UniProtKB - Q9P2K8 (E2AK4_HUMAN)

BLAST

>sp|Q9P2K8|E2AK4_HUMAN eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3
MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
DEIYNIKVEKKVSVLFLYSYRDDYYRILF

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History
Entry version 163 (12 Sep 2018)
Sequence version 3 (18 May 2010)
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Protein

eIF-2-alpha kinase GCN2

Gene

EIF2AK4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity).By similarity2 Publications

(Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4⁺ and CD8⁺ T-cells under amino acid starvation (PubMed:24310610).1 Publication

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	619	ATPPROSITE-ProRule annotation		1
Active siteⁱ	848	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	596 – 604	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
eukaryotic translation initiation factor 2alpha kinase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25329545
protein serine/threonine kinase activity Source: UniProtKB
tRNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
cell cycle arrest Source: UniProtKB-KW
cellular response to amino acid starvation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25329545
cellular response to cold
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25329545
cellular response to leucine starvation Source: UniProtKB
cellular response to UV Source: UniProtKB
defense response to virus Source: UniProtKB-KW
DNA damage checkpoint Source: InterPro
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25329545
induction by virus of host autophagy Source: UniProtKB
learning Source: UniProtKB
long-term memory Source: UniProtKB
negative regulation by host of viral genome replication Source: UniProtKB
negative regulation of CREB transcription factor activity Source: UniProtKB
negative regulation of neuron differentiation Source: UniProtKB
negative regulation of translational initiation Source: UniProtKB
negative regulation of translational initiation in response to stress Source: UniProtKB
neuron projection extension Source: UniProtKB
positive regulation of adaptive immune response Source: UniProtKB
positive regulation of defense response to virus by host Source: UniProtKB
positive regulation of long-term synaptic potentiation Source: UniProtKB
positive regulation of translational initiation in response to starvation Source: UniProtKB
protein autophosphorylation Source: UniProtKB
protein phosphorylation Source: UniProtKB
regulation of eIF2 alpha phosphorylation by amino acid starvation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26102367
regulation of feeding behavior Source: UniProtKB
regulation of translational initiation Source: UniProtKB
regulation of translational initiation by eIF2 alpha phosphorylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26102367
T cell activation involved in immune response Source: UniProtKB
viral translation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase, tRNA-binding
Biological process	Activation of host autophagy by virus, Adaptive immunity, Antiviral defense, Cell cycle, Growth arrest, Host-virus interaction, Immunity, Neurogenesis, Stress response, Translation regulation
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q9P2K8
SIGNORⁱ	Q9P2K8

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: eIF-2-alpha kinase GCN2By similarity (EC:2.7.11.1By similarity) Alternative name(s): Eukaryotic translation initiation factor 2-alpha kinase 4Imported GCN2-like protein
Gene namesⁱ	Name:EIF2AK4Imported Synonyms:GCN2, KIAA1338
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128829.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19687 EIF2AK4
MIMⁱ	609280 gene
neXtProtⁱ	NX_Q9P2K8

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Pulmonary venoocclusive disease 2, autosomal recessive (PVOD2)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by widespread fibrous obstruction and intimal thickening of septal veins and preseptal venules, a low diffusing capacity for carbon monoxide, occult alveolar hemorrhage, and nodular ground-glass opacities, septal lines and lymph node enlargement showed by high-resolution computed tomography of the chest. It is frequently associated with pulmonary capillary dilatation and proliferation, and is a rare and devastating cause of pulmonary hypertension.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_070990	585	R → Q in PVOD2. 1 PublicationCorresponds to variant dbSNP:rs587777106EnsemblClinVar.		1
Natural variantⁱVAR_070991	643	L → R in PVOD2. 1 PublicationCorresponds to variant dbSNP:rs757852728EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	440275
MalaCards human disease database More...MalaCardsⁱ	EIF2AK4
MIMⁱ	234810 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000128829
Orphanetⁱ	199241 Pulmonary capillary hemangiomatosis 31837 Pulmonary venoocclusive disease
PharmGKBⁱ	PA134947616

Chemistry databases

ChEMBLⁱ	CHEMBL5358
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2018

Polymorphism and mutation databases

BioMutaⁱ	EIF2AK4
DMDMⁱ	296439368

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085947	1 – 1649	eIF-2-alpha kinase GCN2Add BLAST		1649

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	230	PhosphoserineCombined sources	1
Modified residueⁱ	667	PhosphothreonineCombined sources	1
Modified residueⁱ	871	PhosphothreonineCombined sources	1
Modified residueⁱ	899	Phosphothreonine; by autocatalysisBy similarity	1
Modified residueⁱ	904	Phosphothreonine; by autocatalysisBy similarity	1
Modified residueⁱ	1259	N6-acetyllysineCombined sources	1

Post-translational modificationⁱ

Autophosphorylated; autophosphorylation on Thr-899 is increased upon amino acid starvation and in UV irradiation cells and inhibited in presence of IMPACT.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9P2K8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P2K8
PaxDbⁱ	Q9P2K8
PeptideAtlas More...PeptideAtlasⁱ	Q9P2K8
PRIDEⁱ	Q9P2K8
ProteomicsDBⁱ	83838 83839 [Q9P2K8-2] 83840 [Q9P2K8-3]

PTM databases

iPTMnetⁱ	Q9P2K8
PhosphoSitePlusⁱ	Q9P2K8

Expressionⁱ

Tissue specificityⁱ

Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000128829 Expressed in 202 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_EIF2AK4
ExpressionAtlasⁱ	Q9P2K8 baseline and differential
Genevisibleⁱ	Q9P2K8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA011811

HPAⁱ

HPA011811

Interactionⁱ

Subunit structureⁱ

Homodimer; homodimerization is important for kinase activation by uncharged tRNAs. Interacts with GCN1; this interaction stimulates EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Interacts with DNAJC3; this interaction inhibits EIF2AK4/GCN2 kinase activity during endoplasmic reticulum (ER), hypothermic and amino acid-starving stress conditions.By similarity

Protein-protein interaction databases

BioGridⁱ	136426, 26 interactors
IntActⁱ	Q9P2K8, 20 interactors
STRINGⁱ	9606.ENSP00000263791

Chemistry databases

BindingDBⁱ

Q9P2K8

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P2K8
SMRⁱ	Q9P2K8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	25 – 137	RWDPROSITE-ProRule annotationAdd BLAST	113
Domainⁱ	296 – 539	Protein kinase 1PROSITE-ProRule annotationAdd BLAST	244
Domainⁱ	590 – 1001	Protein kinase 2PROSITE-ProRule annotationAdd BLAST	412

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1022 – 1493	Histidyl-tRNA synthetase-likeAdd BLAST		472

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	146 – 205	Sequence analysisAdd BLAST		60

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	484 – 491	Poly-Leu		8

Domainⁱ

The histidyl-tRNA synthetase-like region and protein kinase domains are necessary for eIF-2-alpha kinase activity and eIF-2-alpha-mediated translational control. The histidyl-tRNA synthetase-like domain is necessary for binding to uncharged tRNAs. Kinase domain 1 is a degenerate kinase domain.By similarity

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG1035 Eukaryota COG0124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062984
HOVERGENⁱ	HBG051432
InParanoidⁱ	Q9P2K8
KEGG Orthology (KO) More...KOⁱ	K16196
OMAⁱ	KCVCLDD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NNL
PhylomeDBⁱ	Q9P2K8
TreeFamⁱ	TF101512

Family and domain databases

Gene3Dⁱ	3.10.110.10, 1 hit 3.40.50.800, 1 hit
InterProⁱ	View protein in InterPro IPR036621 Anticodon-bd_dom_sf IPR016255 Gcn2 IPR024435 HisRS-related_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR006575 RWD-domain IPR008271 Ser/Thr_kinase_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12745 HGTP_anticodon2, 1 hit PF00069 Pkinase, 3 hits PF05773 RWD, 1 hit
PIRSFⁱ	PIRSF000660 Ser/Thr_PK_GCN2, 1 hit
SMARTⁱ	View protein in SMART SM00591 RWD, 1 hit SM00220 S_TKc, 2 hits
SUPFAMⁱ	SSF54495 SSF54495, 1 hit SSF56112 SSF56112, 3 hits
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 2 hits PS00108 PROTEIN_KINASE_ST, 1 hit PS50908 RWD, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9P2K8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGRGAPGR GRDEPPESYP QRQDHELQAL EAIYGADFQD LRPDACGPVK 
        60         70         80         90        100
EPPEINLVLY PQGLTGEEVY VKVDLRVKCP PTYPDVVPEI ELKNAKGLSN 
       110        120        130        140        150
ESVNLLKSRL EELAKKHCGE VMIFELAYHV QSFLSEHNKP PPKSFHEEML 
       160        170        180        190        200
ERRAQEEQQR LLEAKRKEEQ EQREILHEIQ RRKEEIKEEK KRKEMAKQER 
       210        220        230        240        250
LEIASLSNQD HTSKKDPGGH RTAAILHGGS PDFVGNGKHR ANSSGRSRRE 
       260        270        280        290        300
RQYSVCNSED SPGSCEILYF NMGSPDQLMV HKGKCIGSDE QLGKLVYNAL 
       310        320        330        340        350
ETATGGFVLL YEWVLQWQKK MGPFLTSQEK EKIDKCKKQI QGTETEFNSL 
       360        370        380        390        400
VKLSHPNVVR YLAMNLKEQD DSIVVDILVE HISGVSLAAH LSHSGPIPVH 
       410        420        430        440        450
QLRRYTAQLL SGLDYLHSNS VVHKVLSASN VLVDAEGTVK ITDYSISKRL 
       460        470        480        490        500
ADICKEDVFE QTRVRFSDNA LPYKTGKKGD VWRLGLLLLS LSQGQECGEY 
       510        520        530        540        550
PVTIPSDLPA DFQDFLKKCV CLDDKERWSP QQLLKHSFIN PQPKMPLVEQ 
       560        570        580        590        600
SPEDSEGQDY VETVIPSNRL PSAAFFSETQ RQFSRYFIEF EELQLLGKGA 
       610        620        630        640        650
FGAVIKVQNK LDGCCYAVKR IPINPASRQF RRIKGEVTLL SRLHHENIVR 
       660        670        680        690        700
YYNAWIERHE RPAGPGTPPP DSGPLAKDDR AARGQPASDT DGLDSVEAAA 
       710        720        730        740        750
PPPILSSSVE WSTSGERSAS ARFPATGPGS SDDEDDDEDE HGGVFSQSFL 
       760        770        780        790        800
PASDSESDII FDNEDENSKS QNQDEDCNEK NGCHESEPSV TTEAVHYLYI 
       810        820        830        840        850
QMEYCEKSTL RDTIDQGLYR DTVRLWRLFR EILDGLAYIH EKGMIHRDLK 
       860        870        880        890        900
PVNIFLDSDD HVKIGDFGLA TDHLAFSADS KQDDQTGDLI KSDPSGHLTG 
       910        920        930        940        950
MVGTALYVSP EVQGSTKSAY NQKVDLFSLG IIFFEMSYHP MVTASERIFV 
       960        970        980        990       1000
LNQLRDPTSP KFPEDFDDGE HAKQKSVISW LLNHDPAKRP TATELLKSEL 
      1010       1020       1030       1040       1050
LPPPQMEESE LHEVLHHTLT NVDGKAYRTM MAQIFSQRIS PAIDYTYDSD 
      1060       1070       1080       1090       1100
ILKGNFSIRT AKMQQHVCET IIRIFKRHGA VQLCTPLLLP RNRQIYEHNE 
      1110       1120       1130       1140       1150
AALFMDHSGM LVMLPFDLRI PFARYVARNN ILNLKRYCIE RVFRPRKLDR 
      1160       1170       1180       1190       1200
FHPKELLECA FDIVTSTTNS FLPTAEIIYT IYEIIQEFPA LQERNYSIYL 
      1210       1220       1230       1240       1250
NHTMLLKAIL LHCGIPEDKL SQVYIILYDA VTEKLTRREV EAKFCNLSLS 
      1260       1270       1280       1290       1300
SNSLCRLYKF IEQKGDLQDL MPTINSLIKQ KTGIAQLVKY GLKDLEEVVG 
      1310       1320       1330       1340       1350
LLKKLGIKLQ VLINLGLVYK VQQHNGIIFQ FVAFIKRRQR AVPEILAAGG 
      1360       1370       1380       1390       1400
RYDLLIPQFR GPQALGPVPT AIGVSIAIDK ISAAVLNMEE SVTISSCDLL 
      1410       1420       1430       1440       1450
VVSVGQMSMS RAINLTQKLW TAGITAEIMY DWSQSQEELQ EYCRHHEITY 
      1460       1470       1480       1490       1500
VALVSDKEGS HVKVKSFEKE RQTEKRVLET ELVDHVLQKL RTKVTDERNG 
      1510       1520       1530       1540       1550
REASDNLAVQ NLKGSFSNAS GLFEIHGATV VPIVSVLAPE KLSASTRRRY 
      1560       1570       1580       1590       1600
ETQVQTRLQT SLANLHQKSS EIEILAVDLP KETILQFLSL EWDADEQAFN 
      1610       1620       1630       1640 
TTVKQLLSRL PKQRYLKLVC DEIYNIKVEK KVSVLFLYSY RDDYYRILF

Length:1,649

Mass (Da):186,911

Last modified:May 18, 2010 - v3

Checksum:ⁱECF3CFFA51AEE67C

Isoform 2 (identifier: Q9P2K8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
774-801: Missing.

« Hide

        10         20         30         40         50
MAGGRGAPGR GRDEPPESYP QRQDHELQAL EAIYGADFQD LRPDACGPVK 
        60         70         80         90        100
EPPEINLVLY PQGLTGEEVY VKVDLRVKCP PTYPDVVPEI ELKNAKGLSN 
       110        120        130        140        150
ESVNLLKSRL EELAKKHCGE VMIFELAYHV QSFLSEHNKP PPKSFHEEML 
       160        170        180        190        200
ERRAQEEQQR LLEAKRKEEQ EQREILHEIQ RRKEEIKEEK KRKEMAKQER 
       210        220        230        240        250
LEIASLSNQD HTSKKDPGGH RTAAILHGGS PDFVGNGKHR ANSSGRSRRE 
       260        270        280        290        300
RQYSVCNSED SPGSCEILYF NMGSPDQLMV HKGKCIGSDE QLGKLVYNAL 
       310        320        330        340        350
ETATGGFVLL YEWVLQWQKK MGPFLTSQEK EKIDKCKKQI QGTETEFNSL 
       360        370        380        390        400
VKLSHPNVVR YLAMNLKEQD DSIVVDILVE HISGVSLAAH LSHSGPIPVH 
       410        420        430        440        450
QLRRYTAQLL SGLDYLHSNS VVHKVLSASN VLVDAEGTVK ITDYSISKRL 
       460        470        480        490        500
ADICKEDVFE QTRVRFSDNA LPYKTGKKGD VWRLGLLLLS LSQGQECGEY 
       510        520        530        540        550
PVTIPSDLPA DFQDFLKKCV CLDDKERWSP QQLLKHSFIN PQPKMPLVEQ 
       560        570        580        590        600
SPEDSEGQDY VETVIPSNRL PSAAFFSETQ RQFSRYFIEF EELQLLGKGA 
       610        620        630        640        650
FGAVIKVQNK LDGCCYAVKR IPINPASRQF RRIKGEVTLL SRLHHENIVR 
       660        670        680        690        700
YYNAWIERHE RPAGPGTPPP DSGPLAKDDR AARGQPASDT DGLDSVEAAA 
       710        720        730        740        750
PPPILSSSVE WSTSGERSAS ARFPATGPGS SDDEDDDEDE HGGVFSQSFL 
       760        770        780        790        800
PASDSESDII FDNEDENSKS QNQMEYCEKS TLRDTIDQGL YRDTVRLWRL 
       810        820        830        840        850
FREILDGLAY IHEKGMIHRD LKPVNIFLDS DDHVKIGDFG LATDHLAFSA 
       860        870        880        890        900
DSKQDDQTGD LIKSDPSGHL TGMVGTALYV SPEVQGSTKS AYNQKVDLFS 
       910        920        930        940        950
LGIIFFEMSY HPMVTASERI FVLNQLRDPT SPKFPEDFDD GEHAKQKSVI 
       960        970        980        990       1000
SWLLNHDPAK RPTATELLKS ELLPPPQMEE SELHEVLHHT LTNVDGKAYR 
      1010       1020       1030       1040       1050
TMMAQIFSQR ISPAIDYTYD SDILKGNFSI RTAKMQQHVC ETIIRIFKRH 
      1060       1070       1080       1090       1100
GAVQLCTPLL LPRNRQIYEH NEAALFMDHS GMLVMLPFDL RIPFARYVAR 
      1110       1120       1130       1140       1150
NNILNLKRYC IERVFRPRKL DRFHPKELLE CAFDIVTSTT NSFLPTAEII 
      1160       1170       1180       1190       1200
YTIYEIIQEF PALQERNYSI YLNHTMLLKA ILLHCGIPED KLSQVYIILY 
      1210       1220       1230       1240       1250
DAVTEKLTRR EVEAKFCNLS LSSNSLCRLY KFIEQKGDLQ DLMPTINSLI 
      1260       1270       1280       1290       1300
KQKTGIAQLV KYGLKDLEEV VGLLKKLGIK LQVLINLGLV YKVQQHNGII 
      1310       1320       1330       1340       1350
FQFVAFIKRR QRAVPEILAA GGRYDLLIPQ FRGPQALGPV PTAIGVSIAI 
      1360       1370       1380       1390       1400
DKISAAVLNM EESVTISSCD LLVVSVGQMS MSRAINLTQK LWTAGITAEI 
      1410       1420       1430       1440       1450
MYDWSQSQEE LQEYCRHHEI TYVALVSDKE GSHVKVKSFE KERQTEKRVL 
      1460       1470       1480       1490       1500
ETELVDHVLQ KLRTKVTDER NGREASDNLA VQNLKGSFSN ASGLFEIHGA 
      1510       1520       1530       1540       1550
TVVPIVSVLA PEKLSASTRR RYETQVQTRL QTSLANLHQK SSEIEILAVD 
      1560       1570       1580       1590       1600
LPKETILQFL SLEWDADEQA FNTTVKQLLS RLPKQRYLKL VCDEIYNIKV 
      1610       1620 
EKKVSVLFLY SYRDDYYRIL F

Note: No experimental confirmation available.

Show »

Length:1,621

Mass (Da):183,717

Checksum:ⁱ40B21FA4D721C758

Isoform 3 (identifier: Q9P2K8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
608-616: QNKLDGCCY → WYRVIPSPL
617-1649: Missing.

« Hide

        10         20         30         40         50
MAGGRGAPGR GRDEPPESYP QRQDHELQAL EAIYGADFQD LRPDACGPVK 
        60         70         80         90        100
EPPEINLVLY PQGLTGEEVY VKVDLRVKCP PTYPDVVPEI ELKNAKGLSN 
       110        120        130        140        150
ESVNLLKSRL EELAKKHCGE VMIFELAYHV QSFLSEHNKP PPKSFHEEML 
       160        170        180        190        200
ERRAQEEQQR LLEAKRKEEQ EQREILHEIQ RRKEEIKEEK KRKEMAKQER 
       210        220        230        240        250
LEIASLSNQD HTSKKDPGGH RTAAILHGGS PDFVGNGKHR ANSSGRSRRE 
       260        270        280        290        300
RQYSVCNSED SPGSCEILYF NMGSPDQLMV HKGKCIGSDE QLGKLVYNAL 
       310        320        330        340        350
ETATGGFVLL YEWVLQWQKK MGPFLTSQEK EKIDKCKKQI QGTETEFNSL 
       360        370        380        390        400
VKLSHPNVVR YLAMNLKEQD DSIVVDILVE HISGVSLAAH LSHSGPIPVH 
       410        420        430        440        450
QLRRYTAQLL SGLDYLHSNS VVHKVLSASN VLVDAEGTVK ITDYSISKRL 
       460        470        480        490        500
ADICKEDVFE QTRVRFSDNA LPYKTGKKGD VWRLGLLLLS LSQGQECGEY 
       510        520        530        540        550
PVTIPSDLPA DFQDFLKKCV CLDDKERWSP QQLLKHSFIN PQPKMPLVEQ 
       560        570        580        590        600
SPEDSEGQDY VETVIPSNRL PSAAFFSETQ RQFSRYFIEF EELQLLGKGA 
       610 
FGAVIKVWYR VIPSPL

Note: No experimental confirmation available.

Show »

Length:616

Mass (Da):69,797

Checksum:ⁱCBFF2B4F683C5DB3

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YME5	H0YME5_HUMAN	eIF-2-alpha kinase GCN2 eIF-2-alpha kinase GCN2	EIF2AK4	1,427	Annotation score:
H0YND8	H0YND8_HUMAN	eIF-2-alpha kinase GCN2 eIF-2-alpha kinase GCN2	EIF2AK4	136	Annotation score:
H0YNY9	H0YNY9_HUMAN	eIF-2-alpha kinase GCN2 eIF-2-alpha kinase GCN2	EIF2AK4	80	Annotation score:

Sequence cautionⁱ

The sequence BAA92576 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

The sequence BAB15625 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	556	E → G in BAA92576 (PubMed:10718198).Curated	1
Sequence conflictⁱ	556	E → G in CAH10626 (PubMed:17974005).Curated	1
Sequence conflictⁱ	629	Q → K in CAH10626 (PubMed:17974005).Curated	1
Sequence conflictⁱ	858	S → F in BAB15625 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1133	N → I in CAB58360 (PubMed:10504407).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040479	137	H → R1 PublicationCorresponds to variant dbSNP:rs35509999Ensembl.	1
Natural variantⁱVAR_040480	166	R → W1 PublicationCorresponds to variant dbSNP:rs34439704Ensembl.	1
Natural variantⁱVAR_040481	441	I → L2 PublicationsCorresponds to variant dbSNP:rs2291627EnsemblClinVar.	1
Natural variantⁱVAR_070990	585	R → Q in PVOD2. 1 PublicationCorresponds to variant dbSNP:rs587777106EnsemblClinVar.	1
Natural variantⁱVAR_070991	643	L → R in PVOD2. 1 PublicationCorresponds to variant dbSNP:rs757852728EnsemblClinVar.	1
Natural variantⁱVAR_040482	872	D → V1 PublicationCorresponds to variant dbSNP:rs34665481Ensembl.	1
Natural variantⁱVAR_040483	939	H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040484	1060	T → R1 PublicationCorresponds to variant dbSNP:rs55781333Ensembl.	1
Natural variantⁱVAR_040485	1306	G → C2 PublicationsCorresponds to variant dbSNP:rs35602605EnsemblClinVar.	1
Natural variantⁱVAR_040486	1336	K → R1 PublicationCorresponds to variant dbSNP:rs35480871Ensembl.	1
Natural variantⁱVAR_040487	1406	Q → H1 PublicationCorresponds to variant dbSNP:rs55721315EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_039185	608 – 616	QNKLDGCCY → WYRVIPSPL in isoform 3. 1 Publication	9
Alternative sequenceⁱVSP_039186	617 – 1649	Missing in isoform 3. 1 PublicationAdd BLAST	1033
Alternative sequenceⁱVSP_013038	774 – 801	Missing in isoform 2. CuratedAdd BLAST	28

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC012377 Genomic DNA No translation available. AC025168 Genomic DNA No translation available. BC009350 mRNA Translation: AAH09350.2 BC078179 mRNA Translation: AAH78179.1 AB037759 mRNA Translation: BAA92576.1 Sequence problems. AL137627 mRNA Translation: CAB70849.1 AL157497 mRNA Translation: CAB75678.1 AL832907 mRNA Translation: CAH10626.1 AK027011 mRNA Translation: BAB15625.1 Different initiation. AJ243428 mRNA Translation: CAB58360.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42016.1 [Q9P2K8-1]
PIRⁱ	T46924
NCBI Reference Sequences More...RefSeqⁱ	NP_001013725.2, NM_001013703.3 [Q9P2K8-1]
UniGeneⁱ	Hs.656673

Genome annotation databases

Ensemblⁱ	ENST00000263791; ENSP00000263791; ENSG00000128829 [Q9P2K8-1] ENST00000559624; ENSP00000453148; ENSG00000128829 [Q9P2K8-3]
GeneIDⁱ	440275
KEGGⁱ	hsa:440275
UCSC genome browser More...UCSCⁱ	uc001zkl.4 human [Q9P2K8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P2K8	eIF-2-alpha kinase GCN2	)	MOUSE		1648	UniRef90_Q9QZ05
eIF-2-alpha kinase GCN2		RAT		1649
Uncharacterized protein		PANPA		1734
eukaryotic translation initiation factor 2-alpha kinase 4		TARSY		1710
eIF-2-alpha kinase GCN2 isoform X1		PHYCD		1664
+177
Q9P2K8-2	EIF2AK4 isoform 2		PANTR		1621	UniRef90_Q9P2K8-2
Uncharacterized protein		PIG		1610
EIF2AK4 isoform 6 (Fragment)		PONAB		1573
eIF-2-alpha kinase GCN2 (Fragment)		HUMAN		1427
UPI0005F4BD2B		MANLE		1500
+1
Q9P2K8-3	Eukaryotic translation initiation factor 2-alpha kinase 4 (Fragment)		MACMU		687	UniRef90_Q9P2K8-3
EIF2AK4 isoform 1		PANTR		616
EIF2AK4 isoform 1		PONAB		616
UPI00075FB8A6		MACFA		595

Protein	Similar proteins		Species	Score	Length	Source
Q9P2K8	eIF-2-alpha kinase GCN2	)	MOUSE		1648	UniRef50_Q9QZ05
eIF-2-alpha kinase GCN2		RAT		1649
Uncharacterized protein		PANPA		1734
eukaryotic translation initiation factor 2-alpha kinase 4		TARSY		1710
eIF-2-alpha kinase GCN2 isoform X1		PHYCD		1664
+542
Q9P2K8-2	EIF2AK4 isoform 2		PANTR		1621	UniRef50_Q9P2K8-2
Uncharacterized protein		PIG		1610
EIF2AK4 isoform 6 (Fragment)		PONAB		1573
eIF-2-alpha kinase GCN2 (Fragment)		HUMAN		1427
eIF-2-alpha kinase GCN2 isoform X5		Florida manatee		1418
+34
Q9P2K8-3	Isoform 6 of eIF-2-alpha kinase GCN2		MOUSE		532	UniRef50_Q9QZ05-6
EIF2AK4 isoform 1		PANTR		616
Eukaryotic translation initiation factor 2-alpha kinase 4 (Fragment)		MACMU		687
EIF2AK4 isoform 1		PONAB		616
Uncharacterized protein		LEPOC		623
+4

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC012377 Genomic DNA No translation available. AC025168 Genomic DNA No translation available. BC009350 mRNA Translation: AAH09350.2 BC078179 mRNA Translation: AAH78179.1 AB037759 mRNA Translation: BAA92576.1 Sequence problems. AL137627 mRNA Translation: CAB70849.1 AL157497 mRNA Translation: CAB75678.1 AL832907 mRNA Translation: CAH10626.1 AK027011 mRNA Translation: BAB15625.1 Different initiation. AJ243428 mRNA Translation: CAB58360.1
CCDSⁱ	CCDS42016.1 [Q9P2K8-1]
PIRⁱ	T46924
RefSeqⁱ	NP_001013725.2, NM_001013703.3 [Q9P2K8-1]
UniGeneⁱ	Hs.656673

3D structure databases

ProteinModelPortalⁱ	Q9P2K8
SMRⁱ	Q9P2K8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	136426, 26 interactors
IntActⁱ	Q9P2K8, 20 interactors
STRINGⁱ	9606.ENSP00000263791

Chemistry databases

BindingDBⁱ	Q9P2K8
ChEMBLⁱ	CHEMBL5358
GuidetoPHARMACOLOGYⁱ	2018

PTM databases

iPTMnetⁱ	Q9P2K8
PhosphoSitePlusⁱ	Q9P2K8

Polymorphism and mutation databases

BioMutaⁱ	EIF2AK4
DMDMⁱ	296439368

Proteomic databases

EPDⁱ	Q9P2K8
MaxQBⁱ	Q9P2K8
PaxDbⁱ	Q9P2K8
PeptideAtlasⁱ	Q9P2K8
PRIDEⁱ	Q9P2K8
ProteomicsDBⁱ	83838 83839 [Q9P2K8-2] 83840 [Q9P2K8-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	440275
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263791; ENSP00000263791; ENSG00000128829 [Q9P2K8-1] ENST00000559624; ENSP00000453148; ENSG00000128829 [Q9P2K8-3]
GeneIDⁱ	440275
KEGGⁱ	hsa:440275
UCSCⁱ	uc001zkl.4 human [Q9P2K8-1]

Organism-specific databases

CTDⁱ	440275
DisGeNETⁱ	440275
EuPathDBⁱ	HostDB:ENSG00000128829.11
GeneCardsⁱ	EIF2AK4
H-InvDBⁱ	HIX0012119
HGNCⁱ	HGNC:19687 EIF2AK4
HPAⁱ	HPA011811
MalaCardsⁱ	EIF2AK4
MIMⁱ	234810 phenotype 609280 gene
neXtProtⁱ	NX_Q9P2K8
OpenTargetsⁱ	ENSG00000128829
Orphanetⁱ	199241 Pulmonary capillary hemangiomatosis 31837 Pulmonary venoocclusive disease
PharmGKBⁱ	PA134947616
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1035 Eukaryota COG0124 LUCA
GeneTreeⁱ	ENSGT00530000062984
HOVERGENⁱ	HBG051432
InParanoidⁱ	Q9P2K8
KOⁱ	K16196
OMAⁱ	KCVCLDD
OrthoDBⁱ	EOG091G0NNL
PhylomeDBⁱ	Q9P2K8
TreeFamⁱ	TF101512

Enzyme and pathway databases

SignaLinkⁱ	Q9P2K8
SIGNORⁱ	Q9P2K8

Miscellaneous databases

ChiTaRSⁱ	EIF2AK4 human
GeneWikiⁱ	EIF2AK4
GenomeRNAiⁱ	440275
Protein Ontology More...PROⁱ	PR:Q9P2K8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128829 Expressed in 202 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_EIF2AK4
ExpressionAtlasⁱ	Q9P2K8 baseline and differential
Genevisibleⁱ	Q9P2K8 HS

Family and domain databases

Gene3Dⁱ	3.10.110.10, 1 hit 3.40.50.800, 1 hit
InterProⁱ	View protein in InterPro IPR036621 Anticodon-bd_dom_sf IPR016255 Gcn2 IPR024435 HisRS-related_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR006575 RWD-domain IPR008271 Ser/Thr_kinase_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfamⁱ	View protein in Pfam PF12745 HGTP_anticodon2, 1 hit PF00069 Pkinase, 3 hits PF05773 RWD, 1 hit
PIRSFⁱ	PIRSF000660 Ser/Thr_PK_GCN2, 1 hit
SMARTⁱ	View protein in SMART SM00591 RWD, 1 hit SM00220 S_TKc, 2 hits
SUPFAMⁱ	SSF54495 SSF54495, 1 hit SSF56112 SSF56112, 3 hits
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 2 hits PS00108 PROTEIN_KINASE_ST, 1 hit PS50908 RWD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E2AK4_HUMAN
Accessionⁱ	Q9P2K8Primary (citable) accession number: Q9P2K8 Secondary accession number(s): C9JEC4 Q9UJ56
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9P2K8 (E2AK4_HUMAN)

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eIF-2-alpha kinase GCN2

EIF2AK4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

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Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Region

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Chemistry databases

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Proteomic databases

Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ