UniProtKB - Q9P2M4 (TBC14_HUMAN)

BLAST

>sp|Q9P2M4|TBC14_HUMAN TBC1 domain family member 14 OS=Homo sapiens OX=9606 GN=TBC1D14 PE=1 SV=3
MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS
LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH

Align

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History
Entry version 135 (12 Sep 2018)
Sequence version 3 (26 Feb 2008)
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Protein

TBC1 domain family member 14

Gene

TBC1D14

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Negative regulator of starvation-induced autophagosome formation.1 Publication

GO - Molecular functionⁱ

GTPase activator activity Source: GO_Central
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 22613832
Rab GTPase binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of GTPase activity Source: GO_Central
intracellular protein transport Source: GO_Central
negative regulation of autophagy
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22613832
recycling endosome to Golgi transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17562788
regulation of autophagosome assembly
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22613832
regulation of vesicle fusion Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation

Molecular function

GTPase activation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854214 TBC/RABGAPs

Reactomeⁱ

R-HSA-8854214 TBC/RABGAPs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TBC1 domain family member 14
Gene namesⁱ	Name:TBC1D14 Synonyms:KIAA1322
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000132405.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29246 TBC1D14
MIMⁱ	614855 gene
neXtProtⁱ	NX_Q9P2M4

Keywords - Cellular componentⁱ

Golgi apparatus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	472	R → A: Loss of inhibition of autophagosome formation; when associated with A-508. 1 Publication		1
Mutagenesisⁱ	508	Q → A: Loss of inhibition of autophagosome formation; when associated with A-472. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57533
Open Targets More...OpenTargetsⁱ	ENSG00000132405
PharmGKBⁱ	PA128394697

Polymorphism and mutation databases

BioMutaⁱ	TBC1D14
DMDMⁱ	172044690

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000208040	1 – 693	TBC1 domain family member 14Add BLAST		693

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	91	PhosphoserineCombined sources		1
Modified residueⁱ	295	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9P2M4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P2M4
PaxDbⁱ	Q9P2M4
PeptideAtlas More...PeptideAtlasⁱ	Q9P2M4
PRIDEⁱ	Q9P2M4
ProteomicsDBⁱ	83847 83848 [Q9P2M4-2]

PTM databases

iPTMnetⁱ	Q9P2M4
PhosphoSitePlusⁱ	Q9P2M4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000132405 Expressed in 200 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_TBC1D14
ExpressionAtlasⁱ	Q9P2M4 baseline and differential
Genevisibleⁱ	Q9P2M4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036930 HPA067398

HPAⁱ

HPA036930
HPA067398

Interactionⁱ

Subunit structureⁱ

Interacts with ULK1. May interact with RAB11A and RAB11B, but does not exhibit any GTPase-activating activity toward these proteins.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RAB11B	Q15907	2	EBI-2797718,EBI-722234
ULK1	O75385	4	EBI-2797718,EBI-908831

GO - Molecular functionⁱ

protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 22613832
Rab GTPase binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121592, 26 interactors
IntActⁱ	Q9P2M4, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q9P2M4
STRINGⁱ	9606.ENSP00000386921

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	373 – 379	Combined sources	7
Helixⁱ	382 – 384	Combined sources	3
Helixⁱ	392 – 399	Combined sources	8
Helixⁱ	404 – 415	Combined sources	12
Helixⁱ	423 – 436	Combined sources	14
Helixⁱ	462 – 471	Combined sources	10
Helixⁱ	475 – 477	Combined sources	3
Beta strandⁱ	479 – 481	Combined sources	3
Helixⁱ	487 – 500	Combined sources	14
Turnⁱ	502 – 504	Combined sources	3
Helixⁱ	510 – 520	Combined sources	11
Helixⁱ	523 – 534	Combined sources	12
Helixⁱ	537 – 543	Combined sources	7
Helixⁱ	548 – 564	Combined sources	17
Helixⁱ	566 – 574	Combined sources	9
Helixⁱ	579 – 581	Combined sources	3
Helixⁱ	583 – 588	Combined sources	6
Turnⁱ	589 – 594	Combined sources	6
Helixⁱ	597 – 610	Combined sources	14
Helixⁱ	612 – 625	Combined sources	14
Helixⁱ	627 – 631	Combined sources	5
Helixⁱ	635 – 643	Combined sources	9
Helixⁱ	651 – 660	Combined sources	10
Helixⁱ	670 – 678	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9P2M4
SMRⁱ	Q9P2M4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9P2M4

EvolutionaryTraceⁱ

Q9P2M4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	401 – 611	Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST		211

Phylogenomic databases

eggNOGⁱ	KOG2223 Eukaryota COG5210 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00750000117238
HOGENOMⁱ	HOG000016604
HOVERGENⁱ	HBG061665
InParanoidⁱ	Q9P2M4
KEGG Orthology (KO) More...KOⁱ	K20167
OMAⁱ	EYEDKAG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09QI
PhylomeDBⁱ	Q9P2M4
TreeFamⁱ	TF313318

Family and domain databases

InterProⁱ	View protein in InterPro IPR000195 Rab-GTPase-TBC_dom IPR035969 Rab-GTPase_TBC_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00566 RabGAP-TBC, 1 hit
SMARTⁱ	View protein in SMART SM00164 TBC, 1 hit
SUPFAMⁱ	SSF47923 SSF47923, 2 hits
PROSITEⁱ	View protein in PROSITE PS50086 TBC_RABGAP, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9P2M4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDGKLSTST NGVAFMGILD GRPGNPLQNL QHVNLKAPRL LSAPEYGPKL 
        60         70         80         90        100
KLRALEDRHS LQSVDSGIPT LEIGNPEPVP CSAVHVRRKQ SDSDLIPERA 
       110        120        130        140        150
FQSACALPSC APPAPSSTER EQSVRKSSTF PRTGYDSVKL YSPTSKALTR 
       160        170        180        190        200
SDDVSVCSVS SLGTELSTTL SVSNEDILDL VVTSSSSAIV TLENDDDPQF 
       210        220        230        240        250
TNVTLSSIKE TRGLHQQDCV HEAEEGSKLK ILGPFSNFFA RNLLARKQSA 
       260        270        280        290        300
RLDKHNDLGW KLFGKAPLRE NAQKDSKRIQ KEYEDKAGRP SKPPSPKQNV 
       310        320        330        340        350
RKNLDFEPLS TTALILEDRP ANLPAKPAEE AQKHRQQYEE MVVQAKKREL 
       360        370        380        390        400
KEAQRRKKQL EERCRVEESI GNAVLTWNNE ILPNWETMWC SRKVRDLWWQ 
       410        420        430        440        450
GIPPSVRGKV WSLAIGNELN ITHELFDICL ARAKERWRSL STGGSEVENE 
       460        470        480        490        500
DAGFSAADRE ASLELIKLDI SRTFPNLCIF QQGGPYHDML HSILGAYTCY 
       510        520        530        540        550
RPDVGYVQGM SFIAAVLILN LDTADAFIAF SNLLNKPCQM AFFRVDHGLM 
       560        570        580        590        600
LTYFAAFEVF FEENLPKLFA HFKKNNLTPD IYLIDWIFTL YSKSLPLDLA 
       610        620        630        640        650
CRIWDVFCRD GEEFLFRTAL GILKLFEDIL TKMDFIHMAQ FLTRLPEDLP 
       660        670        680        690 
AEELFASIAT IQMQSRNKKW AQVLTALQKD SREMEKGSPS LRH

Length:693

Mass (Da):78,137

Last modified:February 26, 2008 - v3

Checksum:ⁱ6E1332D236DE45BD

Isoform 2 (identifier: Q9P2M4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-280: Missing.
281-281: K → M

« Hide

        10         20         30         40         50
MEYEDKAGRP SKPPSPKQNV RKNLDFEPLS TTALILEDRP ANLPAKPAEE 
        60         70         80         90        100
AQKHRQQYEE MVVQAKKREL KEAQRRKKQL EERCRVEESI GNAVLTWNNE 
       110        120        130        140        150
ILPNWETMWC SRKVRDLWWQ GIPPSVRGKV WSLAIGNELN ITHELFDICL 
       160        170        180        190        200
ARAKERWRSL STGGSEVENE DAGFSAADRE ASLELIKLDI SRTFPNLCIF 
       210        220        230        240        250
QQGGPYHDML HSILGAYTCY RPDVGYVQGM SFIAAVLILN LDTADAFIAF 
       260        270        280        290        300
SNLLNKPCQM AFFRVDHGLM LTYFAAFEVF FEENLPKLFA HFKKNNLTPD 
       310        320        330        340        350
IYLIDWIFTL YSKSLPLDLA CRIWDVFCRD GEEFLFRTAL GILKLFEDIL 
       360        370        380        390        400
TKMDFIHMAQ FLTRLPEDLP AEELFASIAT IQMQSRNKKW AQVLTALQKD 
       410 
SREMEKGSPS LRH

Note: No experimental confirmation available.

Show »

Length:413

Mass (Da):47,691

Checksum:ⁱE3BF0E3B0730079C

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B9A071	B9A071_HUMAN	TBC1 domain family member 14 TBC1 domain family member 14	TBC1D14	465	Annotation score:
F5GXK4	F5GXK4_HUMAN	TBC1 domain family member 14 TBC1 domain family member 14	TBC1D14	353	Annotation score:
H7BZD7	H7BZD7_HUMAN	TBC1 domain family member 14 TBC1 domain family member 14	TBC1D14	200	Annotation score:
C9JP26	C9JP26_HUMAN	TBC1 domain family member 14 TBC1 domain family member 14	TBC1D14	127	Annotation score:
C9J541	C9J541_HUMAN	TBC1 domain family member 14 TBC1 domain family member 14	TBC1D14	56	Annotation score:

Sequence cautionⁱ

The sequence AAH41167 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAA92560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_067442	41	L → V2 PublicationsCorresponds to variant dbSNP:rs34860182Ensembl.		1
Natural variantⁱVAR_059856	446	E → Q. Corresponds to variant dbSNP:rs11731231Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041460	1 – 280	Missing in isoform 2. CuratedAdd BLAST		280
Alternative sequenceⁱVSP_041461	281	K → M in isoform 2. Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB449900 mRNA Translation: BAH16643.1 AB037743 mRNA Translation: BAA92560.1 Different initiation. AC092463 Genomic DNA No translation available. AC097382 Genomic DNA No translation available. AC106045 Genomic DNA No translation available. CH471131 Genomic DNA Translation: EAW82375.1 CH471131 Genomic DNA Translation: EAW82376.1 CH471131 Genomic DNA Translation: EAW82377.1 BC041167 mRNA Translation: AAH41167.1 Different initiation. AL833868 mRNA Translation: CAD38726.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3394.2 [Q9P2M4-1] CCDS47006.1 [Q9P2M4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001106832.1, NM_001113361.1 [Q9P2M4-1] NP_001106834.1, NM_001113363.1 [Q9P2M4-2] NP_001273734.1, NM_001286805.1 NP_001317567.1, NM_001330638.1 NP_065824.2, NM_020773.2 [Q9P2M4-1] XP_006713958.1, XM_006713895.2 [Q9P2M4-1]
UniGeneⁱ	Hs.518611

Genome annotation databases

Ensemblⁱ	ENST00000409757; ENSP00000386921; ENSG00000132405 [Q9P2M4-1] ENST00000448507; ENSP00000404041; ENSG00000132405 [Q9P2M4-1] ENST00000451522; ENSP00000388886; ENSG00000132405 [Q9P2M4-2]
GeneIDⁱ	57533
KEGGⁱ	hsa:57533
UCSC genome browser More...UCSCⁱ	uc003gjs.5 human [Q9P2M4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P2M4	TBC1 domain family member 14		MYODS		773	UniRef90_Q9P2M4
TBC1 domain family member 14		PANTR		693
Uncharacterized protein		PANPA		693
TBC1 domain family member 14 isoform a		CALJA		693
TBC1 domain family member 14		SAIBB		693
+35
Q9P2M4-2	KIAA1322		MOUSE		413	UniRef90_Q76LY3
Uncharacterized protein		MACMU		495
TBC1 domain family member 14 isoform A		ALLMI		413
TBC1 domain family member 14 isoform X4		ALLSI		413
TBC1 domain family member 14 isoform A		Patagioenas fasciata monilis		413
+86

Protein	Similar proteins		Species	Score	Length	Source
Q9P2M4	TBC1 domain family member 14		BOVIN		692	UniRef50_Q9P2M4
TBC1 domain family member 14		MOUSE		694
TBC1 domain family member 14		RAT		694
TBC1 domain family member 14		MYODS		773
Uncharacterized protein		AILME		693
+170
Q9P2M4-2	KIAA1322		MOUSE		413	UniRef50_Q76LY3
Uncharacterized protein		MACMU		495
TBC1 domain family member 14		RAT		413
TBC1 domain family member 14		PANTR		413
TBC1D14 isoform 6		PONAB		413
+88

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB449900 mRNA Translation: BAH16643.1 AB037743 mRNA Translation: BAA92560.1 Different initiation. AC092463 Genomic DNA No translation available. AC097382 Genomic DNA No translation available. AC106045 Genomic DNA No translation available. CH471131 Genomic DNA Translation: EAW82375.1 CH471131 Genomic DNA Translation: EAW82376.1 CH471131 Genomic DNA Translation: EAW82377.1 BC041167 mRNA Translation: AAH41167.1 Different initiation. AL833868 mRNA Translation: CAD38726.1
CCDSⁱ	CCDS3394.2 [Q9P2M4-1] CCDS47006.1 [Q9P2M4-2]
RefSeqⁱ	NP_001106832.1, NM_001113361.1 [Q9P2M4-1] NP_001106834.1, NM_001113363.1 [Q9P2M4-2] NP_001273734.1, NM_001286805.1 NP_001317567.1, NM_001330638.1 NP_065824.2, NM_020773.2 [Q9P2M4-1] XP_006713958.1, XM_006713895.2 [Q9P2M4-1]
UniGeneⁱ	Hs.518611

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2QQ8	X-ray	2.00	A	372-687	[»]
ProteinModelPortalⁱ	Q9P2M4
SMRⁱ	Q9P2M4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121592, 26 interactors
IntActⁱ	Q9P2M4, 16 interactors
MINTⁱ	Q9P2M4
STRINGⁱ	9606.ENSP00000386921

PTM databases

iPTMnetⁱ	Q9P2M4
PhosphoSitePlusⁱ	Q9P2M4

Polymorphism and mutation databases

BioMutaⁱ	TBC1D14
DMDMⁱ	172044690

Proteomic databases

EPDⁱ	Q9P2M4
MaxQBⁱ	Q9P2M4
PaxDbⁱ	Q9P2M4
PeptideAtlasⁱ	Q9P2M4
PRIDEⁱ	Q9P2M4
ProteomicsDBⁱ	83847 83848 [Q9P2M4-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000409757; ENSP00000386921; ENSG00000132405 [Q9P2M4-1] ENST00000448507; ENSP00000404041; ENSG00000132405 [Q9P2M4-1] ENST00000451522; ENSP00000388886; ENSG00000132405 [Q9P2M4-2]
GeneIDⁱ	57533
KEGGⁱ	hsa:57533
UCSCⁱ	uc003gjs.5 human [Q9P2M4-1]

Organism-specific databases

CTDⁱ	57533
DisGeNETⁱ	57533
EuPathDBⁱ	HostDB:ENSG00000132405.18
GeneCardsⁱ	TBC1D14
HGNCⁱ	HGNC:29246 TBC1D14
HPAⁱ	HPA036930 HPA067398
MIMⁱ	614855 gene
neXtProtⁱ	NX_Q9P2M4
OpenTargetsⁱ	ENSG00000132405
PharmGKBⁱ	PA128394697
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2223 Eukaryota COG5210 LUCA
GeneTreeⁱ	ENSGT00750000117238
HOGENOMⁱ	HOG000016604
HOVERGENⁱ	HBG061665
InParanoidⁱ	Q9P2M4
KOⁱ	K20167
OMAⁱ	EYEDKAG
OrthoDBⁱ	EOG091G09QI
PhylomeDBⁱ	Q9P2M4
TreeFamⁱ	TF313318

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854214 TBC/RABGAPs

Reactomeⁱ

R-HSA-8854214 TBC/RABGAPs

Miscellaneous databases

ChiTaRSⁱ	TBC1D14 human
EvolutionaryTraceⁱ	Q9P2M4
GenomeRNAiⁱ	57533
Protein Ontology More...PROⁱ	PR:Q9P2M4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000132405 Expressed in 200 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_TBC1D14
ExpressionAtlasⁱ	Q9P2M4 baseline and differential
Genevisibleⁱ	Q9P2M4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000195 Rab-GTPase-TBC_dom IPR035969 Rab-GTPase_TBC_sf
Pfamⁱ	View protein in Pfam PF00566 RabGAP-TBC, 1 hit
SMARTⁱ	View protein in SMART SM00164 TBC, 1 hit
SUPFAMⁱ	SSF47923 SSF47923, 2 hits
PROSITEⁱ	View protein in PROSITE PS50086 TBC_RABGAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TBC14_HUMAN
Accessionⁱ	Q9P2M4Primary (citable) accession number: Q9P2M4 Secondary accession number(s): B9A6L5 , D3DVT4, E9PAZ6, Q8IW15, Q8NDK3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 21, 2004
	Last sequence update:	February 26, 2008
	Last modified:	September 12, 2018
	This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9P2M4 (TBC14_HUMAN)

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TBC1 domain family member 14

TBC1D14

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Cytosol

Endosome

Golgi apparatus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ