
MassIVEiQ9P2Q2
MaxQBiQ9P2Q2
PaxDbiQ9P2Q2
PeptideAtlasiQ9P2Q2
PRIDEiQ9P2Q2
ProteomicsDBi83879

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50861, 46 antibodies from 10 providers

The DNASU plasmid repository

More...DNASUi		55691

Genome annotation databases

EnsembliENST00000357447.7; ENSP00000350032.2; ENSG00000151474.23
GeneIDi55691
KEGGihsa:55691
MANE-SelectiENST00000357447.7; ENSP00000350032.2; NM_018027.5; NP_060497.3
UCSCiuc001ims.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55691
DisGeNETi55691

GeneCards: human genes, protein and diseases

More...GeneCardsi		FRMD4A
HGNCiHGNC:25491, FRMD4A
HPAiENSG00000151474, Tissue enhanced (adipose)
MalaCardsiFRMD4A
MIMi616305, gene
616819, phenotype
neXtProtiNX_Q9P2Q2
OpenTargetsiENSG00000151474
Orphaneti466688, Severe intellectual disability-corpus callosum agenesis-facial dysmorphism-cerebellar ataxia syndrome
PharmGKBiPA134946784
VEuPathDBiHostDB:ENSG00000151474

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3529, Eukaryota
GeneTreeiENSGT01020000230354
InParanoidiQ9P2Q2
OMAiXSQESDS
OrthoDBi125121at2759
PhylomeDBiQ9P2Q2
TreeFamiTF328984

Enzyme and pathway databases

PathwayCommonsiQ9P2Q2
SignaLinkiQ9P2Q2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55691, 5 hits in 1076 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FRMD4A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55691
PharosiQ9P2Q2, Tbio

Protein Ontology

More...PROi		PR:Q9P2Q2
RNActiQ9P2Q2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151474, Expressed in forebrain and 226 other tissues
ExpressionAtlasiQ9P2Q2, baseline and differential
GenevisibleiQ9P2Q2, HS

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd13191, FERM_C_FRMD4A_FRMD4B, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR021774, DUF3338
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR041785, FRMD4A/B_FERM_C
IPR011993, PH-like_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF11819, CUPID, 1 hit
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PRINTSiPR00935, BAND41
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM01196, FERM_C, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRM4A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2Q2
Secondary accession number(s): A7E2Y3, Q5T377
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: September 2, 2008
Last modified: May 25, 2022
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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