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Protein

Kelch-like protein 42

Gene

KLHL42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • post-translational protein modification Source: Reactome
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
  • protein polyubiquitination Source: UniProtKB
  • regulation of microtubule-based process Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 42
Alternative name(s):
Cullin-3-binding protein 9
Short name:
Ctb9
Kelch domain-containing protein 5
Gene namesi
Name:KLHL42
Synonyms:KIAA1340, KLHDC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000087448.9
HGNCiHGNC:29252 KLHL42
neXtProtiNX_Q9P2K6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi57542
OpenTargetsiENSG00000087448
PharmGKBiPA142671579

Polymorphism and mutation databases

BioMutaiKLHL42
DMDMi84028217

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191281 – 505Kelch-like protein 42Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P2K6
MaxQBiQ9P2K6
PaxDbiQ9P2K6
PeptideAtlasiQ9P2K6
PRIDEiQ9P2K6
ProteomicsDBi83837

PTM databases

iPTMnetiQ9P2K6
PhosphoSitePlusiQ9P2K6

Expressioni

Inductioni

Up-regulated during mitosis.1 Publication

Gene expression databases

BgeeiENSG00000087448 Expressed in 203 organ(s), highest expression level in medial globus pallidus
CleanExiHS_KLHDC5
ExpressionAtlasiQ9P2K6 baseline and differential
GenevisibleiQ9P2K6 HS

Organism-specific databases

HPAiHPA020979

Interactioni

Subunit structurei

Component of the BCR(KLHL42) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL42. Interacts (via the BTB domain) with CUL3. Interacts (via the kelch domains) with KATNA1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi121601, 52 interactors
IntActiQ9P2K6, 34 interactors
STRINGi9606.ENSP00000370671

Structurei

3D structure databases

ProteinModelPortaliQ9P2K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 78BTBPROSITE-ProRule annotationAdd BLAST74
Repeati176 – 234Kelch 1Add BLAST59
Repeati235 – 282Kelch 2Add BLAST48
Repeati284 – 325Kelch 3Add BLAST42
Repeati327 – 372Kelch 4Add BLAST46
Repeati374 – 429Kelch 5Add BLAST56
Repeati431 – 480Kelch 6Add BLAST50

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00900000140914
HOGENOMiHOG000060089
HOVERGENiHBG052263
InParanoidiQ9P2K6
OMAiTCTLHND
OrthoDBiEOG091G06AG
PhylomeDBiQ9P2K6
TreeFamiTF328485

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF01344 Kelch_1, 2 hits
SMARTiView protein in SMART
SM00612 Kelch, 3 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9P2K6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAEEMVQIR LEDRCYPVSK RKLIEQSDYF RALYRSGMRE ALSQEAGGPE
60 70 80 90 100
VQQLRGLSAP GLRLVLDFIN AGGAREGWLL GPRGEKGGGV DEDEEMDEVS
110 120 130 140 150
LLSELVEAAS FLQVTSLLQL LLSQVRLNNC LEMYRLAQVY GLPDLQEACL
160 170 180 190 200
RFMVVHFHEV LCKPQFHLLG SPPQAPGDVS LKQRLREARM TGTPVLVALG
210 220 230 240 250
DFLGGPLAPH PYQGEPPSML RYEEMTERWF PLANNLPPDL VNVRGYGSAI
260 270 280 290 300
LDNYLFIVGG YRITSQEISA AHSYNPSTNE WLQVASMNQK RSNFKLVAVN
310 320 330 340 350
SKLYAIGGQA VSNVECYNPE QDAWNFVAPL PNPLAEFSAC ECKGKIYVIG
360 370 380 390 400
GYTTRDRNMN ILQYCPSSDM WTLFETCDVH IRKQQMVSVE ETIYIVGGCL
410 420 430 440 450
HELGPNRRSS QSEDMLTVQS YNTVTRQWLY LKENTSKSGL NLTCALHNDG
460 470 480 490 500
IYIMSRDVTL STSLEHRVFL KYNIFSDSWE AFRRFPAFGH NLLVSSLYLP

NKAET
Length:505
Mass (Da):56,868
Last modified:December 20, 2005 - v2
Checksum:i999DF22ED3A546ED
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H523F5H523_HUMAN
Kelch-like protein 42
KLHL42
369Annotation score:
H0YGN2H0YGN2_HUMAN
Kelch-like protein 42
KLHL42
179Annotation score:

Sequence cautioni

The sequence AAH28742 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009511 Genomic DNA No translation available.
BC108669 mRNA Translation: AAI08670.1
BC028742 mRNA Translation: AAH28742.2 Different initiation.
AB037761 mRNA Translation: BAA92578.1
CCDSiCCDS31763.1
RefSeqiNP_065833.1, NM_020782.1
UniGeneiHs.505104

Genome annotation databases

EnsembliENST00000381271; ENSP00000370671; ENSG00000087448
GeneIDi57542
KEGGihsa:57542
UCSCiuc001rij.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009511 Genomic DNA No translation available.
BC108669 mRNA Translation: AAI08670.1
BC028742 mRNA Translation: AAH28742.2 Different initiation.
AB037761 mRNA Translation: BAA92578.1
CCDSiCCDS31763.1
RefSeqiNP_065833.1, NM_020782.1
UniGeneiHs.505104

3D structure databases

ProteinModelPortaliQ9P2K6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121601, 52 interactors
IntActiQ9P2K6, 34 interactors
STRINGi9606.ENSP00000370671

PTM databases

iPTMnetiQ9P2K6
PhosphoSitePlusiQ9P2K6

Polymorphism and mutation databases

BioMutaiKLHL42
DMDMi84028217

Proteomic databases

EPDiQ9P2K6
MaxQBiQ9P2K6
PaxDbiQ9P2K6
PeptideAtlasiQ9P2K6
PRIDEiQ9P2K6
ProteomicsDBi83837

Protocols and materials databases

DNASUi57542
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381271; ENSP00000370671; ENSG00000087448
GeneIDi57542
KEGGihsa:57542
UCSCiuc001rij.4 human

Organism-specific databases

CTDi57542
DisGeNETi57542
EuPathDBiHostDB:ENSG00000087448.9
GeneCardsiKLHL42
HGNCiHGNC:29252 KLHL42
HPAiHPA020979
neXtProtiNX_Q9P2K6
OpenTargetsiENSG00000087448
PharmGKBiPA142671579
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00900000140914
HOGENOMiHOG000060089
HOVERGENiHBG052263
InParanoidiQ9P2K6
OMAiTCTLHND
OrthoDBiEOG091G06AG
PhylomeDBiQ9P2K6
TreeFamiTF328485

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiKLHL42 human
GenomeRNAii57542
PROiPR:Q9P2K6

Gene expression databases

BgeeiENSG00000087448 Expressed in 203 organ(s), highest expression level in medial globus pallidus
CleanExiHS_KLHDC5
ExpressionAtlasiQ9P2K6 baseline and differential
GenevisibleiQ9P2K6 HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF01344 Kelch_1, 2 hits
SMARTiView protein in SMART
SM00612 Kelch, 3 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLH42_HUMAN
AccessioniPrimary (citable) accession number: Q9P2K6
Secondary accession number(s): Q2VPK1, Q8N334
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: December 20, 2005
Last modified: September 12, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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