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Protein

TBC1 domain family member 14

Gene

TBC1D14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of starvation-induced autophagosome formation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • protein kinase binding Source: BHF-UCL
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8854214 TBC/RABGAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D14
Synonyms:KIAA1322
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000132405.18

Human Gene Nomenclature Database

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HGNCi
HGNC:29246 TBC1D14

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614855 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9P2M4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi472R → A: Loss of inhibition of autophagosome formation; when associated with A-508. 1 Publication1
Mutagenesisi508Q → A: Loss of inhibition of autophagosome formation; when associated with A-472. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
57533

Open Targets

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OpenTargetsi
ENSG00000132405

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA128394697

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TBC1D14

Domain mapping of disease mutations (DMDM)

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DMDMi
172044690

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002080401 – 693TBC1 domain family member 14Add BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei91PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9P2M4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9P2M4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9P2M4

PeptideAtlas

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PeptideAtlasi
Q9P2M4

PRoteomics IDEntifications database

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PRIDEi
Q9P2M4

ProteomicsDB human proteome resource

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ProteomicsDBi
83847
83848 [Q9P2M4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9P2M4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9P2M4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000132405 Expressed in 200 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_TBC1D14

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9P2M4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9P2M4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036930
HPA067398

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ULK1. May interact with RAB11A and RAB11B, but does not exhibit any GTPase-activating activity toward these proteins.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121592, 26 interactors

Protein interaction database and analysis system

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IntActi
Q9P2M4, 16 interactors

Molecular INTeraction database

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MINTi
Q9P2M4

STRING: functional protein association networks

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STRINGi
9606.ENSP00000386921

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1693
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9P2M4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9P2M4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9P2M4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini401 – 611Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST211

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2223 Eukaryota
COG5210 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157250

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000016604

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG061665

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9P2M4

KEGG Orthology (KO)

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KOi
K20167

Identification of Orthologs from Complete Genome Data

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OMAi
PERACQS

Database of Orthologous Groups

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OrthoDBi
EOG091G09QI

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9P2M4

TreeFam database of animal gene trees

More...
TreeFami
TF313318

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2M4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDGKLSTST NGVAFMGILD GRPGNPLQNL QHVNLKAPRL LSAPEYGPKL
60 70 80 90 100
KLRALEDRHS LQSVDSGIPT LEIGNPEPVP CSAVHVRRKQ SDSDLIPERA
110 120 130 140 150
FQSACALPSC APPAPSSTER EQSVRKSSTF PRTGYDSVKL YSPTSKALTR
160 170 180 190 200
SDDVSVCSVS SLGTELSTTL SVSNEDILDL VVTSSSSAIV TLENDDDPQF
210 220 230 240 250
TNVTLSSIKE TRGLHQQDCV HEAEEGSKLK ILGPFSNFFA RNLLARKQSA
260 270 280 290 300
RLDKHNDLGW KLFGKAPLRE NAQKDSKRIQ KEYEDKAGRP SKPPSPKQNV
310 320 330 340 350
RKNLDFEPLS TTALILEDRP ANLPAKPAEE AQKHRQQYEE MVVQAKKREL
360 370 380 390 400
KEAQRRKKQL EERCRVEESI GNAVLTWNNE ILPNWETMWC SRKVRDLWWQ
410 420 430 440 450
GIPPSVRGKV WSLAIGNELN ITHELFDICL ARAKERWRSL STGGSEVENE
460 470 480 490 500
DAGFSAADRE ASLELIKLDI SRTFPNLCIF QQGGPYHDML HSILGAYTCY
510 520 530 540 550
RPDVGYVQGM SFIAAVLILN LDTADAFIAF SNLLNKPCQM AFFRVDHGLM
560 570 580 590 600
LTYFAAFEVF FEENLPKLFA HFKKNNLTPD IYLIDWIFTL YSKSLPLDLA
610 620 630 640 650
CRIWDVFCRD GEEFLFRTAL GILKLFEDIL TKMDFIHMAQ FLTRLPEDLP
660 670 680 690
AEELFASIAT IQMQSRNKKW AQVLTALQKD SREMEKGSPS LRH
Length:693
Mass (Da):78,137
Last modified:February 26, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E1332D236DE45BD
GO
Isoform 2 (identifier: Q9P2M4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-280: Missing.
     281-281: K → M

Note: No experimental confirmation available.
Show »
Length:413
Mass (Da):47,691
Checksum:iE3BF0E3B0730079C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9A071B9A071_HUMAN
TBC1 domain family member 14
TBC1D14
465Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXK4F5GXK4_HUMAN
TBC1 domain family member 14
TBC1D14
353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZD7H7BZD7_HUMAN
TBC1 domain family member 14
TBC1D14
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JP26C9JP26_HUMAN
TBC1 domain family member 14
TBC1D14
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J541C9J541_HUMAN
TBC1 domain family member 14
TBC1D14
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH41167 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA92560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06744241L → V2 PublicationsCorresponds to variant dbSNP:rs34860182Ensembl.1
Natural variantiVAR_059856446E → Q. Corresponds to variant dbSNP:rs11731231Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0414601 – 280Missing in isoform 2. CuratedAdd BLAST280
Alternative sequenceiVSP_041461281K → M in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB449900 mRNA Translation: BAH16643.1
AB037743 mRNA Translation: BAA92560.1 Different initiation.
AC092463 Genomic DNA No translation available.
AC097382 Genomic DNA No translation available.
AC106045 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82375.1
CH471131 Genomic DNA Translation: EAW82376.1
CH471131 Genomic DNA Translation: EAW82377.1
BC041167 mRNA Translation: AAH41167.1 Different initiation.
AL833868 mRNA Translation: CAD38726.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3394.2 [Q9P2M4-1]
CCDS47006.1 [Q9P2M4-2]

NCBI Reference Sequences

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RefSeqi
NP_001106832.1, NM_001113361.1 [Q9P2M4-1]
NP_001106834.1, NM_001113363.1 [Q9P2M4-2]
NP_001273734.1, NM_001286805.1
NP_001317567.1, NM_001330638.1
NP_065824.2, NM_020773.2 [Q9P2M4-1]
XP_006713958.1, XM_006713895.2 [Q9P2M4-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.518611

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000409757; ENSP00000386921; ENSG00000132405 [Q9P2M4-1]
ENST00000448507; ENSP00000404041; ENSG00000132405 [Q9P2M4-1]
ENST00000451522; ENSP00000388886; ENSG00000132405 [Q9P2M4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57533

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57533

UCSC genome browser

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UCSCi
uc003gjs.5 human [Q9P2M4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449900 mRNA Translation: BAH16643.1
AB037743 mRNA Translation: BAA92560.1 Different initiation.
AC092463 Genomic DNA No translation available.
AC097382 Genomic DNA No translation available.
AC106045 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82375.1
CH471131 Genomic DNA Translation: EAW82376.1
CH471131 Genomic DNA Translation: EAW82377.1
BC041167 mRNA Translation: AAH41167.1 Different initiation.
AL833868 mRNA Translation: CAD38726.1
CCDSiCCDS3394.2 [Q9P2M4-1]
CCDS47006.1 [Q9P2M4-2]
RefSeqiNP_001106832.1, NM_001113361.1 [Q9P2M4-1]
NP_001106834.1, NM_001113363.1 [Q9P2M4-2]
NP_001273734.1, NM_001286805.1
NP_001317567.1, NM_001330638.1
NP_065824.2, NM_020773.2 [Q9P2M4-1]
XP_006713958.1, XM_006713895.2 [Q9P2M4-1]
UniGeneiHs.518611

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QQ8X-ray2.00A372-687[»]
ProteinModelPortaliQ9P2M4
SMRiQ9P2M4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121592, 26 interactors
IntActiQ9P2M4, 16 interactors
MINTiQ9P2M4
STRINGi9606.ENSP00000386921

PTM databases

iPTMnetiQ9P2M4
PhosphoSitePlusiQ9P2M4

Polymorphism and mutation databases

BioMutaiTBC1D14
DMDMi172044690

Proteomic databases

EPDiQ9P2M4
MaxQBiQ9P2M4
PaxDbiQ9P2M4
PeptideAtlasiQ9P2M4
PRIDEiQ9P2M4
ProteomicsDBi83847
83848 [Q9P2M4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409757; ENSP00000386921; ENSG00000132405 [Q9P2M4-1]
ENST00000448507; ENSP00000404041; ENSG00000132405 [Q9P2M4-1]
ENST00000451522; ENSP00000388886; ENSG00000132405 [Q9P2M4-2]
GeneIDi57533
KEGGihsa:57533
UCSCiuc003gjs.5 human [Q9P2M4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57533
DisGeNETi57533
EuPathDBiHostDB:ENSG00000132405.18

GeneCards: human genes, protein and diseases

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GeneCardsi
TBC1D14
HGNCiHGNC:29246 TBC1D14
HPAiHPA036930
HPA067398
MIMi614855 gene
neXtProtiNX_Q9P2M4
OpenTargetsiENSG00000132405
PharmGKBiPA128394697

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2223 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00940000157250
HOGENOMiHOG000016604
HOVERGENiHBG061665
InParanoidiQ9P2M4
KOiK20167
OMAiPERACQS
OrthoDBiEOG091G09QI
PhylomeDBiQ9P2M4
TreeFamiTF313318

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TBC1D14 human
EvolutionaryTraceiQ9P2M4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57533

Protein Ontology

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PROi
PR:Q9P2M4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000132405 Expressed in 200 organ(s), highest expression level in secondary oocyte
CleanExiHS_TBC1D14
ExpressionAtlasiQ9P2M4 baseline and differential
GenevisibleiQ9P2M4 HS

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBC14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2M4
Secondary accession number(s): B9A6L5
, D3DVT4, E9PAZ6, Q8IW15, Q8NDK3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: February 26, 2008
Last modified: December 5, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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