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Entry version 131 (12 Aug 2020)
Sequence version 2 (15 May 2007)
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Protein

KAT8 regulatory NSL complex subunit 3

Gene

KANSL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P2N6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214847, HATs acetylate histones

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-KANSL3, NLS3-Tex30

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KAT8 regulatory NSL complex subunit 3
Alternative name(s):
NSL complex protein NSL3
Non-specific lethal 3 homolog
Serum inhibited-related protein
Testis development protein PRTD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KANSL3
Synonyms:KIAA1310, NSL3, PRTD, SI1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000114982.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25473, KANSL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617742, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P2N6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55683

Open Targets

More...
OpenTargetsi
ENSG00000114982

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162393058

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P2N6, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03467, Naringenin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KANSL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147646907

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004162421 – 904KAT8 regulatory NSL complex subunit 3Add BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei523PhosphoserineCombined sources1
Modified residuei536PhosphoserineBy similarity1
Modified residuei540PhosphoserineCombined sources1
Modified residuei773PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P2N6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P2N6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P2N6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2N6

PeptideAtlas

More...
PeptideAtlasi
Q9P2N6

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2N6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83859 [Q9P2N6-1]
83860 [Q9P2N6-2]
83861 [Q9P2N6-3]
83862 [Q9P2N6-4]
83863 [Q9P2N6-5]
83864 [Q9P2N6-6]
83865 [Q9P2N6-7]
83866 [Q9P2N6-8]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2906, 1 O-Linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2N6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2N6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114982, Expressed in metanephros and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P2N6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P2N6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000114982, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120811, 16 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-809, NSL histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9P2N6

Protein interaction database and analysis system

More...
IntActi
Q9P2N6, 16 interactors

Molecular INTeraction database

More...
MINTi
Q9P2N6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000396749

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P2N6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P2N6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi700 – 766Ser-richAdd BLAST67

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3253, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007636

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009783_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P2N6

KEGG Orthology (KO)

More...
KOi
K16719

Identification of Orthologs from Complete Genome Data

More...
OMAi
HFSHKPI

Database of Orthologous Groups

More...
OrthoDBi
316190at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P2N6

TreeFam database of animal gene trees

More...
TreeFami
TF323466

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR026555, NSL3/Tex30

The PANTHER Classification System

More...
PANTHERi
PTHR13136, PTHR13136, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2N6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHRGGERDF QTSARRMGTS LLFQLSVHER ELDLVFLDHS YAKPWSAHPD
60 70 80 90 100
ASSARPTRML FVTPRRQHES TIESDVPIDV ETVTSTPMPL YDNQKARSVM
110 120 130 140 150
NECERHVIFA RTDADAPPPP EDWEEHVNRT GWTMAQNKLF NKILKALQSD
160 170 180 190 200
RLARLANEGA CNEPVLRRVA VDKCARRVRQ ALASVSWDTK LIQWLHTTLV
210 220 230 240 250
ETLSLPMLAA YLDALQTLKG KIPTLIDRML VSSNTKTGAA GAEALSLLLK
260 270 280 290 300
RPWDPAVGVL SHNKPSKLPG SPLILIASSG PSSSVFPTSR RHRFWQSQLS
310 320 330 340 350
CLGKVIPVAT HLLNNGSGVG VLQCLEHMIG AVRSKVLEIH SHFPHKPIIL
360 370 380 390 400
IGWNTGALVA CHVSVMEYVT AVVCLGFPLL TVDGPRGDVD DPLLDMKTPV
410 420 430 440 450
LFVIGQNSLQ CHPEAMEDFR EKIRAENSLV VVGGADDNLR ISKAKKKSEG
460 470 480 490 500
LTQSMVDRCI QDEIVDFLTG VLTRAEGHMG SEPRDQDAEK KKKPRDVARR
510 520 530 540 550
DLAFEVPERG SRPASPAAKL PASPSGSEDL SSVSSSPTSS PKTKVTTVTS
560 570 580 590 600
AQKSSQIGSS QLLKRHVQRT EAVLTHKQAQ AQFAAFLKQN MLVRKALPPG
610 620 630 640 650
TSSCLFVPIS SEPPEEGEKE DLRVQLKRHH PSSPLPGSKT SKRPKIKVSL
660 670 680 690 700
ISQGDTAGGP CAPSQGSAPE AAGGKPITMT LGQASAGAKE LTGLLTTAKS
710 720 730 740 750
SSSEGGVSAS PVPSVVSSST APSALHTLQS RLVATSPGSS LPGATSASSL
760 770 780 790 800
LQGLSFSLQD ISSKTSGLPA NPSPGPAPQA TSVKLPTPMQ SLGAITTGTS
810 820 830 840 850
TIVRTIPVAT TLSSLGATPG GKPTAIHQLL TNGGLAKLAS SLPGLAQISN
860 870 880 890 900
QASGLKVPTT ITLTLRGQPS RITTLSPMGS GAAPSEESSS QVLPSSSQRL

PPAP
Length:904
Mass (Da):95,992
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i698DD46EC443B5DD
GO
Isoform 2 (identifier: Q9P2N6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     781-904: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:780
Mass (Da):83,673
Checksum:iFDE372433A0CDDC7
GO
Isoform 3 (identifier: Q9P2N6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     581-606: Missing.

Show »
Length:878
Mass (Da):93,170
Checksum:i5D9DD9A62F3A20FA
GO
Isoform 4 (identifier: Q9P2N6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     581-606: Missing.

Show »
Length:791
Mass (Da):83,296
Checksum:iE77BB055740C1F91
GO
Isoform 5 (identifier: Q9P2N6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     581-606: Missing.
     671-672: Missing.

Show »
Length:789
Mass (Da):83,154
Checksum:iA3D9541D40C75FD0
GO
Isoform 6 (identifier: Q9P2N6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     113-129: DADAPPPPEDWEEHVNR → MTLPHCHRLMLTHHLFW
     581-606: Missing.
     671-672: Missing.

Show »
Length:764
Mass (Da):80,362
Checksum:i8BDC155A0AC701FB
GO
Isoform 7 (identifier: Q9P2N6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     222-228: IPTLIDR → VILTFCG
     229-904: Missing.

Show »
Length:141
Mass (Da):16,016
Checksum:i0E8A108B46959AF7
GO
Isoform 8 (identifier: Q9P2N6-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     581-606: Missing.
     637-643: GSKTSKR → VYSWFHH
     644-904: Missing.

Show »
Length:530
Mass (Da):58,199
Checksum:i018418758112918F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A590UJ53A0A590UJ53_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL3
903Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD76F8WD76_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL3
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5A4C9J5A4_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL3
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JF16C9JF16_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL3
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J491C9J491_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL3
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB58F8WB58_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL3
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEN2F8WEN2_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL3
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B6P7A0A075B6P7_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL3
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3B6M0R3B6_HUMAN
KAT8 regulatory NSL complex subunit...
KANSL3
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15469 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI27821 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence BAA92548 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti529D → G in BAA91437 (PubMed:14702039).Curated1
Sequence conflicti640T → I in AAG33852 (Ref. 2) Curated1
Sequence conflicti640T → I in BAB14688 (PubMed:14702039).Curated1
Sequence conflicti660P → S in AAG33852 (Ref. 2) Curated1
Sequence conflicti660P → S in BAB14688 (PubMed:14702039).Curated1
Sequence conflicti667S → C in AAG33852 (Ref. 2) Curated1
Sequence conflicti667S → C in BAB14688 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032268707V → I. Corresponds to variant dbSNP:rs34406082Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0253241 – 112Missing in isoform 6. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_0253251 – 87Missing in isoform 4, isoform 5, isoform 7 and isoform 8. 3 PublicationsAdd BLAST87
Alternative sequenceiVSP_025326113 – 129DADAP…EHVNR → MTLPHCHRLMLTHHLFW in isoform 6. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_025327222 – 228IPTLIDR → VILTFCG in isoform 7. 1 Publication7
Alternative sequenceiVSP_025328229 – 904Missing in isoform 7. 1 PublicationAdd BLAST676
Alternative sequenceiVSP_025329581 – 606Missing in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8. 4 PublicationsAdd BLAST26
Alternative sequenceiVSP_025330637 – 643GSKTSKR → VYSWFHH in isoform 8. 1 Publication7
Alternative sequenceiVSP_025331644 – 904Missing in isoform 8. 1 PublicationAdd BLAST261
Alternative sequenceiVSP_025332671 – 672Missing in isoform 5 and isoform 6. 2 Publications2
Alternative sequenceiVSP_025333781 – 904Missing in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY050169 mRNA Translation: AAL13159.1
AF311326 mRNA Translation: AAG33852.1
AB037731 mRNA Translation: BAA92548.1 Different initiation.
AK000943 mRNA Translation: BAA91437.1
AK023813 mRNA Translation: BAB14688.1
AC079754 Genomic DNA Translation: AAX88890.1
CH471207 Genomic DNA Translation: EAW71349.1
CH471207 Genomic DNA Translation: EAW71350.1
CH471207 Genomic DNA Translation: EAW71352.1
CH471207 Genomic DNA Translation: EAW71357.1
CH471207 Genomic DNA Translation: EAW71358.1
BC015469 mRNA Translation: AAH15469.1 Sequence problems.
BC032746 mRNA Translation: AAH32746.1
BC051763 mRNA Translation: AAH51763.1
BC063792 mRNA Translation: AAH63792.1
BC127820 mRNA Translation: AAI27821.1 Sequence problems.
AL136849 mRNA Translation: CAB66783.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS46361.1 [Q9P2N6-3]

NCBI Reference Sequences

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RefSeqi
NP_001108488.1, NM_001115016.2 [Q9P2N6-3]
XP_005264041.1, XM_005263984.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000420155; ENSP00000414426; ENSG00000114982 [Q9P2N6-2]
ENST00000431828; ENSP00000396749; ENSG00000114982 [Q9P2N6-3]
ENST00000666923; ENSP00000499674; ENSG00000114982 [Q9P2N6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55683

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55683

UCSC genome browser

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UCSCi
uc002swn.6, human [Q9P2N6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050169 mRNA Translation: AAL13159.1
AF311326 mRNA Translation: AAG33852.1
AB037731 mRNA Translation: BAA92548.1 Different initiation.
AK000943 mRNA Translation: BAA91437.1
AK023813 mRNA Translation: BAB14688.1
AC079754 Genomic DNA Translation: AAX88890.1
CH471207 Genomic DNA Translation: EAW71349.1
CH471207 Genomic DNA Translation: EAW71350.1
CH471207 Genomic DNA Translation: EAW71352.1
CH471207 Genomic DNA Translation: EAW71357.1
CH471207 Genomic DNA Translation: EAW71358.1
BC015469 mRNA Translation: AAH15469.1 Sequence problems.
BC032746 mRNA Translation: AAH32746.1
BC051763 mRNA Translation: AAH51763.1
BC063792 mRNA Translation: AAH63792.1
BC127820 mRNA Translation: AAI27821.1 Sequence problems.
AL136849 mRNA Translation: CAB66783.2
CCDSiCCDS46361.1 [Q9P2N6-3]
RefSeqiNP_001108488.1, NM_001115016.2 [Q9P2N6-3]
XP_005264041.1, XM_005263984.1

3D structure databases

SMRiQ9P2N6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120811, 16 interactors
ComplexPortaliCPX-809, NSL histone acetyltransferase complex
CORUMiQ9P2N6
IntActiQ9P2N6, 16 interactors
MINTiQ9P2N6
STRINGi9606.ENSP00000396749

Chemistry databases

DrugBankiDB03467, Naringenin

Protein family/group databases

ESTHERihuman-KANSL3, NLS3-Tex30

PTM databases

GlyConnecti2906, 1 O-Linked glycan (1 site)
iPTMnetiQ9P2N6
PhosphoSitePlusiQ9P2N6

Polymorphism and mutation databases

BioMutaiKANSL3
DMDMi147646907

Proteomic databases

jPOSTiQ9P2N6
MassIVEiQ9P2N6
MaxQBiQ9P2N6
PaxDbiQ9P2N6
PeptideAtlasiQ9P2N6
PRIDEiQ9P2N6
ProteomicsDBi83859 [Q9P2N6-1]
83860 [Q9P2N6-2]
83861 [Q9P2N6-3]
83862 [Q9P2N6-4]
83863 [Q9P2N6-5]
83864 [Q9P2N6-6]
83865 [Q9P2N6-7]
83866 [Q9P2N6-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32468, 110 antibodies

The DNASU plasmid repository

More...
DNASUi
55683

Genome annotation databases

EnsembliENST00000420155; ENSP00000414426; ENSG00000114982 [Q9P2N6-2]
ENST00000431828; ENSP00000396749; ENSG00000114982 [Q9P2N6-3]
ENST00000666923; ENSP00000499674; ENSG00000114982 [Q9P2N6-1]
GeneIDi55683
KEGGihsa:55683
UCSCiuc002swn.6, human [Q9P2N6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55683
DisGeNETi55683
EuPathDBiHostDB:ENSG00000114982.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KANSL3
HGNCiHGNC:25473, KANSL3
HPAiENSG00000114982, Low tissue specificity
MIMi617742, gene
neXtProtiNX_Q9P2N6
OpenTargetsiENSG00000114982
PharmGKBiPA162393058

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3253, Eukaryota
GeneTreeiENSGT00390000007636
HOGENOMiCLU_009783_0_0_1
InParanoidiQ9P2N6
KOiK16719
OMAiHFSHKPI
OrthoDBi316190at2759
PhylomeDBiQ9P2N6
TreeFamiTF323466

Enzyme and pathway databases

PathwayCommonsiQ9P2N6
ReactomeiR-HSA-3214847, HATs acetylate histones

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55683, 617 hits in 866 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KANSL3, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FLJ10081

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55683
PharosiQ9P2N6, Tbio

Protein Ontology

More...
PROi
PR:Q9P2N6
RNActiQ9P2N6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114982, Expressed in metanephros and 226 other tissues
ExpressionAtlasiQ9P2N6, baseline and differential
GenevisibleiQ9P2N6, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR026555, NSL3/Tex30
PANTHERiPTHR13136, PTHR13136, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKANL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2N6
Secondary accession number(s): A1L184
, D3DXH3, D3DXH4, Q05BU4, Q6P3X2, Q6PJH6, Q86T19, Q96L64, Q9H0C9, Q9H8C9, Q9HAP8, Q9NWE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: August 12, 2020
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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