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Entry version 125 (12 Aug 2020)
Sequence version 3 (15 Jan 2008)
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Protein

Protein NYNRIN

Gene

NYNRIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

The gene encoding this protein may have arisen from the fusion of a cellular gene with retroviral sequences prior to the marsupial-eutherian split. Sequence and structural analyses suggest that the integrase catalytic domain is inactive.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P2P1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NYNRIN
Alternative name(s):
NYN domain and retroviral integrase catalytic domain-containing protein
Protein cousin of GIN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NYNRIN
Synonyms:CGIN1, KIAA1305
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000205978.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20165, NYNRIN

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P2P1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1372 – 1392HelicalSequence analysisAdd BLAST21
Transmembranei1408 – 1428HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57523

Open Targets

More...
OpenTargetsi
ENSG00000205978

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165479228

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P2P1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NYNRIN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166218833

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003141741 – 1898Protein NYNRINAdd BLAST1898

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P2P1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P2P1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P2P1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P2P1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2P1

PeptideAtlas

More...
PeptideAtlasi
Q9P2P1

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2P1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83872 [Q9P2P1-1]
83873 [Q9P2P1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2P1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2P1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205978, Expressed in stomach and 165 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P2P1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000205978, Tissue enhanced (epididymis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121584, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P2P1, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371994

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P2P1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1609 – 1774Integrase catalyticPROSITE-ProRule annotationAdd BLAST166

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0017, Eukaryota
KOG3740, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161519

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_235862_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P2P1

Identification of Orthologs from Complete Genome Data

More...
OMAi
THMAVAQ

Database of Orthologous Groups

More...
OrthoDBi
583605at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P2P1

TreeFam database of animal gene trees

More...
TreeFami
TF351195

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 2 hits
3.30.70.270, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR001584, Integrase_cat-core
IPR041588, Integrase_H2C2
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR021869, RNase_Zc3h12_NYN
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR041577, RT_RNaseH_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17921, Integrase_H2C2, 1 hit
PF11977, RNase_Zc3h12a, 1 hit
PF17919, RT_RNaseH_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098, SSF53098, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50994, INTEGRASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9P2P1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLSGGDPPA QEWFMVQTKS KPRVQRQRLQ VQRIFRVKLN AFQSRPDTPY
60 70 80 90 100
FWLQLEGPRE NMGKAKEYLK GLCSPELWKE VRYPPILHCA FLGAQGLFLD
110 120 130 140 150
CLCWSTLAYL VPGPPGSLMV GGLTESFIMT QNWLEELVGR LRWGPAPLLT
160 170 180 190 200
PRGIWEAEVT RAFGALVWIR GDQHAGDLLQ LPPAVQELLL SLVRDAAGKE
210 220 230 240 250
DIIEWLSRFG ISDSHSDPEV LICPPQQQKE APAMVSVGES PGPFVDMGTL
260 270 280 290 300
QNRGPENSKR LSSLGATGSL ITAQSTPQEA ANQLVRVGSN NQDGMDSAQE
310 320 330 340 350
EGTVQATSSQ DSTNHTQALL KQRQVQKIED KLLFQPPVSA LGVCPPWKAW
360 370 380 390 400
TPGPAFGPLW PGAIAATFWR INELHSLHLA WLLSQACFNF PFWQRPLGPI
410 420 430 440 450
QLKLPGQNPL PLNLEWKQKE LAPLPSAESP AGRPDGGLGG EAALQNCPRP
460 470 480 490 500
EISPKVTSLL VVPGSSDVKD KVSSDLPQIG PPLTSTPQLQ AGGEPGDQGS
510 520 530 540 550
MQLDFKGLEE GPAPVLPTGQ GKPVAQGGLT DQSVPGAQTV PETLKVPMAA
560 570 580 590 600
AVPKAENPSR TQVPSAAPKL PTSRMMLAVH TEPAAPEVPL APTKPTAQLM
610 620 630 640 650
ATAQKTVVNQ PVLVAQVEPT TPKTPQAQKM PVAKTSPAGP KTPKAQAGPA
660 670 680 690 700
ATVSKAPAAS KAPAAPKVPV TPRVSRAPKT PAAQKVPTDA GPTLDVARLL
710 720 730 740 750
SEVQPTSRAS VSLLKGQGQA GRQGPQSSGT LALSSKHQFQ MEGLLGAWEG
760 770 780 790 800
APRQPPRHLQ ANSTVTSFQR YHEALNTPFE LNLSGEPGNQ GLRRVVIDGS
810 820 830 840 850
SVAMVHGLQH FFSCRGIAMA VQFFWNRGHR EVTVFVPTWQ LKKNRRVRES
860 870 880 890 900
HFLTKLHSLK MLSITPSQLE NGKKITTYDY RFMVKLAEET DGIIVTNEQI
910 920 930 940 950
HILMNSSKKL MVKDRLLPFT FAGNLFMVPD DPLGRDGPTL DEFLKKPNRL
960 970 980 990 1000
DTDIGNFLKV WKTLPPSSAS VTELSDDADS GPLESLPNME EVREEKEERQ
1010 1020 1030 1040 1050
DEEQRQGQGT QKAAEEDDLD SSLASVFRVE CPSLSEEILR CLSLHDPPDG
1060 1070 1080 1090 1100
ALDIDLLPGA ASPYLGIPWD GKAPCQQVLA HLAQLTIPSN FTALSFFMGF
1110 1120 1130 1140 1150
MDSHRDAIPD YEALVGPLHS LLKQKPDWQW DQEHEEAFLA LKRALVSALC
1160 1170 1180 1190 1200
LMAPNSQLPF RLEVTVSHVA LTAILHQEHS GRKHPIAYTS KPLLPDEESQ
1210 1220 1230 1240 1250
GPQSGGDSPY AVAWALKHFS RCIGDTPVVL DLSYASRTTA DPEVREGRRV
1260 1270 1280 1290 1300
SKAWLIRWSL LVQDKGKRAL ELALLQGLLG ENRLLTPAAS MPRFFQVLPP
1310 1320 1330 1340 1350
FSDLSTFVCI HMSGYCFYRE DEWCAGFGLY VLSPTSPPVS LSFSCSPYTP
1360 1370 1380 1390 1400
TYAHLAAVAC GLERFGQSPL PVVFLTHCNW IFSLLWELLP LWRARGFLSS
1410 1420 1430 1440 1450
DGAPLPHPSL LSYIISLTSG LSSLPFIYRT SYRGSLFAVT VDTLAKQGAQ
1460 1470 1480 1490 1500
GGGQWWSLPK DVPAPTVSPH AMGKRPNLLA LQLSDSTLAD IIARLQAGQK
1510 1520 1530 1540 1550
LSGSSPFSSA FNSLSLDKES GLLMFKGDKK PRVWVVPTQL RRDLIFSVHD
1560 1570 1580 1590 1600
IPLGAHQRPE ETYKKLRLLG WWPGMQEHVK DYCRSCLFCI PRNLIGSELK
1610 1620 1630 1640 1650
VIESPWPLRS TAPWSNLQIE VVGPVTISEE GHKHVLIVAD PNTRWVEAFP
1660 1670 1680 1690 1700
LKPYTHTAVA QVLLQHVFAR WGVPVRLEAA QGPQFARHVL VSCGLALGAQ
1710 1720 1730 1740 1750
VASLSRDLQF PCLTSSGAYW EFKRALKEFI FLHGKKWAAS LPLLHLAFRA
1760 1770 1780 1790 1800
SSTDATPFKV LTGGESRLTE PLWWEMSSAN IEGLKMDVFL LQLVGELLEL
1810 1820 1830 1840 1850
HWRVADKASE KAENRRFKRE SQEKEWNVGD QVLLLSLPRN GSSAKWVGPF
1860 1870 1880 1890
YIGDRLSLSL YRIWGFPTPE KLGCIYPSSL MKAFAKSGTP LSFKVLEQ
Length:1,898
Mass (Da):208,366
Last modified:January 15, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i081533041B25CA08
GO
Isoform 2 (identifier: Q9P2P1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1471: Missing.
     1606-1621: WPLRSTAPWSNLQIEV → ASVLRGQGVCNRSGTR
     1622-1898: Missing.

Show »
Length:150
Mass (Da):16,762
Checksum:i9F1B5DE66B3FBADD
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH65283 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1475R → G in BAB13925 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037857457T → M. Corresponds to variant dbSNP:rs12437434Ensembl.1
Natural variantiVAR_037858659A → V. Corresponds to variant dbSNP:rs8008203Ensembl.1
Natural variantiVAR_037859978A → T. Corresponds to variant dbSNP:rs8017377Ensembl.1
Natural variantiVAR_037860997E → K. Corresponds to variant dbSNP:rs3742518Ensembl.1
Natural variantiVAR_0378611551I → V. Corresponds to variant dbSNP:rs17103672Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0302371 – 1471Missing in isoform 2. 1 PublicationAdd BLAST1471
Alternative sequenceiVSP_0302381606 – 1621WPLRS…LQIEV → ASVLRGQGVCNRSGTR in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0302391622 – 1898Missing in isoform 2. 1 PublicationAdd BLAST277

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK021873 mRNA Translation: BAB13925.1
AL132800 Genomic DNA No translation available.
BC065283 mRNA Translation: AAH65283.1 Sequence problems.
AB037726 mRNA Translation: BAA92543.2
BX248773 mRNA Translation: CAD66580.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45090.1 [Q9P2P1-1]

NCBI Reference Sequences

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RefSeqi
NP_079357.2, NM_025081.2 [Q9P2P1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382554; ENSP00000371994; ENSG00000205978 [Q9P2P1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57523

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57523

UCSC genome browser

More...
UCSCi
uc001wpf.4, human [Q9P2P1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021873 mRNA Translation: BAB13925.1
AL132800 Genomic DNA No translation available.
BC065283 mRNA Translation: AAH65283.1 Sequence problems.
AB037726 mRNA Translation: BAA92543.2
BX248773 mRNA Translation: CAD66580.1
CCDSiCCDS45090.1 [Q9P2P1-1]
RefSeqiNP_079357.2, NM_025081.2 [Q9P2P1-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121584, 7 interactors
IntActiQ9P2P1, 6 interactors
STRINGi9606.ENSP00000371994

PTM databases

iPTMnetiQ9P2P1
PhosphoSitePlusiQ9P2P1

Polymorphism and mutation databases

BioMutaiNYNRIN
DMDMi166218833

Proteomic databases

EPDiQ9P2P1
jPOSTiQ9P2P1
MassIVEiQ9P2P1
MaxQBiQ9P2P1
PaxDbiQ9P2P1
PeptideAtlasiQ9P2P1
PRIDEiQ9P2P1
ProteomicsDBi83872 [Q9P2P1-1]
83873 [Q9P2P1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
57476, 12 antibodies

Genome annotation databases

EnsembliENST00000382554; ENSP00000371994; ENSG00000205978 [Q9P2P1-1]
GeneIDi57523
KEGGihsa:57523
UCSCiuc001wpf.4, human [Q9P2P1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57523
DisGeNETi57523
EuPathDBiHostDB:ENSG00000205978.5

GeneCards: human genes, protein and diseases

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GeneCardsi
NYNRIN
HGNCiHGNC:20165, NYNRIN
HPAiENSG00000205978, Tissue enhanced (epididymis)
neXtProtiNX_Q9P2P1
OpenTargetsiENSG00000205978
PharmGKBiPA165479228

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0017, Eukaryota
KOG3740, Eukaryota
GeneTreeiENSGT00940000161519
HOGENOMiCLU_235862_0_0_1
InParanoidiQ9P2P1
OMAiTHMAVAQ
OrthoDBi583605at2759
PhylomeDBiQ9P2P1
TreeFamiTF351195

Enzyme and pathway databases

PathwayCommonsiQ9P2P1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57523, 8 hits in 870 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57523
PharosiQ9P2P1, Tdark

Protein Ontology

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PROi
PR:Q9P2P1
RNActiQ9P2P1, protein

Gene expression databases

BgeeiENSG00000205978, Expressed in stomach and 165 other tissues
GenevisibleiQ9P2P1, HS

Family and domain databases

Gene3Di3.30.420.10, 2 hits
3.30.70.270, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR001584, Integrase_cat-core
IPR041588, Integrase_H2C2
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR021869, RNase_Zc3h12_NYN
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR041577, RT_RNaseH_2
PfamiView protein in Pfam
PF17921, Integrase_H2C2, 1 hit
PF11977, RNase_Zc3h12a, 1 hit
PF17919, RT_RNaseH_2, 1 hit
SUPFAMiSSF53098, SSF53098, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS50994, INTEGRASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNYNRI_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2P1
Secondary accession number(s): Q6P153, Q86TR3, Q9HAC4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: August 12, 2020
This is version 125 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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