UniProtKB - Q9P2M1 (LR2BP_HUMAN)
Protein
LRP2-binding protein
Gene
LRP2BP
Organism
Homo sapiens (Human)
Status
Functioni
May act as an adapter that regulates LRP2 function.
Enzyme and pathway databases
PathwayCommonsi | Q9P2M1 |
Names & Taxonomyi
Protein namesi | Recommended name: LRP2-binding proteinAlternative name(s): Megalin-binding protein Short name: MegBP |
Gene namesi | Name:LRP2BP Synonyms:KIAA1325 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000109771.15 |
HGNCi | HGNC:25434, LRP2BP |
neXtProti | NX_Q9P2M1 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 55805 |
OpenTargetsi | ENSG00000109771 |
PharmGKBi | PA142671538 |
Miscellaneous databases
Pharosi | Q9P2M1, Tdark |
Polymorphism and mutation databases
BioMutai | LRP2BP |
DMDMi | 166199159 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315707 | 1 – 347 | LRP2-binding proteinAdd BLAST | 347 |
Proteomic databases
MassIVEi | Q9P2M1 |
PaxDbi | Q9P2M1 |
PeptideAtlasi | Q9P2M1 |
PRIDEi | Q9P2M1 |
ProteomicsDBi | 83845 [Q9P2M1-1] 83846 [Q9P2M1-2] |
PTM databases
iPTMneti | Q9P2M1 |
PhosphoSitePlusi | Q9P2M1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000109771, Expressed in adenohypophysis and 136 other tissues |
ExpressionAtlasi | Q9P2M1, baseline and differential |
Genevisiblei | Q9P2M1, HS |
Organism-specific databases
HPAi | ENSG00000109771, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Interacts with LRP2.
1 PublicationBinary interactionsi
Hide detailsQ9P2M1
Protein-protein interaction databases
BioGRIDi | 120916, 20 interactors |
IntActi | Q9P2M1, 20 interactors |
STRINGi | 9606.ENSP00000332681 |
Miscellaneous databases
RNActi | Q9P2M1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 59 – 92 | TPRAdd BLAST | 34 | |
Repeati | 93 – 125 | Sel1-like 1Add BLAST | 33 | |
Repeati | 133 – 168 | Sel1-like 2Add BLAST | 36 | |
Repeati | 173 – 206 | Sel1-like 3Add BLAST | 34 | |
Repeati | 207 – 242 | Sel1-like 4Add BLAST | 36 | |
Repeati | 243 – 277 | Sel1-like 5Add BLAST | 35 | |
Repeati | 297 – 332 | Sel1-like 6Add BLAST | 36 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1550, Eukaryota |
GeneTreei | ENSGT00390000013490 |
InParanoidi | Q9P2M1 |
OMAi | DHYTHAN |
OrthoDBi | 1039341at2759 |
PhylomeDBi | Q9P2M1 |
TreeFami | TF315257 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR006597, Sel1-like IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF08238, Sel1, 5 hits |
SMARTi | View protein in SMART SM00671, SEL1, 5 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 1 hit PS50293, TPR_REGION, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P2M1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKLTSEKLPK NPFYASVSQY AAKNQKFFQW KKEKTDYTHA NLVDKALQLL
60 70 80 90 100
KERILKGDTL AYFLRGQLYF EEGWYEEALE QFEEIKEKDH QATYQLGVMY
110 120 130 140 150
YDGLGTTLDA EKGVDYMKKI LDSPCPKARH LKFAAAYNLG RAYYEGKGVK
160 170 180 190 200
RSNEEAERLW LIAADNGNPK ASVKAQSMLG LYYSTKEPKE LEKAFYWHSE
210 220 230 240 250
ACGNGNLESQ GALGLMYLYG QGIRQDTEAA LQCLREAAER GNVYAQGNLV
260 270 280 290 300
EYYYKMKFFT KCVAFSKRIA DYDEVHDIPM IAQVTDCLPE FIGRGMAMAS
310 320 330 340
FYHARCLQLG LGITRDETTA KHYYSKACRL NPALADELHS LLIRQRI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9Z9 | G5E9Z9_HUMAN | LRP2 binding protein, isoform CRA_a | LRP2BP hCG_16628 | 321 | Annotation score: | ||
D6RGF6 | D6RGF6_HUMAN | LRP2-binding protein | LRP2BP | 153 | Annotation score: |
Sequence cautioni
The sequence BAA92563 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030664 | 35 | T → TKS in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037746 mRNA Translation: BAA92563.1 Different initiation. AK126913 mRNA Translation: BAG54395.1 AL161975 mRNA Translation: CAB82313.2 AC106897 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04650.1 BC150161 mRNA Translation: AAI50162.1 BC152444 mRNA Translation: AAI52445.1 |
CCDSi | CCDS3840.1 [Q9P2M1-1] |
PIRi | T47138 |
RefSeqi | NP_060879.2, NM_018409.3 [Q9P2M1-1] XP_006714323.1, XM_006714260.3 XP_016863899.1, XM_017008410.1 [Q9P2M1-1] |
Genome annotation databases
Ensembli | ENST00000328559; ENSP00000332681; ENSG00000109771 [Q9P2M1-1] ENST00000505916; ENSP00000426203; ENSG00000109771 [Q9P2M1-1] |
GeneIDi | 55805 |
KEGGi | hsa:55805 |
UCSCi | uc003ixj.3, human [Q9P2M1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037746 mRNA Translation: BAA92563.1 Different initiation. AK126913 mRNA Translation: BAG54395.1 AL161975 mRNA Translation: CAB82313.2 AC106897 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04650.1 BC150161 mRNA Translation: AAI50162.1 BC152444 mRNA Translation: AAI52445.1 |
CCDSi | CCDS3840.1 [Q9P2M1-1] |
PIRi | T47138 |
RefSeqi | NP_060879.2, NM_018409.3 [Q9P2M1-1] XP_006714323.1, XM_006714260.3 XP_016863899.1, XM_017008410.1 [Q9P2M1-1] |
3D structure databases
SMRi | Q9P2M1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120916, 20 interactors |
IntActi | Q9P2M1, 20 interactors |
STRINGi | 9606.ENSP00000332681 |
PTM databases
iPTMneti | Q9P2M1 |
PhosphoSitePlusi | Q9P2M1 |
Polymorphism and mutation databases
BioMutai | LRP2BP |
DMDMi | 166199159 |
Proteomic databases
MassIVEi | Q9P2M1 |
PaxDbi | Q9P2M1 |
PeptideAtlasi | Q9P2M1 |
PRIDEi | Q9P2M1 |
ProteomicsDBi | 83845 [Q9P2M1-1] 83846 [Q9P2M1-2] |
Protocols and materials databases
Antibodypediai | 28937, 64 antibodies |
Genome annotation databases
Ensembli | ENST00000328559; ENSP00000332681; ENSG00000109771 [Q9P2M1-1] ENST00000505916; ENSP00000426203; ENSG00000109771 [Q9P2M1-1] |
GeneIDi | 55805 |
KEGGi | hsa:55805 |
UCSCi | uc003ixj.3, human [Q9P2M1-1] |
Organism-specific databases
CTDi | 55805 |
DisGeNETi | 55805 |
EuPathDBi | HostDB:ENSG00000109771.15 |
GeneCardsi | LRP2BP |
HGNCi | HGNC:25434, LRP2BP |
HPAi | ENSG00000109771, Tissue enhanced (testis) |
neXtProti | NX_Q9P2M1 |
OpenTargetsi | ENSG00000109771 |
PharmGKBi | PA142671538 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1550, Eukaryota |
GeneTreei | ENSGT00390000013490 |
InParanoidi | Q9P2M1 |
OMAi | DHYTHAN |
OrthoDBi | 1039341at2759 |
PhylomeDBi | Q9P2M1 |
TreeFami | TF315257 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2M1 |
Miscellaneous databases
BioGRID-ORCSi | 55805, 2 hits in 843 CRISPR screens |
GenomeRNAii | 55805 |
Pharosi | Q9P2M1, Tdark |
PROi | PR:Q9P2M1 |
RNActi | Q9P2M1, protein |
Gene expression databases
Bgeei | ENSG00000109771, Expressed in adenohypophysis and 136 other tissues |
ExpressionAtlasi | Q9P2M1, baseline and differential |
Genevisiblei | Q9P2M1, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR006597, Sel1-like IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF08238, Sel1, 5 hits |
SMARTi | View protein in SMART SM00671, SEL1, 5 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 1 hit PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LR2BP_HUMAN | |
Accessioni | Q9P2M1Primary (citable) accession number: Q9P2M1 Secondary accession number(s): A6NJR7 Q9NSN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM