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Entry version 187 (07 Oct 2020)
Sequence version 4 (04 Nov 2008)
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 9

Gene

ADAMTS9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.2 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi223Zinc; in inhibited formBy similarity1
Metal bindingi434Zinc; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei435PROSITE-ProRule annotation1
Metal bindingi438Zinc; catalyticBy similarity1
Metal bindingi444Zinc; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P2N4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214, O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.021

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 9 (EC:3.4.24.-1 Publication)
Short name:
ADAM-TS 9
Short name:
ADAM-TS9
Short name:
ADAMTS-9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADAMTS9
Synonyms:KIAA1312
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163638.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13202, ADAMTS9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605421, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P2N4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi33R → A: No effect on mature form production. 1 Publication1
Mutagenesisi74R → A: No effect on mature form production. 1 Publication1
Mutagenesisi280R → A: No effect on mature form production. 1 Publication1
Mutagenesisi287R → A: No mature form produced. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
56999

MalaCards human disease database

More...
MalaCardsi
ADAMTS9

Open Targets

More...
OpenTargetsi
ENSG00000163638

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93592, Juvenile nephronophthisis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24553

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P2N4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADAMTS9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212276516

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002918219 – 2871 PublicationAdd BLAST269
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000029183288 – 1935A disintegrin and metalloproteinase with thrombospondin motifs 9Add BLAST1648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi368 ↔ 418By similarity
Disulfide bondi394 ↔ 400By similarity
Disulfide bondi412 ↔ 494By similarity
Disulfide bondi450 ↔ 478By similarity
Disulfide bondi521 ↔ 543By similarity
Disulfide bondi532 ↔ 553By similarity
Disulfide bondi538 ↔ 572By similarity
Disulfide bondi566 ↔ 577By similarity
Disulfide bondi600 ↔ 637By similarity
Disulfide bondi604 ↔ 642By similarity
Disulfide bondi615 ↔ 627By similarity
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi840N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi890 ↔ 931By similarity
Disulfide bondi894 ↔ 935By similarity
Disulfide bondi904 ↔ 918By similarity
Glycosylationi1213N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1250 ↔ 1290By similarity
Disulfide bondi1254 ↔ 1295By similarity
Disulfide bondi1265 ↔ 1278By similarity
Glycosylationi1267N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1624 ↔ 1670By similarity
Disulfide bondi1628 ↔ 1675By similarity
Disulfide bondi1639 ↔ 1659By similarity
Glycosylationi1788N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1806N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.1 Publication
N-glycosylated (PubMed:12514189). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei287 – 288Cleavage1 Publication2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P2N4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P2N4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2N4

PeptideAtlas

More...
PeptideAtlasi
Q9P2N4

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2N4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
7269
83855 [Q9P2N4-3]
83856 [Q9P2N4-1]
83857 [Q9P2N4-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9P2N4, 11 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2N4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2N4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163638, Expressed in left coronary artery and 193 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P2N4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P2N4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000163638, Tissue enhanced (adipose)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121314, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9P2N4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000418735

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P2N4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P2N4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini293 – 499Peptidase M12BPROSITE-ProRule annotationAdd BLAST207
Domaini509 – 587DisintegrinAdd BLAST79
Domaini588 – 643TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini878 – 936TSP type-1 2PROSITE-ProRule annotationAdd BLAST59
Domaini939 – 997TSP type-1 3PROSITE-ProRule annotationAdd BLAST59
Domaini998 – 1049TSP type-1 4PROSITE-ProRule annotationAdd BLAST52
Domaini1052 – 1109TSP type-1 5PROSITE-ProRule annotationAdd BLAST58
Domaini1110 – 1166TSP type-1 6PROSITE-ProRule annotationAdd BLAST57
Domaini1182 – 1240TSP type-1 7PROSITE-ProRule annotationAdd BLAST59
Domaini1241 – 1296TSP type-1 8PROSITE-ProRule annotationAdd BLAST56
Domaini1328 – 1379TSP type-1 9PROSITE-ProRule annotationAdd BLAST52
Domaini1382 – 1440TSP type-1 10PROSITE-ProRule annotationAdd BLAST59
Domaini1441 – 1494TSP type-1 11PROSITE-ProRule annotationAdd BLAST54
Domaini1497 – 1555TSP type-1 12PROSITE-ProRule annotationAdd BLAST59
Domaini1556 – 1611TSP type-1 13PROSITE-ProRule annotationAdd BLAST56
Domaini1612 – 1676TSP type-1 14PROSITE-ProRule annotationAdd BLAST65
Domaini1677 – 1734TSP type-1 15PROSITE-ProRule annotationAdd BLAST58
Domaini1735 – 1935GONPROSITE-ProRule annotationAdd BLAST201

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni753 – 877SpacerAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi221 – 228Cysteine switchBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi88 – 96Poly-Ser9
Compositional biasi644 – 752Cys-richAdd BLAST109

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.By similarity
The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for its versicanase and aggrecanase activities.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
The GON domain mediates protease-independent function in ER to Golgi transport.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156409

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000660_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P2N4

KEGG Orthology (KO)

More...
KOi
K08624

Identification of Orthologs from Complete Genome Data

More...
OMAi
GDCYNRN

Database of Orthologous Groups

More...
OrthoDBi
125522at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P2N4

TreeFam database of animal gene trees

More...
TreeFami
TF331949

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 13 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645, ADAM_CR_2
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR012314, Pept_M12B_GON-ADAMTSs
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF08685, GON, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857, ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 14 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS51046, GON, 1 hit
PS50092, TSP1, 14 hits
PS00142, ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2N4-3) [UniParc]FASTAAdd to basket
Also known as: ADAMTS-9B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQFVSWATLL TLLVRDLAEM GSPDAAAAVR KDRLHPRQVK LLETLSEYEI
60 70 80 90 100
VSPIRVNALG EPFPTNVHFK RTRRSINSAT DPWPAFASSS SSSTSSQAHY
110 120 130 140 150
RLSAFGQQFL FNLTANAGFI APLFTVTLLG TPGVNQTKFY SEEEAELKHC
160 170 180 190 200
FYKGYVNTNS EHTAVISLCS GMLGTFRSHD GDYFIEPLQS MDEQEDEEEQ
210 220 230 240 250
NKPHIIYRRS APQREPSTGR HACDTSEHKN RHSKDKKKTR ARKWGERINL
260 270 280 290 300
AGDVAALNSG LATEAFSAYG NKTDNTREKR THRRTKRFLS YPRFVEVLVV
310 320 330 340 350
ADNRMVSYHG ENLQHYILTL MSIVASIYKD PSIGNLINIV IVNLIVIHNE
360 370 380 390 400
QDGPSISFNA QTTLKNFCQW QHSKNSPGGI HHDTAVLLTR QDICRAHDKC
410 420 430 440 450
DTLGLAELGT ICDPYRSCSI SEDSGLSTAF TIAHELGHVF NMPHDDNNKC
460 470 480 490 500
KEEGVKSPQH VMAPTLNFYT NPWMWSKCSR KYITEFLDTG YGECLLNEPE
510 520 530 540 550
SRPYPLPVQL PGILYNVNKQ CELIFGPGSQ VCPYMMQCRR LWCNNVNGVH
560 570 580 590 600
KGCRTQHTPW ADGTECEPGK HCKYGFCVPK EMDVPVTDGS WGSWSPFGTC
610 620 630 640 650
SRTCGGGIKT AIRECNRPEP KNGGKYCVGR RMKFKSCNTE PCLKQKRDFR
660 670 680 690 700
DEQCAHFDGK HFNINGLLPN VRWVPKYSGI LMKDRCKLFC RVAGNTAYYQ
710 720 730 740 750
LRDRVIDGTP CGQDTNDICV QGLCRQAGCD HVLNSKARRD KCGVCGGDNS
760 770 780 790 800
SCKTVAGTFN TVHYGYNTVV RIPAGATNID VRQHSFSGET DDDNYLALSS
810 820 830 840 850
SKGEFLLNGN FVVTMAKREI RIGNAVVEYS GSETAVERIN STDRIEQELL
860 870 880 890 900
LQVLSVGKLY NPDVRYSFNI PIEDKPQQFY WNSHGPWQAC SKPCQGERKR
910 920 930 940 950
KLVCTRESDQ LTVSDQRCDR LPQPGHITEP CGTDCDLRWH VASRSECSAQ
960 970 980 990 1000
CGLGYRTLDI YCAKYSRLDG KTEKVDDGFC SSHPKPSNRE KCSGECNTGG
1010 1020 1030 1040 1050
WRYSAWTECS KSCDGGTQRR RAICVNTRND VLDDSKCTHQ EKVTIQRCSE
1060 1070 1080 1090 1100
FPCPQWKSGD WSECLVTCGK GHKHRQVWCQ FGEDRLNDRM CDPETKPTSM
1110 1120 1130 1140 1150
QTCQQPECAS WQAGPWGQCS VTCGQGYQLR AVKCIIGTYM SVVDDNDCNA
1160 1170 1180 1190 1200
ATRPTDTQDC ELPSCHPPPA APETRRSTYS APRTQWRFGS WTPCSATCGK
1210 1220 1230 1240 1250
GTRMRYVSCR DENGSVADES ACATLPRPVA KEECSVTPCG QWKALDWSSC
1260 1270 1280 1290 1300
SVTCGQGRAT RQVMCVNYSD HVIDRSECDQ DYIPETDQDC SMSPCPQRTP
1310 1320 1330 1340 1350
DSGLAQHPFQ NEDYRPRSAS PSRTHVLGGN QWRTGPWGAC SSTCAGGSQR
1360 1370 1380 1390 1400
RVVVCQDENG YTANDCVERI KPDEQRACES GPCPQWAYGN WGECTKLCGG
1410 1420 1430 1440 1450
GIRTRLVVCQ RSNGERFPDL SCEILDKPPD REQCNTHACP HDAAWSTGPW
1460 1470 1480 1490 1500
SSCSVSCGRG HKQRNVYCMA KDGSHLESDY CKHLAKPHGH RKCRGGRCPK
1510 1520 1530 1540 1550
WKAGAWSQCS VSCGRGVQQR HVGCQIGTHK IARETECNPY TRPESERDCQ
1560 1570 1580 1590 1600
GPRCPLYTWR AEEWQECTKT CGEGSRYRKV VCVDDNKNEV HGARCDVSKR
1610 1620 1630 1640 1650
PVDRESCSLQ PCEYVWITGE WSECSVTCGK GYKQRLVSCS EIYTGKENYE
1660 1670 1680 1690 1700
YSYQTTINCP GTQPPSVHPC YLRDCPVSAT WRVGNWGSCS VSCGVGVMQR
1710 1720 1730 1740 1750
SVQCLTNEDQ PSHLCHTDLK PEERKTCRNV YNCELPQNCK EVKRLKGASE
1760 1770 1780 1790 1800
DGEYFLMIRG KLLKIFCAGM HSDHPKEYVT LVHGDSENFS EVYGHRLHNP
1810 1820 1830 1840 1850
TECPYNGSRR DDCQCRKDYT AAGFSSFQKI RIDLTSMQII TTDLQFARTS
1860 1870 1880 1890 1900
EGHPVPFATA GDCYSAAKCP QGRFSINLYG TGLSLTESAR WISQGNYAVS
1910 1920 1930
DIKKSPDGTR VVGKCGGYCG KCTPSSGTGL EVRVL
Length:1,935
Mass (Da):216,491
Last modified:November 4, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i150B78D4C5CC2CCC
GO
Isoform 2 (identifier: Q9P2N4-1) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     1624-1629: CSVTCG → VPSWEL
     1630-1935: Missing.

Note: May result from the retention of an intron in the cDNA leading to a prematurate stop codon.Curated
Show »
Length:1,629
Mass (Da):182,680
Checksum:iE72B933CEED67809
GO
Isoform 3 (identifier: Q9P2N4-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1064-1072: CLVTCGKGH → VRWEGCYFP
     1073-1935: Missing.

Show »
Length:1,072
Mass (Da):120,717
Checksum:i85251C8E59449E0C
GO
Isoform 4 (identifier: Q9P2N4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     324-351: Missing.

Show »
Length:1,907
Mass (Da):213,420
Checksum:i24BD2199B1142022
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y859H0Y859_HUMAN
A disintegrin and metalloproteinase...
ADAMTS9
991Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWI2C9JWI2_HUMAN
A disintegrin and metalloproteinase...
ADAMTS9
488Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTS1A0A087WTS1_HUMAN
A disintegrin and metalloproteinase...
ADAMTS9
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46S → G in AAF89106 (PubMed:10936055).Curated1
Sequence conflicti182D → G in AAO15765 (PubMed:12514189).Curated1
Sequence conflicti367F → L in AAF89106 (PubMed:10936055).Curated1
Sequence conflicti1117G → V in AAO15765 (PubMed:12514189).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04708196S → P1 PublicationCorresponds to variant dbSNP:rs36115950Ensembl.1
Natural variantiVAR_05159296S → T. Corresponds to variant dbSNP:rs36115950Ensembl.1
Natural variantiVAR_0470821579K → E. Corresponds to variant dbSNP:rs17071010Ensembl.1
Natural variantiVAR_0470831674D → E1 PublicationCorresponds to variant dbSNP:rs6787633Ensembl.1
Natural variantiVAR_0470841740K → R. Corresponds to variant dbSNP:rs17070967Ensembl.1
Natural variantiVAR_0470851791E → Q. Corresponds to variant dbSNP:rs3796381Ensembl.1
Natural variantiVAR_0515931921K → E. Corresponds to variant dbSNP:rs17070909Ensembl.1
Natural variantiVAR_0470861933R → Q. Corresponds to variant dbSNP:rs17070905Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053399324 – 351Missing in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0054991064 – 1072CLVTCGKGH → VRWEGCYFP in isoform 3. 1 Publication9
Alternative sequenceiVSP_0055001073 – 1935Missing in isoform 3. 1 PublicationAdd BLAST863
Alternative sequenceiVSP_0075481624 – 1629CSVTCG → VPSWEL in isoform 2. 1 Publication6
Alternative sequenceiVSP_0075491630 – 1935Missing in isoform 2. 1 PublicationAdd BLAST306

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF261918 mRNA Translation: AAF89106.1
AF488803 mRNA Translation: AAO15765.1
AC096888 Genomic DNA No translation available.
AC122178 Genomic DNA No translation available.
BC130578 mRNA Translation: AAI30579.1
BC171764 mRNA Translation: AAI71764.1
AB037733 mRNA Translation: BAA92550.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2903.1 [Q9P2N4-3]
CCDS82801.1 [Q9P2N4-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001305710.1, NM_001318781.1 [Q9P2N4-4]
NP_891550.1, NM_182920.1 [Q9P2N4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295903; ENSP00000295903; ENSG00000163638 [Q9P2N4-4]
ENST00000498707; ENSP00000418735; ENSG00000163638 [Q9P2N4-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56999

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56999

UCSC genome browser

More...
UCSCi
uc003dmg.4, human [Q9P2N4-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261918 mRNA Translation: AAF89106.1
AF488803 mRNA Translation: AAO15765.1
AC096888 Genomic DNA No translation available.
AC122178 Genomic DNA No translation available.
BC130578 mRNA Translation: AAI30579.1
BC171764 mRNA Translation: AAI71764.1
AB037733 mRNA Translation: BAA92550.1
CCDSiCCDS2903.1 [Q9P2N4-3]
CCDS82801.1 [Q9P2N4-4]
RefSeqiNP_001305710.1, NM_001318781.1 [Q9P2N4-4]
NP_891550.1, NM_182920.1 [Q9P2N4-3]

3D structure databases

SMRiQ9P2N4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121314, 1 interactor
IntActiQ9P2N4, 1 interactor
STRINGi9606.ENSP00000418735

Protein family/group databases

MEROPSiM12.021

PTM databases

GlyGeniQ9P2N4, 11 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ9P2N4
PhosphoSitePlusiQ9P2N4

Polymorphism and mutation databases

BioMutaiADAMTS9
DMDMi212276516

Proteomic databases

jPOSTiQ9P2N4
MassIVEiQ9P2N4
PaxDbiQ9P2N4
PeptideAtlasiQ9P2N4
PRIDEiQ9P2N4
ProteomicsDBi7269
83855 [Q9P2N4-3]
83856 [Q9P2N4-1]
83857 [Q9P2N4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31780, 95 antibodies

Genome annotation databases

EnsembliENST00000295903; ENSP00000295903; ENSG00000163638 [Q9P2N4-4]
ENST00000498707; ENSP00000418735; ENSG00000163638 [Q9P2N4-3]
GeneIDi56999
KEGGihsa:56999
UCSCiuc003dmg.4, human [Q9P2N4-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56999
DisGeNETi56999
EuPathDBiHostDB:ENSG00000163638.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADAMTS9
HGNCiHGNC:13202, ADAMTS9
HPAiENSG00000163638, Tissue enhanced (adipose)
MalaCardsiADAMTS9
MIMi605421, gene
neXtProtiNX_Q9P2N4
OpenTargetsiENSG00000163638
Orphaneti93592, Juvenile nephronophthisis
PharmGKBiPA24553

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
GeneTreeiENSGT00940000156409
HOGENOMiCLU_000660_0_1_1
InParanoidiQ9P2N4
KOiK08624
OMAiGDCYNRN
OrthoDBi125522at2759
PhylomeDBiQ9P2N4
TreeFamiTF331949

Enzyme and pathway databases

PathwayCommonsiQ9P2N4
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix
R-HSA-5083635, Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
56999, 6 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADAMTS9, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ADAMTS9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56999
PharosiQ9P2N4, Tbio

Protein Ontology

More...
PROi
PR:Q9P2N4
RNActiQ9P2N4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163638, Expressed in left coronary artery and 193 other tissues
ExpressionAtlasiQ9P2N4, baseline and differential
GenevisibleiQ9P2N4, HS

Family and domain databases

Gene3Di2.20.100.10, 13 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645, ADAM_CR_2
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR012314, Pept_M12B_GON-ADAMTSs
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF08685, GON, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit
PRINTSiPR01857, ADAMTSFAMILY
SMARTiView protein in SMART
SM00209, TSP1, 15 hits
SUPFAMiSSF82895, SSF82895, 14 hits
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS51046, GON, 1 hit
PS50092, TSP1, 14 hits
PS00142, ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATS9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2N4
Secondary accession number(s): A1L4L0
, B7ZVX9, B9ZVN0, Q9NR29
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 4, 2008
Last modified: October 7, 2020
This is version 187 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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